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  1. Article ; Online: Massively parallel sequencing of urinary DNA-the dawn of non-invasive bladder cancer detection and surveillance?

    Ward, Douglas G / Bryan, Richard T

    Translational cancer research

    2022  Volume 8, Issue Suppl 2, Page(s) S204–S207

    Language English
    Publishing date 2022-01-15
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr.2019.03.03
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Association between treatment of superficial bladder cancer and 10-year mortality in older adults with multiple chronic conditions.

    Bryan, Richard T

    Cancer

    2018  Volume 125, Issue 4, Page(s) 652

    MeSH term(s) Aged ; Carcinoma, Transitional Cell ; Humans ; Multiple Chronic Conditions ; Neoplasm Recurrence, Local ; Urinary Bladder Neoplasms
    Language English
    Publishing date 2018-12-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.31888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cell adhesion and urothelial bladder cancer: the role of cadherin switching and related phenomena.

    Bryan, Richard T

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2014  Volume 370, Issue 1661, Page(s) 20140042

    Abstract: Cadherins are mediators of cell-cell adhesion in epithelial tissues. E-cadherin is a known tumour suppressor and plays a central role in suppressing the invasive phenotype of cancer cells. However, the abnormal expression of N- and P-cadherin ('cadherin ... ...

    Abstract Cadherins are mediators of cell-cell adhesion in epithelial tissues. E-cadherin is a known tumour suppressor and plays a central role in suppressing the invasive phenotype of cancer cells. However, the abnormal expression of N- and P-cadherin ('cadherin switching', CS) has been shown to promote a more invasive and m̀alignant phenotype of cancer, with P-cadherin possibly acting as a key mediator of invasion and metastasis in bladder cancer. Cadherins are also implicated in numerous signalling events related to embryonic development, tissue morphogenesis and homeostasis. It is these wide ranging effects and the serious implications of CS that make the cadherin cell adhesion molecules and their related pathways strong candidate targets for the inhibition of cancer progression, including bladder cancer. This review focuses on CS in the context of bladder cancer and in particular the switch to P-cadherin expression, and discusses other related molecules and phenomena, including EpCAM and the development of the cancer stem cell phenotype.
    MeSH term(s) Cadherins/metabolism ; Cell Adhesion/physiology ; Gene Expression Regulation, Neoplastic/physiology ; Humans ; Signal Transduction/physiology ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/pathology ; Urothelium/pathology
    Chemical Substances Cadherins
    Language English
    Publishing date 2014-12-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2014.0042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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  4. Article ; Online: Molecular Subtypes of T1 Bladder Cancer: Biomolecular Characteristics Versus Clinical Utility.

    Ward, Douglas G / Arnold, Roland / Bryan, Richard T

    European urology

    2020  Volume 78, Issue 4, Page(s) 538–539

    MeSH term(s) Carcinoma, Transitional Cell ; Humans ; Prognosis ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/genetics
    Language English
    Publishing date 2020-08-06
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2020.07.021
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    Zs.A 1247: Show issues Location:
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  5. Article: Trends in urine biomarker discovery for urothelial bladder cancer: DNA, RNA, or protein?

    Humayun-Zakaria, Nada / Ward, Douglas G / Arnold, Roland / Bryan, Richard T

    Translational andrology and urology

    2021  Volume 10, Issue 6, Page(s) 2787–2808

    Abstract: Urothelial bladder cancer is a complex disease displaying a landscape of heterogenous molecular subtypes, mutation profiles and clinical presentations. Diagnosis and surveillance rely on flexible cystoscopy which has high accuracy, albeit accompanied by ... ...

    Abstract Urothelial bladder cancer is a complex disease displaying a landscape of heterogenous molecular subtypes, mutation profiles and clinical presentations. Diagnosis and surveillance rely on flexible cystoscopy which has high accuracy, albeit accompanied by a high-cost burden for healthcare providers and discomfort for patients. Advances in "omic" technologies and computational biology have provided insights into the molecular pathogenesis of bladder cancer and provided powerful tools to identify markers for disease detection, risk stratification, and predicting responses to therapy. To date, numerous attempts have been made to discover and validate diagnostic biomarkers that could be deployed as an adjunct to the cystoscopic diagnosis and long-term surveillance of bladder cancer. We report a comprehensive literature analysis using PubMed to assess the changing trends in investigating DNA, RNA, or proteins as diagnostic urinary biomarkers over a period of 5 decades: 1970-2020. A gradual shift has been observed in research away from protein biomarkers to nucleic acids including different classes of RNA, and DNA methylation and mutation markers. Until 2000, publications involving protein biomarker discovery constituted 87% of the total number of research articles with DNA comprising 6% and RNA 7%. Since 2000 the proportion of protein biomarker articles has fallen to 40%, and DNA and RNA studies increased to 32% and 28%, respectively. Clearly research focus, perhaps driven by technological innovation, has shifted from proteins to nucleic acids. We optimistically hypothesise that, following thorough validation, a clinically useful detection test for bladder cancer based on a panel of DNA or RNA markers could become reality within 5-10 years.
    Language English
    Publishing date 2021-07-22
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau-20-1327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Immunotherapy for non-muscle-invasive bladder cancer: from the origins of BCG to novel therapies.

