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Article ; Online: The European exposure science strategy 2020-2030.

Fantke, Peter / Bruinen de Bruin, Yuri / Schlüter, Urs / Connolly, Alison / Bessems, Jos / Kephalopoulos, Stylianos / Zare Jeddi, Maryam / van Nieuwenhuyse, An / Dudzina, Tatsiana / Scheepers, Paul T J / von Goetz, Natalie

Environment international

2022 Volume 170, Page(s) 107555

Abstract: Exposure science is an emerging and rapidly growing field dedicated to all aspects concerning the contact between chemical, biological, physical or psycho-social stressors and human and ecological receptors. With that, exposure science plays a central ... ...

Abstract	Exposure science is an emerging and rapidly growing field dedicated to all aspects concerning the contact between chemical, biological, physical or psycho-social stressors and human and ecological receptors. With that, exposure science plays a central role in protecting human and ecosystem health, and contributes to the global transition towards a green and sustainable society. In Europe, however, exposure science is currently not sufficiently recognised as a scientific field, resulting in inefficient uptake into policies. In response, the wider European exposure science community developed elements and actions under the auspices of the Europe Regional Chapter of the International Society of Exposure Science (ISES Europe), for identified priority areas, namely education, exposure models, exposure data, human biomonitoring, and policy uptake. In the present document, we synthesize these strategic elements into an overarching 'European Exposure Science Strategy 2020-2030', following three strategic objectives that focus on acknowledging exposure science as an independent and interconnected field, harmonizing approaches and tools across regulations, and exploring collaboration, education and funding mechanisms. To operationalise this strategy, we present concrete key actions and propose initiatives and funding options for advancing the underlying science, cultivating broader education and cross-sector exposure knowledge transfer, and fostering effective uptake of exposure information into policy. We aim at anchoring European efforts in the global exposure science context, with a special focus on the interface between scientific advancements, application in decision support, and dissemination and training. This will help to develop exposure science as a strong scientific field with the ultimate goal to successfully assess and manage various stressors across sectors and geographic scales.
MeSH term(s)	Humans ; Ecosystem ; Europe ; European Union
Language	English
Publishing date	2022-09-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2022.107555
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Book: Exposure of an urban adult population to carbon monoxide

Bruinen de Bruin, Yuri

direct and indirect exposure assessment methods, determinants and sources ; final report

(EUR ; 21502)

2005

Institution	Institute for Health and Consumer Protection
Author's details	IHCP, Institute for Health and Consumer Protection. Yuri Bruinen de Bruin
Series title	EUR ; 21502
Language	English
Size	109 S
Publisher	Office for Official Publications of the European Communities
Publishing place	Luxembourg
Document type	Book
ISBN	9289488492 ; 9789289488495
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Advancing exposure data analytics and repositories as part of the European Exposure Science Strategy 2020-2030.

Kosnik, Marissa B / Kephalopoulos, Stylianos / Muñoz, Amalia / Aurisano, Nicolò / Cusinato, Alberto / Dimitroulopoulou, Sani / Slobodnik, Jaroslav / De Mello, Jonathas / Zare Jeddi, Maryam / Cascio, Claudia / Ahrens, Andreas / Bruinen de Bruin, Yuri / Lieck, Lothar / Fantke, Peter

Environment international

2022 Volume 170, Page(s) 107610

Abstract: High-quality and comprehensive exposure-related data are critical for different decision contexts, including environmental and human health monitoring, and chemicals risk assessment and management. However, exposure-related data are currently scattered, ... ...

Abstract	High-quality and comprehensive exposure-related data are critical for different decision contexts, including environmental and human health monitoring, and chemicals risk assessment and management. However, exposure-related data are currently scattered, frequently of unclear quality and structure, not readily accessible, and stored in various-partly overlapping-data repositories, leading to inefficient and ineffective data usage in Europe and globally. We propose strategic guidance for an integrated European exposure data production and management framework for use in science and policy, building on current and future data analysis and digitalization trends. We map the existing exposure data landscape to requirements for data analytics and repositories across European policies and regulations. We further identify needs and ways forward for improving data generation, sharing, and usage, and translate identified needs into an operational action plan for European and global advancement of exposure data for policies and regulations. Identified key areas of action are to develop consistent exposure data standards and terminology for data production and reporting, increase data transparency and availability, enhance data storage and related infrastructure, boost automation in data management, increase data integration, and advance tools for innovative data analysis. Improving and streamlining exposure data generation and uptake into science and policy is crucial for the European Chemicals Strategy for Sustainability and European Digital Strategy, in line with EU Data policies on data management and interoperability.
MeSH term(s)	Humans ; Data Science ; Europe
Language	English
Publishing date	2022-10-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2022.107610
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Book ; Article ; Online: Initial impacts of global risk mitigation measures taken during the combatting of the COVID-19 pandemic

