Article: Tumori stromali gastrointestinali: descrizione di quattro casi clinici e revisione della letteratura.
2008 Volume 29, Issue 1-2, Page(s) 33–37
Abstract: The Authors describe four cases of gastrointestinal stromal tumours (GIST) two of them were localized in the stomach, the others in the ileum. GIST are neoplasms of mesenchymal origin which develop inside the wall of the digestive tract. The most ... ...
Title translation | Gastrointestinal stromal tumors: case reports and review of the literature. |
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Abstract | The Authors describe four cases of gastrointestinal stromal tumours (GIST) two of them were localized in the stomach, the others in the ileum. GIST are neoplasms of mesenchymal origin which develop inside the wall of the digestive tract. The most frequent site is the stomach, followed by the small bowel; less commonly these tumors can affect the oesophagus, the colon and the rectum. GIST originate from precursors of the interstitial cells of Cajal, which are localized in the gastro-intestinal wall and are involved in the regulation of the peristalsis. The treatment is surgical resection. For advanced disease there is a new interesting treatment based on the imatinib, a tyrosine kinase inhibitor. |
MeSH term(s) | Aged ; Aged, 80 and over ; Antineoplastic Agents/therapeutic use ; Benzamides ; Chemotherapy, Adjuvant ; Coiled Bodies ; Digestive System Surgical Procedures ; Female ; Gastrointestinal Stromal Tumors/drug therapy ; Gastrointestinal Stromal Tumors/surgery ; Humans ; Ileal Neoplasms/drug therapy ; Ileal Neoplasms/surgery ; Imatinib Mesylate ; Male ; Middle Aged ; Piperazines/therapeutic use ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Pyrimidines/therapeutic use ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/surgery |
Chemical Substances | Antineoplastic Agents ; Benzamides ; Piperazines ; Pyrimidines ; Imatinib Mesylate (8A1O1M485B) ; Protein-Tyrosine Kinases (EC 2.7.10.1) |
Language | Italian |
Publishing date | 2008-01 |
Publishing country | Italy |
Document type | Case Reports ; English Abstract ; Journal Article ; Review |
ZDB-ID | 605974-0 |
ISSN | 1971-145X ; 0391-9005 |
ISSN (online) | 1971-145X |
ISSN | 0391-9005 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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