LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 42

Search options

  1. Article ; Online: Anticytokine autoantibody-associated immunodeficiency.

    Browne, Sarah K

    Annual review of immunology

    2014  Volume 32, Page(s) 635–657

    Abstract: Anticytokine autoantibodies are an emerging mechanism of disease in previously healthy adults. Patients with these syndromes demonstrate a unique infectious phenotype associated with neutralizing autoantibodies that target a specific cytokine. Examples ... ...

    Abstract Anticytokine autoantibodies are an emerging mechanism of disease in previously healthy adults. Patients with these syndromes demonstrate a unique infectious phenotype associated with neutralizing autoantibodies that target a specific cytokine. Examples include anti-interferon (IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria; anti-granulocyte macrophage colony-stimulating factor autoantibodies and cryptococcal meningitis; anti-interleukin (IL)-6 autoantibodies and staphylococcal skin infection; and anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies and mucocutaneous candidiasis in the setting of either APECED (autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy syndrome) or thymoma. Other anticytokine autoantibodies may contribute to an infectious phenotype such as anti-granulocyte colony stimulating factor and anti-IFN-α autoantibodies, although the strength of the association is less clear. Their identification not only affects disease management but also may uncover key mechanisms of host defense against specific organisms. Furthermore, it raises the possibility that currently idiopathic diseases will someday be explained by a yet unidentified anticytokine autoantibody. This review focuses on the current understanding, both clinical and mechanistic, of anticytokine autoantibody-associated immunodeficiency.
    MeSH term(s) Animals ; Autoantibodies/immunology ; Candidiasis/diagnosis ; Candidiasis/immunology ; Candidiasis/therapy ; Cytokines/immunology ; Humans ; Immunologic Deficiency Syndromes/diagnosis ; Immunologic Deficiency Syndromes/immunology ; Immunologic Deficiency Syndromes/therapy ; Polyendocrinopathies, Autoimmune/diagnosis ; Polyendocrinopathies, Autoimmune/immunology ; Polyendocrinopathies, Autoimmune/therapy ; Thymoma/diagnosis ; Thymoma/immunology ; Thymoma/therapy
    Chemical Substances Autoantibodies ; Cytokines
    Language English
    Publishing date 2014
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-immunol-032713-120222
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Summary of the Vaccines and Related Biological Products Advisory Committee meeting held to consider evaluation of vaccine candidates for the prevention of respiratory syncytial virus disease in RSV-naïve infants.

    Browne, Sarah K / Beeler, Judy A / Roberts, Jeffrey N

    Vaccine

    2019  Volume 38, Issue 2, Page(s) 101–106

    Abstract: Respiratory syncytial virus (RSV), is a common cause of serious acute lower respiratory tract illness in infants and young children, causing substantial morbidity and mortality globally. Treatment is mainly supportive and currently there is no licensed ... ...

    Abstract Respiratory syncytial virus (RSV), is a common cause of serious acute lower respiratory tract illness in infants and young children, causing substantial morbidity and mortality globally. Treatment is mainly supportive and currently there is no licensed preventive vaccine. Clinical trials conducted in the 1960s evaluating a formalin-inactivated RSV vaccine (FI-RSV) in RSV-naïve infants resulted in observations of enhanced respiratory disease (ERD) following subsequent natural RSV infection in vaccinees. In these studies, infants immunized with FI-RSV had higher rates of severe RSV disease compared with controls. This outcome redirected focus on identifying the immunologic mechanisms that precipitated ERD as a prerequisite to further vaccine development. Improved understanding of the immunopathogenesis of ERD derived from animal models has stimulated development of new candidate vaccines and engendered discussions among RSV experts about the safety data needed to advance these products into the clinic, and ultimately, into the target population of RSV-naïve infants. The recognition that multiple products would soon be ready for testing in infants and children prompted the FDA to hold a Vaccines and Related Biological Products Advisory Committee (VRBPAC) meeting to seek perspectives and advice of experts regarding the types and extent of preclinical and clinical data that might be needed to support testing in RSV-naïve infants for specific types of candidate RSV vaccines. Committee members agreed that, if certain conditions are met in preclinical and early clinical studies, it would be reasonable to move forward from studies in adults and older children and into clinical trials evaluating vaccine safety and efficacy in RSV-naïve infants. Herein, we review and summarize perspectives on the discussion regarding recommendations for RSV vaccine development in this population.
    MeSH term(s) Advisory Committees ; Animals ; Biological Products/administration & dosage ; Child, Preschool ; Disease Models, Animal ; Humans ; Immunization ; Infant ; Respiratory Syncytial Virus Infections/immunology ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Syncytial Virus Vaccines/administration & dosage ; Respiratory Syncytial Virus Vaccines/immunology ; Respiratory Syncytial Virus, Human/immunology ; Severity of Illness Index
    Chemical Substances Biological Products ; Respiratory Syncytial Virus Vaccines
    Language English
    Publishing date 2019-11-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2019.10.048
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Summary of the Vaccines and Related Biological Products Advisory Committee meeting held to consider evaluation of vaccine candidates for the prevention of respiratory syncytial virus disease in RSV-naïve infants

