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  1. Article ; Online: Insights into pediatric multi-system inflammatory syndrome and COVID-19.

    Bar-Or, David / Rael, Leonard T / Brody, Edward N

    Clinica chimica acta; international journal of clinical chemistry

    2020  Volume 510, Page(s) 121–122

    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/therapy ; Cytokines/antagonists & inhibitors ; Cytokines/blood ; Humans ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Serum Albumin, Human/administration & dosage ; Syndrome ; Systemic Inflammatory Response Syndrome/blood ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/therapy
    Chemical Substances Cytokines ; Serum Albumin, Human (ZIF514RVZR)
    Keywords covid19
    Language English
    Publishing date 2020-07-14
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2020.07.025
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  3. Article ; Online: Insights into pediatric multi-system inflammatory syndrome and COVID-19

    Bar-Or, David / Rael, Leonard T. / Brody, Edward N.

    Clinica Chimica Acta

    2020  Volume 510, Page(s) 121–122

    Keywords Clinical Biochemistry ; Biochemistry ; Biochemistry, medical ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2020.07.025
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Use of Saline as a Placebo in Intra-articular Injections in Osteoarthritis: Potential Contributions to Nociceptive Pain Relief.

    Bar-Or, David / Rael, Leonard T / Brody, Edward N

    The open rheumatology journal

    2017  Volume 11, Page(s) 16–22

    Abstract: Background: Osteoarthritis of the knee (OAK) is a severe debilitating condition characterized by joint pain, stiffness, and resultant limited mobility. In recent years, intra-articular (IA) injections have been used to relieve symptoms and have ... ...

    Abstract Background: Osteoarthritis of the knee (OAK) is a severe debilitating condition characterized by joint pain, stiffness, and resultant limited mobility. In recent years, intra-articular (IA) injections have been used to relieve symptoms and have succeeded to varying degrees either with sodium hyaluronate preparations or with a biologic.
    Objective: The objective of this review is to evaluate multiple studies that demonstrate some relief from the symptoms of OAK in the saline arm of various clinical trials.
    Method: A thorough literature search (PubMed) was performed assessing the pain efficacy of various compounds compared to saline injections in clinical trials. A total of 73 studies were identified in the literature search including a total of 5,816 patients. These clinical trials all involved the IA injection of a viscosupplement (hyaluronate, platelet rich plasma (PRP),
    Results: Based on our review of the current literature, the tested compounds performed with mixed results when compared to saline injections. Moreover, OAK is a variable disease, with severity measured on the Kellgren and Lawrence (KL) scale where various hyaluronate preparations have a therapeutic effect mostly on KL 2-3 patients while a biologic works best on KL 3-4 patients.
    Conclusion: Since the effect of saline injection is always greater than no treatment, the evaluations of these treatments can be confounded in clinical trials. Therefore, the question of whether there are known therapeutic effects of saline injections might explain these results.
    Language English
    Publishing date 2017-01-31
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2395999-X
    ISSN 1874-3129
    ISSN 1874-3129
    DOI 10.2174/1874312901711010016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Modified nucleotides may have enhanced early RNA catalysis.

    Wolk, Steven K / Mayfield, Wesley S / Gelinas, Amy D / Astling, David / Guillot, Jessica / Brody, Edward N / Janjic, Nebojsa / Gold, Larry

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 15, Page(s) 8236–8242

    Abstract: The modern version of the RNA World Hypothesis begins with activated ribonucleotides condensing (nonenzymatically) to make RNA molecules, some of which possess (perhaps slight) catalytic activity. We propose that noncanonical ribonucleotides, which would ...

    Abstract The modern version of the RNA World Hypothesis begins with activated ribonucleotides condensing (nonenzymatically) to make RNA molecules, some of which possess (perhaps slight) catalytic activity. We propose that noncanonical ribonucleotides, which would have been inevitable under prebiotic conditions, might decrease the RNA length required to have useful catalytic function by allowing short RNAs to possess a more versatile collection of folded motifs. We argue that modified versions of the standard bases, some with features that resemble cofactors, could have facilitated that first moment in which early RNA molecules with catalytic capability began their evolutionary path toward self-replication.
    MeSH term(s) Evolution, Molecular ; RNA/genetics ; RNA/metabolism ; RNA, Catalytic/genetics ; RNA, Catalytic/metabolism ; Ribonucleotides/metabolism
    Chemical Substances RNA, Catalytic ; Ribonucleotides ; RNA (63231-63-0)
    Language English
    Publishing date 2020-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1809041117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  6. Article ; Online: Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease.

    Yang, Joseph / Brody, Edward N / Murthy, Ashwin C / Mehler, Robert E / Weiss, Sophie J / DeLisle, Robert K / Ostroff, Rachel / Williams, Stephen A / Ganz, Peter

    Journal of the American Heart Association

    2020  Volume 9, Issue 15, Page(s) e016463

    Abstract: Background Chronic kidney disease (CKD) confers increased cardiovascular risk, not fully explained by traditional factors. Proteins regulate biological processes and inform the risk of diseases. Thus, in 938 patients with stable coronary heart disease ... ...

