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Article ; Online: Results of 'two-in-one' single-stage revision total knee arthroplasty for infection with associated bone loss : prospective five-year follow up.

Brunt, Andrew C C / Gillespie, Matthew / Holland, George / Brenkel, Ivan / Walmsley, Phil

Bone & joint open

2022 Volume 3, Issue 2, Page(s) 107–113

Abstract: Aims: Periprosthetic joint infection (PJI) occurs in approximately 1% to 2% of total knee arthroplasties (TKA) presenting multiple challenges, such as difficulty in diagnosis, technical complexity, and financial costs. Two-stage exchange is the gold ... ...

Abstract	Aims: Periprosthetic joint infection (PJI) occurs in approximately 1% to 2% of total knee arthroplasties (TKA) presenting multiple challenges, such as difficulty in diagnosis, technical complexity, and financial costs. Two-stage exchange is the gold standard for treating PJI but emerging evidence suggests 'two-in-one' single-stage revision as an alternative, delivering comparable outcomes, reduced morbidity, and cost-effectiveness. This study investigates five-year results of modified single-stage revision for treatment of PJI following TKA with bone loss. Methods: Patients were identified from prospective data on all TKA patients with PJI following the primary procedure. Inclusion criteria were: revision for PJI with bone loss requiring reconstruction, and a minimum five years' follow-up. Patients were followed up for recurrent infection and assessment of function. Tools used to assess function were Oxford Knee Score (OKS) and American Knee Society Score (AKSS). Results: A total of 24 patients were included with a mean age of 72.7 years (SD 7.6), mean BMI of 33.3 kg/m Conclusion: 'Two-in-one' single-stage revision is effective for treating PJI following TKA with bone loss, providing patients with sustained improvements in outcomes and infection clearance up to five years post-procedure. Cite this article:
Language	English
Publishing date	2022-02-03
Publishing country	England
Document type	Journal Article
ISSN	2633-1462
ISSN (online)	2633-1462
DOI	10.1302/2633-1462.32.BJO-2021-0148.R1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Genetic Analysis Workshop 16 Problem 3

Kraja Aldi T / Culverhouse Robert / Daw E Warwick / Wu Jun / Van Brunt Andrew / Province Michael A / Borecki Ingrid B

BMC Proceedings , Vol 3, Iss Suppl 7, p S

simulation of heritable longitudinal cardiovascular phenotypes based on actual genome-wide single-nucleotide polymorphisms in the Framingham Heart Study

2009 Volume 4

Abstract: Abstract The Genetic Analysis Workshop (GAW) 16 Problem 3 comprises simulated phenotypes emulating the lipid domain and its contribution to cardiovascular disease risk. For each replication there were 6,476 subjects in families from the Framingham Heart ... ...

Abstract	Abstract The Genetic Analysis Workshop (GAW) 16 Problem 3 comprises simulated phenotypes emulating the lipid domain and its contribution to cardiovascular disease risk. For each replication there were 6,476 subjects in families from the Framingham Heart Study (FHS), with their actual genotypes for Affymetrix 550 k single-nucleotide polymorphisms (SNPs) and simulated phenotypes. Phenotypes are simulated at three visits, 10 years apart. There are up to 6 "major" genes influencing variation in high- and low-density lipoprotein cholesterol (HDL, LDL), and triglycerides (TG), and 1,000 "polygenes" simulated for each trait. Some polygenes have pleiotropic effects. The locus-specific heritabilities of the major genes range from 0.1 to 1.0%, under additive, dominant, or overdominant modes of inheritance. The locus-specific effects of the polygenes ranged from 0.002 to 0.15%, with effect sizes selected from negative exponential distributions. All polygenes act independently and have additive effects. Individuals in the LDL upper tail were designated medicated. Subjects medicated increased across visits at 2%, 5%, and 15%. Coronary artery calcification (CAC) was simulated using age, lipid levels, and CAC-specific polymorphisms. The risk of myocardial infarction before each visit was determined by CAC and its interactions with smoking and two genetic loci. Smoking was simulated to be commensurate with rates reported by the Centers for Disease Control. Two hundred replications were simulated.
Keywords	Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	501
Language	English
Publishing date	2009-12-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Variation for heterodimerization and nuclear localization among known and novel oil palm SHELL alleles.

