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Article ; Online: Brushing Up on Cartilage Lubrication: Polyelectrolyte-Enhanced Tribological Rehydration.

Elkington, Robert J / Hall, Richard M / Beadling, Andrew R / Pandit, Hemant / Bryant, Michael G

Langmuir : the ACS journal of surfaces and colloids

2024

Abstract: This study presents new insights into the potential role of polyelectrolyte interfaces in regulating low friction and interstitial fluid pressurization of cartilage. Polymer brushes composed of hydrophilic 3-sulfopropyl methacrylate potassium salt (SPMK) ...

Abstract	This study presents new insights into the potential role of polyelectrolyte interfaces in regulating low friction and interstitial fluid pressurization of cartilage. Polymer brushes composed of hydrophilic 3-sulfopropyl methacrylate potassium salt (SPMK) tethered to a PEEK substrate (SPMK-
Language	English
Publishing date	2024-05-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.4c00598
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Article: Editorial: Advanced pre-clinical and pre-surgical assessment of musculo-skeletal medical devices.

Helgason, Benedikt / Bryant, Michael G / Ferguson, Stephen J / Hall, Richard M

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1264118

Language	English
Publishing date	2023-07-21
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1264118
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Article ; Online: Highly lubricious SPMK-g-PEEK implant surfaces to facilitate rehydration of articular cartilage.

Elkington, Robert J / Hall, Richard M / Beadling, Andrew R / Pandit, Hemant / Bryant, Michael G

Journal of the mechanical behavior of biomedical materials

2023 Volume 147, Page(s) 106084

Abstract: To enable long lasting osteochondral defect repairs which preserve the native function of synovial joint counter-face, it is essential to develop surfaces which are optimised to support healthy cartilage function by providing a hydrated, low friction and ...

Abstract	To enable long lasting osteochondral defect repairs which preserve the native function of synovial joint counter-face, it is essential to develop surfaces which are optimised to support healthy cartilage function by providing a hydrated, low friction and compliant sliding interface. PEEK surfaces were modified using a biocompatible 3-sulfopropyl methacrylate potassium salt (SPMK) through UV photo-polymerisation, resulting in a ∼350 nm thick hydrophilic coating rich in hydrophilic anionic sulfonic acid groups. Characterisation was done through Fourier Transformed Infrared Spectroscopy, Focused Ion Beam Scanning Electron Microscopy, and Water Contact Angle measurements. Using a Bruker UMT TriboLab, bovine cartilage sliding tests were conducted with real-time strain and shear force measurements, comparing untreated PEEK, SPMK functionalised PEEK (SPMK-g-PEEK), and Cobalt Chrome Molybdenum alloy. Tribological tests over 2.5 h at physiological loads (0.75 MPa) revealed that SPMK-g-PEEK maintains low friction (μ< 0.024) and minimises equilibrium strain, significantly reducing forces on the cartilage interface. Post-test analysis showed no notable damage to the cartilage interfacing against the SPMK functionalised surfaces. The application of a constitutive biphasic cartilage model to the experimental strain data reveals that SPMK surfaces increase the interfacial permeability of cartilage in sliding, facilitating fluid and strain recovery. Unlike previous demonstrations of sliding-induced tribological rehydration requiring specific hydrodynamic conditions, the SPMK-g-PEEK introduces a novel mode of tribological rehydration operating at low speeds and in a stationary contact area. SPMK-g-PEEK surfaces provide an enhanced cartilage counter-surface, which provides a highly hydrated and lubricious boundary layer along with supporting biphasic lubrication. Soft polymer surface functionalisation of orthopaedic implant surfaces are a promising approach for minimally invasive synovial joint repair with an enhanced bioinspired polyelectrolyte interface for sliding against cartilage. These hydrophilic surface coatings offer an enabling technology for the next generation of focal cartilage repair and hemiarthroplasty implant surfaces.
Language	English
Publishing date	2023-08-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2023.106084
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Article ; Online: Risk factors for periprosthetic femoral fracture risk around a cemented polished taper-slip stem using an osteoporotic composite bone model.

