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  1. Article ; Online: All in for nuclear PFKP-induced CXCR4 metastasis: a T cell acute lymphoblastic leukemia prognostic marker.

    Broxmeyer, Hal E

    The Journal of clinical investigation

    2021  Volume 131, Issue 16

    Abstract: Phosphofructokinase 1 (PFK1) is expressed in T cell acute lymphoblastic leukemia (T-ALL), where its upregulation is linked with cancer progression. While PFK1 functions in the glycolysis pathway within the cytoplasm, it is also present in the nucleus ... ...

    Abstract Phosphofructokinase 1 (PFK1) is expressed in T cell acute lymphoblastic leukemia (T-ALL), where its upregulation is linked with cancer progression. While PFK1 functions in the glycolysis pathway within the cytoplasm, it is also present in the nucleus where it regulates gene transcription. In this issue of the JCI, Xueliang Gao, Shenghui Qin, et al. focus their mechanism-based investigation on the nucleocytoplasmic shuttling aspect of the PFK1 platelet isoform, PFKP. Functional nuclear export and localization sequences stimulated CXC chemokine receptor type 4 (CXCR4) expression to promote T-ALL invasion that involved cyclin D3/CDK6, c-Myc, and importin-9. Since the presence of nuclear PFKP is associated with poor survival in T-ALL, nuclear PFKP-induced CXCR4 expression might serve as a prognostic marker for T-ALL. More promising, though, are the mechanistic insights suggesting that approaches to dampening metastatic migration may have application to benefit patients with T-ALL.
    MeSH term(s) Glycolysis ; Humans ; Phosphofructokinase-1, Type C/metabolism ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Prognosis ; Receptors, CXCR4/genetics ; T-Lymphocytes/metabolism
    Chemical Substances CXCR4 protein, human ; Receptors, CXCR4 ; Phosphofructokinase-1, Type C (EC 2.7.1.-)
    Language English
    Publishing date 2021-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI151295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Associated guilt: radiation/bystanders.

    Broxmeyer, Hal E

    Blood

    2021  Volume 137, Issue 24, Page(s) 3314–3316

    MeSH term(s) Guilt
    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021011360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Cord blood

    Broxmeyer, Hal E.

    biology, immunology, banking, and clinical transplantation

    2004  

    Author's details ed. by Hal E. Broxmeyer
    Keywords Fetal Blood / transplantation ; Cord Blood Stem Cell Transplantation ; Hematopoietic Stem Cell Transplantation ; Fetal Blood / physiology ; Blood Banks / methods
    Language English
    Size XXII, 455 S. : Ill., graph. Darst.
    Publisher AABB Press
    Publishing place Bethesda, Md
    Publishing country United States
    Document type Book
    HBZ-ID HT014136426
    ISBN 1-56395-176-2 ; 978-1-56395-176-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2004 A 4387 order for loan Magazin

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  4. Article: Ex Vivo Expansion and Homing of Human Cord Blood Hematopoietic Stem Cells.

    Guo, Bin / Huang, Xinxin / Chen, Yandan / Broxmeyer, Hal E

    Advances in experimental medicine and biology

    2024  Volume 1442, Page(s) 85–104

    Abstract: Cord blood (CB) has been proven to be an alternative source of haematopoietic stem cells (HSCs) for clinical transplantation and has multiple advantages, including but not limited to greater HLA compatibility, lower incidence of graft-versus-host disease ...

    Abstract Cord blood (CB) has been proven to be an alternative source of haematopoietic stem cells (HSCs) for clinical transplantation and has multiple advantages, including but not limited to greater HLA compatibility, lower incidence of graft-versus-host disease (GvHD), higher survival rates and lower relapse rates among patients with minimal residual disease. However, the limited number of HSCs in a single CB unit limits the wider use of CB in clinical treatment. Many efforts have been made to enhance the efficacy of CB HSC transplantation, particularly by ex vivo expansion or enhancing the homing efficiency of HSCs. In this chapter, we will document the major advances regarding human HSC ex vivo expansion and homing and will also discuss the possibility of clinical translation of such laboratory work.
    MeSH term(s) Humans ; Fetal Blood ; Neoplasm Recurrence, Local ; Hematopoietic Stem Cells ; Graft vs Host Disease/prevention & control ; Hematopoietic Stem Cell Transplantation
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-981-99-7471-9_6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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  5. Article ; Online: Quickly attainable and highly engrafting hematopoietic stem cells.