Singh, Rajinder / Low, Eng-Ti Leslie / Ooi, Leslie Cheng-Li / Ong-Abdullah, Meilina / Ting, Ngoot-Chin / Nookiah, Rajanaidu / Ithnin, Maizura / Marjuni, Marhalil / Mustaffa, Suzana / Yaakub, Zulkifli / Amiruddin, Mohd Din / Manaf, Mohamad Arif Abdul / Chan, Kuang-Lim / Halim, Mohd Amin Ab / Sanusi, Nik Shazana Nik Mohd / Lakey, Nathan / Sachdeva, Mohit / Bacher, Blaire / Garner, Peggy A /

MacDonald, Jill D / Smith, Steven W / Wischmeyer, Corey / Budiman, Muhammad A / Beil, Melissa / Stroff, Clayton / Reed, Jerry / Van Brunt, Andrew / Berg, Howard / Ordway, Jared M / Sambanthamurthi, Ravigadevi

The New phytologist

2020 Volume 226, Issue 2, Page(s) 426–440

Abstract: Oil palm breeding involves crossing dura and pisifera palms to produce tenera progeny with greatly improved oil yield. Oil yield is controlled by variant alleles of a type II MADS-box gene, SHELL, that impact the presence and thickness of the endocarp, ... ...

Abstract	Oil palm breeding involves crossing dura and pisifera palms to produce tenera progeny with greatly improved oil yield. Oil yield is controlled by variant alleles of a type II MADS-box gene, SHELL, that impact the presence and thickness of the endocarp, or shell, surrounding the fruit kernel. We identified six novel SHELL alleles in noncommercial African germplasm populations from the Malaysian Palm Oil Board. These populations provide extensive diversity to harness genetic, mechanistic and phenotypic variation associated with oil yield in a globally critical crop. We investigated phenotypes in heteroallelic combinations, as well as SHELL heterodimerization and subcellular localization by yeast two-hybrid, bimolecular fluorescence complementation and gene expression analyses. Four novel SHELL alleles were associated with fruit form phenotype. Candidate heterodimerization partners were identified, and interactions with EgSEP3 and subcellular localization were SHELL allele-specific. Our findings reveal allele-specific mechanisms by which variant SHELL alleles impact yield, as well as speculative insights into the potential role of SHELL in single-gene oil yield heterosis. Future field trials for combinability and introgression may further optimize yield and improve sustainability.
MeSH term(s)	Alleles ; Arecaceae/genetics ; Palm Oil ; Phenotype ; Plant Breeding
Chemical Substances	Palm Oil (5QUO05548Z)
Language	English
Publishing date	2020-01-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.16387
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Article: Variation for heterodimerization and nuclear localization among known and novel oil palm SHELL alleles

Singh, Rajinder / Low, Eng‐Ti Leslie / Ooi, Leslie Cheng‐Li / Ong‐Abdullah, Meilina / Ting, Ngoot‐Chin / Nookiah, Rajanaidu / Ithnin, Maizura / Marjuni, Marhalil / Mustaffa, Suzana / Yaakub, Zulkifli / Amiruddin, Mohd Din / Manaf, Mohamad Arif Abdul / Chan, Kuang‐Lim / Halim, Mohd Amin Ab / Sanusi, Nik Shazana Nik Mohd / Lakey, Nathan / Sachdeva, Mohit / Bacher, Blaire / Garner, Peggy A /

new phytologist. 2020 Apr., v. 226, no. 2

2020

Abstract: Oil palm breeding involves crossing dura and pisifera palms to produce tenera progeny with greatly improved oil yield. Oil yield is controlled by variant alleles of a type II MADS‐box gene, SHELL, that impact the presence and thickness of the endocarp, ... ...

