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  1. Article ; Online: Georges Salamon.

    Manelfe, C / Bryan, R N / Strother, C

    AJNR. American journal of neuroradiology

    2015  Volume 37, Issue 1, Page(s) 196–197

    Language English
    Publishing date 2015-11-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A4621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mouse genomic imaging laboratories: an opportunity for radiology to move from the bedside to the bench.

    Bryan, R N

    Academic radiology

    2001  Volume 8, Issue 4, Page(s) 295–298

    MeSH term(s) Animals ; Diagnostic Imaging/instrumentation ; Diagnostic Imaging/veterinary ; Genome ; Mice
    Language English
    Publishing date 2001-04
    Publishing country United States
    Document type Editorial
    ZDB-ID 1355509-1
    ISSN 1076-6332
    ISSN 1076-6332
    DOI 10.1016/S1076-6332(03)80497-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Intensive Blood Pressure Management Preserves Functional Connectivity in Patients with Hypertension from the Systolic Blood Pressure Intervention Randomized Trial.

    Shah, C / Srinivasan, D / Erus, G / Kurella Tamura, M / Habes, M / Detre, J A / Haley, W E / Lerner, A J / Wright, C B / Wright, J T / Oparil, S / Kritchevsky, S B / Punzi, H A / Rastogi, A / Malhotra, R / Still, C H / Williamson, J D / Bryan, R N / Fan, Y /
    Nasrallah, I M

    AJNR. American journal of neuroradiology

    2023  Volume 44, Issue 5, Page(s) 582–588

    Abstract: Background and purpose: The Systolic Blood Pressure Intervention (SPRINT) randomized trial demonstrated that intensive blood pressure management resulted in slower progression of cerebral white matter hyperintensities, compared with standard therapy. We ...

    Abstract Background and purpose: The Systolic Blood Pressure Intervention (SPRINT) randomized trial demonstrated that intensive blood pressure management resulted in slower progression of cerebral white matter hyperintensities, compared with standard therapy. We assessed longitudinal changes in brain functional connectivity to determine whether intensive treatment results in less decline in functional connectivity and how changes in brain functional connectivity relate to changes in brain structure.
    Materials and methods: Five hundred forty-eight participants completed longitudinal brain MR imaging, including resting-state fMRI, during a median follow-up of 3.84 years. Functional brain networks were identified using independent component analysis, and a mean connectivity score was calculated for each network. Longitudinal changes in mean connectivity score were compared between treatment groups using a 2-sample
    Results: Four hundred six participants had longitudinal imaging that passed quality control. The auditory-salience-language network demonstrated a significantly larger decline in the mean connectivity score in the standard treatment group relative to the intensive treatment group (
    Conclusions: Intensive treatment was associated with preservation of functional connectivity of the auditory-salience-language network, while mean network connectivity in other networks was not significantly different between intensive and standard therapy. A longitudinal increase in the white matter hyperintensity burden is associated with a decline in mean connectivity of the default mode network.
    MeSH term(s) Humans ; Blood Pressure ; Brain/diagnostic imaging ; Magnetic Resonance Imaging ; Hypertension/diagnostic imaging ; Hypertension/drug therapy ; Brain Mapping/methods
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A7852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Diffusion-weighted imaging: to treat or not to treat? That is the question.

    Bryan, R N

    AJNR. American journal of neuroradiology

    1998  Volume 19, Issue 2, Page(s) 396–397

    MeSH term(s) Animals ; Brain/drug effects ; Brain/pathology ; Brain Ischemia/diagnosis ; Brain Ischemia/drug therapy ; Diffusion ; Humans ; Intracranial Embolism and Thrombosis/diagnosis ; Intracranial Embolism and Thrombosis/drug therapy ; Magnetic Resonance Imaging/methods ; Sensitivity and Specificity ; Thrombolytic Therapy ; Tissue Plasminogen Activator/adverse effects ; Tissue Plasminogen Activator/therapeutic use ; Treatment Outcome
    Chemical Substances Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 1998-02
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: MR spectroscopy of temporal lobe epilepsy: good news and bad news.

    Bryan, R N

    AJNR. American journal of neuroradiology

    1998  Volume 19, Issue 1, Page(s) 189

    MeSH term(s) Electroencephalography ; Epilepsy, Temporal Lobe/diagnosis ; Fluorodeoxyglucose F18 ; Humans ; Magnetic Resonance Spectroscopy ; Tomography, Emission-Computed ; Tomography, Emission-Computed, Single-Photon
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 1998-01
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
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  6. Article: Diffusion-weighted imaging of stroke: a brief follow-up.

    Bryan, R N

    AJNR. American journal of neuroradiology

    1998  Volume 19, Issue 6, Page(s) 1003–1004

    MeSH term(s) Brain/pathology ; Brain Ischemia/diagnosis ; Cerebral Infarction/diagnosis ; Diffusion ; Echo-Planar Imaging ; Humans ; Image Enhancement
    Language English
    Publishing date 1998-06
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: What's your favorite PET story?

    Bryan, R N

    AJNR. American journal of neuroradiology

    1998  Volume 19, Issue 3, Page(s) 590

    MeSH term(s) Brain Neoplasms/diagnostic imaging ; Diagnosis, Differential ; Fluorodeoxyglucose F18 ; Glioma/diagnostic imaging ; Humans ; Necrosis ; Neoplasm Recurrence, Local/diagnostic imaging ; Radiation Injuries/diagnosis ; Radiopharmaceuticals ; Tomography, Emission-Computed
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 1998-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: White Matter Lesion Penumbra Shows Abnormalities on Structural and Physiologic MRIs in the Coronary Artery Risk Development in Young Adults Cohort.

