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  1. Article ; Online: Synovialt sarkom – en högmalign tumörsjukdom som kan ha egendomligt kliniskt förlopp.

    Brosjö, Otte / Skogman, Roger

    Lakartidningen

    2020  Volume 117

    Abstract: A characteristic feature of soft tissue sarcomas is the absence of alarm symptoms such as pain or abnormal laboratory findings. We present two patients where the diagnostic difficulties delayed the definitive diagnosis, in one case with lethal outcome. ... ...

    Title translation Synovial sarcoma - a rare and highly malignant, tumor with an ambiguous clinical picture at times.
    Abstract A characteristic feature of soft tissue sarcomas is the absence of alarm symptoms such as pain or abnormal laboratory findings. We present two patients where the diagnostic difficulties delayed the definitive diagnosis, in one case with lethal outcome. The two patients highlight the difficulties a clinician may encounter with this particular disease. Even though synovial sarcoma represents around 0,1 % of all cancer forms, we recommend a high degree of awareness and - when in doubt - prompt contact with a Sarcoma center for consultation.
    MeSH term(s) Humans ; Referral and Consultation ; Sarcoma, Synovial/diagnosis ; Soft Tissue Neoplasms/diagnosis
    Language Swedish
    Publishing date 2020-01-16
    Publishing country Sweden
    Document type Case Reports ; Journal Article
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
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    In stock of ZB MED Cologne/Königswinter

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  2. Book: Osteosarcoma and interferon

    Brosjö, Otte

    studies of human xenografts in the nude mouse

    (Acta orthopaedica Scandinavica : Supplementum ; 229)

    1989  

    Author's details Otte Brosjö
    Series title Acta orthopaedica Scandinavica : Supplementum ; 229
    Acta orthopaedica Scandinavica
    Acta orthopaedica Scandinavica ; Supplementum
    Collection Acta orthopaedica Scandinavica
    Acta orthopaedica Scandinavica ; Supplementum
    Keywords Osteosarcoma / transplantation ; Osteosarcoma / drug therapy ; Transplantation, Heterologous ; Mice, Nude ; Osteosarkom ; Interferon ; Nacktmaus ; Maus
    Subject Labormaus ; Weiße Maus ; Nacktmäuse ; Nackte Maus ; Nude mice
    Language English
    Size 36 S. : Ill., graph. Darst.
    Publisher Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book
    HBZ-ID HT003325252
    ISBN 87-16-06446-1 ; 978-87-16-06446-2
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Thesis: Osteosarcoma and interferon

    Brosjö, Otte

    studies of human xenografts in the nude mouse

    1988  

    Size 93 S. : Ill., graph. Darst.
    Publishing country Sweden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Stockholm, Karolinska Inst., Diss., 1988
    HBZ-ID HT003208144
    Database Catalogue ZB MED Medicine, Health

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    88 E 3531 order for loan Magazin

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  4. Article: Preoperative radiotherapy of soft-tissue sarcomas: surgical and radiologic parameters associated with local control and survival.

    Tsagozis, Panagiotis / Brosjö, Otte / Skorpil, Mikael

    Clinical sarcoma research

    2018  Volume 8, Page(s) 19

    Abstract: Background: Preoperative radiotherapy is often used to facilitate excision of soft-tissue sarcomas. We aimed define factors that affect local tumour control and patient survival.: Methods: A single institution registry study of 89 patients with non- ... ...

