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Article ; Online: Efecto de distintos eventos biotecnológicos de maíz en el consumo y mortalidad de la oruga cortadora "áspera" (Agrotis robusta)

Segundo Fernández Madrid / Bruno Andrés Pirchio

Semiárida, Vol 31, Iss

2021 Volume 1

Abstract: Agrotis robusta (Lepidoptera: Noctuidae) es una especie de gran importancia económica en América del Sur perteneciente al complejo de orugas cortadoras, que provocan importantes daños en cultivos de verano en la Región Semiárida Pampeana. Este complejo ... ...

Abstract	Agrotis robusta (Lepidoptera: Noctuidae) es una especie de gran importancia económica en América del Sur perteneciente al complejo de orugas cortadoras, que provocan importantes daños en cultivos de verano en la Región Semiárida Pampeana. Este complejo comprende especies que se alimentan de raíces o brotes de plantas herbáceas y normalmente cortan los tallos tiernos a ras del suelo. En los últimos años se han presentado serios problemas para controlar las poblaciones de estos insectos plagas, ocasionando pérdidas directas por deficiencias de control y/o pérdidas indirectas por un mayor uso de insecticidas y consecuentemente un aumento en los costos de producción del cultivo. Una herramienta disponible al alcance de los productores son los cultivos transgénicos, tal es el caso de los *maíces Bt*, que incorporan por medio de ingeniería genética proteínas insecticidas de la bacteria Bacillius thuringiensis (Gram positiva). Agrotis robusta no es el blanco principal para estas biotecnologías. El objetivo de este trabajo fue determinar el efecto producido por distintos eventos biotecnológicos de maíz sobre el consumo de área foliar, peso y mortandad de larvas de Agrotis robusta. Para ello se recolectaron hembras grávidas de Agrotis robusta de una trampa de luz ubicada en el campo de la Facultad de Agronomía de la UNLPam para obtener huevos y criar larvas hasta los estadios cuarto/quinto. Se aislaron individualmente en cajas de Petri, se sometieron a una hora de inanición y se determinó su peso inicial para luego dar comienzo a los tratamientos que consistieron en distintas dietas en un periodo de evaluación de 10 días consecutivos. Para la obtención del tejido foliar utilizado en la alimentación de las larvas se sembraron en bandejas de germinación los siguientes maíces transgénicos con eventos Bt: Herculex (HX), Maizgard (MG), Powercore (PW), Agrisure Viptera3 (VIP3), VT Triple Pro (VT3P), un maíz sin eventos transgénicos para resistencia a insectos (NBT) y un tratamiento blanco que consistió en hojas ...
Keywords	Agrotis robusta ; Maíz ; Eventos transgénicos piramidados ; Consumo ; Peso y mortandad ; Larvas ; Agriculture (General) ; S1-972 ; Animal culture ; SF1-1100 ; Cattle ; SF191-275
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Universidad Nacional de La Pampa
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Significant progress in improving Atorvastatin dissolution rate: Physicochemical characterization and stability assessment of self-dispersible Atorvastatin/Tween 80® nanocrystals formulated through wet milling and freeze-drying.

Rossetti, Alan / Real, Daniel Andrés / Barrientos, Bruno Andrés / Allemandi, Daniel Alberto / Paredes, Alejandro J / Real, Juan Pablo / Palma, Santiago Daniel

International journal of pharmaceutics

2023 Volume 650, Page(s) 123720

Abstract: Atorvastatin (ATV) is a first-line drug for the treatment of hyperlipidemia. This drug presents biopharmaceutical problems, partly due to its low solubility and dissolution rate. In this work, nanocrystals of ATV stabilized with Tween 80® were designed ... ...