    Abstract Background Chronic kidney disease (CKD) confers increased cardiovascular risk, not fully explained by traditional factors. Proteins regulate biological processes and inform the risk of diseases. Thus, in 938 patients with stable coronary heart disease from the Heart and Soul cohort, we quantified 1054 plasma proteins using modified aptamers (SOMAscan) to: (1) discern how reduced glomerular filtration influences the circulating proteome, (2) learn of the importance of kidney function to the prognostic information contained in recently identified protein cardiovascular risk biomarkers, and (3) identify novel and even unique cardiovascular risk biomarkers among individuals with CKD. Methods and Results Plasma protein levels were correlated to estimated glomerular filtration rate (eGFR) using Spearman-rank correlation coefficients. Cox proportional hazard models were used to estimate the association between individual protein levels and the risk of the cardiovascular outcome (first among myocardial infarction, stroke, heart failure hospitalization, or mortality). Seven hundred and nine (67.3%) plasma proteins correlated with eGFR at
    MeSH term(s) Aged ; Biomarkers/blood ; Cohort Studies ; Coronary Disease/blood ; Coronary Disease/complications ; Female ; Glomerular Filtration Rate ; Heart Disease Risk Factors ; Humans ; Male ; Middle Aged ; Proteome ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/complications
    Chemical Substances Biomarkers ; Proteome
    Language English
    Publishing date 2020-07-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.120.016463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Inflammatory Pathways in Knee Osteoarthritis: Potential Targets for Treatment.

    Bar-Or, David / Rael, Leonard T / Thomas, Gregory W / Brody, Edward N

    Current rheumatology reviews

    2015  Volume 11, Issue 1, Page(s) 50–58

    Abstract: Osteoarthritis (OA) of the knee is a wide-spread, debilitating disease that is prominent in Western countries. It is associated with old age, obesity, and mechanical stress on the knee joint. By examining the recent literature on the effect of the anti- ... ...

    Abstract Osteoarthritis (OA) of the knee is a wide-spread, debilitating disease that is prominent in Western countries. It is associated with old age, obesity, and mechanical stress on the knee joint. By examining the recent literature on the effect of the anti-inflammatory prostaglandins 15d-PGJ2 and Δ12-PGJ2, we propose that new therapeutic agents for this disease could facilitate the transition from the COX-2-dependent pro-inflammatory synthesis of the prostaglandin PGE2 (catalyzed by mPGES-1), to the equally COX-2-dependent synthesis of the aforementioned anti-inflammatory prostaglandins. This transition could be instrumental in halting the breakdown of cartilage via matrix metalloproteinases (MMPs) and aggrecanases, as well as promoting the matrix regeneration and synthesis of cartilage by chondrocytes. Another desirable property of new OA therapeutics could involve the recruitment of mesenchymal stem cells to the damaged cartilage and bone, possibly resulting in the generation of chondrocytes, synoviocytes, and, in the case of bone, osteoblasts. Moreover, we propose that research promoting this transition from pro-inflammatory to anti-inflammatory prostaglandins could aid in the identification of new OA therapeutics.
    Language English
    Publishing date 2015
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1875-6360
    ISSN (online) 1875-6360
    DOI 10.2174/1573397111666150522094131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Oxidative stress in severe acute illness.

    Bar-Or, David / Bar-Or, Raphael / Rael, Leonard T / Brody, Edward N

    Redox biology

    2015  Volume 4, Page(s) 340–345

    Abstract: The overall redox potential of a cell is primarily determined by oxidizable/reducible chemical pairs, including glutathione-glutathione disulfide, reduced thioredoxin-oxidized thioredoxin, and NAD(+)-NADH (and NADP-NADPH). Current methods for evaluating ... ...

