LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: "My (critically ill) patient has only a pneumonia" - the risk of oversimplification and the evidence of post-ICU syndrome

    Bruno Adler Maccagnan Pinheiro Besen / Marcelo Park

    Revista da Associação Médica Brasileira, Vol 62, Iss 1, Pp 29-

    2016  Volume 31

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2016-02-01T00:00:00Z
    Publisher Associação Médica Brasileira
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Association between obesity and COVID-19 mortality and length of stay in intensive care unit patients in Brazil

    Vitor Barreto Paravidino / Tatiana Henriques Leite / Mauro Felippe Felix Mediano / Rosely Sichieri / Gulnar Azevedo e Silva / Victor Cravo / Alex Balduino / Emmanuel Salgueiro / Bruno Adler Maccagnan Pinheiro Besen / Rodrigo de Carvalho Moreira / Carlos Eduardo Brandão / Danilo Cosme Klein Gomes / Cinthia Almeida Guimarães Assemany / Pedro Cougo

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    a retrospective cohort study

    2022  Volume 9

    Abstract: Abstract The present study aimed to evaluate the association between obesity and COVID-19 mortality and length of stay in ICU patients, and how these associations were modified by age groups. We performed a retrospective multicenter cohort study with ... ...

    Abstract Abstract The present study aimed to evaluate the association between obesity and COVID-19 mortality and length of stay in ICU patients, and how these associations were modified by age groups. We performed a retrospective multicenter cohort study with data obtained from a hospital-based registry. The sample consisted of 8183 ICU hospitalized patients who tested positive for SARS-CoV-2. Cox proportional models were used to evaluate the association between BMI categories and COVID-19 mortality and generalized linear models for the length of stay in the ICU. After adjusting for confounders, those in the younger group with severe obesity had an increased risk of COVID-19 mortality compared to those with normal/overweight (HR 1.27; 95% CI 1.01–1.61). An increased risk of death was also observed for patients with underweight (HR 3.74; 95% CI 1.39–10.07). For patients aged ≥ 60 year, mild/moderate obesity was associated with reduced mortality risk (HR 0.87; 95% CI 0.78–0.97). For the age group < 60 year, the length of stay in ICU for those patients with severe obesity was 35% higher compared to the normal/overweight category (eβ 1.35; 95% CI 1.21–1.51). Conversely, for the survivors in the underweight category, the length of stay in ICU was 51% lower compared to the normal/overweight group (eβ 0.49; 95% CI 0.31–0.78). In the age group ≥ 60 year, mild/moderate obesity was associated with an increased length of stay in the ICU (e β 1.10; 95% CI 1.01–1.21), adjusting for confounders. These findings could be helpful for health professionals to identify subgroups at higher risk for worse outcomes.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Perception of usefulness of laboratory tests ordering by internal medicine residents in ambulatory setting

    Dimitria Doi / Romulo Ribeiro do Vale / Jean Michell Correia Monteiro / Glauco Cabral Marinho Plens / Mario Ferreira Junior / Luiz Augusto Marcondes Fonseca / Sandro Félix Perazzio / Bruno Adler Maccagnan Pinheiro Besen / Arnaldo Lichtenstein / Leandro Utino Taniguchi / Nairo Massakazu Sumita / Aline Pivetta Corá / Adriana Pasmanik Eisencraft / Alberto José da Silva Duarte

    PLoS ONE, Vol 16, Iss 5, p e

    A single-center prospective cohort study.

    2021  Volume 0250769

    Abstract: The demand for high value health care uncovered a steady trend in laboratory tests ordering and inappropriate testing practices. Residents' training in laboratory ordering practice provides an opportunity for quality improvement. We collected information ...

