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  1. Article ; Online: [No title information]

    Brunner, Patrick M

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2021  Volume 19, Issue 6, Page(s) 953–954

    Title translation Preisträger stellen sich vor: Thomas Bauer und Patrick M. Brunner erhalten den Wissenschaftspreis der ÖGDV 2020.
    Language German
    Publishing date 2021-06-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14550_g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6148: Show issues Location:
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  2. Article: Treatment of granulomatous perioral dermatitis with 1.5% topical ruxolitinib cream.

    Tran, Sophia S / Ungar, Benjamin / Brunner, Patrick M

    JAAD case reports

    2024  Volume 47, Page(s) 1–3

    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2024.02.022
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  3. Article ; Online: Sphingolipids in viral skin superinfection: Friend or foe?

    Chennareddy, Sumanth / Brunner, Patrick M

    The Journal of allergy and clinical immunology

    2022  Volume 151, Issue 1, Page(s) 108–109

    MeSH term(s) Humans ; Superinfection ; Sphingolipids ; Skin ; Dermatitis, Atopic ; Kaposi Varicelliform Eruption
    Chemical Substances Sphingolipids
    Language English
    Publishing date 2022-10-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.09.031
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  4. Article ; Online: Early immunologic changes during the onset of atopic dermatitis.

    Brunner, Patrick M

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2019  Volume 123, Issue 2, Page(s) 152–157

    Abstract: Objective: Atopic dermatitis (AD), which is commonly called eczema, is the most common chronic inflammatory skin disease. The pipeline of new targeted treatments is currently expanding, a development that is largely based on our increasing understanding ...

    Abstract Objective: Atopic dermatitis (AD), which is commonly called eczema, is the most common chronic inflammatory skin disease. The pipeline of new targeted treatments is currently expanding, a development that is largely based on our increasing understanding of disease mechanisms. Mechanistic insights have long been based on long-standing adult AD. Recently, studies also investigated early pediatric AD at disease onset, and revealed several differences in barrier and immune properties when compared with long-standing adult AD. This review focuses on immunological changes very early in life that predispose to the development of AD, and summarizes characteristics of the molecular AD phenotype in this age group.
    Data sources: Review of published literature.
    Study selections: Studies investigating human AD at disease onset in newborns, toddlers, and young children, in comparison with adults with long-standing disease.
    Results: Already in cord blood, increased Th2 and decreased Th1 levels were found to increase the risk of AD development. Both pediatric and adult AD share Th2/Th22 activation and defects in lipid barrier deposition and tight junction formation, but Th1 activation and epidermal differentiation complex defects are largely absent in pediatric AD.
    Conclusion: Immune changes predisposing to AD development are present very early in life. During the first months of disease, AD shows various differences in immune and barrier properties from long-standing adult AD, which might necessitate tailored treatment approaches depending on the age of the patient.
    MeSH term(s) Antimicrobial Cationic Peptides/biosynthesis ; Blood Chemical Analysis ; Child, Preschool ; Dermatitis, Atopic/immunology ; Disease Susceptibility ; Humans ; Infant ; Infant, Newborn ; Lipid Metabolism/physiology ; Lymphocyte Activation/immunology ; Risk Factors ; Skin/immunology ; Skin/microbiology ; Skin/pathology ; Th17 Cells/immunology ; Th2 Cells/immunology ; Tight Junctions/physiology
    Chemical Substances Antimicrobial Cationic Peptides
    Language English
    Publishing date 2019-04-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2019.03.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Blood will tell: profiling Sézary syndrome.

    Jonak, Constanze / Brunner, Patrick M

    Blood

    2021  Volume 138, Issue 24, Page(s) 2450–2451

    MeSH term(s) Gene Expression Profiling ; Humans ; Sezary Syndrome/diagnosis ; Skin Neoplasms/diagnosis
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2021013433
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Survey of Patient Demographics in Inflammatory Skin Disease Case Reports.