BRUINEN DE BRUIN YURI / LEQUARRE ANNE SOPHIE / MCCOURT JOSEPHINE / CLEVESTIG PETER / PIGAZZANI FILIPO / ZARE JEDDI MARYAM / COLOMBO CLAUDIO / GOULART DE MEDEIROS MARGARIDA

2020

Abstract: This paper presents an analysis of risk mitigation measures taken by countries around the world facing the current COVID-19 outbreak. In light of the current pandemic the authors collated and clustered (using harmonised terminology) the risk mitigation ... ...

Abstract	This paper presents an analysis of risk mitigation measures taken by countries around the world facing the current COVID-19 outbreak. In light of the current pandemic the authors collated and clustered (using harmonised terminology) the risk mitigation measures taken around the globe in the combat to contain, and since March 11 2020, to limiting the spread of the SARS-CoV-2 virus known to cause the Coronavirus disease 2019 (COVID-19). This overview gathers lessons learnt, provides an update on the current knowledge for authorities, sectors and first responders on the effectiveness and may allow enhanced prevention, preparedness and response for future outbreaks. Various measures such as mobility restrictions, physical distancing, hygienic measures, socio economic restrictions, communication and international support mechanisms have been clustered and are reviewed in terms of the nature of the actions taken and their qualitative early-perceived impact. At the time of writing, it is still too premature to express the quantitative effectiveness of each risk mitigation cluster, but it seems that the best mitigation results are reported when applying a combination of voluntary and enforceable measures. JRC.E.7-Knowledge for Security and Migration
Keywords	covid19
Subject code	710
Language	ENG
Publisher	ELSEVIER SCIENCE BV
Publishing country	eu
Document type	Book ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents.

Zare Jeddi, Maryam / Eshaghi Gorji, Mohamad / Rietjens, Ivonne M C M / Louisse, Jochem / Bruinen de Bruin, Yuri / Liska, Roman

International journal of environmental research and public health

2018 Volume 15, Issue 11

Abstract: This study aimed to estimate the exposure and related health risks of phthalates, and to assess the health risks from combined exposure to three of the phthalates sharing the same mode of action (anti-androgenicity) in children. We determined the ... ...

Abstract	This study aimed to estimate the exposure and related health risks of phthalates, and to assess the health risks from combined exposure to three of the phthalates sharing the same mode of action (anti-androgenicity) in children. We determined the internal exposure of 56 Iranian children and adolescents aged 6 to 18 years by analyzing seven urinary metabolites of five phthalates. The estimated daily intake values derived from the biomonitoring data ranged from 0.01 µg/kg bw/day for butyl benzyl phthalate (BBP), to 17.85 µg/kg bw/day for di(2-ethylhexyl) phthalate (DEHP). The risk assessment revealed that not only the exposure to the individual phthalates, but also the combined exposure to the three anti-androgenic phthalates (DEHP, DBP, BBP) did not raise a safety concern (hazard index values averaged 0.2). The range of maximum cumulative ratio values varied from around 1 for most individuals to around 2 in some individuals, indicating that the combined exposures were dominated by one and in some cases by two of the three anti-androgenic phthalates, especially dibutyl phthalate (DBP) and/or DEHP. Based on biomonitoring data, the overall combined exposure of Iranian children to phthalates does not raise a concern, while reduction of exposure is best focused on DEHP and DBP that showed the highest hazard quotient.
MeSH term(s)	Adolescent ; Child ; Environmental Exposure/analysis ; Environmental Monitoring ; Female ; Humans ; Iran ; Male ; Phthalic Acids/analysis ; Risk Assessment
Chemical Substances	Phthalic Acids
Language	English
Publishing date	2018-10-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph15112336
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The European exposure science strategy 2020–2030