    Abstract The demand for high value health care uncovered a steady trend in laboratory tests ordering and inappropriate testing practices. Residents' training in laboratory ordering practice provides an opportunity for quality improvement. We collected information on demographics, the main reason for the appointment, preexisting medical conditions and presence of co-morbidities from first-visit patients to the internal medicine outpatient service of our university general hospital. We also collected information on all laboratory tests ordered by the attending medical residents. At a follow-up visit, we recorded residents' subjective perception on the usefulness of each ordered laboratory test for the purposes of diagnosis, prognosis, treatment or screening. We observed that 17.3% of all ordered tests had no perceived utility by the attending resident. Tests were usually ordered to exclude differential diagnoses (26.7%) and to help prognosis estimation (19.1%). Age and co-morbidity influenced the chosen category to legitimate usefulness of tests ordering. This study suggests that clinical objectives (diagnosis, prognosis, treatment or prevention) as well as personalization to age and previous health conditions should be considered before test ordering to allow a more appropriate laboratory tests ordering, but further studies are necessary to examine this framework beyond this medical training scenario.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19

    Fabio Augusto Rodrigues Gonçalves / Bruno Adler Maccagnan Pinheiro Besen / Clarice Antunes de Lima / Aline Pivetta Corá / Antônio José Rodrigues Pereira / Sandro Félix Perazzio / Christiane Pereira Gouvea / Luiz Augusto Marcondes Fonseca / Evelinda Marramon Trindade / Nairo Massakazu Sumita / Alberto José da Silva Duarte / Arnaldo Lichtenstein / Eloisa Bonfa / Edivaldo M. Utiyama / Aluisio C. Segurado / Beatriz Perondi / Anna Miethke-Morais / Amanda C. Montal / Leila Harima /
    Solange R. G. Fusco / Marjorie F. Silva / Marcelo C. Rocha / Izabel Marcilio / Izabel Cristina Rios / Fabiane Yumi Ogihara Kawano / Maria Amélia de Jesus / Ésper George Kallas / Carolina Carmo / Clarice Tanaka / Heraldo Possolo de Souza / Julio F. M. Marchini / Carlos Carvalho / Juliana C. Ferreira / Anna Sara Shafferman Levin / Maura Salaroli Oliveira / Thaís Guimarães / Carolina dos Santos Lázari / Ester Sabino / Marcello M. C. Magri / Tarcisio E. P. Barros-Filho / Maria Cristina Peres Braido Francisco / Silvia F. Costa

    Clinics, Vol

    A post-hoc analysis of a prospective cohort study

    2021  Volume 76

    Abstract: OBJECTIVE: Coronavirus disease 2019 (COVID-19) is associated with high mortality among hospitalized patients and incurs high costs. Severe acute respiratory syndrome coronavirus 2 infection can trigger both inflammatory and thrombotic processes, and ... ...

    Abstract OBJECTIVE: Coronavirus disease 2019 (COVID-19) is associated with high mortality among hospitalized patients and incurs high costs. Severe acute respiratory syndrome coronavirus 2 infection can trigger both inflammatory and thrombotic processes, and these complications can lead to a poorer prognosis. This study aimed to evaluate the association and temporal trends of D-dimer and C-reactive protein (CRP) levels with the incidence of venous thromboembolism (VTE), hospital mortality, and costs among inpatients with COVID-19. METHODS: Data were extracted from electronic patient records and laboratory databases. Crude and adjusted associations for age, sex, number of comorbidities, Sequential Organ Failure Assessment score at admission, and D-dimer or CRP logistic regression models were used to evaluate associations. RESULTS: Between March and June 2020, COVID-19 was documented in 3,254 inpatients. The D-dimer level ≥4,000 ng/mL fibrinogen equivalent unit (FEU) mortality odds ratio (OR) was 4.48 (adjusted OR: 1.97). The CRP level ≥220 mg/dL OR for death was 7.73 (adjusted OR: 3.93). The D-dimer level ≥4,000 ng/mL FEU VTE OR was 3.96 (adjusted OR: 3.26). The CRP level ≥220 mg/dL OR for VTE was 2.71 (adjusted OR: 1.92). All these analyses were statistically significant (p<0.001). Stratified hospital costs demonstrated a dose-response pattern. Adjusted D-dimer and CRP levels were associated with higher mortality and doubled hospital costs. In the first week, elevated D-dimer levels predicted VTE occurrence and systemic inflammatory harm, while CRP was a hospital mortality predictor. CONCLUSION: D-dimer and CRP levels were associated with higher hospital mortality and a higher incidence of VTE. D-dimer was more strongly associated with VTE, although its discriminative ability was poor, while CRP was a stronger predictor of hospital mortality. Their use outside the usual indications should not be modified and should be discouraged.
    Keywords COVID-19 ; Biomarkers ; Cohort Studies ; Venous Thromboembolism ; Health Care Costs ; Medicine (General) ; R5-920
    Subject code 310
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Elsevier España
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol

    Juliana C. Ferreira / Yeh-Li Ho / Bruno A.M.P. Besen / Luiz M.S. Malbuisson / Leandro U. Taniguchi / Pedro V. Mendes / Eduardo L.V. Costa / Marcelo Park / Renato Daltro-Oliveira / Roberta M.L. Roepke / João M. Silva Jr / Maria José C. Carmona / Carlos Roberto Ribeiro Carvalho / Adriana Hirota / Alberto Kendy Kanasiro / Alessandra Crescenzi / Amanda Coelho Fernandes / Anna Miethke-Morais / Arthur Petrillo Bellintani /
    Artur Ribeiro Canasiro / Bárbara Vieira Carneiro / Beatriz Keiko Zanbon / Bernardo Pinheiro De Senna Nogueira Batista / Bianca Ruiz Nicolao / Bruno Adler Maccagnan Pinheiro Besen / Bruno Biselli / Bruno Rocha De Macedo / Caio Machado Gomes De Toledo / Carlos Eduardo Pompilio / Carlos Roberto Ribeiro De Carvalho / Caroline Gomes Mol / Cassio Stipanich / Caue Gasparotto Bueno / Cibele Garzillo / Clarice Tanaka / Daniel Neves Forte / Daniel Joelsons / Daniele Robira / Eduardo Leite Vieira Costa / Elson Mendes Da Silva Júnior / Fabiane Aliotti Regalio / Gabriela Cardoso Segura / Gustavo Brasil Marcelino / Giulia Sefrin Louro / Isabela Argollo Ferreira / Jeison de Oliveira Gois / Joao Manoel Da Silva Junior / Jose Otto Reusing Junior / Julia Fray Ribeiro

    Clinics

    Abstract: OBJECTIVES: We designed a cohort study to describe characteristics and outcomes of patients with coronavirus disease (COVID-19) admitted to the intensive care unit (ICU) in the largest public hospital in Sao Paulo, Brazil, as Latin America becomes the ... ...

    Abstract OBJECTIVES: We designed a cohort study to describe characteristics and outcomes of patients with coronavirus disease (COVID-19) admitted to the intensive care unit (ICU) in the largest public hospital in Sao Paulo, Brazil, as Latin America becomes the epicenter of the pandemic. METHODS: This is the protocol for a study being conducted at an academic hospital in Brazil with 300 adult ICU beds dedicated to COVID-19 patients. We will include adult patients admitted to the ICU with suspected or confirmed COVID-19 during the study period. The main outcome is ICU survival at 28 days. Data will be collected prospectively and retrospectively by trained investigators from the hospital’s electronic medical records, using an electronic data capture tool. We will collect data on demographics, comorbidities, severity of disease, and laboratorial test results at admission. Information on the need for advanced life support and ventilator parameters will be collected during ICU stay. Patients will be followed up for 28 days in the ICU and 60 days in the hospital. We will plot Kaplan-Meier curves to estimate ICU and hospital survival and perform survival analysis using the Cox proportional hazards model to identify the main risk factors for mortality. ClinicalTrials.gov: NCT04378582. RESULTS: We expect to include a large sample of patients with COVID-19 admitted to the ICU and to be able to provide data on admission characteristics, use of advanced life support, ICU survival at 28 days, and hospital survival at 60 days. CONCLUSIONS: This study will provide epidemiological data about critically ill patients with COVID-19 in Brazil, which could inform health policy and resource allocation in low- and middle-income countries.
    Keywords Ventilation ; Artificial ; Severe Acute Respiratory Syndrome ; Intensive Care Units ; SARS Virus ; COVID-19 ; Medicine (General) ; R5-920
    Language English
    Publisher Elsevier España
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top