    Browne, Sarah K / Beeler, Judy A / Roberts, Jeffrey N

    Vaccine. 2020 Jan. 10, v. 38, no. 2

    2020  

    Abstract: Respiratory syncytial virus (RSV), is a common cause of serious acute lower respiratory tract illness in infants and young children, causing substantial morbidity and mortality globally. Treatment is mainly supportive and currently there is no licensed ... ...

    Abstract Respiratory syncytial virus (RSV), is a common cause of serious acute lower respiratory tract illness in infants and young children, causing substantial morbidity and mortality globally. Treatment is mainly supportive and currently there is no licensed preventive vaccine. Clinical trials conducted in the 1960s evaluating a formalin-inactivated RSV vaccine (FI-RSV) in RSV-naïve infants resulted in observations of enhanced respiratory disease (ERD) following subsequent natural RSV infection in vaccinees. In these studies, infants immunized with FI-RSV had higher rates of severe RSV disease compared with controls. This outcome redirected focus on identifying the immunologic mechanisms that precipitated ERD as a prerequisite to further vaccine development. Improved understanding of the immunopathogenesis of ERD derived from animal models has stimulated development of new candidate vaccines and engendered discussions among RSV experts about the safety data needed to advance these products into the clinic, and ultimately, into the target population of RSV-naïve infants. The recognition that multiple products would soon be ready for testing in infants and children prompted the FDA to hold a Vaccines and Related Biological Products Advisory Committee (VRBPAC) meeting to seek perspectives and advice of experts regarding the types and extent of preclinical and clinical data that might be needed to support testing in RSV-naïve infants for specific types of candidate RSV vaccines. Committee members agreed that, if certain conditions are met in preclinical and early clinical studies, it would be reasonable to move forward from studies in adults and older children and into clinical trials evaluating vaccine safety and efficacy in RSV-naïve infants. Herein, we review and summarize perspectives on the discussion regarding recommendations for RSV vaccine development in this population.
    Keywords adults ; animal models ; children ; clinical trials ; experts ; infants ; morbidity ; mortality ; Respiratory syncytial virus ; respiratory tract diseases ; vaccine development ; vaccines
    Language English
    Dates of publication 2020-0110
    Size p. 101-106.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2019.10.048
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  4. Article: Good syndrome, bad problem.

    Martinez, Bianca / Browne, Sarah K

    Frontiers in oncology

    2014  Volume 4, Page(s) 307

    Language English
    Publishing date 2014-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2014.00307
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Anti-Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency.

    Cheng, Aristine / Kashyap, Anuj / Salvator, Helene / Rosen, Lindsey B / Colby, Devon / Ardeshir-Larijani, Fatemeh / Loehrer, Patrick J / Ding, Li / Lugo Reyes, Saul O / Riminton, Sean / Ballman, Madison / Rocco, Joseph M / Marciano, Beatriz E / Freeman, Alexandra F / Browne, Sarah K / Hsu, Amy P / Zelazny, Adrian / Rajan, Arun / Sereti, Irini /
    Zerbe, Christa S / Lionakis, Michail S / Holland, Steven M

    The New England journal of medicine

    2024  Volume 390, Issue 12, Page(s) 1105–1117

    Abstract: Background: Autoantibodies against interleukin-12 (anti-interleukin-12) are often identified in patients with thymoma, but opportunistic infections develop in only some of these patients. Interleukin-12 (with subunits p40 and p35) shares a common ... ...

