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  1. Article ; Online: Fungal resilience and host-pathogen interactions: Future perspectives and opportunities.

    Brown, Alistair J P

    Parasite immunology

    2022  Volume 45, Issue 2, Page(s) e12946

    Abstract: We are constantly exposed to the threat of fungal infection. The outcome-clearance, commensalism or infection-depends largely on the ability of our innate immune defences to clear infecting fungal cells versus the success of the fungus in mounting ... ...

    Abstract We are constantly exposed to the threat of fungal infection. The outcome-clearance, commensalism or infection-depends largely on the ability of our innate immune defences to clear infecting fungal cells versus the success of the fungus in mounting compensatory adaptive responses. As each seeks to gain advantage during these skirmishes, the interactions between host and fungal pathogen are complex and dynamic. Nevertheless, simply compromising the physiological robustness of fungal pathogens reduces their ability to evade antifungal immunity, their virulence, and their tolerance against antifungal therapy. In this article I argue that this physiological robustness is based on a 'Resilience Network' which mechanistically links and controls fungal growth, metabolism, stress resistance and drug tolerance. The elasticity of this network probably underlies the phenotypic variability of fungal isolates and the heterogeneity of individual cells within clonal populations. Consequently, I suggest that the definition of the fungal Resilience Network represents an important goal for the future which offers the clear potential to reveal drug targets that compromise drug tolerance and synergise with current antifungal therapies.
    MeSH term(s) Antifungal Agents ; Virulence ; Host-Pathogen Interactions
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2022-08-27
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 424444-8
    ISSN 1365-3024 ; 0141-9838
    ISSN (online) 1365-3024
    ISSN 0141-9838
    DOI 10.1111/pim.12946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1509: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Slicing through the challenge of maintaining

    Nev, Olga A / Duvenage, Lucian / Brown, Alistair J P / Dangarembizi, Rachael / Hoving, Jennifer Claire

    mBio

    2024  Volume 15, Issue 3, Page(s) e0327723

    Abstract: Pneumocystis ... ...

    Abstract Pneumocystis jirovecii
    MeSH term(s) Humans ; Animals ; Mice ; Pneumonia, Pneumocystis ; Pneumocystis ; Antifungal Agents ; Lung
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03277-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Candida auris undergoes adhesin-dependent and -independent cellular aggregation.

    Pelletier, Chloe / Shaw, Sophie / Alsayegh, Sakinah / Brown, Alistair J P / Lorenz, Alexander

    PLoS pathogens

    2024  Volume 20, Issue 3, Page(s) e1012076

    Abstract: Candida auris is a fungal pathogen of humans responsible for nosocomial infections with high mortality rates. High levels of resistance to antifungal drugs and environmental persistence mean these infections are difficult to treat and eradicate from a ... ...

    Abstract Candida auris is a fungal pathogen of humans responsible for nosocomial infections with high mortality rates. High levels of resistance to antifungal drugs and environmental persistence mean these infections are difficult to treat and eradicate from a healthcare setting. Understanding the life cycle and the genetics of this fungus underpinning clinically relevant traits, such as antifungal resistance and virulence, is of the utmost importance to develop novel treatments and therapies. Epidemiological and genomic studies have identified five geographical clades (I-V), which display phenotypic and genomic differences. Aggregation of cells, a phenotype primarily of clade III strains, has been linked to reduced virulence in some infection models. The aggregation phenotype has thus been associated with conferring an advantage for (skin) colonisation rather than for systemic infection. However, strains with different clade affiliations were compared to infer the effects of different morphologies on virulence. This makes it difficult to distinguish morphology-dependent causes from clade-specific or even strain-specific genetic factors. Here, we identify two different types of aggregation: one induced by antifungal treatment which is a result of a cell separation defect; and a second which is controlled by growth conditions and only occurs in strains with the ability to aggregate. The latter aggregation type depends on an ALS-family adhesin which is differentially expressed during aggregation in an aggregative C. auris strain. Finally, we demonstrate that macrophages cannot clear aggregates, suggesting that aggregation might after all provide a benefit during systemic infection and could facilitate long-term persistence in the host.
    MeSH term(s) Humans ; Antifungal Agents/therapeutic use ; Candida/genetics ; Candida auris ; Virulence ; Drug Resistance, Fungal ; Adhesins, Bacterial/metabolism ; Microbial Sensitivity Tests
    Chemical Substances Antifungal Agents ; Adhesins, Bacterial
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1012076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Analysis of Pneumocystis Transcription Factor Evolution and Implications for Biology and Lifestyle.

    Ames, Ryan / Brown, Alistair J P / Gudelj, Ivana / Nev, Olga A

    mBio

    2023  Volume 14, Issue 1, Page(s) e0271122

    Abstract: Pneumocystis jirovecii kills hundreds of thousands of immunocompromised patients each year. Yet many aspects of the biology of this obligate pathogen remain obscure because it is not possible to culture the ... ...

    Abstract Pneumocystis jirovecii kills hundreds of thousands of immunocompromised patients each year. Yet many aspects of the biology of this obligate pathogen remain obscure because it is not possible to culture the fungus
    MeSH term(s) Humans ; Pneumocystis/genetics ; Phylogeny ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Pneumonia, Pneumocystis/microbiology ; Pneumocystis carinii/genetics ; Genomics ; Life Style
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02711-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Characterising phagocytes and measuring phagocytosis from live Galleria mellonella larvae.

