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  1. Article: Pharmacokinetic/Pharmacodynamic Target Attainment of Continuous Infusion Piperacillin-Tazobactam or Meropenem and Microbiological Outcome among Urologic Patients with Documented Gram-Negative Infections.

    Berrino, Pasquale Maria / Gatti, Milo / Rinaldi, Matteo / Brunocilla, Eugenio / Viale, Pierluigi / Pea, Federico

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 9

    Abstract: 1) Objectives: To describe the relationship between pharmacokinetic/pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) piperacillin-tazobactam or meropenem monotherapy and microbiological outcome in a case series of urological ... ...

    Abstract (1) Objectives: To describe the relationship between pharmacokinetic/pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) piperacillin-tazobactam or meropenem monotherapy and microbiological outcome in a case series of urological patients with documented Gram-negative infections. (2) Methods: Patients admitted to the urology ward who were treated with CI piperacillin-tazobactam or meropenem monotherapy for documented Gram-negative infections and underwent real-time therapeutic drug monitoring (TDM)-guided expert clinical pharmacological advice (ECPA) program from June 2021 to May 2023 were retrospectively retrieved. Average steady-state (C
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12091388
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  2. Article ; Online: The new classification of renal cell carcinoma: what is the clinical issue?

    Piazza, Pietro / Bianchi, Lorenzo / Fiorentino, Michelangelo / Gaudiano, Caterina / Giunchi, Francesca / Brunocilla, Eugenio / Schiavina, Riccardo

    Minerva urology and nephrology

    2023  Volume 75, Issue 3, Page(s) 269–271

    MeSH term(s) Humans ; Carcinoma, Renal Cell ; Kidney Neoplasms
    Language English
    Publishing date 2023-03-22
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 3062840-4
    ISSN 2724-6442
    ISSN (online) 2724-6442
    DOI 10.23736/S2724-6051.23.05293-X
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 16: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: En-bloc resection of non-muscle invasive bladder cancer: does it really make a difference?

    Tonin, Elena / Shariat, Shahrokh F / Schiavina, Riccardo / Brunocilla, Eugenio / D'Andrea, David

    Current opinion in urology

    2023  Volume 33, Issue 2, Page(s) 147–151

    Abstract: Purpose of review: Transurethral resection of bladder tumour (TURBT) followed by pathology investigation of the obtained specimens is the initial step in the management of urinary bladder cancer (UBC). By following the basic principles of oncological ... ...

    Abstract Purpose of review: Transurethral resection of bladder tumour (TURBT) followed by pathology investigation of the obtained specimens is the initial step in the management of urinary bladder cancer (UBC). By following the basic principles of oncological surgery, en-bloc resection of bladder tumour (ERBT) aims to overcome the limitations associated with conventional transurethral resection, and to improve the quality of pathological specimens for a better decision making. The current bulk of evidence provides controversial results regarding the superiority of one technique over the other. The aim of this article is to summarize the recent data and provide evidence on this unanswered question.
    Recent findings: Despite heterogeneous and controversial data, ERBT seems to have a better safety profile and deliver higher quality pathologic specimens. However, the recent evidence failed to support the hypothesized oncological potential benefits of ERBT in the initial surgical treatment of patients with UBC.
    Summary: ERBT has gained increasing interest globally in the past decade. It continues to represent a promising strategy with a variety of features intended to solve the inherent limitations of TURBT. However, the current quality of evidence does not allow solid conclusions to be drawn about its presumed superiority compared with the conventional technique.
    MeSH term(s) Humans ; Non-Muscle Invasive Bladder Neoplasms ; Cystectomy/adverse effects ; Cystectomy/methods ; Urologic Surgical Procedures/adverse effects ; Urologic Surgical Procedures/methods ; Urinary Bladder Neoplasms/surgery ; Urinary Bladder Neoplasms/pathology ; Medical Oncology
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1091792-5
    ISSN 1473-6586 ; 0963-0643
    ISSN (online) 1473-6586
    ISSN 0963-0643
    DOI 10.1097/MOU.0000000000001073
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    Zs.A 3345: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: How can mpMRI help surgical planning in high risk prostate cancer?