Abstract	Oil palm breeding involves crossing dura and pisifera palms to produce tenera progeny with greatly improved oil yield. Oil yield is controlled by variant alleles of a type II MADS‐box gene, SHELL, that impact the presence and thickness of the endocarp, or shell, surrounding the fruit kernel. We identified six novel SHELL alleles in noncommercial African germplasm populations from the Malaysian Palm Oil Board. These populations provide extensive diversity to harness genetic, mechanistic and phenotypic variation associated with oil yield in a globally critical crop. We investigated phenotypes in heteroallelic combinations, as well as SHELL heterodimerization and subcellular localization by yeast two‐hybrid, bimolecular fluorescence complementation and gene expression analyses. Four novel SHELL alleles were associated with fruit form phenotype. Candidate heterodimerization partners were identified, and interactions with EgSEP3 and subcellular localization were SHELL allele‐specific. Our findings reveal allele‐specific mechanisms by which variant SHELL alleles impact yield, as well as speculative insights into the potential role of SHELL in single‐gene oil yield heterosis. Future field trials for combinability and introgression may further optimize yield and improve sustainability.
Keywords	Elaeis guineensis ; alleles ; dimerization ; endocarp ; field experimentation ; fluorescence ; gene expression ; germplasm ; heterosis ; introgression ; palm oils ; phenotype ; phenotypic variation ; plant breeding ; progeny ; seeds ; two hybrid system techniques
Language	English
Dates of publication	2020-04
Size	p. 426-440.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.16387
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Genetic Analysis Workshop 16 Problem 3: simulation of heritable longitudinal cardiovascular phenotypes based on actual genome-wide single-nucleotide polymorphisms in the Framingham Heart Study.

Kraja, Aldi T / Culverhouse, Robert / Daw, E Warwick / Wu, Jun / Van Brunt, Andrew / Province, Michael A / Borecki, Ingrid B

BMC proceedings

2009 Volume 3 Suppl 7, Page(s) S4

Abstract: The Genetic Analysis Workshop (GAW) 16 Problem 3 comprises simulated phenotypes emulating the lipid domain and its contribution to cardiovascular disease risk. For each replication there were 6,476 subjects in families from the Framingham Heart Study ( ... ...

Abstract	The Genetic Analysis Workshop (GAW) 16 Problem 3 comprises simulated phenotypes emulating the lipid domain and its contribution to cardiovascular disease risk. For each replication there were 6,476 subjects in families from the Framingham Heart Study (FHS), with their actual genotypes for Affymetrix 550 k single-nucleotide polymorphisms (SNPs) and simulated phenotypes. Phenotypes are simulated at three visits, 10 years apart. There are up to 6 "major" genes influencing variation in high- and low-density lipoprotein cholesterol (HDL, LDL), and triglycerides (TG), and 1,000 "polygenes" simulated for each trait. Some polygenes have pleiotropic effects. The locus-specific heritabilities of the major genes range from 0.1 to 1.0%, under additive, dominant, or overdominant modes of inheritance. The locus-specific effects of the polygenes ranged from 0.002 to 0.15%, with effect sizes selected from negative exponential distributions. All polygenes act independently and have additive effects. Individuals in the LDL upper tail were designated medicated. Subjects medicated increased across visits at 2%, 5%, and 15%. Coronary artery calcification (CAC) was simulated using age, lipid levels, and CAC-specific polymorphisms. The risk of myocardial infarction before each visit was determined by CAC and its interactions with smoking and two genetic loci. Smoking was simulated to be commensurate with rates reported by the Centers for Disease Control. Two hundred replications were simulated.
Language	English
Publishing date	2009-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2411867-9
ISSN	1753-6561 ; 1753-6561
ISSN (online)	1753-6561
ISSN	1753-6561
DOI	10.1186/1753-6561-3-s7-s4
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Article ; Online: A framework for analyzing both linkage and association: an analysis of Genetic Analysis Workshop 16 simulated data.

Daw, E Warwick / Plunkett, Jevon / Feitosa, Mary / Gao, Xiaoyi / Van Brunt, Andrew / Ma, Duanduan / Czajkowski, Jacek / Province, Michael A / Borecki, Ingrid

BMC proceedings

2009 Volume 3 Suppl 7, Page(s) S98

Abstract: We examine a Bayesian Markov-chain Monte Carlo framework for simultaneous segregation and linkage analysis in the simulated single-nucleotide polymorphism data provided for Genetic Analysis Workshop 16. We conducted linkage only, linkage and association, ...

