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  1. Article ; Online: 124 A wild rice byproduct compares well to traditional wood sawdust as bedding material

    Becker, O.G. / Brown, M.A. / Dobrzelecki, A.M. / Pyles, M.B.

    Journal of Equine Veterinary Science. 2023 May, v. 124 p.104426-

    2023  

    Abstract: Minnesota is one of the largest producers of cultivated wild rice in the US, and the straw-like byproduct (rice knuckles) may provide an alternative bedding material for horses while supporting sustainability. Bedding selection is an important factor to ... ...

    Abstract Minnesota is one of the largest producers of cultivated wild rice in the US, and the straw-like byproduct (rice knuckles) may provide an alternative bedding material for horses while supporting sustainability. Bedding selection is an important factor to provide a healthy environment for horses. This study evaluated the suitability of wild rice knuckles (RK) as an alternative bedding material to traditional wood sawdust (WS) by comparing water absorptive capacity (WAC), air quality, and ammonia levels. Four mature horses (>3 yr old) were used in the crossover study. Horses were randomly assigned to bedding type (RK or WS) for 5 d, then switched to the other bedding type for the next 5 d. Horses were housed in box stalls at night and turned out in paddocks during the day. Total muck production was recorded daily after stall cleaning by 3 individuals. The WAC was tested by soaking bedding material (n = 2) in water using nylon pantyhose for 0, 1, 3, 6, 9, and 24 h and recording the change in weight. An Elitech air quality monitor recorded the concentration of 3 sizes of suspended particulate matter (PM < 2.5 µg/m³, 10 µg/m³, and total PM). Air quality was recorded 3 m above the stall surface after horses were stalled over night and during stall cleaning. Ammonia was measured in the horse's breathing zone by attaching Draeger tubes to horse's halters for 12 h overnight and instantaneous ammonia levels were measured each morning in the stalls.Changes over time in WAC, ammonia, muck production, and air quality were analyzed using a mixed model ANOVA with repeated measures (SAS 9.4). The WAC was higher in WS compared with RK (P = 0.0057) but there was no difference in total muck produced (P = 0.5931). There was no main effect of bedding type on suspended PM (P > 0.05) but there was an increase over time across bedding types (P < 0.05). Suspended PM was lowest the first day and increased during subsequent days. During stall cleaning there were no differences in air quality between bedding type (P > 0.05), however, the average PM 2.5 level (51.5 ± 14.7 µg/m³) was higher than recommended exposure levels (35 µg/m³) for caretakers. Ammonia levels in the RK stalls were lower than stalls bedded with WS (4.65 ± 2.4 ppm and 6.88 ± 2.4 ppm, respectively; P = 0.0125). Horses bedded on RK were exposed to lower levels of ammonia in their breathing zone compared with horses bedded on WS (P = 0.003). Overall, RK appear to be a suitable alternative bedding type to traditional WS. Although the WAC is lower, bedding with RK reduces ammonia exposure of horses and their caretakers. Utilization of agricultural byproducts as bedding provides an opportunity to extract value from these byproducts.
    Keywords air quality ; ammonia ; byproducts ; cross-over studies ; horses ; nylon ; particulates ; sawdust ; statistical models ; veterinary medicine ; wild rice ; wood ; Minnesota
    Language English
    Dates of publication 2023-05
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 2102631-2
    ISSN 1542-7412 ; 0737-0806
    ISSN (online) 1542-7412
    ISSN 0737-0806
    DOI 10.1016/j.jevs.2023.104426
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Re: Zhu et al, "A novel gene variation of TNF alpha associated with ankylosing spondylitis: a reconfirmed study".

    Brown, M A

    Annals of the rheumatic diseases

    2008  Volume 67, Issue 3, Page(s) 434; discussion 434–6

    MeSH term(s) Genetic Predisposition to Disease ; Humans ; Linkage Disequilibrium ; Polymorphism, Single Nucleotide ; Spondylitis, Ankylosing/genetics ; Tumor Necrosis Factor-alpha/genetics
    Chemical Substances Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2008-03
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Breakthroughs in genetic studies of ankylosing spondylitis.