Abstract	Atorvastatin (ATV) is a first-line drug for the treatment of hyperlipidemia. This drug presents biopharmaceutical problems, partly due to its low solubility and dissolution rate. In this work, nanocrystals of ATV stabilized with Tween 80® were designed by wet milling. A full factorial design was applied to optimize the process. Additionally, a cryoprotectant agent (maltodextrin, MTX) was identified, which allowed maintaining the properties of the nanocrystals after lyophilization. The storage stability of the nanocrystals was demonstrated for six months in different conditions. The obtained nanocrystal powder was characterized using SEM, EDXS, TEM, DSC, TGA, FT-IR, and XRD, showing the presence of irregular crystals with semi-amorphous characteristics, likely due to the particle collision process. Based on the reduction in particle size and the decrease in drug crystallinity, a significant increase in water and phosphate buffer (pH 6.8) solubility by 4 and 6 times, respectively, was observed. On the other hand, a noticeable increase in the dissolution rate was observed, with 90 % of the drug dissolved within 60 min of study, compared to 30 % of the drug dissolved within 12 h in the case of the untreated drug or the physical mixture of components. Based on these results, it can be concluded that the nano-milling of Atorvastatin stabilized with Tween 80® is a promising strategy for developing new formulations with improved biopharmaceutical properties of this widely used drug.
MeSH term(s)	Polysorbates ; Atorvastatin/chemistry ; Spectroscopy, Fourier Transform Infrared ; Solubility ; Nanoparticles/chemistry ; Freeze Drying ; Biological Products ; Particle Size
Chemical Substances	Polysorbates ; Atorvastatin (A0JWA85V8F) ; Biological Products
Language	English
Publishing date	2023-12-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2023.123720
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Article ; Online: Efecto de distintos eventos biotecnológicos de maíz en el consumo y mortalidad de la “oruga cortadora áspera” (Agrotis robusta)

Bruno Andres Pirchio / Segundo Fernandez Madrid / Andrés Ezequiel Corró Molas / Estela Maris Baudino

Semiárida, Vol 29, Iss

2020 Volume 2

Abstract: Agrotis robusta es una especie perteneciente al complejo de orugas cortadoras que provocan daños en cultivos de la Región Semiárida Pampeana. Una herramienta utilizada para el control de lepidópteros son los “maíces Bt”, cultivos transgénicos que ... ...

Abstract	Agrotis robusta es una especie perteneciente al complejo de orugas cortadoras que provocan daños en cultivos de la Región Semiárida Pampeana. Una herramienta utilizada para el control de lepidópteros son los “maíces Bt”, cultivos transgénicos que incorporan proteínas insecticidas de laba cteria Bacillus thuringiensis. El objetivo fue determinar el efecto de distintos eventos biotecnológicos de maíz sobre el consumo de área foliar, peso y mortandad de larvas de Agrotis robusta. Para ello se alimentaron larvas durante 10 días con tejido foliar procedente de cinco híbridos de “maíz Bt”: Herculex(HX), Maizgard(MG), Powercore(PW), Agrisure Viptera3(VIP3), VT Triple Pro(VT3P), un maíz sin eventos transgénicos para resistencia a insectos (NBT) y un tratamiento blanco con quinoa silvestre (Q). Se dispuso un diseño experimental en bloques al azar con tres repeticiones. Se evaluó el peso de larvas, consumo y mortandad. Los híbridos de maíz PW, VT3P y VIP3, que incorporan más de una toxina Bt, producen disminución del consumo de área foliar y pérdidas de peso en larvas de A. robusta. La mayor mortandad se observa en el tratamiento PW, seguido por VT3P y VIP3. Los híbridos MG y HX registran un consumo de área foliar, peso y mortandad de larvas similar al tratamiento NBT.
Keywords	maíz transgénico ; orugas cortadoras ; consumo ; peso ; mortandad ; Agriculture (General) ; S1-972 ; Animal culture ; SF1-1100 ; Cattle ; SF191-275
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Universidad Nacional de La Pampa
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Use of Mobile Phone App Interventions to Promote Weight Loss: Meta-Analysis.

Islam, Md Mohaimenul / Poly, Tahmina Nasrin / Walther, Bruno Andres / Jack Li, Yu-Chuan

JMIR mHealth and uHealth

2020 Volume 8, Issue 7, Page(s) e17039

Abstract: Background: Obesity and lack of physical activity are major health risk factors for many life-threatening diseases, such as cardiovascular diseases, type 2 diabetes, and cancer. The use of mobile app interventions to promote weight loss and boost ... ...

