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Article ; Online: Medical foods for lowering homocysteine in hypertensive patients.

Elias, Merrill F / Brown, Craig J

Journal of clinical hypertension (Greenwich, Conn.)

2022 Volume 25, Issue 1, Page(s) 111–114

MeSH term(s)	Humans ; Hypertension ; Blood Pressure ; Enalapril ; Homocysteine
Chemical Substances	Enalapril (69PN84IO1A) ; Homocysteine (0LVT1QZ0BA)
Language	English
Publishing date	2022-12-14
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2077222-1
ISSN	1751-7176 ; 1524-6175
ISSN (online)	1751-7176
ISSN	1524-6175
DOI	10.1111/jch.14608
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Article ; Online: Case series of retinal vein occlusions showing early recovery using oral l-methylfolate.

Baker, Steven / Baker, Dylan / Baker, Robert / Brown, Craig J

Therapeutic advances in ophthalmology

2024 Volume 16, Page(s) 25158414241240687

Abstract: This case series describes the aggregate rate of recovery in five consecutive subjects (six eyes) with retinal vein occlusion (RVO) who received l-methylfolate and other ... ...

Abstract	This case series describes the aggregate rate of recovery in five consecutive subjects (six eyes) with retinal vein occlusion (RVO) who received l-methylfolate and other vitamins
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Case Reports
ISSN	2515-8414
ISSN (online)	2515-8414
DOI	10.1177/25158414241240687
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: New Evidence for Homocysteine Lowering for Management of Treatment-Resistant Hypertension.

Elias, Merrill F / Brown, Craig J

American journal of hypertension

2021 Volume 35, Issue 4, Page(s) 303–305

MeSH term(s)	Folic Acid ; Homocysteine ; Humans ; Hyperhomocysteinemia/diagnosis ; Hyperhomocysteinemia/drug therapy ; Hypertension/diagnosis ; Hypertension/drug therapy ; Vitamin B Complex
Chemical Substances	Homocysteine (0LVT1QZ0BA) ; Vitamin B Complex (12001-76-2) ; Folic Acid (935E97BOY8)
Language	English
Publishing date	2021-12-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	639383-4
ISSN	1941-7225 ; 1879-1905 ; 0895-7061
ISSN (online)	1941-7225 ; 1879-1905
ISSN	0895-7061
DOI	10.1093/ajh/hpab194
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2329: Show issues

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Article ; Online: Multispectral multibeam backscatter response of heterogeneous rhodolith beds.

Menandro, Pedro S / Misiuk, Benjamin / Brown, Craig J / Bastos, Alex C

Scientific reports

2023 Volume 13, Issue 1, Page(s) 20220

Abstract: Acoustic backscatter has been used as a tool to map the seafloor in greater detail and plays an increasingly important role in seafloor mapping to meet multiple ocean management needs. An outstanding challenge to the use of backscatter for seafloor ... ...

Abstract	Acoustic backscatter has been used as a tool to map the seafloor in greater detail and plays an increasingly important role in seafloor mapping to meet multiple ocean management needs. An outstanding challenge to the use of backscatter for seafloor mapping is the distinction between acoustically similar substrates, such as mixed sediments from rhodoliths. Rhodolith beds are a biogenic substrate that provides important ecological services, and are typically classified as a single categorical substrate type-though nodules coverage may be spatially variable. Recently, multispectral acoustic backscatter has demonstrated great potential to improve thematic seafloor mapping compared to single-frequency systems. This work employs multispectral multibeam backscatter and underwater imagery to characterize and map rhodolith beds in the Costa das Algas Marine Protected Area (Brazil). A support vector machine classifier was used to classify multifrequency backscatter mosaics according to rhodolith classes identified from underwater imagery. Results suggest that multispectral backscatter is effective both in providing information for mapping different proportions of rhodolith coverage and in predicting the presence or absence of these nodules. The backscatter of the lowest frequency was the most useful for distinguishing variable proportions of rhodolith coverage, and the two higher frequencies were better predictors of presence and absence.
Language	English
Publishing date	2023-11-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-46240-7
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Article: Preservation of retinal structure and function after cilioretinal artery occlusion: a case report.