    Brown, M A

    Rheumatology (Oxford, England)

    2008  Volume 47, Issue 2, Page(s) 132–137

    Abstract: Ankylosing spondylitis (AS), the prototypic seronegative arthropathy, is known to be highly heritable, with >90% of the risk of developing the disease determined genetically. As with most common heritable diseases, progress in identifying the genes ... ...

    Abstract Ankylosing spondylitis (AS), the prototypic seronegative arthropathy, is known to be highly heritable, with >90% of the risk of developing the disease determined genetically. As with most common heritable diseases, progress in identifying the genes involved using family-based or candidate gene approaches has been slow. The recent development of the genome-wide association study approach has revolutionized genetic studies of such diseases. Early studies in ankylosing spondylitis have produced two major breakthroughs in the identification of genes contributing roughly one third of the population attributable risk of the disease, and pointing directly to a potential therapy. These exciting findings highlight the potential of future more comprehensive genetic studies of determinants of disease risk and clinical manifestations, and are the biggest advance in our understanding of the causation of the disease since the discovery of the association with HLA-B27.
    MeSH term(s) Aminopeptidases/genetics ; Chromosome Mapping ; Frameshift Mutation ; Genetic Predisposition to Disease ; Genome, Human ; Humans ; Major Histocompatibility Complex/genetics ; Minor Histocompatibility Antigens ; Polymerase Chain Reaction ; Receptors, Interleukin/genetics ; Spondylitis, Ankylosing/diagnosis ; Spondylitis, Ankylosing/epidemiology ; Spondylitis, Ankylosing/genetics
    Chemical Substances IL23R protein, human ; Minor Histocompatibility Antigens ; Receptors, Interleukin ; Aminopeptidases (EC 3.4.11.-) ; ERAP1 protein, human (EC 3.4.11.-)
    Language English
    Publishing date 2008-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kem269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases.

    Agrawal, N / Brown, M A

    Genes and immunity

    2014  Volume 15, Issue 8, Page(s) 521–527

    Abstract: Endosplasmic reticulum aminopeptidase 1 (ERAP1), endoplasmic reticulum aminopeptidase 2 (ERAP2) and puromycin-sensitive aminopeptidase (NPEPPS) are key zinc metallopeptidases that belong to the oxytocinase subfamily of M1 aminopeptidase family. NPEPPS ... ...

    Abstract Endosplasmic reticulum aminopeptidase 1 (ERAP1), endoplasmic reticulum aminopeptidase 2 (ERAP2) and puromycin-sensitive aminopeptidase (NPEPPS) are key zinc metallopeptidases that belong to the oxytocinase subfamily of M1 aminopeptidase family. NPEPPS catalyzes the processing of proteosome-derived peptide repertoire followed by trimming of antigenic peptides by ERAP1 and ERAP2 for presentation on major histocompatibility complex (MHC) Class I molecules. A series of genome-wide association studies have demonstrated associations of these aminopeptidases with a range of immune-mediated diseases such as ankylosing spondylitis, psoriasis, Behçet's disease, inflammatory bowel disease and type I diabetes, and significantly, genetic interaction between some aminopeptidases and HLA Class I loci with which these diseases are strongly associated. In this review, we highlight the current state of understanding of the genetic associations of this class of genes, their functional role in disease, and potential as therapeutic targets.
    MeSH term(s) Aminopeptidases/genetics ; Genetic Association Studies ; Genetic Predisposition to Disease/genetics ; HLA Antigens/genetics ; Humans ; Immune System Diseases/genetics ; Metalloendopeptidases/genetics ; Minor Histocompatibility Antigens ; Models, Genetic ; Polymorphism, Single Nucleotide
    Chemical Substances HLA Antigens ; Minor Histocompatibility Antigens ; Aminopeptidases (EC 3.4.11.-) ; ERAP1 protein, human (EC 3.4.11.-) ; ERAP2 protein, human (EC 3.4.11.-) ; Metalloendopeptidases (EC 3.4.24.-) ; NPEPPS protein, human (EC 3.4.24.-)
    Language English
    Publishing date 2014-08-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2060566-3
    ISSN 1476-5470 ; 1466-4879
    ISSN (online) 1476-5470
    ISSN 1466-4879
    DOI 10.1038/gene.2014.46
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: THE PLACE OF THE TEACHER IN A SCHOOL HEALTH PROGRAM.