Abstract	Background: Obesity and lack of physical activity are major health risk factors for many life-threatening diseases, such as cardiovascular diseases, type 2 diabetes, and cancer. The use of mobile app interventions to promote weight loss and boost physical activity among children and adults is fascinating owing to the demand for cutting-edge and more efficient interventions. Previously published studies have examined different types of technology-based interventions and their impact on weight loss and increase in physical activity, but evidence regarding the impact of only a mobile phone app on weight loss and increase in physical activity is still lacking. Objective: The main objective of this study was to assess the efficacy of a mobile phone app intervention for reducing body weight and increasing physical activity among children and adults. Methods: PubMed, Google Scholar, Scopus, EMBASE, and the Web of Science electronic databases were searched for studies published between January 1, 2000, and April 30, 2019, without language restrictions. Two experts independently screened all the titles and abstracts to find the most appropriate studies. To be included, studies had to be either a randomized controlled trial or a case-control study that assessed a mobile phone app intervention with body weight loss and physical activity outcomes. The Cochrane Collaboration Risk of Bias tool was used to examine the risk of publication bias. Results: A total of 12 studies involving a mobile phone app intervention were included in this meta-analysis. Compared with the control group, the use of a mobile phone app was associated with significant changes in body weight (-1.07 kg, 95% CI -1.92 to -0.21, P=.01) and body mass index (-0.45 kg/m2, 95% CI -0.78 to -0.12, P=.008). Moreover, a nonsignificant increase in physical activity was observed (0.17, 95% CI -2.21 to 2.55, P=.88). Conclusions: The findings of this study demonstrate the promising and emerging efficacy of using mobile phone app interventions for weight loss. Future studies are needed to explore the long-term efficacy of mobile app interventions in larger samples.
MeSH term(s)	Adolescent ; Adult ; Aged ; Case-Control Studies ; Cell Phone ; Child ; Diabetes Mellitus, Type 2/prevention & control ; Female ; Health Promotion ; Humans ; Male ; Middle Aged ; Mobile Applications ; Pregnancy ; Randomized Controlled Trials as Topic ; Weight Loss ; Young Adult
Language	English
Publishing date	2020-07-22
Publishing country	Canada
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2719220-9
ISSN	2291-5222 ; 2291-5222
ISSN (online)	2291-5222
ISSN	2291-5222
DOI	10.2196/17039
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Article: 3D-Printed Gastroretentive Tablets Loaded with Niclosamide Nanocrystals by the Melting Solidification Printing Process (MESO-PP).

Real, Juan Pablo / Real, Daniel Andrés / Lopez-Vidal, Lucía / Barrientos, Bruno Andrés / Bolaños, Karen / Tinti, Mariano Guillermo / Litterio, Nicolás Javier / Kogan, Marcelo Javier / Palma, Santiago Daniel

Pharmaceutics

2023 Volume 15, Issue 5

Abstract: Niclosamide (NICLO) is a recognized antiparasitic drug being repositioned ... ...

Abstract	Niclosamide (NICLO) is a recognized antiparasitic drug being repositioned for
Language	English
Publishing date	2023-04-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15051387
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Article ; Online: Use of Mobile Phone App Interventions to Promote Weight Loss

Islam, Md Mohaimenul / Poly, Tahmina Nasrin / Walther, Bruno Andres / (Jack) Li, Yu-Chuan

JMIR mHealth and uHealth, Vol 8, Iss 7, p e

Meta-Analysis

2020 Volume 17039

Abstract: BackgroundObesity and lack of physical activity are major health risk factors for many life-threatening diseases, such as cardiovascular diseases, type 2 diabetes, and cancer. The use of mobile app interventions to promote weight loss and boost physical ... ...

Abstract	BackgroundObesity and lack of physical activity are major health risk factors for many life-threatening diseases, such as cardiovascular diseases, type 2 diabetes, and cancer. The use of mobile app interventions to promote weight loss and boost physical activity among children and adults is fascinating owing to the demand for cutting-edge and more efficient interventions. Previously published studies have examined different types of technology-based interventions and their impact on weight loss and increase in physical activity, but evidence regarding the impact of only a mobile phone app on weight loss and increase in physical activity is still lacking. ObjectiveThe main objective of this study was to assess the efficacy of a mobile phone app intervention for reducing body weight and increasing physical activity among children and adults. MethodsPubMed, Google Scholar, Scopus, EMBASE, and the Web of Science electronic databases were searched for studies published between January 1, 2000, and April 30, 2019, without language restrictions. Two experts independently screened all the titles and abstracts to find the most appropriate studies. To be included, studies had to be either a randomized controlled trial or a case-control study that assessed a mobile phone app intervention with body weight loss and physical activity outcomes. The Cochrane Collaboration Risk of Bias tool was used to examine the risk of publication bias. ResultsA total of 12 studies involving a mobile phone app intervention were included in this meta-analysis. Compared with the control group, the use of a mobile phone app was associated with significant changes in body weight (−1.07 kg, 95% CI −1.92 to −0.21, P=.01) and body mass index (−0.45 kg/m2, 95% CI −0.78 to −0.12, P=.008). Moreover, a nonsignificant increase in physical activity was observed (0.17, 95% CI −2.21 to 2.55, P=.88). ConclusionsThe findings of this study demonstrate the promising and emerging efficacy of using mobile phone app interventions for weight loss. Future studies ...
Keywords	Information technology ; T58.5-58.64 ; Public aspects of medicine ; RA1-1270
Subject code	796
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	JMIR Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Drug-induced liver injury caused by adalimumab: a case report and review of the bibliography.