    Abstract Background: Preoperative radiotherapy is often used to facilitate excision of soft-tissue sarcomas. We aimed define factors that affect local tumour control and patient survival.
    Methods: A single institution registry study of 89 patients with non-metastatic soft-tissue sarcomas having preoperative radiotherapy between 1994 and 2014. Radiologic (presence of peritumoural oedema and volume change following radiotherapy) and histopathologic (tumour volume, grade and surgical margin) parameters were recorded. Outcomes were the events of local recurrence, amputation, metastasis and death.
    Results: Local recurrence rate was low (12%) and marginal excision gave equal local control to wide excision. Pelvic localization was associated with a higher risk for amputation. The absence of peritumoural oedema on MRI defined a subgroup of tumours with more favourable oncologic outcome. Reduction of tumour volume following radiotherapy was also associated with better patient survival. Both these radiologic parameters were associated with lower tumour grade. Tumour necrosis was not significant for patient survival. The local complication rate, mainly wound healing problems and infection, was high (40%), but did not lead to any amputation.
    Conclusion: Preoperative radiotherapy of high-risk soft-tissue sarcomas allows for good local control rate at the expense of local wound complications, which are however manageable. Marginal excision is sufficient for local control. Absence of peritumoural oedema on MRI, as well as tumour size reduction following radiotherapy are associated to superior patient survival and can be used ass early prognostic factors.
    Language English
    Publishing date 2018-10-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2623217-0
    ISSN 2045-3329
    ISSN 2045-3329
    DOI 10.1186/s13569-018-0106-x
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  5. Article: Current Strategies for the Treatment of Aneurysmal Bone Cysts.

    Tsagozis, Panagiotis / Brosjö, Otte

    Orthopedic reviews

    2015  Volume 7, Issue 4, Page(s) 6182

    Abstract: Aneurysmal bone cysts are benign bone tumors that usually present in childhood and early adulthood. They usually manifest as expansile osteolytic lesions with a varying potential to be locally aggressive. Since their first description in 1942, a variety ... ...

    Abstract Aneurysmal bone cysts are benign bone tumors that usually present in childhood and early adulthood. They usually manifest as expansile osteolytic lesions with a varying potential to be locally aggressive. Since their first description in 1942, a variety of treatment methods has been proposed. Traditionally, these tumors were treated with open surgery. Either intralesional surgical procedures or en bloc excisions have been described. Furthermore, a variety of chemical or physical adjuvants has been utilized in order to reduce the risk for local recurrence after excision. Currently, there is a shift to more minimally invasive procedures in order to avoid the complications of open surgical excision. Good results have been reported during percutaneous surgery, or the use of embolization. Recently, sclerotherapy has emerged as a promising treatment, showing effective consolidation of the lesions and functional results that appear to be superior to the ones of open surgery. Lastly, non-invasive treatment, such as pharmaceutical intervention with denosumab or bisphosphonates has been reported to be effective in the management of the disease. Radiotherapy has also been shown to confer good local control, either alone or in conjunction to other treatment modalities, but is associated with serious adverse effects. Here, we review the current literature on the methods of treatment of aneurysmal bone cysts. The indication for each type of treatment along reported outcome of the intervention, as well as potential complications are systematically presented. Our review aims to increase awareness of the different treatment modalities and facilitate decision-making regarding each individual patient.
    Language English
    Publishing date 2015-12-28
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2508171-8
    ISSN 2035-8164 ; 2035-8237
    ISSN (online) 2035-8164
    ISSN 2035-8237
    DOI 10.4081/or.2015.6182
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  6. Article ; Online: Giant hydatid cyst of the pelvis, femur and retroperitoneal space: surgical treatment with extended hemipelvectomy.

    Tsagozis, Panagiotis / Brosjö, Otte

    BMJ case reports

    2015  Volume 2015

    Abstract: Hydatid disease of the bone is a very rare manifestation of the disease, and is often associated with debilitating symptoms. We present a rare case of skeletal hydatidosis in a 56-year-old man who had been misdiagnosed for many years. Massive involvement ...

    Abstract Hydatid disease of the bone is a very rare manifestation of the disease, and is often associated with debilitating symptoms. We present a rare case of skeletal hydatidosis in a 56-year-old man who had been misdiagnosed for many years. Massive involvement of the pelvic bones and soft tissues was evident. An extended hemipelvectomy was performed in order to achieve resection of the affected segments with a clear surgical margin. The patient recovered uneventfully and there are no signs of recurrence of the disease.
    MeSH term(s) Animals ; Echinococcosis/diagnosis ; Echinococcosis/pathology ; Echinococcosis/surgery ; Echinococcus/pathogenicity ; Femur/pathology ; Hemipelvectomy/methods ; Humans ; Male ; Middle Aged ; Pelvis/pathology ; Pelvis/surgery ; Retroperitoneal Space/pathology ; Treatment Outcome
    Language English
    Publishing date 2015-05-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2015-209715
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  7. Article ; Online: Treatment of an aggressive aneurysmal bone cyst with percutaneous injection of polidocanol: a case report.