Brown, Craig J

International medical case reports journal

2016 Volume 9, Page(s) 29–34

Abstract: Cilioretinal artery occlusion is a cause of sudden, often catastrophic loss of central vision. There are no established effective treatments. Recently, a patient presented 24 hours after a cilioretinal artery occlusion, following a cardiac ... ...

Abstract	Cilioretinal artery occlusion is a cause of sudden, often catastrophic loss of central vision. There are no established effective treatments. Recently, a patient presented 24 hours after a cilioretinal artery occlusion, following a cardiac catheterization prior to which her blood thinners had been discontinued. Lacking an effective way to address the severe retinal ischemic oxidative stress, she was offered, under compassionate use, a multivitamin complex designed to address retinal ischemia and oxidative stress. Significant components of this product are L-methylfolate and n-acetyl cysteine. The patient experienced a rapid unexpected improvement in vision and preservation of retinal structure, suggesting that marked improvement in retinal artery occlusions outcomes may be possible as late as 24 hours postocclusion. This is the third reported case of cilioretinal artery occlusion associated with cardiac catheterization.
Language	English
Publishing date	2016-02-11
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2495077-4
ISSN	1179-142X
ISSN	1179-142X
DOI	10.2147/IMCRJ.S96858
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Article ; Online: Estimating Lithium Concentrations in Groundwater Used as Drinking Water for the Conterminous United States.

Lombard, Melissa A / Brown, Eric E / Saftner, Daniel M / Arienzo, Monica M / Fuller-Thomson, Esme / Brown, Craig J / Ayotte, Joseph D

Environmental science & technology

2024 Volume 58, Issue 2, Page(s) 1255–1264

Abstract: Lithium (Li) concentrations in drinking-water supplies are not regulated in the United States; however, Li is included in the 2022 U.S. Environmental Protection Agency list of unregulated contaminants for monitoring by public water systems. Li is used ... ...

Abstract	Lithium (Li) concentrations in drinking-water supplies are not regulated in the United States; however, Li is included in the 2022 U.S. Environmental Protection Agency list of unregulated contaminants for monitoring by public water systems. Li is used pharmaceutically to treat bipolar disorder, and studies have linked its occurrence in drinking water to human-health outcomes. An extreme gradient boosting model was developed to estimate geogenic Li in drinking-water supply wells throughout the conterminous United States. The model was trained using Li measurements from ∼13,500 wells and predictor variables related to its natural occurrence in groundwater. The model predicts the probability of Li in four concentration classifications, ≤4 μg/L, >4 to ≤10 μg/L, >10 to ≤30 μg/L, and >30 μg/L. Model predictions were evaluated using wells held out from model training and with new data and have an accuracy of 47-65%. Important predictor variables include average annual precipitation, well depth, and soil geochemistry. Model predictions were mapped at a spatial resolution of 1 km
MeSH term(s)	United States ; Humans ; Drinking Water ; Lithium ; Groundwater ; Water Supply ; Water Wells ; Water Pollutants, Chemical/analysis ; Environmental Monitoring
Chemical Substances	Drinking Water ; Lithium (9FN79X2M3F) ; Water Pollutants, Chemical
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c03315
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prioritizing water availability study settings to address geogenic contaminants and related societal factors.

Erickson, Melinda L / Brown, Craig J / Tomaszewski, Elizabeth J / Ayotte, Joseph D / Böhlke, John K / Kent, Douglas B / Qi, Sharon

Environmental monitoring and assessment

2024 Volume 196, Issue 3, Page(s) 303

Abstract: Water availability for human and ecological uses depends on both water quantity and water quality. The U.S. Geological Survey (USGS) is developing strategies for prioritizing regional-scale and watershed basin-scale studies of water availability across ... ...