Frider, Bernardo / Bruno, Andres / Ponte, Marcelo / Amante, Marcelo

Case reports in hepatology

2013 Volume 2013, Page(s) 406901

Abstract: The most serious adverse drug reaction of adalimumab (ADR) is tuberculosis reactivation. We describe a case of a 35-year-old man, with rheumatoid arthritis (RA) and hepatitis C virus genotype 1a with a liver biopsy in 2001 with a METAVIR score pattern A1 ...

Abstract	The most serious adverse drug reaction of adalimumab (ADR) is tuberculosis reactivation. We describe a case of a 35-year-old man, with rheumatoid arthritis (RA) and hepatitis C virus genotype 1a with a liver biopsy in 2001 with a METAVIR score pattern A1 F0; he received interferon alpha 2b for six months, but treatment was suspended because of reactivation of RA. Liver function tests after treatment were similar to previous ones showing a minimal cholestatic pattern. In 2008, methotrexate was prescribed, but the drug was withdrawn at the third month because of the appearance of pruritus and Ggt rise. Viral load at that moment was 9300000 UI/mL, log 6,9. The liver biopsy showed a Metavir Score A2 F1. Adalimumab was started in 2010, and at the third month of treatment, Ggt showed a rise of 23 times normal value (NV), alkaline phosphatase 2,5 times NV with AST and ALT with no change. A new liver biopsy showed portal inflammation with eosinophils and a METAVIR A1 F2. We think that adalimumab appears to be responsible for the liver injury, because of temporal relationship, liver biopsy findings, other clinical conditions being discarded, and the improvement of clinical symptoms and biochemical abnormalities when adalimumab was suspended.
Language	English
Publishing date	2013-05-14
Publishing country	United States
Document type	Journal Article
ISSN	2090-6587
ISSN	2090-6587
DOI	10.1155/2013/406901
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Article: Autoimmune cholangitis associated to IgG4 related sclerosing disease.

Frider, Bernardo / Bruno, Andrés / Zylberman, Marcelo / Oría, Alejandro / Amante, Marcelo

Acta gastroenterologica Latinoamericana

2011 Volume 41, Issue 1, Page(s) 55–59

Abstract: The IgG4-related sclerosing disease is characterized by the presence of plasmatic IgG4 positive cells and T-lymphocytes infiltration in different organs. We herein report a case of cholestasis due to autoimmune cholangitis associated to IgG4 disease. A ... ...