Abstract	We examine a Bayesian Markov-chain Monte Carlo framework for simultaneous segregation and linkage analysis in the simulated single-nucleotide polymorphism data provided for Genetic Analysis Workshop 16. We conducted linkage only, linkage and association, and association only tests under this framework. We also compared these results with variance-component linkage analysis and regression analyses. The results indicate that the method shows some promise, but finding genes that have very small (<0.1%) contributions to trait variance may require additional sources of information. All methods examined fared poorly for the smallest in the simulated "polygene" range (h2 of 0.0015 to 0.0002).
Language	English
Publishing date	2009-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2411867-9
ISSN	1753-6561 ; 1753-6561
ISSN (online)	1753-6561
ISSN	1753-6561
DOI	10.1186/1753-6561-3-s7-s98
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Article ; Online: The characteristics and predictors of mortality in periprosthetic fractures around the knee.

Nasser, Ahmed A H H / Sidhu, Manpreet / Prakash, Rohan / Mahmood, Ansar / Osman, Khabab / Chauhan, Govind S / Nandra, Rajpal / Dewan, Varun / Davidson, Jerome / Al-Azzawi, Mohammed / Smith, Christian / Gawad, Mothana / Palaiologos, Ioannis / Cuthbert, Rory / Wignadasan, Warran / Banks, Daniel / Archer, James / Odeh, Abdulrahman / Moores, Thomas /

Tahir, Muaaz / Brooks, Margaret / Biring, Gurdeep / Jordan, Stevan / Elahi, Zain / Shaath, Mohammed / Veettil, Manoj / De, Chiranjit / Handford, Charles / Bansal, Mohit / Bawa, Akshdeep / Mattar, Ahmed / Tandra, Varun / Daadipour, Audrina / Taha, Ahmed / Gangoo, Shafat / Srinivasan, Sriram / Tarisai, Mandishona / Budair, Basil / Subbaraman, Krishna / Khan, Farrukh / Gomindes, Austin / Samuel, Arjun / Kang, Niel / Kapur, Karan / Mainwaring, Elizabeth / Bridgwater, Hannah / Lo, Andre / Ahmed, Usman / Khaleeq, Tahir / El-Bakoury, Ahmed / Rashed, Ramy / Hosny, Hazem / Yarlagadda, Rathan / Keenan, Jonathan / Hamed, Ahmed / Riemer, Bryan / Qureshi, Arham / Gupta, Vatsal / Waites, Matthew / Bleibleh, Sabri / Westacott, David / Phillips, Jonathan / East, Jamie / Huntley, Daniel / Masud, Saqib / Mirza, Yusuf / Mishra, Sandeep / Dunlop, David / Khalefa, Mohamed / Balakumar, Balasubramanian / Thibbaiah, Mahesh / Payton, Olivia / Berstock, James / Deano, Krisna / Sarraf, Khaled M / Logishetty, Kartik / Lee, George / Subbiah-Ponniah, Hariharan / Shah, Nirav / Venkatesan, Aakaash / Cheseldene-Culley, James / Ayathamattam, Joseph / Tross, Samantha / Randhawa, Sukhwinder / Mohammed, Faisal / Ali, Ramla / Bird, Jonathan / Khan, Kursheed / Akhtar, Muhammad A / Brunt, Andrew / Roupakiotis, Panagiotis / Subramanian, Padmanabhan / Bua, Nelson / Hakimi, Mounir / Bitar, Samer / Al Najjar, Majed / Radhakrishnan, Ajay / Gamble, Charlie / James, Andrew / Gilmore, Catherine / Dawson, Dan / Sofat, Rajesh / Antar, Mohamed / Raghu, Aashish / Heaton, Sam / Tawfeek, Waleed / Charles, Christerlyn / Burnand, Henry / Duffy, Sean / Taylor, Luke / Magill, Laura / Perry, Rita / Pettitt, Michala / Okoth, Kelvin / Pinkney, Thomas

The bone & joint journal

2024 Volume 106-B, Issue 2, Page(s) 158–165

Abstract: Aims: Periprosthetic fractures (PPFs) around the knee are challenging injuries. This study aims to describe the characteristics of knee PPFs and the impact of patient demographics, fracture types, and management modalities on in-hospital mortality.: ... ...

