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  1. Article: Quantifying population substructure: extending the graph-theoretic approach

    Brooks, C.P

    Ecology. 2006 Apr., v. 87, no. 4

    2006  

    Keywords population structure ; population ecology ; Ustilago violacea ; fungal diseases of plants ; Silene latifolia ; salamanders and newts ; gene flow ; spatial distribution
    Language English
    Dates of publication 2006-04
    Size p. 864-872.
    Document type Article
    ZDB-ID 1797-8
    ISSN 0012-9658
    ISSN 0012-9658
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: A comparative study of Schistosoma mansoni in Tropicorbis havanensis and Australorbis glabratus.

    BROOKS, C P

    The Journal of parasitology

    1953  Volume 39, Issue 2, Page(s) 159–163

    MeSH term(s) Animals ; Biomphalaria ; Schistosoma ; Schistosoma mansoni ; Snails
    Language English
    Publishing date 1953-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 300870-8
    ISSN 1937-2345 ; 0022-3395
    ISSN (online) 1937-2345
    ISSN 0022-3395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Flutamide-associated liver toxicity during treatment with total androgen suppression and radiation therapy for prostate cancer.

    Rosenthal, S A / Linstadt, D E / Leibenhaut, M H / Andras, E J / Brooks, C P / Stickney, D R / Chang, G C / Wolkov, H B / Gilbert, R M

    Radiology

    1996  Volume 199, Issue 2, Page(s) 451–455

    Abstract: Purpose: To examine the frequency and severity of toxicity associated with flutamide inpatients treated with total androgen suppression before and during pelvic radiation therapy (RT) for prostate cancer.: Materials and methods: Sixty-five patients ... ...

    Abstract Purpose: To examine the frequency and severity of toxicity associated with flutamide inpatients treated with total androgen suppression before and during pelvic radiation therapy (RT) for prostate cancer.
    Materials and methods: Sixty-five patients with T2b-T4 prostate cancer received flutamide and goserelin acetate for 4 months, with RT beginning at the 3rd month. Treatment records including liver function test (LFT) results at baseline and during treatment were reviewed and toxicities noted.
    Results: In 30 (46%) of 65 patients, flutamide was discontinued prematurely. Primary reasons included elevation in LFT levels (n=14); gastro-intestinal toxicity (n=9); decreased hemoglobin level (n=2); patient refusal (n=2); and arthralgia, rash, and malaise (n=1 each). Hepatotoxicity generally was manifest as asymptomatic transaminase level elevation. Grade 3-4 hepatotoxicity was noted in four of 65 patients. Mean aspartase aminotransferase increased from 23 (baseline) to 67 U/L (during flutamide treatment) (P<.02); mean alanine aminotransferase level increased from 26 (baseline) to 94 U/L (during flutamide treatment) (P<.005).
    Conclusion: Flutamide toxicity was common. LFTs should be monitored during flutamide therapy. The role of flutamide in this treatment regimen may need to be reevaluated.
    MeSH term(s) Aged ; Alanine Transaminase/blood ; Alkaline Phosphatase/blood ; Androgen Antagonists/adverse effects ; Androgen Antagonists/therapeutic use ; Antineoplastic Agents, Hormonal/therapeutic use ; Aspartate Aminotransferases/blood ; Chemical and Drug Induced Liver Injury/etiology ; Clinical Enzyme Tests ; Cohort Studies ; Combined Modality Therapy ; Flutamide/adverse effects ; Flutamide/therapeutic use ; Gastrointestinal Diseases/chemically induced ; Goserelin/therapeutic use ; Humans ; Liver Function Tests ; Male ; Prospective Studies ; Prostatic Neoplasms/therapy ; Radiotherapy Dosage
    Chemical Substances Androgen Antagonists ; Antineoplastic Agents, Hormonal ; Goserelin (0F65R8P09N) ; Flutamide (76W6J0943E) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; Alkaline Phosphatase (EC 3.1.3.1)
    Language English
    Publishing date 1996-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiology.199.2.8668793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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