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  1. Article ; Online: Postoperative continuous non-invasive cardiac output monitoring on the ward: a feasibility study.

    King, C E / Kermode, A / Saxena, G / Carvelli, P / Edwards, M / Creagh-Brown, B C

    Journal of clinical monitoring and computing

    2020  Volume 35, Issue 6, Page(s) 1349–1356

    Abstract: Postoperative hypotension is common (occurring in one third of patients) and is associated with worse clinical outcomes. The LiDCO CNAP (continuous non-invasive arterial pressure) device measures haemodynamics but has not been widely adopted in ward ... ...

    Abstract Postoperative hypotension is common (occurring in one third of patients) and is associated with worse clinical outcomes. The LiDCO CNAP (continuous non-invasive arterial pressure) device measures haemodynamics but has not been widely adopted in ward environments. Improved early detection of hypotension by CNAP might guide interventions to improve clinical outcomes. We aimed to find the proportion of patients who tolerated LiDCO CNAP for 12 h postoperatively, to unmask episodes of hypotension detected by continuous monitoring and to characterise the haemodynamic profile at the time of hypotension. In this feasibility study, patients undergoing major elective surgery were continuously postoperatively monitored using CNAP. Haemodynamic data gathered from CNAP, including nSVRI (nominal systemic vascular resistance index), nSVI (nominal stroke volume index), SVV (stroke volume variation) and blood pressure, were analysed using Microsoft Excel and GraphPad Prism 8. 104 patients (age (mean ± sd): 68 ± 14, male (56%)) had CNAP sited postoperatively. 39% tolerated the CNAP device for at least 12 h. Within the 104 patients a mean of 81.2 min of hypotension detected by CNAP was not detected by usual care. The proportion of low/normal/high nSVI was 71%, 27% and 2%, nSVRI was 43%, 17% and 40%, respectively. CNAP monitoring was not tolerated for 12 h in the majority of patients. There were many episodes of hypotension unmasked through continuous monitoring. Based on the advanced haemodynamic data provided it is possible that the underlying cause of a third of postoperative hypotensive episodes is vasodilation rather than hypovolaemia.Trial registry number: NCT04010058 (ClinicalTrials.gov) Date of registration: 08/07/2019.
    MeSH term(s) Aged ; Aged, 80 and over ; Blood Pressure ; Blood Pressure Determination ; Blood Pressure Monitors ; Cardiac Output ; Feasibility Studies ; Female ; Humans ; Male ; Middle Aged ; Stroke Volume
    Language English
    Publishing date 2020-10-22
    Publishing country Netherlands
    Document type Clinical Trial ; Journal Article
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-020-00601-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The determination of lead in mosses by means of its catalytic effect on the persulphate oxidation of Pyrogallol Red.

    Anderson, R G / Brown, B C

    Talanta

    2006  Volume 28, Issue 6, Page(s) 365–368

    Abstract: Lead is determined in aqueous solution in the concentration range 0.002-10 mug/ml by its catalytic effect on the oxidation of Pyrogallol Red at pH 8.5. The method has been applied to the determination of lead in mosses by means of a wet ashing procedure ... ...

    Abstract Lead is determined in aqueous solution in the concentration range 0.002-10 mug/ml by its catalytic effect on the oxidation of Pyrogallol Red at pH 8.5. The method has been applied to the determination of lead in mosses by means of a wet ashing procedure using nitric and perchloric acids and separation from interfering ions by extraction as the dithizone complex into chloroform, and back-extraction.
    Language English
    Publishing date 2006-01-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/0039-9140(81)80186-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A career in O&G? No thanks!

    Brown, B C / Vause, S

    BJOG : an international journal of obstetrics and gynaecology

    2006  Volume 113, Issue 8, Page(s) 975

    MeSH term(s) Career Choice ; Forecasting ; Gynecology ; Humans ; Obstetrics ; Sex Factors
    Language English
    Publishing date 2006-08
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 1470-0328 ; 0306-5456
    ISSN (online) 1471-0528
    ISSN 1470-0328 ; 0306-5456
    DOI 10.1111/j.1471-0528.2006.01022.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Palliative and end-of-life care for patients with severe COPD.

    Creagh-Brown, B C / Shee, C

    The European respiratory journal

    2009  Volume 33, Issue 2, Page(s) 445–6; author reply 446

    MeSH term(s) Advance Care Planning ; Attitude to Death ; Health Services Accessibility ; Humans ; Palliative Care/methods ; Physician-Patient Relations ; Pulmonary Disease, Chronic Obstructive/therapy ; Terminal Care/methods
    Language English
    Publishing date 2009-02
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/09031936.00143208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Adalimumab for psoriasis: practical experience in a U.K. tertiary referral centre.