    Unsworth-White, Samantha R / Kitchen, Mark O / Bryan, Richard T

    Future oncology (London, England)

    2021  Volume 18, Issue 1, Page(s) 105–115

    Abstract: Supplies of intravesical Bacillus Calmette-Guérin (BCG), the first-line treatment for most intermediate- and high-risk non-muscle-invasive bladder cancers (NMIBC), have proven unreliable over the past decade. This review considers the evolution of BCG ... ...

    Abstract Supplies of intravesical Bacillus Calmette-Guérin (BCG), the first-line treatment for most intermediate- and high-risk non-muscle-invasive bladder cancers (NMIBC), have proven unreliable over the past decade. This review considers the evolution of BCG immunotherapy for NMIBC: from the discovery of the antitumour side effects of tuberculosis and subsequently the BCG vaccine, to recent advances in novel immunotherapeutic agents. We summarize the evidence for alternative options to standard intravesical BCG therapy regimens and describe the potential for immune response manipulating drugs in the treatment of NMIBC. These new agents, including immune checkpoint inhibitors, toll-like receptor agonists and recombinant viral vectors, may provide better options in the management of NMIBC in the future.
    MeSH term(s) BCG Vaccine/therapeutic use ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Mitomycin/therapeutic use ; Toll-Like Receptors/agonists ; Urinary Bladder Neoplasms/drug therapy
    Chemical Substances BCG Vaccine ; Immune Checkpoint Inhibitors ; Toll-Like Receptors ; Mitomycin (50SG953SK6)
    Language English
    Publishing date 2021-11-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2021-0781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6478: Show issues Location:
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  7. Article: Novel intravesical therapeutics in the treatment of non-muscle invasive bladder cancer: Horizon scanning.

    Ward, Kelly / Kitchen, Mark O / Mathias, Suresh-Jay / Khanim, Farhat L / Bryan, Richard T

    Frontiers in surgery

    2022  Volume 9, Page(s) 912438

    Abstract: Introduction: Non-muscle-invasive bladder cancer (NMIBC) is a common and heterogeneous disease; many patients develop recurrent or progress to muscle-invasive disease. Intravesical drug therapy is a pillar in the current management of NMIBC; ... ...

    Abstract Introduction: Non-muscle-invasive bladder cancer (NMIBC) is a common and heterogeneous disease; many patients develop recurrent or progress to muscle-invasive disease. Intravesical drug therapy is a pillar in the current management of NMIBC; notwithstanding, Mitomycin C (MMC) and Bacillus Calmette-Guérin (BCG) have numerous limitations including international supply issues, and local and systemic toxicity. Here we review novel intravesical therapeutic options and drug delivery devices with potential for clinical use in the treatment of NMIBC.
    Methods: PubMed, ClinicalTrials.gov and Cochrane Library searches were undertaken. Systematic reviews, meta-analyses, randomised controlled trials, single-arm clinical trials and national/international conference proceedings were included.
    Results: Novel intravesical drugs, including chemotherapeutic agents, immune checkpoint inhibitors, monoclonal antibodies and gene therapies, have demonstrated varying efficacy in the treatment of NMIBC. Current evidence for the majority of treatments is mostly limited to single-arm trials in patients with recurrent NMIBC. Various novel methods of drug delivery have also been investigated, with encouraging preliminary results supporting the intravesical delivery of hyperthermic MMC and MMC hydrogel formulations.
    Conclusions: Novel therapeutic agents and drug delivery systems will be important in the future intravesical management of NMIBC. As our understanding of the molecular diversity of NMIBC develops, molecular subtyping will become fundamental in the personalisation of intravesical treatments. Further randomised studies are urgently required to investigate the efficacy of novel intravesical treatments and novel regimens, in comparison to current standards-of-care, particularly in the context of international BCG shortages.
    Language English
    Publishing date 2022-07-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.912438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Liquid biopsies for bladder cancer.