Abstract	Water availability for human and ecological uses depends on both water quantity and water quality. The U.S. Geological Survey (USGS) is developing strategies for prioritizing regional-scale and watershed basin-scale studies of water availability across the nation. Previous USGS ranking processes for basin-scale studies incorporated primarily water quantity factors but are now considering additional water quality factors. This study presents a ranking based on the potential impacts of geogenic constituents on water quality and consideration of societal factors related to water quality. High-concentration geogenic constituents, including trace elements and radionuclides, are among the most prevalent contaminants limiting water availability in the USA and globally. Geogenic constituents commonly occur in groundwater because of subsurface water-rock interactions, and their distributions are controlled by complex geochemical processes. Geogenic constituent mobility can also be affected by human activities (e.g., mining, energy production, irrigation, and pumping). Societal factors and relations to drinking water sources and water quality information are often overlooked when evaluating research priorities. Sociodemographic characteristics, data gaps resulting from historical data-collection disparities, and infrastructure condition/age are examples of factors to consider regarding environmental justice. This paper presents approaches for ranking and prioritizing potential basin-scale study areas across the contiguous USA by considering a suite of conventional physical and geochemical variables related to geogenic constituents, with and without considering variables related to societal factors. Simultaneous consideration of societal and conventional factors could provide decision makers with more diverse, interdisciplinary tools to increase equity and reduce bias in prioritizing focused research areas and future water availability studies.
MeSH term(s)	Humans ; Environmental Monitoring/methods ; Water Pollutants, Chemical/analysis ; Groundwater/chemistry ; Water Quality ; Trace Elements
Chemical Substances	Water Pollutants, Chemical ; Trace Elements
Language	English
Publishing date	2024-02-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-024-12362-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Z 5186: Show issues

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Book ; Online: Seafloor sediment characterization to improve estimate of organic carbon standing stocks in continental shelves

Brenan, Catherine / Kienast, Markus / Maselli, Vittorio / Algar, Christopher / Misiuk, Benjamin / Brown, Craig J.

eISSN:

2024

Abstract: Continental shelf sediments contain some of the largest stocks of organic carbon (OC) on Earth and play a vital role in influencing the global carbon cycle. Quantifying how much OC is stored in shelf sediments and determining its residence time is key to ...

Abstract	Continental shelf sediments contain some of the largest stocks of organic carbon (OC) on Earth and play a vital role in influencing the global carbon cycle. Quantifying how much OC is stored in shelf sediments and determining its residence time is key to assessing how human activities can accelerate the process of OC remineralization into carbon dioxide. Spatial variations in terrestrial carbon stocks are well studied and mapped at high resolution, but our knowledge of the distribution of marine OC in different seafloor settings is still very limited, particularly in the highly dynamic and spatially variable shelf environments. The lack of knowledge reduces our ability to understand and predict how much and for how long oceans sequester CO 2 . In this study, we use high-resolution multibeam echosounder (MBES) data from the Eastern Shore Islands offshore Nova Scotia (Canada), combined with OC measurements from discrete samples, to assess the distribution of OC content in seafloor sediments. We derive three different spatial estimates of organic carbon: i) assuming a homogenous seafloor the carbon stock estimates were scaled to the entire study region; ii) using a high-resolution substrate map, the estimates were scaled to the areas of soft substrate only, and, finally, iii) using Empirical Bayesian Regression Kriging (EBRK) regression prediction within the area of soft substrate, carbon stock estimates in areas of soft substrate were refined to account for spatial variability in the concentration of OC. These three distinct spatial models yielded dramatically different estimates of average standing stock of OC in our study area, 1275, 259 and 203 Mt of OC respectively. Our study demonstrates that high-resolution mapping is critically important for improved estimates of OC stocks on continental shelves, and to the identification of carbon hotspots that need to be considered in seabed management and climate mitigation strategies.
Subject code	550 ; 333
Language	English
Publishing date	2024-01-19
Publishing country	de
Document type	Book ; Online
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Article: Utilizing benthic habitat maps to inform biodiversity monitoring in marine protected areas

Lacharité, Myriam / Brown, Craig J

Aquatic conservation. 2019 June, v. 29, no. 6

2019

Abstract: The designation of marine protected areas (MPAs) requires the development of a monitoring design to assess the effectiveness of the closure in meeting its conservation objectives. Natural variability should be considered in the design, ideally determined ...