    Warren, R B / Brown, B C / Lavery, D / Griffiths, C E M

    The British journal of dermatology

    2010  Volume 163, Issue 4, Page(s) 859–862

    Abstract: Background: There are few reports of the practical use of adalimumab outside of a clinical trial setting and, to our knowledge, none from the U.K.: Objectives: We assessed the efficacy and safety of adalimumab in a cohort of patients with severe ... ...

    Abstract Background: There are few reports of the practical use of adalimumab outside of a clinical trial setting and, to our knowledge, none from the U.K.
    Objectives: We assessed the efficacy and safety of adalimumab in a cohort of patients with severe psoriasis attending a tertiary dermatology referral centre in the U.K.
    Methods: A retrospective case-note review was used to identify all patients initiated on adalimumab for psoriasis. RESI;TS: Baseline Psoriasis Area and Severity Index (PASI) was 24+/-11 (range 9-54; n=46). After 4 months' treatment with adalimumab 64% (29/45), of patients had achieved PASI 75 (75% decrease from baseline) whilst 80% (36/45) of patients met NICE criteria for continuation of treatment. Therapy was well-tolerated. Importantly, 68% (21/31) of patients who had previously received another tumour necrosis factor alpha inhibitor met NICE criteria for continuation of treatment at 16 weeks.
    Conclusions: In a cohort of U.K. patients with severe psoriasis, adalimumab has proved to be a significant addition to the expanding armamentarium of biologics for psoriasis. Pharmacovigilance, in the form of registries, is essential to assess the long-term safety of such drugs.
    MeSH term(s) Adalimumab ; Adult ; Aged ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/therapeutic use ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Psoriasis/drug therapy ; Quality of Life ; Retrospective Studies ; Salvage Therapy ; Treatment Outcome
    Chemical Substances Anti-Inflammatory Agents ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Adalimumab (FYS6T7F842)
    Language English
    Publishing date 2010-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/j.1365-2133.2010.09986.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: What's new in psoriasis? Analysis of the clinical significance of new guidelines and systematic reviews on psoriasis published in 2008 and 2009.

    Warren, R B / Brown, B C / Grindlay, D J C / Griffiths, C E M

    Clinical and experimental dermatology

    2010  Volume 35, Issue 7, Page(s) 688–91; quiz 692

    Abstract: This review summarizes the clinical importance of 18 systematic reviews and guidelines on psoriasis published or indexed between November 2008 and October 2009. The topics covered include guidance on the use of topical, systemic and biological therapies ... ...

    Abstract This review summarizes the clinical importance of 18 systematic reviews and guidelines on psoriasis published or indexed between November 2008 and October 2009. The topics covered include guidance on the use of topical, systemic and biological therapies for the treatment of psoriasis; comorbidities associated with psoriasis; and complementary therapies for psoriasis. A similar and more detailed review to this appeared in the 2009 Annual Evidence Update on Psoriasis from NHS Evidence - Skin Disorders in November 2009.
    MeSH term(s) Dermatologic Agents/therapeutic use ; Humans ; Immunologic Factors/therapeutic use ; Practice Guidelines as Topic ; Psoriasis/drug therapy ; Review Literature as Topic
    Chemical Substances Dermatologic Agents ; Immunologic Factors
    Language English
    Publishing date 2010-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/j.1365-2230.2010.03880.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Skin scar preconceptions must be challenged: importance of self-perception in skin scarring.

    Brown, B C / Moss, T P / McGrouther, D A / Bayat, A

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2010  Volume 63, Issue 6, Page(s) 1022–1029

    Abstract: Greater objective scar severity and visibility should intuitively cause greater psychosocial distress for patients. Previous research is contradictory and has employed non-validated scar severity measures whilst neglecting patient-rated severity. The aim ...

