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  1. Article ; Online: Competing Magnetic Interactions and the Role of Unpaired 4

    Brown, Alex J / Avdeev, Maxim / Manjón-Sanz, Alicia / Brand, Helen E A / Ling, Chris D

    Inorganic chemistry

    2023  Volume 62, Issue 17, Page(s) 6786–6793

    Abstract: Oxygen-deficient perovskite compounds with the general formula ... ...

    Abstract Oxygen-deficient perovskite compounds with the general formula Ba
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c00524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A fast ceramic mixed OH

    Zou, Peimiao / Iuga, Dinu / Ling, Sanliang / Brown, Alex J / Chen, Shigang / Zhang, Mengfei / Han, Yisong / Fortes, A Dominic / Howard, Christopher M / Tao, Shanwen

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 909

    Abstract: Low temperature ionic conducting materials such as ... ...

    Abstract Low temperature ionic conducting materials such as OH
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45060-1
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  3. Article ; Online: Synthesis, Structure, and Properties of 2O-BaPtO

    Brown, Alex J / Miller, Laura A / Berry, Andrew J / Lewis, William / Barnett, Christopher / Yuen, Alexander / Brennan, Mia J / Auckett, Josie E / Maynard-Casely, Helen E / Ling, Chris D

    Inorganic chemistry

    2024  Volume 63, Issue 11, Page(s) 5098–5106

    Abstract: We have made the compound 2O- ... ...

    Abstract We have made the compound 2O-BaPtO
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.4c00002
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  4. Article ; Online: The value of decreasing health cost volatility.

    Herant, Marc / Brown, Alex J

    The American journal of managed care

    2016  Volume 22, Issue 6, Page(s) 448

    Language English
    Publishing date 2016-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2035781-3
    ISSN 1936-2692 ; 1088-0224 ; 1096-1860
    ISSN (online) 1936-2692
    ISSN 1088-0224 ; 1096-1860
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5353: Show issues Location:
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  5. Article ; Online: Dose and duration of interferon γ pre-licensing interact with donor characteristics to influence the expression and function of indoleamine-2,3-dioxygenase in mesenchymal stromal cells.

    Boyt, Devlin T / Boland, Lauren K / Burand, Anthony J / Brown, Alex J / Ankrum, James A

    Journal of the Royal Society, Interface

    2020  Volume 17, Issue 167, Page(s) 20190815

    Abstract: Human mesenchymal stromal cells (MSCs) are a leading cell therapy candidate for the treatment of immune and inflammatory diseases due to their potent regulation of immune cells. MSC expression of indoleamine-2,3-dioxygenase (IDO) upon interferon γ (IFNγ) ...

    Abstract Human mesenchymal stromal cells (MSCs) are a leading cell therapy candidate for the treatment of immune and inflammatory diseases due to their potent regulation of immune cells. MSC expression of indoleamine-2,3-dioxygenase (IDO) upon interferon γ (IFNγ) exposure has been proposed as both a sentinel marker and key mediator of MSC immunomodulatory potency. Rather than wait for
    MeSH term(s) Cell Proliferation ; Cells, Cultured ; Humans ; Immunomodulation ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Interferon-gamma ; Leukocytes, Mononuclear ; Mesenchymal Stem Cells
    Chemical Substances Indoleamine-Pyrrole 2,3,-Dioxygenase ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2020-06-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2156283-0
    ISSN 1742-5662 ; 1742-5689
    ISSN (online) 1742-5662
    ISSN 1742-5689
    DOI 10.1098/rsif.2019.0815
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  6. Article: Vitamin D analogs for secondary hyperparathyroidism: what does the future hold?

    Brown, Alex J

    The Journal of steroid biochemistry and molecular biology

    2007  Volume 103, Issue 3-5, Page(s) 578–583

    Abstract: Secondary hyperparathyroidism (2 degrees HPT) commonly develops in patients with chronic kidney disease (CKD) in response to high phosphate, low calcium and low 1,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)]. High PTH levels increase the rate of bone ... ...

