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  1. Book ; Thesis: Mesenchymal stem

    Brune, Jan C.

    and stromal cells in bone marrow and osteosarcoma

    (Doctoral dissertation series ; 2011,22)

    2011  

    Author's details Jan C. Brune
    Series title Doctoral dissertation series ; 2011,22
    Collection
    Language English ; Swedish
    Size Getr. Zählung : Ill., graph. Darst.
    Publishing country Sweden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Lund, Univ., Diss., 2011
    Note Zsfassung in schwed. Sprache
    HBZ-ID HT017115246
    ISBN 978-91-86671-71-6 ; 91-86671-71-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 E 167 order for loan Magazin

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  2. Article ; Online: Peracetic acid sterilized tendon and ligament allografts for knee reconstruction : For anterior cruciate ligament (ACL), posterior cruciate ligament (PCL) and complex knee surgery.

    Ahrens, Philipp / Borchert, Gudrun H / Freutel, Christin / Ahmed, Norus / Brune, Jan C

    Orthopadie (Heidelberg, Germany)

    2024  Volume 53, Issue 5, Page(s) 341–347

    Abstract: Background: The use of allografts and autografts has been met with mixed views on whether allografts are a suitable alternative to autografts.: Question: We aimed to investigate if chemically sterilized allografts show similar rerupture rates to ... ...

    Title translation Mit Peressigsäure sterilisierte Sehnen- und Bändertransplantate für die Knierekonstruktion : Für vorderes (VKB) und hinteres (HKB) Kreuzband, und komplexe Knieoperationen.
    Abstract Background: The use of allografts and autografts has been met with mixed views on whether allografts are a suitable alternative to autografts.
    Question: We aimed to investigate if chemically sterilized allografts show similar rerupture rates to those reported in the literature for allografts and autografts in anterior (ACL) and posterior cruciate ligaments (PCL) and complex knee surgery.
    Materials and methods: Retrospective data on knee reconstructions performed between 2011 and 2015 with tendon/ligamnet allografts sterilized with peracetic acid were collected in the form of a questionnaire. The inclusion criteria of 2 years for each patient were met by 38 patients, representing 22 ACL reconstructions, 5 PCL reconstructions, 3 OTHER surgeries, including the Larson technique and medial patellofemoral ligament (MPFL) reconstruction and 8 COMPLEX surgeries. The main endpoints were rerupture and complication rate. Secondary endpoints included stability of the knee (Lachman test, Pivot shift test) and the range of motion.
    Results: The rerupture rate was 7.9% (3 grafts). Reruptures only occurred in the ACL group. No reruptures were observed in the PCL, OTHER and COMPLEX surgery groups. Stability improved significantly after surgery and the range of motion returned to values similar to that of healthy knees.
    Conclusions: Tendon allografts sterilized with peracetic acid show promising low rerupture rates and good clinical scores and the results are comparable to the literature on autografts and other allografts.
    MeSH term(s) Humans ; Male ; Female ; Retrospective Studies ; Adult ; Tendons/transplantation ; Middle Aged ; Sterilization/methods ; Allografts ; Peracetic Acid ; Anterior Cruciate Ligament Reconstruction/methods ; Posterior Cruciate Ligament Reconstruction/methods ; Posterior Cruciate Ligament/surgery ; Transplantation, Homologous/methods
    Chemical Substances Peracetic Acid (I6KPI2E1HD)
    Language English
    Publishing date 2024-03-18
    Publishing country Germany
    Document type Journal Article
    ISSN 2731-7153
    ISSN (online) 2731-7153
    DOI 10.1007/s00132-024-04486-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Functional Recovery after the Application of Amniotic Tissues and Methylene Blue during Radical Prostatectomy-A Pilot Study.

    Barski, Dimitri / Tsaur, Igor / Boros, Mihaly / Brune, Jan / Otto, Thomas

    Biomedicines

    2023  Volume 11, Issue 8

    Abstract: Amniotic tissues and methylene blue (MB) provide the ability for neuroregeneration, and MB enables intraoperative neurostaining. We first combined the techniques to explore a neuroprotective effect on early functional outcomes in a retrospective proof-of- ...

    Abstract Amniotic tissues and methylene blue (MB) provide the ability for neuroregeneration, and MB enables intraoperative neurostaining. We first combined the techniques to explore a neuroprotective effect on early functional outcomes in a retrospective proof-of-concept trial of 14 patients undergoing radical prostatectomy (RP). The patients were followed up at a median of 13 months, and the continence and potency rates were reported. Early recovery of continence was found after three months. No effect on potency was detected. The findings indicate the feasibility of this tissue-engineering strategy, and justify prospective comparative studies.
    Language English
    Publishing date 2023-08-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11082260
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  4. Article: Anatomical acromioclavicular joint stabilization with chemically sterilized tendon allografts: A retrospective study.