Fantke, Peter / Bruinen De Bruin, Yuri / Schlüter, Urs / Connolly, Alison / Bessems, Jos / Kephalopoulos, Stylianos / Zare Jeddi, Maryam / van Nieuwenhuyse, An / Dudzina, Tatsiana / Scheepers, Paul T.J. / von Götz, Natalie

Environment International, 170

2022

Abstract	Exposure science is an emerging and rapidly growing field dedicated to all aspects concerning the contact between chemical, biological, physical or psycho-social stressors and human and ecological receptors. With that, exposure science plays a central role in protecting human and ecosystem health, and contributes to the global transition towards a green and sustainable society. In Europe, however, exposure science is currently not sufficiently recognised as a scientific field, resulting in inefficient uptake into policies. In response, the wider European exposure science community developed elements and actions under the auspices of the Europe Regional Chapter of the International Society of Exposure Science (ISES Europe), for identified priority areas, namely education, exposure models, exposure data, human biomonitoring, and policy uptake. In the present document, we synthesize these strategic elements into an overarching ‘European Exposure Science Strategy 2020–2030’, following three strategic objectives that focus on acknowledging exposure science as an independent and interconnected field, harmonizing approaches and tools across regulations, and exploring collaboration, education and funding mechanisms. To operationalise this strategy, we present concrete key actions and propose initiatives and funding options for advancing the underlying science, cultivating broader education and cross-sector exposure knowledge transfer, and fostering effective uptake of exposure information into policy. We aim at anchoring European efforts in the global exposure science context, with a special focus on the interface between scientific advancements, application in decision support, and dissemination and training. This will help to develop exposure science as a strong scientific field with the ultimate goal to successfully assess and manage various stressors across sectors and geographic scales. ISSN:0160-4120 ISSN:1873-6750
Keywords	Human exposure ; Ecosystem exposure ; Exposure assessment ; Risk assessment ; Safe and sustainable-by-design (SSbD) ; International Society of Exposure Science
Subject code	333
Language	English
Publisher	Elsevier
Publishing country	ch
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Initial impacts of global risk mitigation measures taken during the combatting of the COVID-19 pandemic.

Bruinen de Bruin, Yuri / Lequarre, Anne-Sophie / McCourt, Josephine / Clevestig, Peter / Pigazzani, Filippo / Zare Jeddi, Maryam / Colosio, Claudio / Goulart, Margarida

Safety science

2020 Volume 128, Page(s) 104773

Abstract	This paper presents an analysis of risk mitigation measures taken by countries around the world facing the current COVID-19 outbreak. In light of the current pandemic the authors collated and clustered (using harmonised terminology) the risk mitigation measures taken around the globe in the combat to contain, and since March 11, 2020, to limit the spread of the SARS-CoV-2 virus known to cause the Coronavirus disease 2019 (COVID-19). This overview gathers lessons learnt, providing an update on the current knowledge for authorities, sectors and first responders on the effectiveness of said measures, and may allow enhanced prevention, preparedness and response for future outbreaks. Various measures such as mobility restrictions, physical distancing, hygienic measures, socio-economic restrictions, communication and international support mechanisms have been clustered and are reviewed in terms of the nature of the actions taken and their qualitative early-perceived impact. At the time of writing, it is still too premature to express the quantitative effectiveness of each risk mitigation cluster, but it seems that the best mitigation results are reported when applying a combination of voluntary and enforceable measures.
Keywords	covid19
Language	English
Publishing date	2020-04-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1074634-1
ISSN	1879-1042 ; 0925-7535
ISSN (online)	1879-1042
ISSN	0925-7535
DOI	10.1016/j.ssci.2020.104773
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Article ; Online: Towards further harmonization of a glossary for exposure science-an ISES Europe statement.

Heinemeyer, Gerhard / Connolly, Alison / von Goetz, Natalie / Bessems, Jos / Bruinen de Bruin, Yuri / Coggins, Marie A / Fantke, Peter / Galea, Karen S / Gerding, Johannes / Hader, John D / Heussen, Henri / Kephalopoulos, Stylianos / McCourt, Josephine / Scheepers, Paul T J / Schlueter, Urs / van Tongeren, Martie / Viegas, Susana / Zare Jeddi, Maryam / Vermeire, Theo

Journal of exposure science & environmental epidemiology

2021 Volume 32, Issue 4, Page(s) 526–529

MeSH term(s)	Environmental Exposure ; Europe ; Humans
Language	English
Publishing date	2021-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2218551-3
ISSN	1559-064X ; 1559-0631
ISSN (online)	1559-064X
ISSN	1559-0631
DOI	10.1038/s41370-021-00390-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Z 7529: Show issues

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Article ; Online: Enhancing the use of exposure science across EU chemical policies as part of the European Exposure Science Strategy 2020-2030.

