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  1. AU="Brusseau, Valentin"
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  35. AU="Yasuda, Michiyuki"
  36. AU="Theodoratou, Evropi"
  37. AU="Ernfors, Patrik"
  38. AU="Pingel, Simon"
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  40. AU="Tietzmann, Marcel"
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  1. Artikel: Effect of Hyperthyroidism Treatments on Heart Rate Variability: A Systematic Review and Meta-Analysis.

    Brusseau, Valentin / Tauveron, Igor / Bagheri, Reza / Ugbolue, Ukadike Chris / Magnon, Valentin / Bouillon-Minois, Jean-Baptiste / Navel, Valentin / Dutheil, Frederic

    Biomedicines

    2022  Band 10, Heft 8

    Abstract: The reversibility of HRV abnormalities in hyperthyroidism remains contradictory. The design of this study involves conducting a systematic review and meta-analysis on the effect of antithyroid treatments on HRV in hyperthyroidism. PubMed, Cochrane, ... ...

    Abstract The reversibility of HRV abnormalities in hyperthyroidism remains contradictory. The design of this study involves conducting a systematic review and meta-analysis on the effect of antithyroid treatments on HRV in hyperthyroidism. PubMed, Cochrane, Embase, and Google Scholar were searched until 4 April 2022. Multiple reviewers selected articles reporting HRV parameters in treated and untreated hyperthyroidism. Independent data extraction by multiple observers was stratified by degree of hyperthyroidism for each HRV parameter: RR intervals, SDNN (standard deviation of RR intervals), RMSSD (square root of the mean difference of successive RR intervals), pNN50 (percentage of RR intervals with >50 ms of variation), total power (TP), LFnu (low-frequency normalized unit) and HFnu (high-frequency), VLF (very low-frequency), and LF/HF ratio. We included 11 studies for a total of 471 treated hyperthyroid patients, 495 untreated hyperthyroid patients, and 781 healthy controls. After treatment, there was an increase in RR, SDNN, RMSSD, pNN50, TP, HFnu, and VLF and a decrease in LFnu and LF/HF ratio (p < 0.01). Overt hyperthyroidism showed similar results, in contrast to subclinical hyperthyroidism. Compared with controls, some HRV parameter abnormalities persist in treated hyperthyroid patients (p < 0.05) with lower SDNN, LFnu, and higher HFnu, without significant difference in other parameters. We showed a partial reversibility of HRV abnormalities following treatment of overt hyperthyroidism. The improvement in HRV may translate the clinical cardiovascular benefits of treatments in hyperthyroidism and may help to follow the evolution of the cardiovascular morbidity.
    Sprache Englisch
    Erscheinungsdatum 2022-08-16
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10081982
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Does an increase in physiological indexes predict better cognitive performance: the PhyCog randomised cross-over protocol in type 2 diabetes.

    Magnon, Valentin / Dutheil, Frederic / Tauveron, Igor / Mille, Jordan / Baker, Julien S / Brusseau, Valentin / Silvert, Laetitia / Izaute, Marie / Vallet, Guillaume T

    BMJ open

    2022  Band 12, Heft 7, Seite(n) e060057

    Abstract: Introduction: There has been a growing interest towards cognitive-training programmes to improve cognition and prevent cognitive impairment despite discrepant findings. Physical activity has been recognised in maintaining or improving cognitive ability. ...

    Abstract Introduction: There has been a growing interest towards cognitive-training programmes to improve cognition and prevent cognitive impairment despite discrepant findings. Physical activity has been recognised in maintaining or improving cognitive ability. Based on a psychoneurophysiological approach, physiological indexes should partly determine neuronal dynamics and influence cognition as any effects of cognitive training. This study's primary aim was to examine if improved physiological indexes predict improved cognitive variables in the context of a clinical intervention programme for type 2 diabetes (T2D).
    Method and analysis: PhyCog will be a 22-week randomised controlled trial comparing cognitive performance between three arms: (1) physical activity (1 month), a 15-day wash-out, then cognitive training (1 month), (2) cognitive training (1 month), a 15-day wash-out and physical activity (1 month), and (3) an active breathing condition (psychoeducation and resonance frequency breathing for 1 month), then a 15-day wash-out, and combined physical activity and cognitive training (1 month), allowing to determine the most effective intervention to prevent cognitive impairment associated with T2D. All participants will be observed for 3 months following the intervention. The study will include a total of 81 patients with T2D.Cognitive performance and physiological variables will be assessed at baseline (week 0-W0), during the washout (W5, 72-96 hours after week 4), at the end of the intervention (W10), and at the end of the follow-up (W22). The main variables of interest will be executive function, memory and attention. Physiological testing will involve allostatic load such as heart rate variability, microcirculation, cortisol and dehydroepiandrosterone sulfate levels. Sociodemographic and body composition will also be a consideration. Assessors will all be blinded to outcomes. To test the primary hypothesis, the relationship between improvement in physiological variables and improvement in cognitive variables (executive, memory and attention) will be collected.
    Ethics and dissemination: This protocol was approved by the Est III French Ethics Committee (2020-A03228-31). Results will be published in peer-reviewed journals.
    Trial registration number: NCT04915339.
    Mesh-Begriff(e) Cognition ; Cognition Disorders ; Cognitive Dysfunction/prevention & control ; Diabetes Mellitus, Type 2/therapy ; Exercise ; Humans ; Randomized Controlled Trials as Topic
    Sprache Englisch
    Erscheinungsdatum 2022-07-01
    Erscheinungsland England
    Dokumenttyp Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-060057
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Heart rate variability in hypothyroid patients: A systematic review and meta-analysis.

