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Article ; Online: Nouvelles AMMs : pembrolizumab en adjuvant pour les carcinomes rénaux à cellules claires à haut risque de récidive après néphrectomie.

Brunet, Maxime / Malouf, Gabriel G

2022 Volume 109, Issue 9, Page(s) 875–876

Title translation	New drug approval: Adjuvant Pembrolizumab in clear-cell renal-cell carcinoma at high risk for recurrence after nephrectomy.
MeSH term(s)	Antibodies, Monoclonal, Humanized ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/surgery ; Drug Approval ; Humans ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Nephrectomy
Chemical Substances	Antibodies, Monoclonal, Humanized ; pembrolizumab (DPT0O3T46P)
Language	French
Publishing date	2022-06-28
Publishing country	France
Document type	Letter
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2022.05.005
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Book ; Online: Enabling safe walking rehabilitation on the exoskeleton Atalante

Brunet, Maxime / Pétriaux, Marine / Di Meglio, Florent / Petit, Nicolas

experimental results

2023

Abstract: This paper exposes a control architecture enabling rehabilitation of walking impaired patients with the lower-limb exoskeleton Atalante. Atalante's control system is modified to allow the patient to contribute to the walking motion through their efforts. ...

Abstract	This paper exposes a control architecture enabling rehabilitation of walking impaired patients with the lower-limb exoskeleton Atalante. Atalante's control system is modified to allow the patient to contribute to the walking motion through their efforts. Only the swing leg degree of freedom along the nominal path is relaxed. An online trajectory optimization checks that the muscle forces do not jeopardize stability. The optimization generates reference trajectories that satisfy several key constraints from the current point to the end of the step. One of the constraints requires that the center or pressure remains inside the support polygon, which ensures that the support leg subsystem successfully tracks the reference trajectory. As a result of the presented works, the robot provides a non-zero force in the direction of motion only when required, helping the patient go fast enough to maintain balance (or preventing him from going too fast). Experimental results are reported. They illustrate that variations of $\pm$50% of the duration of the step can be achieved in response to the patient's efforts and that many steps are achieved without falling. A video of the experiments can be viewed at https://youtu.be/_1A-2nLy5ZE
Keywords	Computer Science - Robotics
Subject code	629
Publishing date	2023-04-17
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Shortcut to Geostrophy in Wave-Driven Rotating Turbulence: The Quartetic Instability.

Brunet, Maxime / Gallet, Basile / Cortet, Pierre-Philippe

Physical review letters

2020 Volume 124, Issue 12, Page(s) 124501

Abstract: We report on laboratory experiments of wave-driven rotating turbulence. A set of wave makers produces inertial-wave beams that interact nonlinearly in the central region of a water tank mounted on a rotating platform. The forcing thus injects energy into ...

Abstract	We report on laboratory experiments of wave-driven rotating turbulence. A set of wave makers produces inertial-wave beams that interact nonlinearly in the central region of a water tank mounted on a rotating platform. The forcing thus injects energy into inertial waves only. For moderate forcing amplitude, part of the energy of the forced inertial waves is transferred to subharmonic waves, through a standard triadic resonance instability. This first step is broadly in line with the theory of weak turbulence. Surprisingly however, stronger forcing does not lead to an inertial-wave turbulence regime. Instead, most of the kinetic energy condenses into a vertically invariant geostrophic flow, even though the latter is unforced. We show that resonant quartets of inertial waves can trigger an instability-the "quartetic instability"-that leads to such spontaneous emergence of geostrophy. In the present experiment, this instability sets in as a secondary instability of the classical triadic instability.
Language	English
Publishing date	2020-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.124.124501
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Article: Enabling Precision Medicine for Rare Head and Neck Tumors: The Example of BRAF/MEK Targeting in Patients With Metastatic Ameloblastoma.

Brunet, Maxime / Khalifa, Emmanuel / Italiano, Antoine

Frontiers in oncology

2019 Volume 9, Page(s) 1204

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2019-11-12
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2019.01204
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Article ; Online: Quantitative Experimental Observation of Weak Inertial-Wave Turbulence.

Monsalve, Eduardo / Brunet, Maxime / Gallet, Basile / Cortet, Pierre-Philippe

Physical review letters

2020 Volume 125, Issue 25, Page(s) 254502

Abstract: We report the quantitative experimental observation of the weak inertial-wave turbulence regime of rotating turbulence. We produce a statistically steady homogeneous turbulent flow that consists of nonlinearly interacting inertial waves, using rough top ... ...