    Ward, Douglas G / Bryan, Richard T

    Translational andrology and urology

    2017  Volume 6, Issue 2, Page(s) 331–335

    Abstract: The development of accurate urinary biomarkers for the non-invasive detection of urothelial bladder cancer (UBC) could transform patient pathways by reducing reliance on cystoscopy, and the identification of highly prognostic (or even predictive) ... ...

    Abstract The development of accurate urinary biomarkers for the non-invasive detection of urothelial bladder cancer (UBC) could transform patient pathways by reducing reliance on cystoscopy, and the identification of highly prognostic (or even predictive) biomarkers could better guide patient management. A number of approaches are being utilised to address these challenges in both urinary- and plasma-borne tumour DNA (tDNA), so-called "liquid biopsies". Next generation sequencing (NGS) and droplet digital PCR (ddPCR) allow detection of very low levels of such tDNA amongst a large excess of non-tumour DNA, the former permitting large mutation panels to be assessed and the latter potentially identifying ultrarare mutant alleles yet restricted for multiplexing. Christensen
    Language English
    Publishing date 2017-05-01
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2851630-8
    ISSN 2223-4691 ; 2223-4691 ; 2223-4683
    ISSN (online) 2223-4691
    ISSN 2223-4691 ; 2223-4683
    DOI 10.21037/tau.2017.03.08
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The sex gap in bladder cancer survival - a missing link in bladder cancer care?

    Toren, Paul / Wilkins, Anna / Patel, Keval / Burley, Amy / Gris, Typhaine / Kockelbergh, Roger / Lodhi, Taha / Choudhury, Ananya / Bryan, Richard T

    Nature reviews. Urology

    2023  Volume 21, Issue 3, Page(s) 181–192

    Abstract: The differences in bladder cancer outcomes between the sexes has again been highlighted. Uncommon among cancers, bladder cancer outcomes are notably worse for women than for men. Furthermore, bladder cancer is three to four times more common among men ... ...

    Abstract The differences in bladder cancer outcomes between the sexes has again been highlighted. Uncommon among cancers, bladder cancer outcomes are notably worse for women than for men. Furthermore, bladder cancer is three to four times more common among men than among women. Factors that might explain these sex differences include understanding the importance of haematuria as a symptom of bladder cancer by both clinicians and patients, the resultant delays in diagnosis and referral of women with haematuria, and health-care access. Notably, these factors seem to have geographical variation and are not consistent across all health-care systems. Likewise, data relating to sex-specific treatment responses for patients with non-muscle-invasive or muscle-invasive bladder cancer are inconsistent. The influence of differences in the microbiome, bladder wall thickness and urine dwell times remain to be elucidated. The interplay of hormone signalling, gene expression, immunology and the tumour microenvironment remains complex but probably underpins the sexual dimorphism in disease incidence and stage and histology at presentation. The contribution of these biological phenomena to sex-specific outcome differences is probable, albeit potentially treatment-specific, and further understanding is required. Notwithstanding these aspects, we identify opportunities to harness biological differences to improve treatment outcomes, as well as areas of fundamental and translational research to pursue. At the level of policy and health-care delivery, improvements can be made across the domains of patient awareness, clinician education, referral pathways and guideline-based care. Together, we aim to highlight opportunities to close the sex gap in bladder cancer outcomes.
    MeSH term(s) Humans ; Female ; Male ; Urinary Bladder/pathology ; Hematuria ; Sex Factors ; Urinary Bladder Neoplasms/pathology ; Treatment Outcome ; Tumor Microenvironment
    Language English
    Publishing date 2023-08-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/s41585-023-00806-2
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  10. Article ; Online: Optimising existing therapeutic strategies for the treatment of non-muscle-invasive bladder cancer: the role of intensive neoadjuvant intravesical mitomycin C.

    Bryan, Richard T

    European urology

    2012  Volume 62, Issue 5, Page(s) 803–805

    MeSH term(s) Antibiotics, Antineoplastic/administration & dosage ; Female ; Humans ; Male ; Mitomycin/administration & dosage ; Neoadjuvant Therapy ; Neoplasm Recurrence, Local ; Urinary Bladder Neoplasms/drug therapy
    Chemical Substances Antibiotics, Antineoplastic ; Mitomycin (50SG953SK6)
    Language English
    Publishing date 2012-11
    Publishing country Switzerland
    Document type Comment ; Editorial
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2012.06.023
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