    Abstract The overall redox potential of a cell is primarily determined by oxidizable/reducible chemical pairs, including glutathione-glutathione disulfide, reduced thioredoxin-oxidized thioredoxin, and NAD(+)-NADH (and NADP-NADPH). Current methods for evaluating oxidative stress rely on detecting levels of individual byproducts of oxidative damage or by determining the total levels or activity of individual antioxidant enzymes. Oxidation-reduction potential (ORP), on the other hand, is an integrated, comprehensive measure of the balance between total (known and unknown) pro-oxidant and antioxidant components in a biological system. Much emphasis has been placed on the role of oxidative stress in chronic diseases, such as Alzheimer's disease and atherosclerosis. The role of oxidative stress in acute diseases often seen in the emergency room and intensive care unit is considerable. New tools for the rapid, inexpensive measurement of both redox potential and total redox capacity should aid in introducing a new body of literature on the role of oxidative stress in acute illness and how to screen and monitor for potentially beneficial pharmacologic agents.
    MeSH term(s) Acute Disease ; Antioxidants/therapeutic use ; Brain Injuries/drug therapy ; Brain Injuries/metabolism ; Brain Injuries/pathology ; Glutathione/metabolism ; Glutathione Peroxidase/metabolism ; Glutathione Reductase/metabolism ; Humans ; Multiple Trauma/drug therapy ; Multiple Trauma/metabolism ; Multiple Trauma/pathology ; Myocardial Infarction/drug therapy ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; NAD/metabolism ; Oxidative Stress ; Reactive Oxygen Species/antagonists & inhibitors ; Reactive Oxygen Species/metabolism ; Sepsis/drug therapy ; Sepsis/metabolism ; Sepsis/pathology ; Stroke/drug therapy ; Stroke/metabolism ; Stroke/pathology ; Superoxide Dismutase/metabolism ; Thioredoxins/metabolism
    Chemical Substances Antioxidants ; Reactive Oxygen Species ; NAD (0U46U6E8UK) ; Thioredoxins (52500-60-4) ; Glutathione Peroxidase (EC 1.11.1.9) ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione Reductase (EC 1.8.1.7) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2015
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2213-2317
    ISSN (online) 2213-2317
    DOI 10.1016/j.redox.2015.01.006
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  9. Article: Photoaptamer chips for clinical diagnostics.

    Gander, Todd R / Brody, Edward N

    Expert review of molecular diagnostics

    2005  Volume 5, Issue 1, Page(s) 1–3

    MeSH term(s) Biomarkers ; Clinical Laboratory Techniques ; Diagnosis ; Electrophoresis, Gel, Two-Dimensional ; Enzyme-Linked Immunosorbent Assay ; Humans ; Male ; Mass Spectrometry ; Organophosphorus Compounds ; Prostatic Neoplasms/diagnosis
    Chemical Substances Biomarkers ; Organophosphorus Compounds ; phosphoramidite
    Language English
    Publishing date 2005-01
    Publishing country England
    Document type Editorial
    ZDB-ID 2112530-2
    ISSN 1744-8352 ; 1473-7159
    ISSN (online) 1744-8352
    ISSN 1473-7159
    DOI 10.1586/14737159.5.1.1
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    Zs.A 6073: Show issues Location:
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  10. Article ; Online: Sepsis, oxidative stress, and hypoxia: Are there clues to better treatment?

    Bar-Or, David / Carrick, Matthew M / Mains, Charles W / Rael, Leonard T / Slone, Denetta / Brody, Edward N

    Redox report : communications in free radical research

    2015  Volume 20, Issue 5, Page(s) 193–197

    Abstract: Sepsis is a clinical syndrome characterized by systemic inflammation, usually in response to infection. The signs and symptoms are very similar to Systemic Inflammatory Response Syndrome (SIRS), which typically occur consequent to trauma and auto-immune ... ...

    Abstract Sepsis is a clinical syndrome characterized by systemic inflammation, usually in response to infection. The signs and symptoms are very similar to Systemic Inflammatory Response Syndrome (SIRS), which typically occur consequent to trauma and auto-immune diseases. Common treatments of sepsis include administration of antibiotics and oxygen. Oxygen is administered due to ischemia in tissues, which results in the production of free radicals. Poor utilization of oxygen by the mitochondrial electron transport chain can increase oxidative stress during ischemia and exacerbate the severity and outcome in septic patients. This course of treatment virtually mimics the conditions seen in ischemia-reperfusion disorders. Therefore, this review proposes that the mechanism of free radical production seen in sepsis and SIRS is identical to the oxidative stress seen in ischemia-reperfusion injury. Specifically, this is due to a biochemical mechanism within the mitochondria where the oxidation of succinate to fumarate by succinate dehydrogenase (complex II) is reversed in sepsis (hypoxia), leading to succinate accumulation. Oxygen administration (equivalent to reperfusion) rapidly oxidizes the accumulated succinate, leading to the generation of large amounts of superoxide radical and other free radical species. Organ damage possibly leading to multi-organ failure could result from this oxidative burst seen in sepsis and SIRS. Accordingly, we postulate that temporal administration with anti-oxidants targeting the mitochondria and/or succinate dehydrogenase inhibitors could be beneficial in sepsis and SIRS patients.
    MeSH term(s) Electron Transport/physiology ; Humans ; Hypoxia/metabolism ; Mitochondria/metabolism ; Oxidative Stress/physiology ; Sepsis/metabolism ; Systemic Inflammatory Response Syndrome/metabolism
    Language English
    Publishing date 2015-03-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1305290-1
    ISSN 1743-2928 ; 1351-0002
    ISSN (online) 1743-2928
    ISSN 1351-0002
    DOI 10.1179/1351000215Y.0000000005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4584: Show issues Location:
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