    Abstract Greater objective scar severity and visibility should intuitively cause greater psychosocial distress for patients. Previous research is contradictory and has employed non-validated scar severity measures whilst neglecting patient-rated severity. The aim of this study was to assess the effects of objective and patient-rated scar severity, scar type and location on psychosocial distress. Skin scars were quantitatively assessed on two independent occasions using the 'Manchester Scar Scale' (MSS) - a validated measure. Scars were scored twice independently. Patients also rated their scars (from 'very good' [zero] to 'poor' [four]) and good completed the Derriford Appearance Scale (DAS24) and Dermatology Life Quality Index (DLQI). Eighty-two patients, with an average+/-SD (range) age of 34+/-15 (16-65) years were recruited. Mean psychosocial questionnaire scores were: DAS24 45.5+/-17.8 (15-91); DLQI 7.5+/-6.7 (0-26). Participants had 1.9+/-1.5 (1-8) scars with an MSS score of 31.3+/-24.0 (6.6-162.0) and subjective score of 2.6+/-1.2 (0-4). Correlation between psychosocial distress and objective severity was not significant (DAS24 0.14 p=0.11; DLQI 0.16 p=0.06). Correlation between psychosocial distress and subjective severity was significant (DAS24 0.48 p<0.0001; DLQI 0.46 p<0.0001). Patients with non-visible scars experienced greater psychosocial distress than patients with visible scars (DAS24 9.7 p=0.046; DLQI 4.2 p=0.014). Scar type was unrelated to psychosocial distress. Patient-rated scar severity and scar visibility are correlated with psychosocial distress rather than clinician's objective severity rating or scar type. Although counter-intuitive, results are consistent with research into other disfiguring conditions and patient self-assessment should therefore form an integral part of clinical assessment.
    MeSH term(s) Adolescent ; Adult ; Aged ; Body Image ; Cicatrix/etiology ; Cicatrix/pathology ; Cicatrix/psychology ; Cohort Studies ; Humans ; Middle Aged ; Observer Variation ; Quality of Life ; Reproducibility of Results ; Self Concept ; Severity of Illness Index ; Skin/pathology ; Skin Pigmentation ; Stress, Psychological/epidemiology ; Young Adult
    Language English
    Publishing date 2010-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2009.03.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Long-term control of recalcitrant psoriasis with combination infliximab and methotrexate.

    Warren, R B / Brown, B C / Carmichael, A J / Griffiths, C E M

    Clinical and experimental dermatology

    2009  Volume 34, Issue 3, Page(s) 415–416

    MeSH term(s) Adult ; Antibodies, Monoclonal/therapeutic use ; Dermatologic Agents/therapeutic use ; Drug Therapy, Combination ; Humans ; Infliximab ; Male ; Methotrexate/therapeutic use ; Psoriasis/drug therapy
    Chemical Substances Antibodies, Monoclonal ; Dermatologic Agents ; Infliximab (B72HH48FLU) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2009-04
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/j.1365-2230.2008.02946.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: What's new in psoriasis? Analysis of the clinical significance of systematic reviews on psoriasis published in 2007 and 2008.

    Brown, B C / Warren, R B / Grindlay, D J C / Griffiths, C E M

    Clinical and experimental dermatology

    2009  Volume 34, Issue 6, Page(s) 664–667

    Abstract: This review summarizes the clinical importance of six systematic reviews on psoriasis published between January 2007 and October 2008. A meta-analysis demonstrated that several traditional nonbiological systemic therapies have equal or superior efficacy ... ...

    Abstract This review summarizes the clinical importance of six systematic reviews on psoriasis published between January 2007 and October 2008. A meta-analysis demonstrated that several traditional nonbiological systemic therapies have equal or superior efficacy to some biological therapies used in the treatment of psoriasis. Two further meta-analyses comparing biological therapies for psoriasis (excluding adalimumab) have established a hierarchy of efficacy for short-term treatment (10-16 weeks): infliximab > etanercept 50 mg twice weekly > etanercept 25 mg twice weekly > efalizumab > alefacept. Excluding adalimumab, rates of adverse events are significantly higher for biological therapies than for placebo, except for etanercept at both 25 and 50 mg twice weekly. Further, head to head trials of biological therapies for psoriasis and longer-term safety data on their use are required. Psoriasis can be induced by and/or exacerbated during antitumour necrosis factor (TNF) therapy. It is recommended to initially switch anti-TNF agent in this situation and only discontinue therapy if psoriasis is extensive and/or intolerable, allowing the primary disease to remain under control. Most screening and monitoring tests carried out during treatment of psoriasis with biological therapies are neither supported nor refuted by current evidence and the clinician must assess each case individually. Studies designed specifically to assess appropriate use of these tests are required. Further research is needed to evaluate the effectiveness of existing psychological interventions in psoriasis. The effectiveness of support groups has not been adequately proven, although there are limited data supporting the use of cognitive behavioural therapy.
    MeSH term(s) Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/therapeutic use ; Cognitive Behavioral Therapy ; Humans ; Psoriasis/chemically induced ; Psoriasis/therapy ; Randomized Controlled Trials as Topic ; Self-Help Groups ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2009-06-30
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1111/j.1365-2230.2009.03414.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The use of the Tempa.Dot thermometer in routine clinical practice.

    Creagh-Brown, B C / James, D Armstrong / Jackson, S H D

    Age and ageing

    2005  Volume 34, Issue 3, Page(s) 297–299

    MeSH term(s) Clinical Nursing Research ; Diagnostic Errors ; Disposable Equipment/standards ; Education, Nursing, Continuing ; Equipment Design ; Fever/diagnosis ; Fever/nursing ; Humans ; Thermometers/standards ; United Kingdom
    Language English
    Publishing date 2005-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 186788-x
    ISSN 1468-2834 ; 0002-0729
    ISSN (online) 1468-2834
    ISSN 0002-0729
    DOI 10.1093/ageing/afi069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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