Bruinen de Bruin, Yuri / Franco, Antonio / Ahrens, Andreas / Morris, Alick / Verhagen, Hans / Kephalopoulos, Stylianos / Dulio, Valeria / Slobodnik, Jaroslav / Sijm, Dick T H M / Vermeire, Theo / Ito, Takaaki / Takaki, Koki / De Mello, Jonathas / Bessems, Jos / Zare Jeddi, Maryam / Tanarro Gozalo, Celia / Pollard, Kevin / McCourt, Josephine / Fantke, Peter

Journal of exposure science & environmental epidemiology

2021 Volume 32, Issue 4, Page(s) 513–525

Abstract: Background: A scientific framework on exposure science will boost the multiuse of exposure knowledge across EU chemicals-related policies and improve risk assessment, risk management and communication across EU safety, security and sustainability ... ...

Abstract	Background: A scientific framework on exposure science will boost the multiuse of exposure knowledge across EU chemicals-related policies and improve risk assessment, risk management and communication across EU safety, security and sustainability domains. Objective: To stimulate public and private actors to align and strengthen the cross-policy adoption of exposure assessment data, methods and tools across EU legislation. Methods: By mapping and analysing the EU regulatory landscape making use of exposure information, policy and research challenges and key areas of action are identified and translated into opportunities enhancing policy and scientific efficiency. Results: Identified key areas of actions are to develop a common scientific exposure assessment framework, supported by baseline acceptance criteria and a shared knowledge base enhancing exchangeability and acceptability of exposure knowledge within and across EU chemicals-related policies. Furthermore, such framework will improve communication and management across EU chemical safety, security and sustainability policies comprising sourcing, manufacturing and global trade of goods and waste management. In support of building such a common framework and its effective use in policy and industry, exposure science innovation needs to be better embedded along the whole policymaking cycle, and be integrated into companies' safety and sustainability management systems. This will help to systemically improve regulatory risk management practices. Significance: This paper constitutes an important step towards the implementation of the EU Green Deal and its underlying policy strategies, such as the Chemicals Strategy for Sustainability.
MeSH term(s)	Humans ; Policy ; Risk Assessment
Language	English
Publishing date	2021-10-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2218551-3
ISSN	1559-064X ; 1559-0631
ISSN (online)	1559-064X
ISSN	1559-0631
DOI	10.1038/s41370-021-00388-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents

Zare Jeddi, Maryam / Eshaghi Gorji, Mohamad / Rietjens, Ivonne M.C.M. / Louisse, Jochem / Bruinen de Bruin, Yuri / Liska, Roman

International Journal of Environmental Research and Public Health

2018 Volume 15, Issue 11

Abstract	This study aimed to estimate the exposure and related health risks of phthalates, and to assess the health risks from combined exposure to three of the phthalates sharing the same mode of action (anti-androgenicity) in children. We determined the internal exposure of 56 Iranian children and adolescents aged 6 to 18 years by analyzing seven urinary metabolites of five phthalates. The estimated daily intake values derived from the biomonitoring data ranged from 0.01 µg/kg bw/day for butyl benzyl phthalate (BBP), to 17.85 µg/kg bw/day for di(2-ethylhexyl) phthalate (DEHP). The risk assessment revealed that not only the exposure to the individual phthalates, but also the combined exposure to the three anti-androgenic phthalates (DEHP, DBP, BBP) did not raise a safety concern (hazard index values averaged 0.2). The range of maximum cumulative ratio values varied from around 1 for most individuals to around 2 in some individuals, indicating that the combined exposures were dominated by one and in some cases by two of the three anti-androgenic phthalates, especially dibutyl phthalate (DBP) and/or DEHP. Based on biomonitoring data, the overall combined exposure of Iranian children to phthalates does not raise a concern, while reduction of exposure is best focused on DEHP and DBP that showed the highest hazard quotient.
Keywords	anti-androgenic phthalates ; daily intake (DI) ; human biomonitoring (HBM) ; maximum cumulative ratio (MCR) ; mixture
Subject code	600
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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