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  1. Article ; Online: Postvaccination immune-mediated hepatitis: what do we really know?

    Lasagna, Angioletta / Pedrazzoli, Paolo / Bruno, Raffaele / Sacchi, Paolo

    Immunotherapy

    2023  Volume 15, Issue 9, Page(s) 627–630

    Abstract: Tweetable abstract The percentage of patients with immune-mediated vaccine-associated hepatitis is minimal compared with the number of patients vaccinated worldwide. ...

    Abstract Tweetable abstract The percentage of patients with immune-mediated vaccine-associated hepatitis is minimal compared with the number of patients vaccinated worldwide.
    MeSH term(s) Humans ; Hepatitis, Autoimmune ; Vaccination ; Immunization
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2023-0038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial of Special Issues "Gut Microbiota-Host Interactions: From Symbiosis to Dysbiosis 2.0".

    Zuccaro, Valentina / Ponziani, Francesca Romana / Bruno, Raffaele

    International journal of molecular sciences

    2023  Volume 24, Issue 10

    Abstract: The gastrointestinal (GI) tract is where external agents meet the internal environment [ ... ]. ...

    Abstract The gastrointestinal (GI) tract is where external agents meet the internal environment [...].
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Dysbiosis ; Symbiosis ; Gastrointestinal Tract
    Language English
    Publishing date 2023-05-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24108977
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  3. Article ; Online: Direct-acting antiviral agents in lymphoproliferative disorders: more complex than expected.

    Arcaini, Luca / Bruno, Raffaele

    British journal of haematology

    2020  Volume 191, Issue 5, Page(s) 661–662

    MeSH term(s) Antiviral Agents/therapeutic use ; Cryoglobulinemia ; Hepacivirus ; Hepatitis C ; Hepatitis C, Chronic/drug therapy ; Humans ; Lymphoproliferative Disorders/drug therapy
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2020-08-18
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17037
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    In stock of ZB MED Cologne/Königswinter

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  4. Book ; Online: A Machine-Learned Ranking Algorithm for Dynamic and Personalised Car Pooling Services

    Campana, Mattia Giovanni / Delmastro, Franca / Bruno, Raffaele

    2023  

    Abstract: Car pooling is expected to significantly help in reducing traffic congestion and pollution in cities by enabling drivers to share their cars with travellers with similar itineraries and time schedules. A number of car pooling matching services have been ... ...

    Abstract Car pooling is expected to significantly help in reducing traffic congestion and pollution in cities by enabling drivers to share their cars with travellers with similar itineraries and time schedules. A number of car pooling matching services have been designed in order to efficiently find successful ride matches in a given pool of drivers and potential passengers. However, it is now recognised that many non-monetary aspects and social considerations, besides simple mobility needs, may influence the individual willingness of sharing a ride, which are difficult to predict. To address this problem, in this study we propose GoTogether, a recommender system for car pooling services that leverages on learning-to-rank techniques to automatically derive the personalised ranking model of each user from the history of her choices (i.e., the type of accepted or rejected shared rides). Then, GoTogether builds the list of recommended rides in order to maximise the success rate of the offered matches. To test the performance of our scheme we use real data from Twitter and Foursquare sources in order to generate a dataset of plausible mobility patterns and ride requests in a metropolitan area. The results show that the proposed solution quickly obtain an accurate prediction of the personalised user's choice model both in static and dynamic conditions.

    Comment: Accepted from the IEEE 19th International Conference on Intelligent Transportation Systems (ITSC), 2016
    Keywords Computer Science - Information Retrieval ; Computer Science - Machine Learning
    Subject code 380
    Publishing date 2023-07-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Long-COVID in Patients with Cancer Previously Treated with Early Anti-SARS-CoV-2 Therapies in an Out-of-Hospital Setting: A Single-Center Experience.

    Lasagna, Angioletta / Albi, Giuseppe / Figini, Simone / Basile, Sara / Sacchi, Paolo / Bruno, Raffaele / Pedrazzoli, Paolo

    Cancers

    2023  Volume 15, Issue 4

    Abstract: The incidence of long COVID in a cohort of patients with cancer with or without previous treatment with early therapies anti-SARS-CoV-2 in an out-of-hospital setting have to be elucidated. We prospectively enrolled all patients treated for a solid tumor ... ...