    Abstract Background: Autoantibodies against interleukin-12 (anti-interleukin-12) are often identified in patients with thymoma, but opportunistic infections develop in only some of these patients. Interleukin-12 (with subunits p40 and p35) shares a common subunit with interleukin-23 (subunits p40 and p19). In a patient with disseminated
    Methods: Among the patients (most of whom had thymoma) who were known to have anti-interleukin-12, we screened for autoantibodies against interleukin-23 (anti-interleukin-23). To validate the potential role of anti-interleukin-23 with respect to opportunistic infection, we tested a second cohort of patients with thymoma as well as patients without either thymoma or known anti-interleukin-12 who had unusual infections.
    Results: Among 30 patients with anti-interleukin-12 who had severe mycobacterial, bacterial, or fungal infections, 15 (50%) also had autoantibodies that neutralized interleukin-23. The potency of such neutralization was correlated with the severity of these infections. The neutralizing activity of anti-interleukin-12 alone was not associated with infection. In the validation cohort of 91 patients with thymoma, the presence of anti-interleukin-23 was associated with infection status in 74 patients (81%). Overall, neutralizing anti-interleukin-23 was detected in 30 of 116 patients (26%) with thymoma and in 30 of 36 patients (83%) with disseminated, cerebral, or pulmonary infections. Anti-interleukin-23 was present in 6 of 32 patients (19%) with severe intracellular infections and in 2 of 16 patients (12%) with unusual intracranial infections, including
    Conclusions: Among patients with a variety of mycobacterial, bacterial, or fungal infections, the presence of neutralizing anti-interleukin-23 was associated with severe, persistent opportunistic infections. (Funded by the National Institute of Allergy and Infectious Diseases and others.).
    MeSH term(s) Adult ; Humans ; Autoantibodies/immunology ; Immunologic Deficiency Syndromes/immunology ; Interleukin-12/antagonists & inhibitors ; Interleukin-12/immunology ; Interleukin-23/antagonists & inhibitors ; Interleukin-23/immunology ; Mycoses/immunology ; Opportunistic Infections/immunology ; Thymoma/immunology ; Thymus Neoplasms/immunology ; Antibodies, Neutralizing/immunology ; Bacterial Infections/immunology
    Chemical Substances Autoantibodies ; Interleukin-12 (187348-17-0) ; Interleukin-23 ; Antibodies, Neutralizing
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article ; Validation Study
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa2210665
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Anticytokine autoantibodies in infectious diseases: pathogenesis and mechanisms.

    Browne, Sarah K / Holland, Steven M

    The Lancet. Infectious diseases

    2010  Volume 10, Issue 12, Page(s) 875–885

    Abstract: Autoantibodies to cytokines occur in many different conditions and situations and can cause a wide range of disease, including pulmonary alveolar proteinosis, disseminated non-tuberculous mycobacterial disease, pure red-cell aplasia, and chronic ... ...

    Abstract Autoantibodies to cytokines occur in many different conditions and situations and can cause a wide range of disease, including pulmonary alveolar proteinosis, disseminated non-tuberculous mycobacterial disease, pure red-cell aplasia, and chronic mucocutaneous candidiasis. Anticytokine autoantibodies may also develop against exogenously administered cytokines, sometimes diminishing their effects or inhibiting the activity of the endogenous cytokine. Unlike primary congenital immunodeficiencies, autoantibodies may develop over time, wax and wane, and may change in titre or avidity. Naturally occurring autoantibodies to interferons α, β, and γ, interleukins 1α, 2, 6, and 10, tumour necrosis factor, and granulocyte-macrophage colony-stimulating factor have been reported in healthy individuals and have been identified in rheumatological diseases, graft-versus-host disease, and cancer. Therapeutic antibodies, growth factors, other biological agents, and cytokines used to treat acute, chronic, malignant, and immune diseases may elicit or overcome autoantibodies, hence influencing the primary intended therapy. The increasing number of biologically active anticytokine autoantibodies being reported suggests that currently "idiopathic" diseases may someday be explained by neutralising or agonising autoantibodies. Their protean roles in causing, treating, preventing, and responding to disease, as well as simply maintaining normal homoeostasis, offer fascinating insights into the biology of immunity, inflammation, and infection.
    MeSH term(s) Autoantibodies/immunology ; Autoimmune Diseases/immunology ; Colony-Stimulating Factors/immunology ; Communicable Diseases/immunology ; Cytokines/immunology ; Humans
    Chemical Substances Autoantibodies ; Colony-Stimulating Factors ; Cytokines
    Language English
    Publishing date 2010-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(10)70196-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Immunodeficiency secondary to anticytokine autoantibodies.

    Browne, Sarah K / Holland, Steven M

    Current opinion in allergy and clinical immunology

    2010  Volume 10, Issue 6, Page(s) 534–541

    Abstract: Purpose of review: Anticytokine autoantibodies are an important and emerging mechanism of disease pathogenesis. We will review the clinical and laboratory features of syndromes in which immunodeficiency is caused by or associated with neutralizing ... ...