    Vogt, Wolfgang / Borchert, Gudrun H / Ahmed, Norus / Brune, Jan C

    Shoulder & elbow

    2022  Volume 15, Issue 4, Page(s) 411–423

    Abstract: Background: The purpose of this retrospective study was to analyze whether chemically sterilized tendon allografts perform as well as other non-sterilized allografts and autografts as described in the literature for anatomical acromioclavicular joint ... ...

    Abstract Background: The purpose of this retrospective study was to analyze whether chemically sterilized tendon allografts perform as well as other non-sterilized allografts and autografts as described in the literature for anatomical acromioclavicular joint stabilization for the treatment of Rockwood III-V. Allografts are still described as a factor for higher re-rupture rates.
    Methods: Retrospective data were collected from 21 acromioclavicular joint stabilizations performed by a single surgeon and performed between 2011 and 2014 using sterilized semitendinosus allografts. The primary endpoints were re-rupture and complication rates. Secondary endpoints were AC-joint stability, pain level, return to work and sport and the range of motion.
    Results: No re-ruptures occurred during the mean follow-up time of 33 months. Zero complications occurred directly after surgery, but three complications later than three weeks after surgery. All cases resolved without further surgery. After surgery, stability significantly improved for all patients. Post-surgery, 19 patients had stable acromioclavicular joints and only two patients showed minor instabilities. Range of motion returned to the range of the healthy shoulders for all patients.
    Conclusion: Chemically sterilized semitendinosus allograft use for anatomic AC-joint stabilization is equivalent to the use of other allografts or autografts and required no hardware removal. No donor age or graft size dependence was observed, due to zero re-ruptures.
    Language English
    Publishing date 2022-11-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2503275-6
    ISSN 1758-5732
    ISSN 1758-5732
    DOI 10.1177/17585732221136863
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6789: Show issues Location:
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  5. Conference proceedings: The biomechanical properties of different types of tendon allografts

    Eras, Volker / Hoetzel, Kassandra / Brune, Jan Claas

    2022  , Page(s) AB22–1023

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2022); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2022
    Keywords Medizin, Gesundheit ; tendon allograft
    Publishing date 2022-10-25
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/22dkou103
    Database German Medical Science

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  6. Article: Influence of peracetic acid-ethanol sterilisation on the biomechanical properties of human meniscus transplants.

    Eras, Volker / Graffunder, Josefine / Ahmed, Norus / Brune, Jan C

    Journal of experimental orthopaedics

    2021  Volume 8, Issue 1, Page(s) 18

    Abstract: Purpose: Meniscus allograft transplantation (MAT) is a possible treatment for patients suffering with pain after meniscectomy. Here, peracetic acid (PAA) sterilised meniscus transplants were investigated on whether they would provide an adequate ... ...

    Abstract Purpose: Meniscus allograft transplantation (MAT) is a possible treatment for patients suffering with pain after meniscectomy. Here, peracetic acid (PAA) sterilised meniscus transplants were investigated on whether they would provide an adequate alternative to fresh-frozen transplants in their viscoelastic and mechanical properties.
    Methods: In this analysis, 31 menisci donors (26 male and 5 female) were included. The average donor age was 49.87 years, ranging from 32 to 65 years. Menisci of matched pairs of knees underwent chemical sterilisation while counterparts were left fresh-frozen. Stiffness and load to failure were determined via suture retention. Further menisci were analysed while attached to the tibial bone block using a novel test device to mimic physiological load distribution. Meniscus relaxation, stiffness and failure loads were determined. Histology and biphasic properties of the menisci were examined and results were analysed using paired t-tests.
    Results: A novel custom built test device allowed the application of physiological loads for suture retention testing and revealed no significant differences between PAA sterilised (14.85 ± 4.46 N/mm, 50.49 ± 17.01 N) and fresh-frozen (18.26 ± 4.46 N/mm, 59.49 ± 21.07 N) regarding stiffness and failure load, respectively. Furthermore, initial 200 N loading showed significantly higher strain in sterilised menisci (18.87 ± 1.56) compared to fresh frozen (13.81 ± 1.04). Load relaxation experiments demonstrated significantly lower relaxation for sterilised menisci (77.71 ± 1.62) compared to fresh-frozen (89.11 ± 1.00, p-value < 0.0001).
    Conclusion: Peracetic acid sterilised human menisci performed equally to fresh-frozen counterparts in a suture retention test and in physiological failure testing providing an adequate alternative. However, meniscus relaxation, biphasic properties and strain were shown to be significantly different between the groups. A common problem of MAT is graft extrusion or shrinkage, therefore the parameters measured here should be considered and may influence meniscus extrusion after transplantation.
    Level of evidence: n/a (experimental study).
    Language English
    Publishing date 2021-03-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2780021-0
    ISSN 2197-1153
    ISSN 2197-1153
    DOI 10.1186/s40634-021-00336-z
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  7. Article ; Online: Allografts: expanding the surgeon's armamentarium.