Abstract	We report the quantitative experimental observation of the weak inertial-wave turbulence regime of rotating turbulence. We produce a statistically steady homogeneous turbulent flow that consists of nonlinearly interacting inertial waves, using rough top and bottom boundaries to prevent the emergence of a geostrophic flow. As the forcing amplitude increases, the temporal spectrum evolves from a discrete set of peaks to a continuous spectrum. Maps of the bicoherence of the velocity field confirm such a gradual transition between discrete wave interactions at weak forcing amplitude and the regime described by weak turbulence theory (WTT) for stronger forcing. In the former regime, the bicoherence maps display a near-zero background level, together with sharp localized peaks associated with discrete resonances. By contrast, in the latter regime, the bicoherence is a smooth function that takes values of the order of the Rossby number in line with the infinite-domain and random-phase assumptions of WTT. The spatial spectra then display a power-law behavior, both the spectral exponent and the spectral level being accurately predicted by WTT at high Reynolds number and low Rossby number.
Language	English
Publishing date	2020-09-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.125.254502
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Article ; Online: From palliative to curative intent: PET/CT findings in the light of breast cancer intrinsic subgroup.

Brunet, Maxime / Cazeau, Anne-Laure / Ben Rejeb, Houda / Catena, Vittorio / Grellety, Thomas

Tumori

2019 Volume 105, Issue 6, Page(s) NP79–NP82

Abstract: Purpose: Among breast cancer subgroups, Luminal A is the subgroup with the best prognosis. We report the case of a young woman presenting with a localized luminal A breast cancer with a suspicious liver lesion on initial positron emission tomography ( ... ...

Abstract	Purpose: Among breast cancer subgroups, Luminal A is the subgroup with the best prognosis. We report the case of a young woman presenting with a localized luminal A breast cancer with a suspicious liver lesion on initial positron emission tomography (PET)/computed tomography (CT) scan staging. Case description: A 31-year-old woman presented with localized breast cancer accessible to curative treatment. However, PET/CT staging revealed an increase of focal activity in the liver, suspicious of a secondary malignant localization, changing the care towards palliative intent. Discrepancy between breast cancer luminal A subtype and the liver lesion led to further investigations (contrast ultrasound, magnetic resonance imaging, and biopsy), excluding a malignant process, and were in favor of toxic hepatitis, probably secondary to herbal tea consumption. Conclusions: Questioning PET/CT findings in light of the cancer subtype enabled us to rectify the diagnosis and allow this patient to be treated with curative intent.
MeSH term(s)	Adult ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biopsy ; Breast Neoplasms/diagnosis ; Breast Neoplasms/etiology ; Breast Neoplasms/therapy ; Female ; Humans ; Immunohistochemistry ; Neoplasm Staging ; Palliative Care/methods ; Positron Emission Tomography Computed Tomography/methods ; Prognosis ; Sensitivity and Specificity ; Treatment Outcome
Language	English
Publishing date	2019-10-23
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	280962-x
ISSN	2038-2529 ; 0300-8916
ISSN (online)	2038-2529
ISSN	0300-8916
DOI	10.1177/0300891619882491
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Article ; Online: Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodies.

Larroquette, Mathieu / Guegan, Jean-Philippe / Besse, Benjamin / Cousin, Sophie / Brunet, Maxime / Le Moulec, Sylvestre / Le Loarer, François / Rey, Christophe / Soria, Jean-Charles / Barlesi, Fabrice / Bessede, Alban / Scoazec, Jean-Yves / Soubeyran, Isabelle / Italiano, Antoine

Journal for immunotherapy of cancer

2022 Volume 10, Issue 5

Abstract: Background: Tumor-associated macrophages (TAMs) having immunosuppressive properties are one of the most abundant immune cells in the tumor microenvironment (TME). Preclinical studies have highlighted the potential role of TAMs in resistance to immune ... ...

Abstract	Background: Tumor-associated macrophages (TAMs) having immunosuppressive properties are one of the most abundant immune cells in the tumor microenvironment (TME). Preclinical studies have highlighted the potential role of TAMs in resistance to immune checkpoint blockers (ICBs). Here, we investigated the predictive value of TAM infiltration in patients with non-small cell lung cancer (NSCLC) treated with ICBs and characterized their transcriptomic profiles. Methods: Tumor samples were collected from 152 patients with NSCLC before ICB treatment onset. After immunohistochemical staining and image analysis, the correlation between CD163+ cell infiltration and survival was analyzed. Spatial transcriptomic analyses were performed using the NanoString GeoMx Immune Pathways assay to compare the gene expression profile of tumors with high or low levels of CD163+ cell infiltration and to identify determinants of response to ICBs in tumors with high CD163+ infiltration. Results: Low intratumoral CD163+ cell infiltration was associated with longer progression-free survival (PFS; HR 0.61, 95% CI 0.40 to 0.94, p=0.023) and overall survival (OS; HR 0.48, 95% CI 0.28 to 0.80, p=0.004) under ICB treatment. Spatial transcriptomic profiles of 16 tumors revealed the upregulation of Conclusions: Enrichment of TAMs in the TME of NSCLC is associated with resistance to immunotherapy regardless of the programmed death ligand 1 status and is driven by upregulation of
MeSH term(s)	B7-H1 Antigen/metabolism ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Humans ; Immune Checkpoint Inhibitors ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Macrophages ; Transcriptome ; Tumor Microenvironment
Chemical Substances	B7-H1 Antigen ; Immune Checkpoint Inhibitors
Language	English
Publishing date	2022-05-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2021-003890
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Article ; Online: Standardized Pathology Screening of Mature Tertiary Lymphoid Structures in Cancers.