    Broxmeyer, Hal E

    Blood science (Baltimore, Md.)

    2019  Volume 1, Issue 1, Page(s) 113–115

    Language English
    Publishing date 2019-09-17
    Publishing country United States
    Document type Journal Article
    ISSN 2543-6368
    ISSN (online) 2543-6368
    DOI 10.1097/BS9.0000000000000003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hematopoietic Stem Cell Intracellular Levels of Ca

    Broxmeyer, Hal E

    Cell stem cell

    2019  Volume 25, Issue 2, Page(s) 171–173

    Abstract: Calcium ions ( ... ...

    Abstract Calcium ions (Ca
    MeSH term(s) Calcium ; Calcium Signaling ; Cytoplasm ; Hematopoietic Stem Cells
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-07-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2019.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Long-Overdue Guidelines for the Cord Blood Banking Community.

    Broxmeyer, Hal E

    Stem cells translational medicine

    2019  Volume 8, Issue 4, Page(s) 320–322

    MeSH term(s) Blood Banks/standards ; Cord Blood Stem Cell Transplantation/standards ; Fetal Blood/cytology ; Humans
    Language English
    Publishing date 2019-03-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2642270-0
    ISSN 2157-6580 ; 2157-6580
    ISSN (online) 2157-6580
    ISSN 2157-6580
    DOI 10.1002/sctm.19-0056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Enhancement of stem cell engraftment on a WHIM.

    Broxmeyer, Hal E

    The Journal of clinical investigation

    2018  Volume 128, Issue 8, Page(s) 3240–3242

    Abstract: WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a genetic autoimmune disorder that results from gain-of-function mutations in the gene encoding chemokine receptor CXCR4. A previous study characterized a patient with WHIM ... ...

    Abstract WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a genetic autoimmune disorder that results from gain-of-function mutations in the gene encoding chemokine receptor CXCR4. A previous study characterized a patient with WHIM who underwent a chromothriptic event that resulted in spontaneous deletion of the WHIM allele in a single hematopoietic stem cell and subsequent cure of the disease. In this issue of the JCI, Gao et al. extend this work and show that Cxcl4-haplosufficient bone marrow has a selective advantage for long-term engraftment in murine WHIM models. Moreover, successful engraftment occurred without prior conditioning of recipients. Together, these results have important implications for improving hematopoietic stem/progenitor cell transplant not only for patients with WHIM but also for all patients who may require the procedure.
    MeSH term(s) Agammaglobulinemia ; Animals ; Bone Marrow Transplantation ; Humans ; Immunologic Deficiency Syndromes ; Mice ; Receptors, CXCR4 ; Warts
    Chemical Substances CXCR4 protein, human ; Receptors, CXCR4
    Language English
    Publishing date 2018-06-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI121857
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Role for Leptin and Leptin Receptors in Stem Cells During Health and Diseases.

    Trinh, Thao / Broxmeyer, Hal E

    Stem cell reviews and reports

    2021  Volume 17, Issue 2, Page(s) 511–522

    Abstract: Hematopoietic stem cells (HSCs) give rise to all blood and immune cells in the body. These rare cells reside in the hypoxic niche of the bone marrow (BM) where they are subjected to a complex network of regulatory factors including cellular and molecular ...