    Abstract The incidence of long COVID in a cohort of patients with cancer with or without previous treatment with early therapies anti-SARS-CoV-2 in an out-of-hospital setting have to be elucidated. We prospectively enrolled all patients treated for a solid tumor at the department of Medical Oncology of the Fondazione IRCCS Policlinico San Matteo with a positive SARS-CoV-2 antigen or polymerase chain reaction test from January to September 2022 (Omicron surge). Ninety-seven patients answered the survey questions by telephone at least 12 weeks after COVID-19 diagnosis in order to evaluate the incidence of long COVID symptoms. Only twelve patients (12.4%) reported long COVID. No significant difference between early therapies anti-SARS-CoV-2 31 and long COVID (
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15041269
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  6. Article ; Online: Optimizing Antibiotic Therapy for Intravenous Drug Users: A Narrative Review Unraveling Pharmacokinetics/Pharmacodynamics Challenges.

    Colaneri, Marta / Genovese, Camilla / Valsecchi, Pietro / Calia, Matteo / Cattaneo, Dario / Gori, Andrea / Bruno, Raffaele / Seminari, Elena

    European journal of drug metabolism and pharmacokinetics

    2024  Volume 49, Issue 2, Page(s) 123–129

    Abstract: Intravenous drug users (IVDUs) face heightened susceptibility to life-threatening gram-positive bacterial infections, particularly methicillin-resistant Staphylococcus aureus (MRSA). While the standard antibiotic dosing strategies for special patients, ... ...

    Abstract Intravenous drug users (IVDUs) face heightened susceptibility to life-threatening gram-positive bacterial infections, particularly methicillin-resistant Staphylococcus aureus (MRSA). While the standard antibiotic dosing strategies for special patients, such as obese or critically ill individuals, are known to be inadequate, raising concerns about treatment efficacy, a similar sort of understanding has not been assessed for IVDUs yet. With this in mind, this review examines the pharmacokinetic/pharmacodynamic characteristics of antibiotics commonly used against gram-positive bacteria in IVDUs. Focusing on daptomycin, vancomycin, teicoplanin, aminoglycosides, and the novel lipoglycopeptide dalbavancin, the study reveals significant pharmacokinetic variations in IVDUs, suggesting the need for personalized dosing. Concomitant opioid substitution therapy and other factors, such as malnutrition, contribute to altered pharmacokinetics/pharmacodynamics, emphasizing the importance of targeted therapeutic drug monitoring. Overall, our study calls for increased awareness among clinicians regarding the unique pharmacokinetic/pharmacodynamic challenges in IVDUs and advocates for tailored antibiotic dosing strategies to enhance treatment outcomes in this marginalized population.
    MeSH term(s) Humans ; Drug Users ; Methicillin-Resistant Staphylococcus aureus ; Substance Abuse, Intravenous/drug therapy ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Vancomycin
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2024-02-08
    Publishing country France
    Document type Review ; Journal Article
    ZDB-ID 196729-0
    ISSN 2107-0180 ; 0398-7639 ; 0378-7966
    ISSN (online) 2107-0180
    ISSN 0398-7639 ; 0378-7966
    DOI 10.1007/s13318-024-00882-8
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: A case of leprosy in a nonendemic country.

    Asperges, Erika / Bagnarino, Jessica / Ancarani, Cinzia / Baggini, Ginevra / Filardo, Matteo / Monzillo, Vincenzina / Barbarini, Daniela / Bruno, Raffaele / Paulli, Marco / Baldanti, Fausto

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2024  Volume 143, Page(s) 107004

    Language English
    Publishing date 2024-03-11
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2024.107004
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
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  8. Article ; Online: A worldwide survey on perioperative antimicrobial prophylaxis for heart transplantation: From theory to clinical practice.