Abstract	The IgG4-related sclerosing disease is characterized by the presence of plasmatic IgG4 positive cells and T-lymphocytes infiltration in different organs. We herein report a case of cholestasis due to autoimmune cholangitis associated to IgG4 disease. A 40-year-old woman with a history of pruritus, anosmia, Sjögren's syndrome and diabetes, was referred for a pancreatic tumor. Alkaline phosphatase was 24-fold upper limit of normal (ULN), gamma-glutamyl transpeptidase 21-fold ULN, aspartate aminotransferase 3-fold ULN, alanine aminotransferase 2-fold ULN, cholesterol 408 mg/dL, bilirubin normal, gamma-globulin 3.92 g/dL, IgG4 4.6 g/L, antinuclear antibody positive (1/320), and antimitochondrial antibodies negative. Ultrasound scan (US) showed a mass in the pancreatic head and thickening of the gallbladder and the bile duct walls. Dilation and strictures of the main pancreatic duct and intrahepatic bile ducts were detected by MR cholangiopancreatography. Liver biopsy showed chronic inflammatory lesions, ductal damage (autoimmune cholangitis) (METAVIRA2, F2) and IgG4 bearing plasmatic cells. A cervical lymph node showed IgG4 bearing plasmatic cells. After 2 weeks of treatment with meprednisone, ursodeoxycholic acid and insulin, pruritus and anosmia disappeared. After eleven months of treatment imaging studies showed disappearance of the pancreatic tumor, atrophy of the body and the pancreatic tail and normal biochemical parameters, except for alkaline phosphatase 2-fold ULN. The final diagnosis of our patient was autoimmune hepatitis with cholangitis associated to IgG4 systemic diseases.
MeSH term(s)	Adult ; Autoimmune Diseases/complications ; Autoimmune Diseases/diagnosis ; Cholangitis, Sclerosing/complications ; Cholangitis, Sclerosing/diagnosis ; Cholestasis/diagnosis ; Cholestasis/etiology ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2011-03
Publishing country	Argentina
Document type	Case Reports ; Journal Article
ZDB-ID	730001-3
ISSN	0300-9033
ISSN	0300-9033
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Article: Reversal of advanced fibrosis after long-term ursodeoxycholic acid therapy in a patient with residual expression of MDR3.

Frider, Bernardo / Castillo, Amalia / Gordo-Gilart, Raquel / Bruno, Andrés / Amante, Marcelo / Alvarez, Luis / Mathet, Verónica

Annals of hepatology

2015 Volume 14, Issue 5, Page(s) 745–751

Abstract: Introduction: Progressive familial intrahepatic cholestasis type 3 (PFIC-3) is a severe liver disorder associated with inherited dysfunction of multidrug resistance protein 3 (MDR3/ABCB4), which functions as a phospholipid floppase, translocating ... ...

Abstract	Introduction: Progressive familial intrahepatic cholestasis type 3 (PFIC-3) is a severe liver disorder associated with inherited dysfunction of multidrug resistance protein 3 (MDR3/ABCB4), which functions as a phospholipid floppase, translocating phosphatidylcholine from the inner to the outer hemileaflet of the canalicular membrane of hepatocytes. MDR3 deficiency results in a disbalanced bile which may damage the luminal membrane of cells of the hepatobiliary system. We evaluated clinical, biochemical and histological improvement in a genetically proven PFIC-3 patient after long-term ursodeoxycholic acid (UDCA) administration. Material and methods: A PFIC-3 patient and a relative with cholestatic liver disease were studied. Hepatic MDR3 expression was analyzed by immunohistochemistry and ABCB4 mutations were identified. The effect of the mutations on MDR3 expression and subcellular localization was studied in vitro. Results: A 23-year-old man presented cholestasis with severe fibrosis and incomplete cirrhosis. Canalicular staining for MDR3 was faint. Sequence analysis of ABCB4 revealed two missense mutations that reduce drastically protein expression levels. After 9 years of treatment with UDCA disappearance of fibrosis and cirrhosis was achieved. Conclusion: These data indicate that fibrosis associated with MDR3 deficiency can be reversed by long-term treatment with UDCA, at least when there is residual expression of the protein.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B/deficiency ; ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Animals ; Cholagogues and Choleretics/therapeutic use ; Cholestasis, Intrahepatic/diagnosis ; Cholestasis, Intrahepatic/drug therapy ; Cholestasis, Intrahepatic/genetics ; DNA Mutational Analysis ; Dogs ; Elasticity Imaging Techniques ; Genetic Predisposition to Disease ; HEK293 Cells ; Humans ; Immunohistochemistry ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/genetics ; Madin Darby Canine Kidney Cells ; Male ; Mutation, Missense ; Phenotype ; Remission Induction ; Severity of Illness Index ; Time Factors ; Transfection ; Treatment Outcome ; Ursodeoxycholic Acid/therapeutic use ; Young Adult
Chemical Substances	ATP Binding Cassette Transporter, Subfamily B ; Cholagogues and Choleretics ; Ursodeoxycholic Acid (724L30Y2QR) ; multidrug resistance protein 3 (9EI49ZU76O)
Language	English
Publishing date	2015-08-07
Publishing country	Mexico
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2188733-0
ISSN	1665-2681
ISSN	1665-2681
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Article: Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay.