Abstract	The designation of marine protected areas (MPAs) requires the development of a monitoring design to assess the effectiveness of the closure in meeting its conservation objectives. Natural variability should be considered in the design, ideally determined using baseline information collected at the scale of the closure. Monitoring benthos informs on general ecosystem state. Benthic habitat maps are widely used as surrogates of benthos in marine spatial planning, and could potentially be used to inform monitoring by minimizing confounding habitat effects. Here, epibenthic diversity was assessed in the St. Anns Bank MPA in Atlantic Canada, the first assessment of benthic patterns at the scale of this closure. Epibenthic assemblages were determined using a photographic camera system along a single transect (~100–150 m in length) at 44 locations in 2013 and 2014 (with 10 or 11 images per location, providing a total of 438 images), prior to the designation of the MPA. Epibenthic patterns were correlated with a previously developed benthic habitat (benthoscape) map to determine the potential of using benthoscape classes as units for monitoring. Hierarchical agglomerative clustering of epibenthic assemblages and similarity profile analysis revealed five clusters of assemblages in the MPA (P < 0.01), each of which were associated with specific indicator taxa. Some clusters of assemblages correlated well with distinct benthoscape classes representing either hard/coarse (gravel) or soft sediment (sand and mud), whereas clusters associated with mixed sediment segregated spatially. The within‐cluster variability in assemblages between locations was lower overall than within the management zones, but differed between clusters. Similarities were detected with previous coarser‐scale assessments of epibenthic diversity in the St. Anns Bank MPA, but this study revealed a more complex benthic structure than previously thought. A monitoring design should thus consider this natural variability to reliably monitor change and aid in determining the effectiveness of the MPA.
Keywords	benthic organisms ; biodiversity ; cameras ; ecosystems ; gravel ; habitats ; indicator species ; marine protected areas ; monitoring ; planning ; sand ; Canada
Language	English
Dates of publication	2019-06
Size	p. 938-951.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1146285-1
ISSN	1052-7613
ISSN	1052-7613
DOI	10.1002/aqc.3074
Database	NAL-Catalogue (AGRICOLA)

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Z 7590: Show issues

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Article: Integrating fine‐scale seafloor mapping and spatial pattern metrics into marine conservation prioritization

Proudfoot, Beatrice / Devillers, Rodolphe / Brown, Craig J

Aquatic conservation. 2020 Aug., v. 30, no. 8

2020

Abstract: Marine protected area (MPA) planning often relies on scientific principles that help ensure that an area selected for conservation will effectively protect biodiversity. Capturing ecological processes in MPA network planning has received increased ... ...

Abstract	Marine protected area (MPA) planning often relies on scientific principles that help ensure that an area selected for conservation will effectively protect biodiversity. Capturing ecological processes in MPA network planning has received increased attention in recent years. High‐resolution seafloor maps, which show patterns in seafloor bio‐physical characteristics, can support our understanding of ecological processes. In part, owing to a global lack of high‐resolution seafloor maps, studies that aim to integrate seascape spatial pattern and conservation prioritization often focus on shallow biogenic habitats with less attention paid to deeper benthic seascapes (benthoscapes) mapped using acoustic techniques. Acoustic seafloor mapping strategies yield the spatial information required to extend conservation prioritization research into these environments, making incorporating seafloor ecological processes into conservation prioritization increasingly achievable. Here, a new method is proposed and tested that combines benthoscape mapping, landscape ecology metrics and a conservation decision support tool to prioritize areas with structural and potential connectivity value in MPA placement. Using a case study in eastern Canada, benthoscape composition and configuration were quantified using spatial pattern metrics and integrated into Marxan. Results illustrate how large patches of seafloor habitat in close proximity to neighbouring patches can be preferentially selected when benthoscape configuration is considered. The flexibility of the method for including relevant spatial pattern metrics or species‐specific movement data is discussed to illustrate how benthic habitat maps can improve existing conservation planning methods and complement existing and future work to support marine biodiversity conservation.
Keywords	acoustics ; benthic ecosystems ; biodiversity ; biodiversity conservation ; case studies ; complement ; decision support systems ; habitats ; landscape ecology ; marine protected areas ; prioritization ; spatial data ; Canada
Language	English
Dates of publication	2020-08
Size	p. 1613-1625.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	1146285-1
ISSN	1052-7613
ISSN	1052-7613
DOI	10.1002/aqc.3360
Database	NAL-Catalogue (AGRICOLA)

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