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  1. Article: Neutron scattering for STRUCTURAL BIOLOGY: Modern neutron sources illuminate the complex functions of living systems.

    Hoogerheide, David P / Forsyth, V Trevor / Brown, Katherine A

    Physics today

    2024  Volume 73, Issue 6

    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2031187-4
    ISSN 0031-9228
    ISSN 0031-9228
    DOI 10.1063/pt.3.4498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characterizing Autism Spectrum Disorder and Predicting Suicide Risk for Pediatric Psychiatric Emergency Services Encounters.

    Brown, Katherine A / Donise, Kathleen R / Cancilliere, Mary Kathryn / Aluthge, Dilum P / Chen, Elizabeth S

    AMIA ... Annual Symposium proceedings. AMIA Symposium

    2024  Volume 2023, Page(s) 864–873

    Abstract: Individuals diagnosed with autism spectrum disorder (ASD) are at a higher risk for mental health concerns including suicidal thoughts and behaviors (STB). Limited studies have focused on suicidal risk factors that are more prevalent or unique to the ... ...

    Abstract Individuals diagnosed with autism spectrum disorder (ASD) are at a higher risk for mental health concerns including suicidal thoughts and behaviors (STB). Limited studies have focused on suicidal risk factors that are more prevalent or unique to the population with ASD. This study sought to characterize and classify youth presenting to the psychiatric emergency department (ED) for a chief complaint of STB. The results of this study validated that a high number of patients with ASD present to the ED with STB. There were important differences in clinical characteristics to those with ASD versus those without. Clinical features that showed important impact in predicting high suicide risk in the ASD cases include elements of the mental status exam such as affect, trauma symptoms, abuse history, and auditory hallucinations. Focused attention is needed on these unique differences in ASD cases so that suicide risk level can be appropriately and promptly addressed.
    MeSH term(s) Adolescent ; Humans ; Child ; Autism Spectrum Disorder/psychology ; Emergency Services, Psychiatric ; Suicidal Ideation ; Emergency Service, Hospital
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ISSN 1942-597X
    ISSN (online) 1942-597X
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  3. Article ; Online: The Relationship Between Speech Characteristics and Motor Subtypes of Parkinson's Disease.

    Brown, Katherine A / Spencer, Kristie A

    American journal of speech-language pathology

    2020  Volume 29, Issue 4, Page(s) 2145–2154

    Abstract: Purpose The aim of this study was to examine whether acoustic dysarthria characteristics align with overall motor profile in individuals with Parkinson's disease (PD). Potential speech differences between tremor-dominant and non-tremor-dominant subtypes ... ...

    Abstract Purpose The aim of this study was to examine whether acoustic dysarthria characteristics align with overall motor profile in individuals with Parkinson's disease (PD). Potential speech differences between tremor-dominant and non-tremor-dominant subtypes are theoretically motivated but empirically inconclusive. Method Twenty-seven individuals with dysarthria from PD provided a contextual speech sample. Participants were grouped into non-tremor-dominant (
    MeSH term(s) Dysarthria/diagnosis ; Dysarthria/etiology ; Humans ; Parkinson Disease/complications ; Parkinson Disease/diagnosis ; Phonation ; Speech ; Speech Production Measurement
    Language English
    Publishing date 2020-09-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1154406-5
    ISSN 1558-9110 ; 1058-0360
    ISSN (online) 1558-9110
    ISSN 1058-0360
    DOI 10.1044/2020_AJSLP-20-00058
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    Zs.A 3716: Show issues Location:
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  4. Article ; Online: Clinical Note Section Detection Using a Hidden Markov Model of Unified Medical Language System Semantic Types.

    Eisman, Aaron S / Brown, Katherine A / Chen, Elizabeth S / Sarkar, Indra Neil

    AMIA ... Annual Symposium proceedings. AMIA Symposium

    2022  Volume 2021, Page(s) 418–427

    Abstract: Clinical notes are a rich source of biomedical data for natural language processing (NLP). The identification of note sections represents a first step in creating portable NLP tools. Here, a system that used a heterogeneous hidden Markov model (HMM) was ... ...

    Abstract Clinical notes are a rich source of biomedical data for natural language processing (NLP). The identification of note sections represents a first step in creating portable NLP tools. Here, a system that used a heterogeneous hidden Markov model (HMM) was designed to identify seven note sections: (1) Medical History, (2) Medications, (3) Family and Social History, (4) Physical Exam, (5) Labs and Imaging, (6) Assessment and Plan, and (7) Review of Systems. Unified Medical Language System (UMLS) concepts were identified using MetaMap, and UMLS semantic type distributions for each section type were empirically determined. The UMLS semantic type distributions were used to train the HMM for identifying clinical note sections. The system was evaluated relative to a template boundary model using manually annotated notes from the Medical Information Mart for Intensive Care III. The results show promise for an approach to segment clinical notes into sections for subsequent NLP tasks.
    MeSH term(s) Humans ; Natural Language Processing ; Semantics ; Unified Medical Language System
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1942-597X
    ISSN (online) 1942-597X
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  5. Article ; Online: An Unsupervised Cluster Analysis of Post-COVID-19 Mental Health Outcomes and Associated Comorbidities.