Vazquez, Carolina / Gutierrez-Acevedo, María Nelly / Barbero, Sabrina / Notari, Lorena Del Carmen / Agozino, Marina / Fernandez, José Luis / Anders, María Margarita / Grigera, Nadia Lorena / Antinucci, Florencia / Orozco-Ganem, Orlando Nicolas Federico / Murga, María Dolores / Perez, María Daniela / Palazzo, Ana Gracia / Rejtman, Liria Martinez / Duarte, Ivonne Giselle / Vorobioff, Julio Daniel / Trevizan, Victoria / Bulaty, Sofía / Bessone, Fernando /

Valverde, Marcelo / Elizondo, Martín / Borzi, Silvia Mabel / Stieben, Teodoro Eduardo / Masola, Adriano Carlos / Ferretti, Sebastian Eduardo / Arufe, Diego / Demirdjian, Ezequiel / Raffa, María Pia / Peralta, Mirta / Fainboim, Hugo Alberto / Vazquez, Cintia Elizabet / Ruiz, Pablo Marcelo / Martínez, José Emanuel / Heffner, Leandro Alfredo / Odzak, Andrea / Dirchwolf, Melisa / Smud, Astrid / Mendizabal, Manuel / Calzetta, Pablo Anibal / Martinez, Ana / Tomatis, Jesica / Bruno, Andres / Ramos, Agñel / Pages, Josefina / Tevez, Silvina / Gadano, Adrian Carlos / Giunta, Diego Hernan / Marciano, Sebastián

Annals of hepatology

2023 Volume 28, Issue 4, Page(s) 101097

Abstract: Introduction and objectives: there is insufficient data regarding bacterial infections in patients with cirrhosis to support recommendations for empiric antibiotic treatments, particularly in Latin America. This study aimed to evaluate bacterial ... ...

Abstract	Introduction and objectives: there is insufficient data regarding bacterial infections in patients with cirrhosis to support recommendations for empiric antibiotic treatments, particularly in Latin America. This study aimed to evaluate bacterial infection's clinical impact and microbiological characteristics, intending to serve as a platform to revise current practices. Materials and methods: multicenter prospective cohort study of patients with cirrhosis and bacterial infections from Argentina and Uruguay. Patient and infection-related information were collected, focusing on microbiology, antibiotic susceptibility patterns, and outcomes. Results: 472 patients were included. Spontaneous bacterial infections and urinary tract infections (UTIs) were registered in 187 (39.6%) and 116 (24.6%) patients, respectively, representing the most common infections. Of the 256 culture-positive infections, 103 (40.2%) were caused by multidrug-resistant organisms (reaching 50% for UTI), and 181 (70.7%) received adequate initial antibiotic treatment. The coverage of cefepime and ceftriaxone was over 70% for the empirical treatment of community-acquired spontaneous infections, but ceftazidime´s coverage was only 40%. For all UTI cases and for healthcare-associated or nosocomial spontaneous bacterial infections, the lower-spectrum antibiotics that covered at least 70% of the isolations were imipenem and meropenem. During hospitalization, a second bacterial infection was diagnosed in 9.8% of patients, 23.9% required at least one organ support, and 19.5% died. Conclusions: short-term mortality of bacterial infections in patients with cirrhosis is very high, and a high percentage were caused by multidrug-resistant organisms, particularly in UTIs. The information provided might serve to adapt recommendations, particularly related to empirical antibiotic treatment in Argentina and Uruguay. The study was registered in Clinical Trials (NCT03919032).
MeSH term(s)	Humans ; Prospective Studies ; Argentina/epidemiology ; Uruguay/epidemiology ; Bacterial Infections/diagnosis ; Bacterial Infections/drug therapy ; Bacterial Infections/epidemiology ; Anti-Bacterial Agents/therapeutic use ; Liver Cirrhosis/complications ; Liver Cirrhosis/diagnosis ; Liver Cirrhosis/drug therapy ; Urinary Tract Infections/diagnosis ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/epidemiology ; Bacteria ; Cross Infection/diagnosis ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Community-Acquired Infections/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-04-06
Publishing country	Mexico
Document type	Multicenter Study ; Journal Article
ZDB-ID	2188733-0
ISSN	1665-2681
ISSN	1665-2681
DOI	10.1016/j.aohep.2023.101097
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