Laboratory investigation; a journal of technical methods and pathology

2023 Volume 103, Issue 5, Page(s) 100063

Abstract: Mature tertiary lymphoid structures (mTLSs) are organized lymphoid structures containing B lymphocytes admixed to CD23+ follicular dendritic cells. Their presence has been linked to improved survival and sensitivity to immune checkpoint inhibitors in ... ...

Abstract	Mature tertiary lymphoid structures (mTLSs) are organized lymphoid structures containing B lymphocytes admixed to CD23+ follicular dendritic cells. Their presence has been linked to improved survival and sensitivity to immune checkpoint inhibitors in several cancers, emerging as a promising pancancer biomarker. However, the requirements for any biomarker are clear methodology, proven feasibility, and reliability. In 357 patients' samples, we studied tertiary lymphoid structures (TLSs) parameters using multiplex immunofluorescence (mIF), hematoxylin-eosin-saffron (HES) staining, double CD20/CD23 staining, and single CD23 immunohistochemistry. The cohort included carcinomas (n = 211) and sarcomas (n = 146), gathering biopsies (n = 170), and surgical specimens (n = 187). mTLSs were defined as TLSs containing either a visible germinal center on HES staining or CD23+ follicular dendritic cells. Focusing on 40 TLSs assessed using mIF, double CD20/CD23 staining was less sensitive than mIF to assess maturity in 27.5% (n = 11/40) but was rescued by single CD23 staining in 90.9% (n = 10/11). In 97 patients, several samples (n = 240) were reviewed to characterize TLS distribution. The likelihood of finding TLSs in surgical material was 6.1 higher than in biopsy and 2.0 higher in primary samples than in metastasis after adjustment with a type of sample. Interrater agreement rates over 4 examiners were 0.65 (Fleiss kappa, 95% CI [0.46, 0.90]) for the presence of TLS and 0.90 for maturity (95% CI [0.83, 0.99]). In this study, we propose a standardized method to screen mTLSs in cancer samples using HES staining and immunohistochemistry that can be applied to all specimens.
MeSH term(s)	Humans ; Tertiary Lymphoid Structures/pathology ; Prognosis ; Reproducibility of Results ; Early Detection of Cancer ; Neoplasms/pathology ; Biomarkers ; Tumor Microenvironment
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80178-1
ISSN	1530-0307 ; 0023-6837
ISSN (online)	1530-0307
ISSN	0023-6837
DOI	10.1016/j.labinv.2023.100063
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Article ; Online: Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression.

Vanhersecke, Lucile / Brunet, Maxime / Guégan, Jean-Philippe / Rey, Christophe / Bougouin, Antoine / Cousin, Sophie / Moulec, Sylvestre Le / Besse, Benjamin / Loriot, Yohann / Larroquette, Mathieu / Soubeyran, Isabelle / Toulmonde, Maud / Roubaud, Guilhem / Pernot, Simon / Cabart, Mathilde / Chomy, François / Lefevre, Corentin / Bourcier, Kevin / Kind, Michèle /

Giglioli, Ilenia / Sautès-Fridman, Catherine / Velasco, Valérie / Courgeon, Félicie / Oflazoglu, Ezoglin / Savina, Ariel / Marabelle, Aurélien / Soria, Jean-Charles / Bellera, Carine / Sofeu, Casimir / Bessede, Alban / Fridman, Wolf H / Loarer, François Le / Italiano, Antoine

Nature cancer

2021 Volume 2, Issue 8, Page(s) 794–802

Abstract: Only a minority of patients derive long-term clinical benefit from anti-PD1/PD-L1 monoclonal antibodies. The presence of tertiary lymphoid structures (TLS) has been associated with improved survival in several tumor types. Here, using a large-scale ... ...

Abstract	Only a minority of patients derive long-term clinical benefit from anti-PD1/PD-L1 monoclonal antibodies. The presence of tertiary lymphoid structures (TLS) has been associated with improved survival in several tumor types. Here, using a large-scale retrospective analysis of three independent cohorts of cancer patients treated with anti-PD1/PD-L1 antibodies, we showed that the presence of mature TLS was associated with improved objective response rate, progression-free survival, and overall survival independently of PD-L1 expression status and CD8+ T-cell density. These results pave the way for using TLS detection to select patients who are more likely to benefit from immune checkpoint blockade.
MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; B7-H1 Antigen/therapeutic use ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Lung Neoplasms/drug therapy ; Retrospective Studies ; Tertiary Lymphoid Structures
Chemical Substances	Antibodies, Monoclonal ; B7-H1 Antigen ; Immune Checkpoint Inhibitors
Language	English
Publishing date	2021-08-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2662-1347
ISSN (online)	2662-1347
DOI	10.1038/s43018-021-00232-6
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