    Brown, Katherine A / Sarkar, Indra Neil / Crowley, Karen M / Aluthge, Dilum P / Chen, Elizabeth S

    AMIA ... Annual Symposium proceedings. AMIA Symposium

    2023  Volume 2022, Page(s) 289–298

    Abstract: The COVID-19 pandemic continues to be widespread, and little is known about mental health impacts from dealing with the disease itself. This retrospective study used a deidentified health information exchange (HIE) dataset of electronic health record ... ...

    Abstract The COVID-19 pandemic continues to be widespread, and little is known about mental health impacts from dealing with the disease itself. This retrospective study used a deidentified health information exchange (HIE) dataset of electronic health record data from the state of Rhode Island and characterized different subgroups of the positive COVID-19 population. Three different clustering methods were explored to identify patterns of condition groupings in this population. Increased incidence of mental health conditions was seen post-COVID-19 diagnosis, and these individuals exhibited higher prevalence of comorbidities compared to the negative control group. A self-organizing map cluster analysis showed patterns of mental health conditions in half of the clusters. One mental health cluster revealed a higher comorbidity index and higher severity of COVID-19 disease. The clinical features identified in this study motivate the need for more in-depth analysis to predict and identify individuals at high risk for developing mental illness post-COVID-19 diagnosis.
    MeSH term(s) Humans ; COVID-19 ; Retrospective Studies ; Pandemics ; COVID-19 Testing ; Comorbidity ; Cluster Analysis ; Outcome Assessment, Health Care
    Language English
    Publishing date 2023-04-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1942-597X
    ISSN (online) 1942-597X
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  6. Article ; Online: Mental Health Comorbidity Analysis in Pediatric Patients with Autism Spectrum Disorder Using Rhode Island Medical Claims Data.

    Brown, Katherine A / Sarkar, Indra Neil / Chen, Elizabeth S

    AMIA ... Annual Symposium proceedings. AMIA Symposium

    2021  Volume 2020, Page(s) 263–272

    Abstract: Identification of comorbidity subgroups linked with Autism Spectrum Disorder (ASD) could provide promising insight into learning more about this disorder. This study sought to use the Rhode Island All-Payer Claims Database to examine mental health ... ...

    Abstract Identification of comorbidity subgroups linked with Autism Spectrum Disorder (ASD) could provide promising insight into learning more about this disorder. This study sought to use the Rhode Island All-Payer Claims Database to examine mental health conditions linked to ASD. Medical claims data for ASD patients and one or more mental health conditions were analyzed using descriptive statistics, association rule mining (ARM), and sequential pattern mining (SPM). The results indicated that patients with ASD have a higher proportion of mental health diagnoses than the general pediatric population. ARM and SPM methods identified patterns of comorbidities commonly seen among ASD patients. Based on the observed patterns and temporal sequences, suicidal ideation, mood disorders, anxiety, and conduct disorders may need focused attention prospectively. Understanding more about groupings of ASD patients and their comorbidity burden can help bridge gaps in knowledge and make strides toward improved outcomes for patients with ASD.
    MeSH term(s) Adolescent ; Anxiety/epidemiology ; Autism Spectrum Disorder/complications ; Autism Spectrum Disorder/epidemiology ; Autism Spectrum Disorder/psychology ; Child ; Child, Preschool ; Comorbidity ; Depression/epidemiology ; Female ; Humans ; Insurance Claim Review/statistics & numerical data ; Male ; Mental Disorders/epidemiology ; Mental Disorders/psychology ; Mental Health ; Rhode Island/epidemiology ; Suicidal Ideation
    Language English
    Publishing date 2021-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1942-597X
    ISSN (online) 1942-597X
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  7. Article ; Online: Coupling biology to synthetic nanomaterials for semi-artificial photosynthesis.

    Brown, Katherine A / King, Paul W

    Photosynthesis research

    2019  Volume 143, Issue 2, Page(s) 193–203

    Abstract: Biohybrid artificial photosynthesis aims to combine the advantages of biological specificity with a range of synthetic nanomaterials to create innovative semi-synthetic systems for solar-to-chemical conversion. Biological systems utilize highly efficient ...