    Abstract Hematopoietic stem cells (HSCs) give rise to all blood and immune cells in the body. These rare cells reside in the hypoxic niche of the bone marrow (BM) where they are subjected to a complex network of regulatory factors including cellular and molecular components. To sustain hematopoiesis over the lifetime of an individual, HSCs maintain distinctive metabolic programs, and in recent years nutritional factors have been increasingly recognized as critical regulators of HSC numbers and functions. Leptin (LEP), a neuroendocrine messenger, and its receptor (LEPR) are well-known for their immunomodulatory and energy balancing effects; yet, how LEP/LEPR signaling plays a role in hematopoiesis is under-appreciated. In this review, we summarize and highlight recent work that demonstrated involvement of LEP/LEPR in hematopoiesis under steady state or stress-associated situations as well as in pathological conditions such as cardiovascular diseases and malignancies. Although the field is only in its infancy, these studies suggest evidence of potential clinical applications and proof-of-principle for more in-depth future research. Under steady state, only a minor subset of long-term hematopoietic stem cells (HSCs) express LEPR. Upon irradiation, LEPR
    MeSH term(s) Hematopoiesis ; Hematopoietic Stem Cells/metabolism ; Humans ; Leptin/metabolism ; Receptors, Leptin/metabolism
    Chemical Substances Leptin ; Receptors, Leptin
    Language English
    Publishing date 2021-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2495577-2
    ISSN 2629-3277 ; 1558-6804 ; 1550-8943
    ISSN (online) 2629-3277 ; 1558-6804
    ISSN 1550-8943
    DOI 10.1007/s12015-021-10132-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Experimental Models of Mouse and Human Hematopoietic Stem Cell Transplantation.

    Cooper, Scott H / Capitano, Maegan L / Broxmeyer, Hal E

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2567, Page(s) 205–232

    Abstract: Experimental hematopoietic stem cell transplantation (HSCT) is an invaluable tool in determining the function and characteristics of hematopoietic stem cells (HSC) from experimental mouse and human donor groups. These groups could include, but are not ... ...

    Abstract Experimental hematopoietic stem cell transplantation (HSCT) is an invaluable tool in determining the function and characteristics of hematopoietic stem cells (HSC) from experimental mouse and human donor groups. These groups could include, but are not limited to, genetically altered populations (gene knockout/knockin models), ex vivo manipulated cell populations, or in vivo modulated cell populations. The basic fundamentals of this process involve taking cells from a mouse/human donor source and putting them into another mouse (recipient) after preconditioning of the recipient with either total body irradiation (TBI) for mouse donor cells or into sublethally irradiated immune-deficient mice for human donor cells. Then, at pre-determined time points post-transplant, sampling a small amount of peripheral blood (PB) and at the termination of the evalaution, bone marrow (BM) to determine donor contribution and function by phenotypic analysis. Exploiting the congenic mouse strains of C57BL/6 (CD45.1<sup>-</sup> CD45.2<sup>+</sup>), BoyJ (CD45.1<sup>+</sup> CD45.2<sup>-</sup>), and their F1-crossed hybrid C57BL/6 × BoyJ (CD45.1<sup>+</sup> CD45.2<sup>+</sup>), we are able to quantify donor, competitor, and recipient mouse cell contributions to the engraftment state. Human donor cell engraftment (e.g., from the cord blood [CB], mobilized PB, or BM) is assessed by human cell phenotyping in sublethally irradiated immune-deficient mouse recipients (e.g., NOD scid gamma mice that are deficient in B cells, T cells, and natural killer cells and have defective dendritic cells and macrophages). Engraftment of cells from primary mouse recipients into secondary mice allows for an estimation of the self-renewal capacity of the original donor HSC. This chapter outlines concepts, methods, and techniques for mouse and human cell models of HSCT and for assessment of donor cells collected and processed in hypoxia versus ambient air.
    MeSH term(s) Animals ; Mice ; Humans ; Mice, Inbred C57BL ; Hematopoietic Stem Cell Transplantation/methods ; Hematopoietic Stem Cells ; Mice, SCID ; Mice, Inbred NOD ; Models, Theoretical
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2679-5_14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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