    Nasrallah, I M / Hsieh, M-K / Erus, G / Battapady, H / Dolui, S / Detre, J A / Launer, L J / Jacobs, D R / Davatzikos, C / Bryan, R N

    AJNR. American journal of neuroradiology

    2019  Volume 40, Issue 8, Page(s) 1291–1298

    Abstract: Background and purpose: White matter lesions are 1 age-related manifestation of cerebrovascular disease, but subthreshold abnormalities have been identified in nonlesional WM. We hypothesized that structural and physiologic MR imaging findings of early ... ...

    Abstract Background and purpose: White matter lesions are 1 age-related manifestation of cerebrovascular disease, but subthreshold abnormalities have been identified in nonlesional WM. We hypothesized that structural and physiologic MR imaging findings of early cerebrovascular disease can be measured in middle-aged subjects in tissue adjacent to WM lesions, termed "penumbra."
    Materials and methods: WM lesions were defined using automated segmentation in 463 subjects, 43-56 years of age, from the Coronary Artery Risk Development in Young Adults (CARDIA) longitudinal observational cohort study. We described 0- to 2-mm and 2- to 4-mm-thick spatially defined penumbral WM tissue ROIs as rings surrounding WM lesions. The remaining WM was defined as distant normal-appearing WM. Mean signal intensities were measured for FLAIR, T1-, and T2-weighted images, and from fractional anisotropy, mean diffusivity, CBF, and vascular reactivity maps. Group comparisons were made using Kruskal-Wallis and pair-wise
    Results: Lesion volumes averaged 0.738 ± 0.842 cm
    Conclusions: Even in relatively healthy 43- to 56-year-old subjects with small white matter lesion burden, structural and functional MR imaging in penumbral tissue reveals significant signal abnormalities versus white matter lesions and other normal WM. Findings suggest that the onset of WM injury starts by middle age and involves substantially more tissue than evident from focal white matter lesions visualized on structural imaging.
    MeSH term(s) Adult ; Brain/diagnostic imaging ; Brain/pathology ; Cerebrovascular Disorders/diagnostic imaging ; Cerebrovascular Disorders/pathology ; Cohort Studies ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Neuroimaging/methods ; White Matter/diagnostic imaging ; White Matter/pathology
    Language English
    Publishing date 2019-07-25
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A6119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Automated Bayesian segmentation of microvascular white-matter lesions in the ACCORD-MIND study.

    Herskovits, E H / Bryan, R N / Yang, F

    Advances in medical sciences

    2008  Volume 53, Issue 2, Page(s) 182–190

    Abstract: Purpose: Automatic brain-lesion segmentation has the potential to greatly expand the analysis of the relationships between brain function and lesion locations in large-scale epidemiologic studies, such as the ACCORD-MIND study. In this manuscript we ... ...

    Abstract Purpose: Automatic brain-lesion segmentation has the potential to greatly expand the analysis of the relationships between brain function and lesion locations in large-scale epidemiologic studies, such as the ACCORD-MIND study. In this manuscript we describe the design and evaluation of a Bayesian lesion-segmentation method, with the expectation that our approach would segment white-matter brain lesions in MR images without user intervention.
    Materials and methods: Each ACCORD-MIND subject has T1-weighted, T2-weighted, spin-density-weighted, and FLAIR sequences. The training portion of our algorithm first registers training images to a standard coordinate space; then, it collects statistics that capture signal-intensity information, and residual spatial variability of normal structures and lesions. The classification portion of our algorithm then uses these statistics to segment lesions in images from new subjects, without the need for user intervention. We evaluated this algorithm using 42 subjects with primarily white-matter lesions from the ACCORD-MIND project.
    Results: Our experiments demonstrated high classification accuracy, using an expert neuroradiologist as a standard.
    Conclusions: A Bayesian lesion-segmentation algorithm that collects multi-channel signal-intensity and spatial information from MR images of the brain shows potential for accurately segmenting brain lesions in images obtained from subjects not used in training.
    MeSH term(s) Adult ; Algorithms ; Bayes Theorem ; Brain/diagnostic imaging ; Brain/pathology ; Brain Diseases/diagnostic imaging ; Brain Diseases/pathology ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Models, Statistical ; Pattern Recognition, Automated ; Prospective Studies ; ROC Curve ; Radiography
    Language English
    Publishing date 2008
    Publishing country Netherlands
    Document type Evaluation Studies ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2273668-2
    ISSN 1896-1126
    ISSN 1896-1126
    DOI 10.2478/v10039-008-0039-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: MR of the temporal bone.

    Bryan, R N

    AJNR. American journal of neuroradiology

    1991  Volume 12, Issue 1, Page(s) 17–18

    MeSH term(s) Ear, Inner/anatomy & histology ; Ear, Inner/diagnostic imaging ; Ear, Inner/pathology ; Humans ; Magnetic Resonance Imaging ; Temporal Bone/anatomy & histology ; Temporal Bone/diagnostic imaging ; Temporal Bone/pathology ; Tomography, X-Ray Computed
    Language English
    Publishing date 1991-01
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Comment
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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