    Abstract Purpose of review: Anticytokine autoantibodies are an important and emerging mechanism of disease pathogenesis. We will review the clinical and laboratory features of syndromes in which immunodeficiency is caused by or associated with neutralizing anticytokine autoantibodies.
    Recent findings: A growing number of patients have been described who demonstrate unique infectious phenotypes associated with neutralizing autoantibodies that target a particular cytokine known to participate in host defense against the offending organism. Examples include antigranulocyte macrophage-colony stimulating factor (GM-CSF) autoantibodies and pulmonary alveolar proteinosis; anti-interferon (IFN)-γ autoantibodies and disseminated nontuberculous mycobacteria (NTM); anti-interleukin-(IL)-6 autoantibodies and severe staphylococcal skin infection; anti-IL-17A, anti-IL-17F, or anti-IL-22 autoantibodies in patients with mucocutaneous candidiasis in the setting of both the autoimmune polyendocrinopathy, candidiasis, ectodermal dystrophy (APECED) syndrome and in cases of thymoma.
    Summary: Anticytokine autoantibodies have manifestations that are diverse, ranging from asymptomatic to life-threatening. These emerging and fascinating causes of acquired immunodeficiency may explain some previously idiopathic syndromes.
    MeSH term(s) Antibodies, Blocking/immunology ; Autoantibodies/immunology ; Candidiasis, Chronic Mucocutaneous/genetics ; Candidiasis, Chronic Mucocutaneous/immunology ; Granulocyte-Macrophage Colony-Stimulating Factor/deficiency ; Granulocyte-Macrophage Colony-Stimulating Factor/immunology ; Humans ; Interferon-gamma/deficiency ; Interferon-gamma/immunology ; Interleukin-17/deficiency ; Interleukin-17/immunology ; Interleukin-6/deficiency ; Interleukin-6/immunology ; Interleukins/deficiency ; Interleukins/immunology ; Mycobacterium Infections, Nontuberculous/genetics ; Mycobacterium Infections, Nontuberculous/immunology ; Polyendocrinopathies, Autoimmune/genetics ; Polyendocrinopathies, Autoimmune/immunology ; Pulmonary Alveolar Proteinosis/genetics ; Pulmonary Alveolar Proteinosis/immunology ; Staphylococcal Skin Infections/genetics ; Staphylococcal Skin Infections/immunology ; Thymoma/genetics ; Thymoma/immunology ; Interleukin-22
    Chemical Substances Antibodies, Blocking ; Autoantibodies ; Interleukin-17 ; Interleukin-6 ; Interleukins ; Interferon-gamma (82115-62-6) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
    Language English
    Publishing date 2010-10-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0b013e3283402b41
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Anti-cytokine autoantibodies explain some chronic mucocutaneous candidiasis.

    Browne, Sarah K / Holland, Steven M

    Immunology and cell biology

    2010  Volume 88, Issue 6, Page(s) 614–615

    MeSH term(s) Autoantibodies/immunology ; Candidiasis, Chronic Mucocutaneous/genetics ; Candidiasis, Chronic Mucocutaneous/immunology ; Humans ; Interferon Type I/immunology ; Interleukin-17/immunology ; Interleukins/immunology ; Mutation/genetics ; Polyendocrinopathies, Autoimmune/immunology ; Signal Transduction/immunology ; Transcription Factors/genetics ; Transcription Factors/immunology ; AIRE Protein ; Interleukin-22
    Chemical Substances Autoantibodies ; Interferon Type I ; Interleukin-17 ; Interleukins ; Transcription Factors
    Language English
    Publishing date 2010-06-15
    Publishing country United States
    Document type News
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1038/icb.2010.72
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: Severe Facial Herpes Vegetans and Viremia in

    Parsons, Karyn / Cipriano, Sarah D / Rosen, Lindsey B / Browne, Sarah K / Walter, Jolan E / Stone, Bryan L / Keeshin, Susana / Chen, Karin

    Frontiers in pediatrics

    2019  Volume 7, Page(s) 61

    Abstract: With the accessibility of next-generation sequencing modalities, an increasing number of primary immunodeficiency disorders (PIDDs) such as common variable immunodeficiency (CVID) have gained improved understanding of molecular pathogenesis and disease ... ...

    Abstract With the accessibility of next-generation sequencing modalities, an increasing number of primary immunodeficiency disorders (PIDDs) such as common variable immunodeficiency (CVID) have gained improved understanding of molecular pathogenesis and disease phenotype with the identification of a genetic etiology. We report a patient with early-onset CVID due to an autosomal dominant loss-of-function mutation in
    Language English
    Publishing date 2019-03-19
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2019.00061
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Reply to Tham et al.

    Xie, Yingda L / Chen, Ray Y / Sereti, Irini / Zerbe, Christa S / Holland, Steven M / Browne, Sarah K

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2016  Volume 63, Issue 4, Page(s) 573–574

    Language English
    Publishing date 2016--15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciw352
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top