    Campbell, Jennie S / Pearce, James C / Bebes, Attila / Pradhan, Arnab / Yuecel, Raif / Brown, Alistair J P / Wakefield, James G

    Virulence

    2024  Volume 15, Issue 1, Page(s) 2313413

    Abstract: Over the last 20 years, the larva of the greater waxmoth, ...

    Abstract Over the last 20 years, the larva of the greater waxmoth,
    MeSH term(s) Animals ; Humans ; Larva ; Proteomics ; Moths ; Phagocytosis ; Phagocytes ; Mammals
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2657572-3
    ISSN 2150-5608 ; 2150-5594
    ISSN (online) 2150-5608
    ISSN 2150-5594
    DOI 10.1080/21505594.2024.2313413
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  6. Article: Fungal spore swelling and germination are restricted by the macrophage phagolysosome.

    Alonso, María Fernanda / Bain, Judith M / Erwig, Lars P / Brown, Alistair J P / Gow, Neil A R

    Fungal biology

    2023  Volume 127, Issue 9, Page(s) 1291–1297

    Abstract: Many species of medically important fungi are prolific in the formation of asexual spores. Spores undergo a process of active swelling and cell wall remodelling before a germ tube is formed and filamentous growth ensues. Highly elongated germ tubes are ... ...

    Abstract Many species of medically important fungi are prolific in the formation of asexual spores. Spores undergo a process of active swelling and cell wall remodelling before a germ tube is formed and filamentous growth ensues. Highly elongated germ tubes are known to be difficult to phagocytose and pose particular challenges for immune phagocytes. However, the significance of the earliest stages of spore germination during immune cell interactions has not been investigated and yet this is likely to be important for defence against sporogenous fungal pathogens. We show here that macrophages restrict the early phases of the spore germination process of Aspergillus fumigatus and Mucor circinelloides including the initial phase of spore swelling, spore germination and early polarised growth. Macrophages are therefore adept at retarding germination as well as subsequent vegetative growth which is likely to be critical for immune surveillance and protection against sporulating fungi.
    MeSH term(s) Spores, Fungal ; Germination ; Macrophages/microbiology ; Phagocytes ; Phagosomes
    Language English
    Publishing date 2023-08-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2532164-X
    ISSN 1878-6162 ; 1878-6146
    ISSN (online) 1878-6162
    ISSN 1878-6146
    DOI 10.1016/j.funbio.2023.08.002
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  7. Book: Yeast gene analysis

    Brown, Alistair J. P.

    (Methods in microbiology ; 26)

    1998  

    Author's details ed. by Alistair J. P. Brown
    Series title Methods in microbiology ; 26
    Collection
    Keywords Hefeartige Pilze ; Molekulargenetik
    Subject Molekulare Genetik ; Biochemische Genetik ; Hefe ; Hefen ; Hefepilze ; Sproßpilze
    Language English
    Size XIII, 502 S. : Ill., graph. Darst.
    Publisher Academic Press
    Publishing place San Diego u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT008600467
    ISBN 0-12-521526-6 ; 0-12-136655-3 ; 978-0-12-521526-8 ; 978-0-12-136655-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 608 -26- verfügbar in Königswinter Königswinter

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  8. Article: Thoughts on the evolution of Core Environmental Responses in yeasts.

    Brown, Alistair J P / Larcombe, Daniel E / Pradhan, Arnab

    Fungal biology

    2020  Volume 124, Issue 5, Page(s) 475–481

    Abstract: The model yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe, display Core Environmental Responses (CERs) that include the induction of a core set of stress genes in response to diverse environmental stresses. CERs underlie the phenomenon of ... ...

    Abstract The model yeasts, Saccharomyces cerevisiae and Schizosaccharomyces pombe, display Core Environmental Responses (CERs) that include the induction of a core set of stress genes in response to diverse environmental stresses. CERs underlie the phenomenon of stress cross-protection, whereby exposure to one type of stress can provide protection against subsequent exposure to a second type of stress. CERs have probably arisen through the accumulation, over evolutionary time, of protective anticipatory responses ("adaptive prediction"). CERs have been observed in other evolutionarily divergent fungi but, interestingly, not in the pathogenic yeast, Candida albicans. We argue that this is because we have not looked in the right place. In response to specific host inputs, C. albicans does activate anticipatory responses that protect it against impending attack from the immune system. Therefore, we suggest that C. albicans has evolved a CER that reflects the environmental challenges it faces in host niches.
    MeSH term(s) Biological Evolution ; Candida albicans/physiology ; Environment ; Saccharomyces cerevisiae/physiology ; Schizosaccharomyces/physiology ; Stress, Physiological ; Yeasts/physiology
    Language English
    Publishing date 2020-01-16
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2532164-X
    ISSN 1878-6162 ; 1878-6146
    ISSN (online) 1878-6162
    ISSN 1878-6146
    DOI 10.1016/j.funbio.2020.01.003
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  9. Article ; Online: Reply to "Unrealistic nonphysiological amounts of reagents and a disregard for published literature".

    Brown, Alistair J P

    mBio

    2015  Volume 6, Issue 2

    MeSH term(s) Candida albicans/metabolism ; Humans ; Oxidative Stress/physiology ; Phagocytes/drug effects ; Phagocytes/metabolism
    Language English
    Publishing date 2015-04-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00450-15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Understanding the Role of Nitronate Monooxygenases in Virulence of the Human Fungal Pathogen

    Nguyen, Phuong Tuyen / Wacker, Theresa / Brown, Alistair J P / da Silva Dantas, Alessandra / Shekhova, Elena

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 7

    Abstract: Aspergillus ... ...

    Abstract Aspergillus fumigatus
    Language English
    Publishing date 2022-07-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8070736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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