    Brosjö, Otte / Tsagozis, Panagiotis

    Journal of medical case reports

    2014  Volume 8, Page(s) 450

    Abstract: Introduction: Aneurysmal bone cysts are benign tumours that usually present in childhood. Aggressive forms have been described, which are often treated with surgery that entails major resection and reconstruction. Polidocanol sclerotherapy has recently ... ...

    Abstract Introduction: Aneurysmal bone cysts are benign tumours that usually present in childhood. Aggressive forms have been described, which are often treated with surgery that entails major resection and reconstruction. Polidocanol sclerotherapy has recently been reported to have excellent results and promises to replace operative treatments, but its efficacy in the case of aggressive aneurysmal bone cysts has not been documented.
    Case presentation: An 18-year-old woman from Sweden presented with pain in her shoulder and a rapidly progressing cystic bone lesion. The differential diagnosis was a rare, aggressive form of aneurysmal bone cyst or a sarcoma of the proximal humerus. She was successfully treated using sequential percutaneous injections of polidocanol after exclusion of malignancy.
    Conclusions: Management of aggressive aneurysmal bone cysts has thus far relied on open surgery. We propose that non-operative treatment with polidocanol is efficient even in the aggressive form of the aneurysmal bone cyst.
    MeSH term(s) Adolescent ; Bone Cysts, Aneurysmal/diagnosis ; Bone Cysts, Aneurysmal/drug therapy ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Humans ; Injections ; Joint Diseases/diagnosis ; Joint Diseases/drug therapy ; Magnetic Resonance Imaging ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/therapeutic use ; Sclerosing Solutions/therapeutic use ; Shoulder Joint ; Treatment Outcome
    Chemical Substances Sclerosing Solutions ; polidocanol (0AWH8BFG9A) ; Polyethylene Glycols (30IQX730WE)
    Language English
    Publishing date 2014-12-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/1752-1947-8-450
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  8. Article ; Online: Disruption of the TP53 locus in osteosarcoma leads to TP53 promoter gene fusions and restoration of parts of the TP53 signalling pathway.

    Saba, Karim H / Difilippo, Valeria / Kovac, Michal / Cornmark, Louise / Magnusson, Linda / Nilsson, Jenny / van den Bos, Hilda / Spierings, Diana Cj / Bidgoli, Mahtab / Jonson, Tord / Sumathi, Vaiyapuri P / Brosjö, Otte / Staaf, Johan / Foijer, Floris / Styring, Emelie / Nathrath, Michaela / Baumhoer, Daniel / Nord, Karolin H

    The Journal of pathology

    2023  Volume 262, Issue 2, Page(s) 147–160

    Abstract: TP53 is the most frequently mutated gene in human cancer. This gene shows not only loss-of-function mutations but also recurrent missense mutations with gain-of-function activity. We have studied the primary bone malignancy osteosarcoma, which harbours ... ...

    Abstract TP53 is the most frequently mutated gene in human cancer. This gene shows not only loss-of-function mutations but also recurrent missense mutations with gain-of-function activity. We have studied the primary bone malignancy osteosarcoma, which harbours one of the most rearranged genomes of all cancers. This is odd since it primarily affects children and adolescents who have not lived the long life thought necessary to accumulate massive numbers of mutations. In osteosarcoma, TP53 is often disrupted by structural variants. Here, we show through combined whole-genome and transcriptome analyses of 148 osteosarcomas that TP53 structural variants commonly result in loss of coding parts of the gene while simultaneously preserving and relocating the promoter region. The transferred TP53 promoter region is fused to genes previously implicated in cancer development. Paradoxically, these erroneously upregulated genes are significantly associated with the TP53 signalling pathway itself. This suggests that while the classical tumour suppressor activities of TP53 are lost, certain parts of the TP53 signalling pathway that are necessary for cancer cell survival and proliferation are retained. In line with this, our data suggest that transposition of the TP53 promoter is an early event that allows for a new normal state of genome-wide rearrangements in osteosarcoma. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
    MeSH term(s) Child ; Adolescent ; Humans ; Genes, p53 ; Osteosarcoma/genetics ; Osteosarcoma/pathology ; Mutation ; Bone Neoplasms/genetics ; Bone Neoplasms/pathology ; Promoter Regions, Genetic/genetics ; Gene Fusion ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
    Chemical Substances Tumor Suppressor Protein p53 ; TP53 protein, human
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.6219
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    Ud II Zs.12: Show issues Location:
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  9. Article ; Online: Reconstruction of metastatic acetabular defects using a modified Harrington procedure.

