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  1. Article ; Online: Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis.

    Brune-Ingebretsen, Synne / Høgestøl, Einar A / de Rosbo, Nicole Kerlero / Berg-Hansen, Pål / Brunborg, Cathrine / Blennow, Kaj / Zetterberg, Henrik / Paul, Friedemann / Uccelli, Antonio / Villoslada, Pablo / Harbo, Hanne F / Berge, Tone

    Journal of neuroimmunology

    2023  Volume 382, Page(s) 578175

    Abstract: Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could ...

    Abstract Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS.
    MeSH term(s) Humans ; Multiple Sclerosis ; Intermediate Filaments ; Biomarkers ; Disease Progression ; Neurofilament Proteins ; Axons
    Chemical Substances Biomarkers ; Neurofilament Proteins
    Language English
    Publishing date 2023-08-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 8335-5
    ISSN 1872-8421 ; 0165-5728
    ISSN (online) 1872-8421
    ISSN 0165-5728
    DOI 10.1016/j.jneuroim.2023.578175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multiscale networks in multiple sclerosis.

    Kennedy, Keith E / Kerlero de Rosbo, Nicole / Uccelli, Antonio / Cellerino, Maria / Ivaldi, Federico / Contini, Paola / De Palma, Raffaele / Harbo, Hanne F / Berge, Tone / Bos, Steffan D / Høgestøl, Einar A / Brune-Ingebretsen, Synne / de Rodez Benavent, Sigrid A / Paul, Friedemann / Brandt, Alexander U / Bäcker-Koduah, Priscilla / Behrens, Janina / Kuchling, Joseph / Asseyer, Susanna /
    Scheel, Michael / Chien, Claudia / Zimmermann, Hanna / Motamedi, Seyedamirhosein / Kauer-Bonin, Josef / Saez-Rodriguez, Julio / Rinas, Melanie / Alexopoulos, Leonidas G / Andorra, Magi / Llufriu, Sara / Saiz, Albert / Blanco, Yolanda / Martinez-Heras, Eloy / Solana, Elisabeth / Pulido-Valdeolivas, Irene / Martinez-Lapiscina, Elena H / Garcia-Ojalvo, Jordi / Villoslada, Pablo

    PLoS computational biology

    2024  Volume 20, Issue 2, Page(s) e1010980

    Abstract: Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes and proteins to cells and tissues, up to the full organism. In fact, any phenotype for an organism is dictated by the interplay among these scales. We ... ...

    Abstract Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes and proteins to cells and tissues, up to the full organism. In fact, any phenotype for an organism is dictated by the interplay among these scales. We conducted a multilayer network analysis and deep phenotyping with multi-omics data (genomics, phosphoproteomics and cytomics), brain and retinal imaging, and clinical data, obtained from a multicenter prospective cohort of 328 patients and 90 healthy controls. Multilayer networks were constructed using mutual information for topological analysis, and Boolean simulations were constructed using Pearson correlation to identified paths within and among all layers. The path more commonly found from the Boolean simulations connects protein MK03, with total T cells, the thickness of the retinal nerve fiber layer (RNFL), and the walking speed. This path contains nodes involved in protein phosphorylation, glial cell differentiation, and regulation of stress-activated MAPK cascade, among others. Specific paths identified were subsequently analyzed by flow cytometry at the single-cell level. Combinations of several proteins (GSK3AB, HSBP1 or RS6) and immune cells (Th17, Th1 non-classic, CD8, CD8 Treg, CD56 neg, and B memory) were part of the paths explaining the clinical phenotype. The advantage of the path identified from the Boolean simulations is that it connects information about these known biological pathways with the layers at higher scales (retina damage and disability). Overall, the identified paths provide a means to connect the molecular aspects of MS with the overall phenotype.
    MeSH term(s) Humans ; Multiple Sclerosis ; Prospective Studies ; Tomography, Optical Coherence/methods ; Retina ; Brain ; Heat-Shock Proteins
    Chemical Substances HSBP1 protein, human ; Heat-Shock Proteins
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1010980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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