    Abstract Biohybrid artificial photosynthesis aims to combine the advantages of biological specificity with a range of synthetic nanomaterials to create innovative semi-synthetic systems for solar-to-chemical conversion. Biological systems utilize highly efficient molecular catalysts for reduction-oxidation reactions. They can operate with minimal overpotentials while selectively channeling reductant energy into specific transformation chemistries and product forming pathways. Nanomaterials can be synthesized to have efficient light-absorption capacity and tuneability of charge separation by manipulation of surface chemistries and bulk compositions. These complementary aspects have been combined in a variety of ways, for example, where biological light-harvesting complexes function as antenna for nanoparticle catalysts or where nanoparticles function as light capture, charge separation components for coupling to chemical conversion by redox enzymes and whole cells. The synthetic diversity that is possible with biohybrids is still being explored. The progress arising from creative approaches is generating new model systems to inspire scale-up technologies and generate understanding of the fundamental mechanisms that control energy conversion at the molecular scale. These efforts are leading to discoveries of essential design principles that can enable the development of scalable artificial photosynthesis systems.
    MeSH term(s) Catalysis ; Hydrogenase/metabolism ; Nanostructures/chemistry ; Photosensitizing Agents/metabolism ; Photosynthesis ; Photosystem I Protein Complex/metabolism ; Photosystem II Protein Complex/metabolism ; Synthetic Biology ; Thylakoids/metabolism
    Chemical Substances Photosensitizing Agents ; Photosystem I Protein Complex ; Photosystem II Protein Complex ; Hydrogenase (EC 1.12.7.2)
    Language English
    Publishing date 2019-10-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1475688-2
    ISSN 1573-5079 ; 0166-8595
    ISSN (online) 1573-5079
    ISSN 0166-8595
    DOI 10.1007/s11120-019-00670-5
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  8. Article ; Online: Dysarthria following Stroke.

    Spencer, Kristie A / Brown, Katherine A

    Seminars in speech and language

    2018  Volume 39, Issue 1, Page(s) 15–24

    Abstract: Dysarthria is a common consequence of stroke and can have a detrimental influence on communication and quality of life. Speech-language pathologists (SLPs) play an important role in the evaluation and rehabilitation of stroke survivors who present with ... ...

    Abstract Dysarthria is a common consequence of stroke and can have a detrimental influence on communication and quality of life. Speech-language pathologists (SLPs) play an important role in the evaluation and rehabilitation of stroke survivors who present with dysarthria. An understanding of the physiologic reason behind the altered speech characteristics, such as weakness or incoordination, can facilitate differential diagnosis, guide evaluation strategies, and influence treatment approaches. An initial comprehensive speech evaluation is comprised of examination of the speech mechanism, screening of speech subsystems, perceptual assessment, and intelligibility measurement. Management strategies focus on optimizing communication through compensatory strategies as well as providing physiologic support. The SLP is also responsible for educating family and staff regarding strategies that can facilitate communication.
    MeSH term(s) Dysarthria/diagnosis ; Dysarthria/etiology ; Dysarthria/therapy ; Female ; Humans ; Male ; Speech/physiology ; Speech-Language Pathology/methods ; Stroke/complications ; Stroke/therapy
    Language English
    Publishing date 2018-01-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604960-6
    ISSN 1098-9056 ; 0734-0478
    ISSN (online) 1098-9056
    ISSN 0734-0478
    DOI 10.1055/s-0037-1608852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2505: Show issues Location:
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  9. Article ; Online: Recent Advances Clarifying the Structure and Function of Plant Apyrases (Nucleoside Triphosphate Diphosphohydrolases).

    Clark, Greg / Brown, Katherine A / Tripathy, Manas K / Roux, Stanley J

    International journal of molecular sciences

    2021  Volume 22, Issue 6

    Abstract: Studies implicating an important role for apyrase (NTPDase) enzymes in plant growth and development began appearing in the literature more than three decades ago. After early studies primarily in potato, ...

    Abstract Studies implicating an important role for apyrase (NTPDase) enzymes in plant growth and development began appearing in the literature more than three decades ago. After early studies primarily in potato,
    MeSH term(s) Apyrase/antagonists & inhibitors ; Apyrase/chemistry ; Apyrase/genetics ; Apyrase/metabolism ; Catalytic Domain ; Chemical Phenomena ; Drug Discovery ; Enzyme Inhibitors/pharmacology ; Gene Expression Regulation, Plant ; Models, Molecular ; Plant Proteins/antagonists & inhibitors ; Plant Proteins/chemistry ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Protein Conformation ; Structure-Activity Relationship
    Chemical Substances Enzyme Inhibitors ; Plant Proteins ; Apyrase (EC 3.6.1.5)
    Language English
    Publishing date 2021-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22063283
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  10. Article ; Online: Correction: The influence of electron utilization pathways on photosystem I photochemistry in

    Smolinski, Sharon L / Lubner, Carolyn E / Guo, Zhanjun / Artz, Jacob H / Brown, Katherine A / Mulder, David W / King, Paul W

    RSC advances

    2023  Volume 13, Issue 1, Page(s) 742

    Abstract: This corrects the article DOI: 10.1039/D2RA01295B.]. ...

    Abstract [This corrects the article DOI: 10.1039/D2RA01295B.].
    Language English
    Publishing date 2023-01-03
    Publishing country England
    Document type Published Erratum
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra90130g
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