Abstract	Aims: Periprosthetic fractures (PPFs) around the knee are challenging injuries. This study aims to describe the characteristics of knee PPFs and the impact of patient demographics, fracture types, and management modalities on in-hospital mortality. Methods: Using a multicentre study design, independent of registry data, we included adult patients sustaining a PPF around a knee arthroplasty between 1 January 2010 and 31 December 2019. Univariate, then multivariable, logistic regression analyses were performed to study the impact of patient, fracture, and treatment on mortality. Results: Out of a total of 1,667 patients in the PPF study database, 420 patients were included. The in-hospital mortality rate was 6.4%. Multivariable analyses suggested that American Society of Anesthesiologists (ASA) grade, history of peripheral vascular disease (PVD), history of rheumatic disease, fracture around a loose implant, and cerebrovascular accident (CVA) during hospital stay were each independently associated with mortality. Each point increase in ASA grade independently correlated with a four-fold greater mortality risk (odds ratio (OR) 4.1 (95% confidence interval (CI) 1.19 to 14.06); p = 0.026). Patients with PVD have a nine-fold increase in mortality risk (OR 9.1 (95% CI 1.25 to 66.47); p = 0.030) and patients with rheumatic disease have a 6.8-fold increase in mortality risk (OR 6.8 (95% CI 1.32 to 34.68); p = 0.022). Patients with a fracture around a loose implant (Unified Classification System (UCS) B2) have a 20-fold increase in mortality, compared to UCS A1 (OR 20.9 (95% CI 1.61 to 271.38); p = 0.020). Mode of management was not a significant predictor of mortality. Patients managed with revision arthroplasty had a significantly longer length of stay (median 16 days; p = 0.029) and higher rates of return to theatre, compared to patients treated nonoperatively or with fixation. Conclusion: The mortality rate in PPFs around the knee is similar to that for native distal femur and neck of femur fragility fractures. Patients with certain modifiable risk factors should be optimized. A national PPF database and standardized management guidelines are currently required to understand these complex injuries and to improve patient outcomes.
MeSH term(s)	Adult ; Humans ; Periprosthetic Fractures/etiology ; Knee Joint/surgery ; Knee/surgery ; Arthroplasty, Replacement, Knee/adverse effects ; Femoral Fractures/surgery ; Rheumatic Diseases/etiology ; Rheumatic Diseases/surgery ; Retrospective Studies ; Reoperation
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2697156-2
ISSN	2049-4408 ; 2049-4394
ISSN (online)	2049-4408
ISSN	2049-4394
DOI	10.1302/0301-620X.106B2.BJJ-2023-0700.R1
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Article ; Online: A framework for analyzing both linkage and association

Daw E Warwick / Plunkett Jevon / Feitosa Mary / Gao Xiaoyi / Van Brunt Andrew / Ma Duanduan / Czajkowski Jacek / Province Michael A / Borecki Ingrid

BMC Proceedings, Vol 3, Iss Suppl 7, p S

an analysis of Genetic Analysis Workshop 16 simulated data

2009 Volume 98

Abstract: Abstract We examine a Bayesian Markov-chain Monte Carlo framework for simultaneous segregation and linkage analysis in the simulated single-nucleotide polymorphism data provided for Genetic Analysis Workshop 16. We conducted linkage only, linkage and ... ...

Abstract	Abstract We examine a Bayesian Markov-chain Monte Carlo framework for simultaneous segregation and linkage analysis in the simulated single-nucleotide polymorphism data provided for Genetic Analysis Workshop 16. We conducted linkage only, linkage and association, and association only tests under this framework. We also compared these results with variance-component linkage analysis and regression analyses. The results indicate that the method shows some promise, but finding genes that have very small (<0.1%) contributions to trait variance may require additional sources of information. All methods examined fared poorly for the smallest in the simulated "polygene" range ( h 2 of 0.0015 to 0.0002).
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2009-12-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Predictors of mortality in periprosthetic fractures of the hip: Results from the national PPF study.