    Brusseau, Valentin / Tauveron, Igor / Bagheri, Reza / Ugbolue, Ukadike Chris / Magnon, Valentin / Navel, Valentin / Bouillon-Minois, Jean-Baptiste / Dutheil, Frederic

    PloS one

    2022  Band 17, Heft 6, Seite(n) e0269277

    Abstract: Introduction: Hypothyroidism may be associated with changes in the autonomic regulation of the cardiovascular system, which may have clinical implications.: Objective: To conduct a systematic review and meta-analysis on the impact of hypothyroidism ... ...

    Abstract Introduction: Hypothyroidism may be associated with changes in the autonomic regulation of the cardiovascular system, which may have clinical implications.
    Objective: To conduct a systematic review and meta-analysis on the impact of hypothyroidism on HRV.
    Materials and methods: PubMed, Cochrane, Embase and Google Scholar were searched until 20 August 2021 for articles reporting HRV parameters in untreated hypothyroidism and healthy controls. Random-effects meta-analysis were stratified by degree of hypothyroidism for each HRV parameters: RR intervals (or normal to normal-NN intervals), SDNN (standard deviation of RR intervals), RMSSD (square root of the mean difference of successive RR intervals), pNN50 (percentage of RR intervals with >50ms variation), total power (TP), LFnu (low-frequency normalized unit), HFnu (high-frequency), VLF (very low frequency), and LF/HF ratio.
    Results: We included 17 studies with 11438 patients: 1163 hypothyroid patients and 10275 healthy controls. There was a decrease in SDNN (effect size = -1.27, 95% CI -1.72 to -0.83), RMSSD (-1.66, -2.32 to -1.00), pNN50 (-1.41, -1.98 to -0.84), TP (-1.55, -2.1 to -1.00), HFnu (-1.21, -1.78 to -0.63) with an increase in LFnu (1.14, 0.63 to 1.66) and LF/HF ratio (1.26, 0.71 to 1.81) (p <0.001). HRV alteration increased with severity of hypothyroidism.
    Conclusions: Hypothyroidism is associated with a decreased HRV, that may be explained by molecular mechanisms involving catecholamines and by the effect of TSH on HRV. The increased sympathetic and decreased parasympathetic activity may have clinical implications.
    Mesh-Begriff(e) Autonomic Nervous System ; Cardiovascular System ; Heart Rate/physiology ; Humans ; Hypothyroidism
    Sprache Englisch
    Erscheinungsdatum 2022-06-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0269277
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Impaired auditory neural performance, another dimension of hearing loss in type-2 diabetes mellitus.

    Giraudet, Fabrice / Mulliez, Aurélien / de Resende, Luciana Macedo / Beaud, Ludivine / Benichou, Thomas / Brusseau, Valentin / Tauveron, Igor / Avan, Paul

    Diabetes & metabolism

    2022  Band 48, Heft 6, Seite(n) 101360

    Abstract: Aim: To evaluate auditory performance in subjects with poorly controlled type-2 diabetes mellitus, using a simple test battery assessing sensitivity to pure tones and neuronal function.: Methods: Enrolled subjects, aged between 23 and 79 years, ... ...