    Brown, M A

    American journal of public health (New York, N.Y. : 1912)

    2007  Volume 14, Issue 9, Page(s) 754–757

    Language English
    Publishing date 2007-10-25
    Publishing country United States
    Document type Journal Article
    ISSN 0271-4353
    ISSN 0271-4353
    DOI 10.2105/ajph.14.9.754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Human leucocyte antigen-B27 and ankylosing spondylitis.

    Brown, M A

    Internal medicine journal

    2007  Volume 37, Issue 11, Page(s) 739–740

    MeSH term(s) Alleles ; Asian Continental Ancestry Group/genetics ; European Continental Ancestry Group/genetics ; Genetic Predisposition to Disease ; Genotype ; HLA-B27 Antigen/genetics ; Humans ; Indians, North American/genetics ; Oceanic Ancestry Group/genetics ; Predictive Value of Tests ; Sensitivity and Specificity ; Spondylitis, Ankylosing/diagnosis ; Spondylitis, Ankylosing/ethnology ; Spondylitis, Ankylosing/genetics ; Spondylitis, Ankylosing/immunology
    Chemical Substances HLA-B27 Antigen
    Language English
    Publishing date 2007-11
    Publishing country Australia
    Document type Comment ; Editorial
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/j.1445-5994.2007.01491.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The P4 study: Subsequent pregnancy maternal physiology after hypertensive and normotensive pregnancies.

    Kennedy, R / Roberts, L / Davis, G / Mangos, G / Pettit, F / Brown, M A / O'Sullivan, A J / Henry, A

    Pregnancy hypertension

    2021  Volume 27, Page(s) 29–34

    Abstract: Objectives: Hypertensive disorders of pregnancy are associated with subsequent increased risk of cardiometabolic disease. Adverse cardiometabolic measures are noted soon after hypertensive versus normotensive pregnancy (NP); to what degree these persist ...

    Abstract Objectives: Hypertensive disorders of pregnancy are associated with subsequent increased risk of cardiometabolic disease. Adverse cardiometabolic measures are noted soon after hypertensive versus normotensive pregnancy (NP); to what degree these persist into a subsequent pregnancy (SP) is unknown. This study aimed to assess women's physiology early in SP after hypertensive pregnancy (HP: preeclampsia or gestational hypertension) or NP and compare SP to 6 months postpartum findings from the index pregnancy.
    Study design: Prospective sub-study of the P4 (Postpartum, Physiology, Psychology and Paediatric) observational cohort. Measurements six months after NP versus HP, and the SP at 11-13 weeks gestation.
    Main outcome measures: Blood pressure (BP), blood and urine tests (urine ACR, HOMA-IR, LDL cholesterol), body composition, and contribution of maternal characteristics and inter-pregnancy factors to BP and body fat (FM%) in SP.
    Results: 49 women (34 NP, 15 HP). In the SP, post-HP women had higher BP (112/70 mmHg HP vs 102/64 mmHg NP; p < .001), with no significant drop from six months postpartum to early SP. On regression analysis, systolic and diastolic BP at 6-months were the major predictors for SP systolic (p < 0.001) and diastolic (p = 0.009) BP respectively in the SP. Longer interpregnancy interval and increased FM% 6-months postpartum were associated with higher SP FM% (p < 0.001).
    Conclusions: BP and body fat six months postpartum were similar early in the SP for HP group, and postpartum BP and FM% were major predictors of their corresponding SP measurements. Postpartum/inter-pregnancy intervention programs to improve these cardiometabolic risk markers might help improve women's long-term health and require investigation.
    MeSH term(s) Adult ; Blood Pressure ; Cardiometabolic Risk Factors ; Case-Control Studies ; Female ; Humans ; Postpartum Period ; Pre-Eclampsia/physiopathology ; Pregnancy ; Prospective Studies
    Language English
    Publishing date 2021-10-30
    Publishing country Netherlands
    Document type Journal Article ; Observational Study
    ZDB-ID 2584464-7
    ISSN 2210-7797 ; 2210-7789
    ISSN (online) 2210-7797
    ISSN 2210-7789
    DOI 10.1016/j.preghy.2021.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comparison of methods to construct a genetic risk score for prediction of rheumatoid arthritis in the population-based Nord-Trøndelag Health Study, Norway.