    Seminari, Elena / Ladini, Giulia Sofia / Colaneri, Marta / Chow, Jennifer / Bruno, Raffaele

    Transplant infectious disease : an official journal of the Transplantation Society

    2023  Volume 25, Issue 2, Page(s) e14034

    Abstract: Background: The aim of our survey was to analyze the current attitudes toward antimicrobial prophylaxis in heart transplanting centers worldwide.: Methods: The survey was composed of a total of 50 questions, it consisted of four different sections as ...

    Abstract Background: The aim of our survey was to analyze the current attitudes toward antimicrobial prophylaxis in heart transplanting centers worldwide.
    Methods: The survey was composed of a total of 50 questions, it consisted of four different sections as follows. The first section collected physicians' personal data and centers' general characteristics, second assessed the approach to patients colonized with multidrug-resistant organisms (MDROs), while the third consisted of the infection risk related to cardiovascular devices, and antimicrobial treatment data, the last focused on donor's colonization.
    Results: A total of 56 answers from 26 different countries were collected, mostly from Europe (n = 30) and the USA (n = 16). A first-generation cephalosporin (58.9%) or a combination therapy with vancomycin (10.7%) were the most frequently prescribed antimicrobial prophylaxis. Roughly 30% of the centers used different antimicrobial prophylaxis,mostly including Gram negative bacteria coverage. The frequency of screening for multidrug resistant Gram-negative bacteria was higher in Europe, where the percentage of centers providing screening for extended spectrum beta-lactamase (46.7%) and carbapenem-resistant Enterobacteriaceae (CRE) (53.3%) was higher than in other geographic area (p = .019; p = .013, respectively).
    Conclusion: This survey highlights a heterogeneity of clinical practice concerning antimicrobial prophylaxis at transplant. The concern for potential Gram-negative bacteria infection was responsible for broader antimicrobial coverage in 30% of centers.
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Gram-Negative Bacteria ; Gram-Negative Bacterial Infections/drug therapy ; Anti-Infective Agents/therapeutic use ; Drug Resistance, Multiple, Bacterial ; Heart Transplantation/adverse effects
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2023-03-06
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.14034
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5100: Show issues Location:
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  9. Article ; Online: Le infezioni e la stewardship antibiotica nel paziente cirrotico.

    Zuccaro, Valentina / Bruno, Raffaele

    Recenti progressi in medicina

    2019  Volume 109, Issue 12, Page(s) 600–604

    Abstract: The aim of this review is to focus on the recent knowledge on antibiotic stewardship and empiric antibiotic treatment in cirrhotic patients. The application of antimicrobial stewardship (AS) rules appears to be the most appropriate strategy to globally ... ...

    Title translation Infections and antimicrobial stewardship in cirrhotic patients.
    Abstract The aim of this review is to focus on the recent knowledge on antibiotic stewardship and empiric antibiotic treatment in cirrhotic patients. The application of antimicrobial stewardship (AS) rules appears to be the most appropriate strategy to globally manage cirrhotic patients with infectious complications: indeed they represent a unique way to provide both early diagnosis and appropriate therapy in order to avoid not only antibiotic over-prescription but, more importantly, selection and spread of antimicrobial resistance. Moreover, cirrhotic patients must be considered "frail" and susceptible to healthcare associated infections: applying AS policies would assure a cost reduction and thus contribute to the improvement of public health strategies.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship/methods ; Bacterial Infections/drug therapy ; Bacterial Infections/etiology ; Cross Infection/drug therapy ; Humans ; Liver Cirrhosis/complications
    Chemical Substances Anti-Bacterial Agents
    Language Italian
    Publishing date 2019-01-22
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/3082.30745
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  10. Article ; Online: The 'hit-and-run' strategy and viral carcinogenesis.

    Lasagna, Angioletta / Cassaniti, Irene / Sacchi, Paolo / Figini, Simone / Baldanti, Fausto / Bruno, Raffaele / Pedrazzoli, Paolo

    Future oncology (London, England)

    2023  Volume 19, Issue 5, Page(s) 341–344

    MeSH term(s) Humans ; Carcinogenesis/genetics ; Herpesvirus 4, Human
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2022-1171
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