Nasser, Ahmed Abdul Hadi Harb / Prakash, Rohan / Handford, Charles / Osman, Khabab / Chauhan, Govind Singh / Nandra, Rajpal / Mahmood, Ansar / Dewan, Varun / Davidson, Jerome / Al-Azzawi, Mohammed / Smith, Christian / Gawad, Mothana / Palaiologos, Ioannis / Cuthbert, Rory / Wignadasan, Warran / Banks, Daniel / Archer, James / Odeh, Abdulrahman / Moores, Thomas /

Tahir, Muaaz / Brooks, Margaret / Biring, Gurdeep / Jordan, Stevan / Elahi, Zain / Shaath, Mohammed / Veettil, Manoj / De, Chiranjit / Bansal, Mohit / Bawa, Akshdeep / Mattar, Ahmed / Tandra, Varun / Daadipour, Audrina / Taha, Ahmed / Gangoo, Shafat / Srinivasan, Sriram / Tarisai, Mandishona / Budair, Basil / Subbaraman, Krishna / Khan, Farrukh / Gomindes, Austin / Samuel, Arjun / Kang, Niel / Kapur, Karan / Mainwaring, Elizabeth / Bridgwater, Hannah / Lo, Andre / Ahmed, Usman / Khaleeq, Tahir / El-Bakoury, Ahmed / Rashed, Ramy / Hosny, Hazem / Yarlagadda, Rathan / Keenan, Jonathan / Hamed, Ahmed / Riemer, Bryan / Qureshi, Arham / Gupta, Vatsal / Waites, Matthew / Bleibleh, Sabri / Westacott, David / Phillips, Jonathan / East, Jamie / Huntley, Daniel / Masud, Saqib / Mirza, Yusuf / Mishra, Sandeep / Dunlop, David / Khalefa, Mohamed / Balasubramanian, Balakumar / Thibbaiah, Mahesh / Payton, Olivia / Berstock, James / Deano, Krisna / Sarraf, Khaled / Logishetty, Kartik / Lee, George / Subbiah-Ponniah, Hariharan / Shah, Nirav / Venkatesan, Aakaash / Cheseldene-Culley, James / Ayathamattam, Joseph / Tross, Samantha / Randhawa, Sukhwinder / Mohammed, Faisal / Ali, Ramla / Bird, Jonathan / Khan, Kursheed / Akhtar, Muhammad Adeel / Brunt, Andrew / Roupakiotis, Panagiotis / Subramanian, Padmanabhan / Bua, Nelson / Hakimi, Mounir / Bitar, Samer / Najjar, Majed Al / Radhakrishnan, Ajay / Gamble, Charlie / James, Andrew / Gilmore, Catherine / Dawson, Dan / Sofat, Rajesh / Antar, Mohamed / Raghu, Aashish / Heaton, Sam / Tawfeek, Waleed / Charles, Christerlyn / Burnand, Henry / Duffy, Sean / Taylor, Luke / Magill, Laura / Perry, Rita / Pettitt, Michala / Okoth, Kelvin / Pinkney, Thomas

Injury

2023 Volume 54, Issue 12, Page(s) 111152

Abstract: Introduction: Periprosthetic fractures (PPFs) around the hip joint are increasing in prevalence. In this collaborative study, we aimed to investigate the impact of patient demographics, fracture characteristics, and modes of management on in-hospital ... ...