    Rostami, S / Hoff, M / Brown, M A / Hveem, K / Videm, V

    Rheumatology (Oxford, England)

    2019  Volume 59, Issue 7, Page(s) 1743–1751

    Abstract: Objectives: To evaluate selection methods among published single-nucleotide polymorphisms (SNPs) associated with RA to construct predictive genetic risk scores (GRSs) in a population-based setting.: Methods: The Nord-Trøndelag Health (HUNT) Study is ... ...

    Abstract Objectives: To evaluate selection methods among published single-nucleotide polymorphisms (SNPs) associated with RA to construct predictive genetic risk scores (GRSs) in a population-based setting.
    Methods: The Nord-Trøndelag Health (HUNT) Study is a prospective cohort study among the whole adult population of northern Trøndelag, Norway. Participants in HUNT2 (1995-1997) and HUNT3 (2006-2008) were included (489 RA cases, 61 584 controls). The initial SNP selection from relevant genome-wide studies included 269 SNPs from 30 studies. Following different selection criteria, SNPs were weighted by published odds ratios. The sum of each person's carriage of all weighted susceptibility variants was calculated for each GRS.
    Results: The best-fitting risk score included 27 SNPs [weighted genetic risk score 27 (wGRS27)] and was identified using P-value selection criterion ≤5 × 10-8, the largest possible SNP selection without high linkage disequilibrium (r2 < 0.8), and lasso regression to select for positive coefficients. In a logistic regression model adjusted for gender, age and ever smoking, wGRS27 was associated with RA [odds ratio 1.86 (95% CI 1.71, 2.04) for each s.d. increase, P < 0.001]. The AUC was 0.76 (95% CI 0.74, 0.78). The positive and negative predictive values were 1.6% and 99.7%, respectively, and the positive predictive value was not improved in sensitivity analyses subselecting participants to illustrate settings with increased RA prevalences. Other schemes selected more SNPs but resulted in GRSs with lower predictive ability.
    Conclusion: Constructing a wGRS based on a smaller selection of informative SNPs improved predictive ability. Even with a relatively high AUC, the low PPV illustrates that there was a large overlap in risk variants among RA patients and controls, precluding clinical usefulness.
    MeSH term(s) Adult ; Aged ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Norway/epidemiology ; Polymorphism, Single Nucleotide ; Prevalence ; Prospective Studies ; Risk Assessment
    Language English
    Publishing date 2019-12-13
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kez638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Genetic studies of osteoporosis--a rethink required.

    Brown, M A

    Calcified tissue international

    2005  Volume 76, Issue 5, Page(s) 319–325

    MeSH term(s) Bone Density/genetics ; Humans ; Molecular Epidemiology ; Osteoporosis/epidemiology ; Osteoporosis/genetics
    Language English
    Publishing date 2005-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 304266-2
    ISSN 1432-0827 ; 0171-967X ; 0944-0747 ; 0008-0594
    ISSN (online) 1432-0827
    ISSN 0171-967X ; 0944-0747 ; 0008-0594
    DOI 10.1007/s00223-004-0179-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Repeatability of USCOM®-measured cardiac output in normotensive non-pregnant and pregnant women.

    Mangos, J G / Pettit, F / Preece, R / Harris, K / Brown, M A

    Pregnancy hypertension

    2018  Volume 12, Page(s) 71–74

    MeSH term(s) Adult ; Aortic Valve/pathology ; Cardiac Output ; Case-Control Studies ; Echocardiography, Doppler/instrumentation ; Female ; Humans ; Monitoring, Physiologic/methods ; Pre-Eclampsia/physiopathology ; Pregnancy ; Reproducibility of Results ; Vascular Resistance ; Young Adult
    Language English
    Publishing date 2018-03-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2584464-7
    ISSN 2210-7797 ; 2210-7789
    ISSN (online) 2210-7797
    ISSN 2210-7789
    DOI 10.1016/j.preghy.2018.03.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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