    Ahmed, Norus / Eras, Volker / Pruß, Axel / Perka, Carsten / Brune, Jan / Vu-Han, Tu-Lan

    Cell and tissue banking

    2022  Volume 24, Issue 1, Page(s) 273–283

    Abstract: In Germany, bone allografts are widely used and their application in clinics has increased over the years. Successful use of allografts depends on many factors such as the procurement, processing, sterilization and the surgeon's surgical experience. ... ...

    Abstract In Germany, bone allografts are widely used and their application in clinics has increased over the years. Successful use of allografts depends on many factors such as the procurement, processing, sterilization and the surgeon's surgical experience. Tissue banks have provided safe and sterile allografts for decades ranging from hard to soft tissue. Allografts are obtained from various tissues such as bone, tendon, amniotic membrane, meniscus and skin. An advantage of allografts is their wide applicability that has never been limited by indication restrictions thus providing a huge benefit for surgeon's. The use of the correct allograft in different indications is extremely important. Thereby surgeons have access to various allograft forms such as mineralized, demineralized, freeze-dried, paste, powder, chips strips and putty. The vast options of allografts allow surgeon's to use allografts in indications they deem fit. Currently, the application of allografts is at the discretion of the expert surgeon. However, regulations are often changed locally or internationally and may impact/limit allograft use to certain indications. Here, we report the different indications where our peracetic acid (PAA) sterilised bone allografts were used as well as general literature on bone allograft use in other indications.
    MeSH term(s) Transplantation, Homologous ; Tissue Banks ; Tendons/transplantation ; Sterilization ; Bone Transplantation ; Allografts
    Language English
    Publishing date 2022-06-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170897-6
    ISSN 1573-6814 ; 1389-9333
    ISSN (online) 1573-6814
    ISSN 1389-9333
    DOI 10.1007/s10561-022-10015-7
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    Zs.A 5972: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Analysis of the Ability of Different Allografts to Act as Carrier Grafts for Local Drug Delivery.

    Bormann, Nicole / Schmock, Aysha / Hanke, Anja / Eras, Volker / Ahmed, Norus / Kissner, Maya S / Wildemann, Britt / Brune, Jan C

    Journal of functional biomaterials

    2023  Volume 14, Issue 6

    Abstract: Bone defects and infections pose significant challenges for treatment, requiring a comprehensive approach for prevention and treatment. Thus, this study sought to evaluate the efficacy of various bone allografts in the absorption and release of ... ...

    Abstract Bone defects and infections pose significant challenges for treatment, requiring a comprehensive approach for prevention and treatment. Thus, this study sought to evaluate the efficacy of various bone allografts in the absorption and release of antibiotics. A specially designed high-absorbency, high-surface-area carrier graft composed of human demineralized cortical fibers and granulated cancellous bone (fibrous graft) was compared to different human bone allograft types. The groups tested here were three fibrous grafts with rehydration rates of 2.7, 4, and 8 mL/g (F(2.7), F(4), and F(8)); demineralized bone matrix (DBM); cortical granules; mineralized cancellous bone; and demineralized cancellous bone. The absorption capacity of the bone grafts was assessed after rehydration, the duration of absorption varied from 5 to 30 min, and the elution kinetics of gentamicin were determined over 21 days. Furthermore, antimicrobial activity was assessed using a zone of inhibition (ZOI) test with
    Language English
    Publishing date 2023-06-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb14060305
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  9. Conference proceedings: Retrospective Analysis on the use of Sterilised Tendon Allografts in Orthopaedic Surgery

    Borchert, Gudrun / Freutel, Christin / Ahmed, Norus / Brune, Jan

    2021  , Page(s) AB89–1208

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2021); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2021
    Keywords Medizin, Gesundheit ; Tendon ; Allograft ; Autograft
    Publishing date 2021-10-26
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21dkou607
    Database German Medical Science

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  10. Conference proceedings: Peracetic acid sterilisation on the biomechanical properties of human tendons

    Hoetzel, Kassandra / Eras, Volker / Brune, Jan

    2021  , Page(s) AB85–1213

    Event/congress Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2021); Berlin; ; Berufsverband für Orthopädie und Unfallchirurgie; 2021
    Keywords Medizin, Gesundheit ; Tendon ; Biomechanics ; Allograft
    Publishing date 2021-10-26
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21dkou583
    Database German Medical Science

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