    O'Hagan, Ross / Caldas, Stella A / Brunner, Patrick M / Ungar, Benjamin

    JMIR dermatology

    2023  Volume 6, Page(s) e49070

    Abstract: Case reports serve many functions in the medical literature. We explore patient demographics in case reports for common inflammatory skin diseases. ...

    Abstract Case reports serve many functions in the medical literature. We explore patient demographics in case reports for common inflammatory skin diseases.
    Language English
    Publishing date 2023-09-25
    Publishing country Canada
    Document type Journal Article
    ISSN 2562-0959
    ISSN (online) 2562-0959
    DOI 10.2196/49070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evaluation of mortality, prognostic parameters, and treatment efficacy in mycosis fungoides.

    Porkert, Stefanie / Griss, Johannes / Hudelist-Venz, Mercedes / Steiner, Irene / Valencak, Julia / Weninger, Wolfgang / Brunner, Patrick M / Jonak, Constanze

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2024  Volume 22, Issue 4, Page(s) 532–550

    Abstract: Background and objectives: Mycosis fungoides (MF), the most common primary cutaneous T-cell lymphoma, is characterized by a variable clinical course, presenting either as indolent disease or showing fatal progression due to extracutaneous involvement. ... ...

    Abstract Background and objectives: Mycosis fungoides (MF), the most common primary cutaneous T-cell lymphoma, is characterized by a variable clinical course, presenting either as indolent disease or showing fatal progression due to extracutaneous involvement. Importantly, the lack of prognostic models and predominantly palliative therapy settings hamper patient care. Here, we aimed to define survival rates, disease prediction accuracy, and treatment impact in MF.
    Patients and methods: Hundred-forty MF patients were assessed retrospectively. Prognosis and disease progression/survival were analyzed using univariate Cox proportional hazards regression model and Kaplan-Meier estimates.
    Results: Skin tumors were linked to shorter progression-free, overall survival and a 3.48 increased risk for disease progression when compared to erythroderma. The Cutaneous Lymphoma International Prognostic Index identified patients at risk in early-stage disease only. Moreover, expression of Ki-67 >20%, CD30 >10%, CD20
    Conclusions: Our data support predictive validity of prognostic factors and models in MF and identified further potential parameters associated with poor survival. Prospective studies on prognostic indices across disease stages and treatment modalities are needed to predict and improve survival.
    MeSH term(s) Humans ; Prognosis ; Retrospective Studies ; Prospective Studies ; Mycosis Fungoides/diagnosis ; Mycosis Fungoides/therapy ; Treatment Outcome ; Skin Neoplasms ; Interferon-alpha ; Disease Progression ; Neoplasm Staging
    Chemical Substances Interferon-alpha
    Language English
    Publishing date 2024-03-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15331
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  8. Article ; Online: [No title information]

    Porkert, Stefanie / Griss, Johannes / Hudelist-Venz, Mercedes / Steiner, Irene / Valencak, Julia / Weninger, Wolfgang / Brunner, Patrick M / Jonak, Constanze

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2024  Volume 22, Issue 4, Page(s) 532–552

    Title translation Mortalität, prognostische Parameter und Behandlungsstrategien bei Mycosis fungoides.
    MeSH term(s) Humans ; Prognosis ; Mycosis Fungoides ; Skin Neoplasms
    Language German
    Publishing date 2024-04-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15331_g
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  9. Article ; Online: Efficacy and safety of abrocitinib in patients with moderate‐to‐severe atopic dermatitis and comorbid allergies

    Schmid‐Grendelmeier, Peter / Gooderham, Melinda J. / Hartmann, Karin / Konstantinou, George N. / Fellmann, Marc / Koulias, Christopher / Clibborn, Claire / Biswas, Pinaki / Brunner, Patrick M.

    Allergy. 2024 Jan., v. 79, no. 1, p. 174-183

    2024  , Page(s) 174–183

    Abstract: BACKGROUND: Abrocitinib efficacy by comorbidity status in patients with moderate‐to‐severe atopic dermatitis (AD) has not been previously assessed. This post hoc analysis evaluated the efficacy and safety of abrocitinib in patients with AD and allergic ... ...