    Tsagozis, Panagiotis / Wedin, Rikard / Brosjö, Otte / Bauer, Henrik

    Acta orthopaedica

    2015  Volume 86, Issue 6, Page(s) 690–694

    Abstract: Background and purpose: Metastases engaging the acetabulum result in significant disability. We investigated the outcome after curettage and reconstruction of the defect with a protrusio cage, retrograde screws, and a cemented total hip arthroplasty.: ...

    Abstract Background and purpose: Metastases engaging the acetabulum result in significant disability. We investigated the outcome after curettage and reconstruction of the defect with a protrusio cage, retrograde screws, and a cemented total hip arthroplasty.
    Patients and methods: We retrospectively identified 70 consecutive patients who were surgically treated for metastatic disease of the acetabulum between 1995 and 2012 using the above technique. The type of primary tumor, extent of the disease, degree of acetabular erosion, and type of implant used were identified. Patient and implant survival, complications, and functional outcome were recorded.
    Results: There were no mortalities in the perioperative period (30 days after surgery). Median overall patient survival was 12 months. Prosthesis survival was 92% at 1 year and 89% at 5 years. One third of the patients suffered a complication, the most frequent one being dislocation. The functional outcome was good. Multiple skeletal or visceral metastases and specific types of cancer were associated with poor patient survival.
    Interpretation: Reconstruction of metastatic acetabular defects using a protrusio cage stabilized with retrograde screws and a cemented total hip arthroplasty is a safe procedure that provides efficient relief of symptoms. Patients with extensive disease, especially when diagnosed with specific types of cancer, have a very poor prognosis. The complication rate is substantial, the most frequent being dislocation. However, revision surgery is seldom required and prosthesis survival is high.
    MeSH term(s) Acetabuloplasty/methods ; Acetabulum/surgery ; Adult ; Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip/methods ; Bone Neoplasms/surgery ; Bone Screws ; Female ; Humans ; Male ; Middle Aged ; Reconstructive Surgical Procedures/methods ; Retrospective Studies ; Survival Analysis ; Treatment Outcome
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article
    ZDB-ID 2180677-9
    ISSN 1745-3682 ; 1745-3674
    ISSN (online) 1745-3682
    ISSN 1745-3674
    DOI 10.3109/17453674.2015.1077308
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    Uk I Zs.99: Show issues Location:
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  10. Article: Femoral Metastasis from Penile Carcinoma: Report of 2 Cases.

    Braumann, Laura / Tsagozis, Panagiotis / Wedin, Rikard / Brosjö, Otte

    Case reports in urology

    2015  Volume 2015, Page(s) 583851

    Abstract: Purpose. Penile cancer rarely gives symptomatic skeletal metastases. Methods. We present 2 patients with squamous carcinoma of the penis who were surgically treated for metastases in the femur. Results. Both patients had pathological fractures and were ... ...

    Abstract Purpose. Penile cancer rarely gives symptomatic skeletal metastases. Methods. We present 2 patients with squamous carcinoma of the penis who were surgically treated for metastases in the femur. Results. Both patients had pathological fractures and were operated on. In one case, the skeletal metastasis preceded any lymphatic spread of the disease, suggesting early haematogenous dissemination. Conclusions. Endoprosthetic reconstruction resulted in pain relief and restored the ambulatory capacity. Clinicians should be aware of the possibility for symptomatic bone metastases with a risk for pathological fracture in patients with penile cancer.
    Language English
    Publishing date 2015-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2627659-8
    ISSN 2090-6978 ; 2090-696X
    ISSN (online) 2090-6978
    ISSN 2090-696X
    DOI 10.1155/2015/583851
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