    Bianchi, Lorenzo / Schiavina, Riccardo / Brunocilla, Eugenio

    Prostate cancer and prostatic diseases

    2019  Volume 23, Issue 2, Page(s) 364–365

    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Male ; Multiparametric Magnetic Resonance Imaging ; Prostatic Neoplasms ; Risk Assessment
    Language English
    Publishing date 2019-11-25
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1419277-9
    ISSN 1476-5608 ; 1365-7852
    ISSN (online) 1476-5608
    ISSN 1365-7852
    DOI 10.1038/s41391-019-0192-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5277: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Response to Johnston re: MRI Displays the Prostatic Cancer Anatomy and Improves the Bundles Management Before Robot-Assisted Radical Prostatectomy by Bianchi et al. (From: Johnston WK, III. J Endourol 2018;32:322-323).

    Bianchi, Lorenzo / Schiavina, Riccardo / Mottrie, Alex / Brunocilla, Eugenio

    Journal of endourology

    2018  Volume 32, Issue 11, Page(s) 1085–1086

    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Male ; Prostatectomy ; Prostatic Neoplasms/surgery ; Robotics
    Language English
    Publishing date 2018-10-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 356931-7
    ISSN 1557-900X ; 0892-7790
    ISSN (online) 1557-900X
    ISSN 0892-7790
    DOI 10.1089/end.2018.0497
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    Zs.A 2628: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 208: Show issues

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  6. Article: Dynamic FDG PET/CT on bladder paraganglioma: A case report.

    Taninokuchi Tomassoni, Makoto / Cattabriga, Arrigo / Gaudiano, Caterina / Ciccarese, Federica / Corcioni, Beniamino / Bianchi, Lorenzo / Schiavina, Riccardo / Brunocilla, Eugenio / Golfieri, Rita

    Frontiers in medicine

    2022  Volume 9, Page(s) 1002663

    Abstract: Paraganglioma (PGL) is characterized by equivocal clinical manifestations and arriving to a suspicion might be challenging. Nevertheless, diagnostic imaging and nuclear medicine are a fundamental part of the diagnosis and management of this particular ... ...

    Abstract Paraganglioma (PGL) is characterized by equivocal clinical manifestations and arriving to a suspicion might be challenging. Nevertheless, diagnostic imaging and nuclear medicine are a fundamental part of the diagnosis and management of this particular neuroendocrine tumor (NET). We herein report a rare case of bladder paraganglioma with unusual onset and typical PET/CT characteristics that led to its recognition.
    Language English
    Publishing date 2022-10-10
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1002663
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  7. Article ; Online: PI-RADS version 2.1 for the evaluation of transition zone lesions: a practical guide for radiologists.

    Gaudiano, Caterina / Rustici, Arianna / Corcioni, Beniamino / Ciccarese, Federica / Bianchi, Lorenzo / Schiavina, Riccardo / Giunchi, Francesca / Fiorentino, Michelangelo / Brunocilla, Eugenio / Golfieri, Rita

    The British journal of radiology

    2022  Volume 95, Issue 1131, Page(s) 20210916

    Abstract: Multiparametric MRI has been established as the most accurate non-invasive diagnostic imaging tool for detecting prostate cancer (PCa) in both the peripheral zone and the transition zone (TZ) using the PI-RADS (Prostate Imaging Reporting and Data System) ...

    Abstract Multiparametric MRI has been established as the most accurate non-invasive diagnostic imaging tool for detecting prostate cancer (PCa) in both the peripheral zone and the transition zone (TZ) using the PI-RADS (Prostate Imaging Reporting and Data System) v. 2.1 released in 2019 as a guideline to reporting. TZ PCa remains the most difficult to diagnose due to a markedly heterogeneous background and a wide variety of atypical imaging presentations as well as other anatomical and pathological processes mimicking PCa. The aim of this paper was to present a spectrum of PCa in the TZ, as a guide for radiologists.
    MeSH term(s) Humans ; Male ; Multiparametric Magnetic Resonance Imaging ; Neoplasm Grading ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Radiology Information Systems ; Reproducibility of Results
    Language English
    Publishing date 2022-02-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2982-8
    ISSN 1748-880X ; 0007-1285
    ISSN (online) 1748-880X
    ISSN 0007-1285
    DOI 10.1259/bjr.20210916
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    Ue I Zs.11: Show issues Location:
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  8. Article ; Online: Robotic partial nephrectomy: a promising treatment option for T1b and complex renal tumors?