    Abstract Aim: To evaluate auditory performance in subjects with poorly controlled type-2 diabetes mellitus, using a simple test battery assessing sensitivity to pure tones and neuronal function.
    Methods: Enrolled subjects, aged between 23 and 79 years, reported several auditory dysfunctions. They were tested using pure-tone audiometry, otoacoustic emissions for cochlear-function evaluation, and measurement of middle-ear muscle-reflex thresholds in search of an auditory neuropathy.
    Results: Compared to the standard established for an age-matched normative population, the distribution of averaged pure-tone thresholds in enrolled subjects shifted by about one standard deviation with respect to the normal distribution, in line with past reports of mild sensorineural hearing impairment in diabetes, even though many diabetic subjects fell well within the normative interval of audiometric thresholds. Otoacoustic emissions showed that pure-tone thresholds correctly predicted the status of cochlear sensory cells that, by amplifying sound, ensure normal hearing sensitivity. Whereas the observed hearing losses should not have affected the acoustic levels above which the protective middle-ear muscle reflex is triggered by intense sounds, this reflex was undetectable in around 40% enrolled subjects, a marker of auditory neuropathy.
    Conclusion: Auditory-neural function should be evaluated to identify diabetic subjects whose hearing is impaired. Simple automatic tests are available for this purpose, for example middle-ear muscle reflex detection, which turns out to be more sensitive than the standard audiogram.
    Mesh-Begriff(e) Humans ; Young Adult ; Adult ; Middle Aged ; Aged ; Auditory Threshold/physiology ; Audiometry, Pure-Tone/methods ; Hearing Loss/diagnosis ; Diabetes Mellitus, Type 2/complications
    Sprache Englisch
    Erscheinungsdatum 2022-06-01
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 1315751-6
    ISSN 1878-1780 ; 1262-3636 ; 0338-1684
    ISSN (online) 1878-1780
    ISSN 1262-3636 ; 0338-1684
    DOI 10.1016/j.diabet.2022.101360
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Heart Rate Variability in Hyperthyroidism: A Systematic Review and Meta-Analysis.

    Brusseau, Valentin / Tauveron, Igor / Bagheri, Reza / Ugbolue, Ukadike Chris / Magnon, Valentin / Bouillon-Minois, Jean-Baptiste / Navel, Valentin / Dutheil, Frédéric

    International journal of environmental research and public health

    2022  Band 19, Heft 6

    Abstract: Objective: Cardiovascular effects of thyroid hormones may be measured through heart rate variability (HRV). We sought to determine the impact of hyperthyroidism on HRV. Design: A systematic review and meta-analysis on the impact of hyperthyroidism on HRV. ...

    Abstract Objective: Cardiovascular effects of thyroid hormones may be measured through heart rate variability (HRV). We sought to determine the impact of hyperthyroidism on HRV. Design: A systematic review and meta-analysis on the impact of hyperthyroidism on HRV. Methods: PubMed, Cochrane, Embase and Google Scholar were searched until 20 August 2021 for articles reporting HRV parameters in untreated hyperthyroidism and healthy controls. Random-effects meta-analysis was stratified by degree of hyperthyroidism for each HRV parameter: RR intervals (or Normal-to-Normal intervals—NN), SDNN (standard deviation of RR intervals), RMSSD (square root of the mean difference of successive RR intervals), pNN50 (percentage of RR intervals with >50 ms of variation), total power (TP), LFnu (low-frequency normalized unit) and HFnu (high-frequency), VLF (very low-frequency), and LF/HF ratio. Results: We included 22 studies with 10,811 patients: 1002 with hyperthyroidism and 9809 healthy controls. There was a decrease in RR (effect size = −4.63, 95% CI −5.7 to −3.56), SDNN (−6.07, −7.42 to −4.71), RMSSD (−1.52, −2.18 to −0.87), pNN50 (−1.36, −1.83 to −0.88), TP (−2.05, −2.87 to −1.24), HFnu (−3.51, −4.76 to −2.26), and VLF power (−2.65, −3.74 to −1.55), and an increase in LFnu (2.66, 1.55 to 3.78) and LF/HF ratio (1.75, 1.02 to 2.48) (p < 0.01). Most parameters had ES that was twice as high in overt compared to subclinical hyperthyroidism. Increased peripheral thyroid hormones and decreased TSH levels were associated with lower RR intervals. Conclusions: Hyperthyroidism is associated with a decreased HRV, which may be explained by the deleterious effect of thyroid hormones and TSH. The increased sympathetic and decreased parasympathetic activity may have clinical implications.
    Mesh-Begriff(e) Cardiovascular System ; Heart ; Heart Rate/physiology ; Humans ; Hyperthyroidism ; Thyrotropin
    Chemische Substanzen Thyrotropin (9002-71-5)
    Sprache Englisch
    Erscheinungsdatum 2022-03-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19063606
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Cannabis Use in Physicians: A Systematic Review and Meta-Analysis.

    Naillon, Pierre-Louis / Flaudias, Valentin / Brousse, Georges / Laporte, Catherine / Baker, Julien S / Brusseau, Valentin / Comptour, Aurélie / Zak, Marek / Bouillon-Minois, Jean-Baptiste / Dutheil, Frédéric

    Medicines (Basel, Switzerland)

    2023  Band 10, Heft 5

    Abstract: ... ...

    Abstract Background
    Sprache Englisch
    Erscheinungsdatum 2023-04-27
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2777965-8
    ISSN 2305-6320
    ISSN 2305-6320
    DOI 10.3390/medicines10050029
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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