Abstract	Introduction: Periprosthetic fractures (PPFs) around the hip joint are increasing in prevalence. In this collaborative study, we aimed to investigate the impact of patient demographics, fracture characteristics, and modes of management on in-hospital mortality of PPFs involving the hip. Methods: Using a multi-centre cohort study design, we retrospectively identified adults presenting with a PPF around the hip over a 10-year period. Univariate and multivariable logistic regression analyses were performed to study the independent correlation between patient, fracture, and treatment factors on mortality. Results: A total of 1,109 patients were included. The in-hospital mortality rate was 5.3%. Multivariable analyses suggested that age, male sex, abbreviated mental test score (AMTS), pneumonia, renal failure, history of peripheral vascular disease (PVD) and deep surgical site infection were each independently associated with mortality. Each yearly increase in age independently correlates with a 7% increase in mortality (OR 1.07, p=0.019). The odds of mortality was 2.99 times higher for patients diagnosed with pneumonia during their hospital stay [OR 2.99 (95% CI 1.07-8.37) p=0.037], and 7.25 times higher for patients that developed renal failure during their stay [OR 7.25 (95% CI 1.85-28.47) p=0.005]. Patients with history of PVD have a six-fold greater mortality risk (OR 6.06, p=0.003). Mode of treatment was not a significant predictor of mortality. Conclusion: The in-hospital mortality rate of PPFs around the hip exceeds 5%. The fracture subtype and mode of management are not independent predictors of mortality, while patient factors such as age, AMTS, history of PVD, pneumonia, and renal failure can independently predict mortality. Peri-operative optimisation of modifiable risk factors such as lung and kidney function in patients with PPFs around the hip during their hospital stay is of utmost importance.
MeSH term(s)	Adult ; Humans ; Male ; Periprosthetic Fractures ; Retrospective Studies ; Cohort Studies ; Arthroplasty, Replacement, Hip/adverse effects ; Peripheral Vascular Diseases/surgery ; Pneumonia ; Renal Insufficiency ; Hip Fractures ; Reoperation
Language	English
Publishing date	2023-10-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2023.111152
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Article: Non-tenera Contamination and the Economic Impact of SHELL Genetic Testing in the Malaysian Independent Oil Palm Industry.

Ooi, Leslie C-L / Low, Eng-Ti L / Abdullah, Meilina O / Nookiah, Rajanaidu / Ting, Ngoot C / Nagappan, Jayanthi / Manaf, Mohamad A A / Chan, Kuang-Lim / Halim, Mohd A / Azizi, Norazah / Omar, Wahid / Murad, Abdul J / Lakey, Nathan / Ordway, Jared M / Favello, Anthony / Budiman, Muhammad A / Van Brunt, Andrew / Beil, Melissa / Leininger, Michael T /

Jiang, Nan / Smith, Steven W / Brown, Clyde R / Kuek, Alex C S / Bahrain, Shabani / Hoynes-O'Connor, Allison / Nguyen, Amelia Y / Chaudhari, Hemangi G / Shah, Shivam A / Choo, Yuen-May / Sambanthamurthi, Ravigadevi / Singh, Rajinder

Frontiers in plant science

2016 Volume 7, Page(s) 771

Abstract: Oil palm (Elaeis guineensis) is the most productive oil bearing crop worldwide. It has three fruit forms, namely dura (thick-shelled), pisifera (shell-less) and tenera (thin-shelled), which are controlled by the SHELL gene. The fruit forms exhibit ... ...

Abstract	Oil palm (Elaeis guineensis) is the most productive oil bearing crop worldwide. It has three fruit forms, namely dura (thick-shelled), pisifera (shell-less) and tenera (thin-shelled), which are controlled by the SHELL gene. The fruit forms exhibit monogenic co-dominant inheritance, where tenera is a hybrid obtained by crossing maternal dura and paternal pisifera palms. Commercial palm oil production is based on planting thin-shelled tenera palms, which typically yield 30% more oil than dura palms, while pisifera palms are female-sterile and have little to no palm oil yield. It is clear that tenera hybrids produce more oil than either parent due to single gene heterosis. The unintentional planting of dura or pisifera palms reduces overall yield and impacts land utilization that would otherwise be devoted to more productive tenera palms. Here, we identify three additional novel mutant alleles of the SHELL gene, which encode a type II MADS-box transcription factor, and determine oil yield via control of shell fruit form phenotype in a manner similar to two previously identified mutant SHELL alleles. Assays encompassing all five mutations account for all dura and pisifera palms analyzed. By assaying for these variants in 10,224 mature palms or seedlings, we report the first large scale accurate genotype-based determination of the fruit forms in independent oil palm planting sites and in the nurseries that supply them throughout Malaysia. The measured non-tenera contamination rate (10.9% overall on a weighted average basis) underscores the importance of SHELL genetic testing of seedlings prior to planting in production fields. By eliminating non-tenera contamination, comprehensive SHELL genetic testing can improve sustainability by increasing yield on existing planted lands. In addition, economic modeling demonstrates that SHELL gene testing will confer substantial annual economic gains to the oil palm industry, to Malaysian gross national income and to Malaysian government tax receipts.
Language	English
Publishing date	2016-06-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711035-7
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2016.00771
Database	MEDical Literature Analysis and Retrieval System OnLINE

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