    Borghesi, M / Brunocilla, E / Schiavina, R / Martorana, G

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2013  Volume 39, Issue 10, Page(s) 1167

    MeSH term(s) Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Neoplasm Grading ; Nephrectomy/methods ; Postoperative Complications/prevention & control ; Robotics/methods
    Language English
    Publishing date 2013-10
    Publishing country England
    Document type Letter
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2013.07.004
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    Zs.A 1149: Show issues Location:
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    Zs.MO 549: Show issues

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  9. Article: Twenty-year survival after iterative surgery for metastatic renal cell carcinoma: A case report and review of literature.

    De Raffele, Emilio / Mirarchi, Mariateresa / Casadei, Riccardo / Ricci, Claudio / Brunocilla, Eugenio / Minni, Francesco

    World journal of clinical cases

    2020  Volume 8, Issue 19, Page(s) 4450–4465

    Abstract: Background: The therapeutic approach of metastatic renal cell carcinoma (RCC) represents a real challenge for clinicians, because of the variable clinical course; the recent availability of numerous targeted therapies that have significantly improved ... ...

    Abstract Background: The therapeutic approach of metastatic renal cell carcinoma (RCC) represents a real challenge for clinicians, because of the variable clinical course; the recent availability of numerous targeted therapies that have significantly improved overall oncological results, but still with a low percentage of complete responses; and the increasing role of metastasectomy (MSX) as an effective strategy to achieve a durable cure, or at least defer initiation of systemic therapies, in selected patients and in the context of multimodality treatment strategies.
    Case summary: We report here the case of a 40-year-old man who was referred to our unit in November 2004 with lung and mediastinal lymph nodes metastases identified during periodic surveillance 6 years after a radical nephrectomy for RCC; he underwent MSX of multiple lung nodules and mediastinal lymphadenectomy, with subsequent systemic therapy with Fluorouracil, Interferon-alpha and Interleukin 2. The subsequent clinical course was characterized by multiple sequential abdominal and thoracic recurrences, successfully treated with multiple systemic treatments, repeated local treatments, including two pancreatic resections, conservative resection and ablation of multiple bilobar liver metastases, resection and stereotactic body radiotherapy of multiple lung metastases. He is alive without evidence of recurrence 20 years after initial nephrectomy and sequential treatment of recurrences in multiple sites, including resection of more than 38 metastases, and 5 years after his last MSX.
    Conclusion: This case highlights that effective multimodality therapeutic strategies, including multiple systemic treatments and iterative aggressive surgical resection, can be safely performed with long-term survival in selected patients with multiple metachronous sequential metastases from RCC.
    Language English
    Publishing date 2020-09-11
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v8.i19.4450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Transverse prostate maximum sectional area can predict clinically significant prostate cancer in PI-RADS 3 lesions at multiparametric magnetic resonance imaging.

    Gaudiano, Caterina / Braccischi, Lorenzo / Taninokuchi Tomassoni, Makoto / Paccapelo, Alexandro / Bianchi, Lorenzo / Corcioni, Beniamino / Ciccarese, Federica / Schiavina, Riccardo / Droghetti, Matteo / Giunchi, Francesca / Fiorentino, Michelangelo / Brunocilla, Eugenio / Golfieri, Rita

    Frontiers in oncology

    2023  Volume 13, Page(s) 1082564

    Abstract: Background: To evaluate multiparametric magnetic resonance imaging (mpMRI) parameters, such as TransPA (transverse prostate maximum sectional area), TransCGA (transverse central gland sectional area), TransPZA (transverse peripheral zone sectional area), ...

    Abstract Background: To evaluate multiparametric magnetic resonance imaging (mpMRI) parameters, such as TransPA (transverse prostate maximum sectional area), TransCGA (transverse central gland sectional area), TransPZA (transverse peripheral zone sectional area), and TransPAI (TransPZA/TransCGA ratio) in predicting prostate cancer (PCa) in prostate imaging reporting and data system (PI-RADS) 3 lesions.
    Methods: Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), the area under the receiver operating characteristic curve (AUC), and the best cut-off, were calculated. Univariate and multivariate analyses were carried out to evaluate the capability to predict PCa.
    Results: Out of 120 PI-RADS 3 lesions, 54 (45.0%) were PCa with 34 (28.3%) csPCas. Median TransPA, TransCGA, TransPZA and TransPAI were 15.4cm
    Conclusions: In PI-RADS 3 lesions, the TransPA could be useful in selecting patients requiring biopsy.
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1082564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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