    Abstract BACKGROUND: Abrocitinib efficacy by comorbidity status in patients with moderate‐to‐severe atopic dermatitis (AD) has not been previously assessed. This post hoc analysis evaluated the efficacy and safety of abrocitinib in patients with AD and allergic comorbidities. METHODS: Data were pooled from patients who received abrocitinib 200 mg, 100 mg, or placebo in phase 2b (NCT02780167) and phase 3 (NCT03349060, NCT03575871) monotherapy trials. Patients with and without allergic comorbidities (allergic asthma, rhinitis, conjunctivitis, or food allergy) were evaluated for Investigator's Global Assessment (IGA) response (clear [0] or almost clear [1]), ≥75% improvement in the Eczema Area and Severity Index (EASI‐75), ≥4‐point improvement in Peak Pruritus Numerical Rating Scale (PP‐NRS4), and Dermatology Life Quality Index (DLQI) response (<2 with baseline score ≥2). Other outcomes were Patient‐Oriented Eczema Measure (POEM), SCORing Atopic Dermatitis (SCORAD), Pruritus and Symptoms Assessment for Atopic Dermatitis (PSAAD), and treatment‐emergent adverse events (TEAEs). RESULTS: Of 942 patients, 498 (53%) reported at least one allergic comorbidity (asthma only, 33%; conjunctivitis only or rhinitis only or both, 17%; food allergies only, 15%; >1 allergic comorbidity, 34%). Regardless of comorbidity status, from Week 2 to Week 12, higher percentages of patients treated with either abrocitinib dose achieved IGA 0/1, EASI‐75, PP‐NRS4, or DLQI 0/1 versus placebo‐treated patients. Changes from baseline in POEM, SCORAD, and PSAAD were greater with abrocitinib than with placebo in patients with and without allergic comorbidities. Most TEAEs were mild or moderate. CONCLUSIONS: Efficacy and safety data support abrocitinib use to manage AD in patients with or without allergic comorbidities.
    Keywords asthma ; atopic dermatitis ; comorbidity ; conjunctivitis ; eczema ; food allergies ; placebos ; pruritus ; quality of life ; rhinitis
    Language English
    Dates of publication 2024-01
    Size p. 174-183
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15952
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Recent advances in understanding and managing cutaneous T-cell lymphomas.

    Brunner, Patrick M / Jonak, Constanze / Knobler, Robert

    F1000Research

    2020  Volume 9

    Abstract: Cutaneous T-cell lymphomas (CTCLs) comprise a heterogeneous group of extranodal non-Hodgkin lymphomas involving primarily the skin and mycosis fungoides is its most frequent entity. Whereas most patients show an indolent course in early disease (clinical ...

    Abstract Cutaneous T-cell lymphomas (CTCLs) comprise a heterogeneous group of extranodal non-Hodgkin lymphomas involving primarily the skin and mycosis fungoides is its most frequent entity. Whereas most patients show an indolent course in early disease (clinical stages IA to IIA), some patients progress to advanced disease (stage IIB or higher), and the 5-year survival rate is unfavorable: only 47% (stage IIB) to 18% (stage IVB). Except for allogeneic stem cell transplantation, there is currently no cure for CTCL and thus treatment approaches are palliative, focusing on patients' health-related quality of life. Our aims were to review the current understanding of the pathogenesis of CTCL, such as the shift in overall immune skewing with progressive disease and the challenges of making a timely diagnosis in early-stage disease because of the lack of reliable positive markers for routine diagnostics, and to discuss established and potential treatment modalities such as immunotherapy and novel targeted therapeutics.
    MeSH term(s) Humans ; Lymphoma, T-Cell, Cutaneous ; Mycosis Fungoides ; Quality of Life ; Sezary Syndrome ; Skin Neoplasms
    Language English
    Publishing date 2020-05-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.21922.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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