    Abstract Secondary hyperparathyroidism (2 degrees HPT) commonly develops in patients with chronic kidney disease (CKD) in response to high phosphate, low calcium and low 1,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)]. High PTH levels increase the rate of bone turnover, with a net efflux of calcium and phosphate leading to vascular calcification and coronary artery disease. Treatment of 2 degrees HPT with 1alpha,25(OH)(2)D(3) and calcium-based phosphate binders often produces hypercalcemia and over-suppression of PTH, resulting in adynamic bone that cannot buffer excess calcium and phosphate, which increases the risk of vascular calcification. It is essential, then, to reduce PTH levels to a range that supports normal bone turnover and minimizes ectopic calcification. Vitamin D analogs that inhibit PTH gene transcription and parathyroid hyperplasia, and that have less calcemic activity than 1alpha,25(OH)(2)D(3,) have provided a greater safety margin for the treatment of 2 degrees HPT, as well as enhancing the survival of CKD patients. Although several analogs with less calcemic activity are now used in patients (paricalcitol and doxercalciferol in the USA, and OCT and falecalcitriol in Japan), efforts to develop even more selective analogs continue. Parathyroid glands express both 25-hydroxylase and 1alpha-hydroxylase and may be capable of activating prohormones or prodrugs to suppress PTH and parathyroid growth by an autocrine mechanism. Moreover, the introduction of non-calcium-based phosphate binders (sevelamer and lanthanum carbonate) and cinacalcet (an allosteric activator of the calcium receptor that reduces PTH and the serum calciumxphosphate product) may reduce the risk of hypercalcemia with vitamin D therapy. Combining these agents with higher doses of vitamin D compounds may achieve greater suppression of PTH and possibly enhance survival in patients with chronic kidney disease.
    MeSH term(s) Animals ; Humans ; Hyperparathyroidism, Secondary/drug therapy ; Hyperparathyroidism, Secondary/metabolism ; Hyperparathyroidism, Secondary/pathology ; Vitamin D/analogs & derivatives ; Vitamin D/therapeutic use
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2007-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1049188-0
    ISSN 1879-1220 ; 0960-0760
    ISSN (online) 1879-1220
    ISSN 0960-0760
    DOI 10.1016/j.jsbmb.2006.12.089
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 708: Show issues Location:
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  7. Article ; Online: Synthesis-Controlled Polymorphism and Magnetic and Electrochemical Properties of Li

    Brown, Alex J / Xia, Qingbo / Avdeev, Maxim / Kennedy, Brendan J / Ling, Chris D

    Inorganic chemistry

    2019  Volume 58, Issue 20, Page(s) 13881–13891

    Abstract: ... ...

    Abstract Li
    Language English
    Publishing date 2019-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.9b01708
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  8. Article ; Online: Bioavailable vitamin D in chronic kidney disease.

    Brown, Alex J / Coyne, Daniel W

    Kidney international

    2012  Volume 82, Issue 1, Page(s) 5–7

    Abstract: Most of the major vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D circulates in a tightly bound state to vitamin D-binding protein (DBP), rendering this fraction unavailable for biological action. A smaller fraction, loosely bound ... ...

    Abstract Most of the major vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D circulates in a tightly bound state to vitamin D-binding protein (DBP), rendering this fraction unavailable for biological action. A smaller fraction, loosely bound to albumin or circulating freely, is bioavailable, and hence bioactive. This Commentary discusses the free hormone hypothesis and the role of DBP in vitamin D metabolism.
    MeSH term(s) Bone Remodeling ; Bone and Bones/metabolism ; Female ; Humans ; Kidney Failure, Chronic/therapy ; Male ; Renal Dialysis ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2012-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1038/ki.2012.135
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
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  9. Article ; Online: Function of Cryopreserved Mesenchymal Stromal Cells With and Without Interferon-γ Prelicensing is Context Dependent.

    Burand, Anthony J / Gramlich, Oliver W / Brown, Alex J / Ankrum, James A

    Stem cells (Dayton, Ohio)

    2017  Volume 35, Issue 5, Page(s) 1437–1439

    Abstract: Tailoring MSCs to fit the disease. Fresh, cryopreserved and, prelicensed cryopreserved MSC are all being explored to treat numerous diseases, but all are not suitable to treat all conditions. injury. "*" denotes preferred therapeutic strategy when both ... ...

    Abstract Tailoring MSCs to fit the disease. Fresh, cryopreserved and, prelicensed cryopreserved MSC are all being explored to treat numerous diseases, but all are not suitable to treat all conditions. injury. "*" denotes preferred therapeutic strategy when both fresh MSC and cryo-MSC have shown utility in treating the disease but one is more efficacious or logistically suitable.
    Abbreviations: CLI, critical limb ischemia; GvHD. graft versus host disease; I/R, ischemia reperfusion (I/R); OI, osteogenesis imperfecta.
    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Letter
    ZDB-ID 1143556-2
    ISSN 1549-4918 ; 1066-5099
    ISSN (online) 1549-4918
    ISSN 1066-5099
    DOI 10.1002/stem.2528
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    Zs.A 1894: Show issues Location:
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  10. Article: A Low-Cost Technique for Intraoperative Imaging of Cell Delivery and Retention in a Model of Delayed Wound Healing.

    Burand, Anthony J / Boland, Lauren / Brown, Alex J / Ankrum, James A

    Advances in wound care

    2017  Volume 6, Issue 12, Page(s) 413–424

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2017-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2650541-1
    ISSN 2162-1934 ; 2162-1918
    ISSN (online) 2162-1934
    ISSN 2162-1918
    DOI 10.1089/wound.2017.0751
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