Jain, Sameer / Lamb, Jonathan N / Drake, Ruth / Entwistle, Ian / Baren, James P / Thompson, Zachary / Beadling, Andrew R / Bryant, Michael G / Shuweihdi, Farag / Pandit, Hemant

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

2024 Volume 238, Issue 3, Page(s) 324–331

Abstract: This biomechanical study aimed to determine if variations in stem material, stem geometry, stem offset and cement viscosity affect mechanical resistance to postoperative periprosthetic fracture (PFF) after hip arthroplasty with a commonly used cemented ... ...

Abstract	This biomechanical study aimed to determine if variations in stem material, stem geometry, stem offset and cement viscosity affect mechanical resistance to postoperative periprosthetic fracture (PFF) after hip arthroplasty with a commonly used cemented polished taper-slip (PTS) stem (CPT, Zimmer Biomet) in a novel osteoporotic composite femoral bone model. Thirty-six osteoporotic composite femoral models were tested using a standardised in-vitro loading technique to simulate a typical PFF. Outcome measures were torque to failure (N), fracture energy (N/m
MeSH term(s)	Humans ; Periprosthetic Fractures/surgery ; Periprosthetic Fractures/complications ; Arthroplasty, Replacement, Hip/adverse effects ; Hip Prosthesis/adverse effects ; Prosthesis Design ; Risk Factors ; Bone Cements ; Femoral Fractures/surgery ; Reoperation/adverse effects
Chemical Substances	Bone Cements
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1065942-0
ISSN	2041-3033 ; 0046-2039 ; 0954-4119
ISSN (online)	2041-3033
ISSN	0046-2039 ; 0954-4119
DOI	10.1177/09544119231225172
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Article ; Online: Multifunctional, Low Friction, Antimicrobial Approach for Biomaterial Surface Enhancement.

Irwin, Nicola J / Bryant, Michael G / McCoy, Colin P / Trotter, Johann L / Turner, Jonathan

ACS applied bio materials

2020 Volume 3, Issue 3, Page(s) 1385–1393

Abstract: Poly(vinyl chloride) (PVC) biomaterials perform a host of life-saving and life-enhancing roles when employed as medical devices within the body. High frictional forces between the device surface and interfacing tissue can, however, lead to a host of ... ...

Abstract	Poly(vinyl chloride) (PVC) biomaterials perform a host of life-saving and life-enhancing roles when employed as medical devices within the body. High frictional forces between the device surface and interfacing tissue can, however, lead to a host of complications including tissue damage, inflammation, pain, and infection. We herein describe a versatile surface modification method using multifunctional hydrogel formulations to increase lubricity and prevent common device-related complications. In a clinically relevant model of the urinary tract, simulating the mechanical and biological environments encountered
Language	English
Publishing date	2020-03-04
Publishing country	United States
Document type	Journal Article
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.9b01042
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Article ; Online: The use of polymeric meshes for pelvic organ prolapse: Current concepts, challenges, and future perspectives.

Mancuso, Elena / Downey, Candice / Doxford-Hook, Elizabeth / Bryant, Michael G / Culmer, Peter

Journal of biomedical materials research. Part B, Applied biomaterials

2019 Volume 108, Issue 3, Page(s) 771–789

Abstract: Pelvic organ prolapse (POP) is one of the most common chronic disorders in women, impacting the quality of life of millions of them worldwide. More than 100 surgical procedures have been developed over the decades to treat POP. However, the failure of ... ...

Abstract	Pelvic organ prolapse (POP) is one of the most common chronic disorders in women, impacting the quality of life of millions of them worldwide. More than 100 surgical procedures have been developed over the decades to treat POP. However, the failure of conservative strategies and the number of patients with recurrence risk have increased the need for further adjuvant treatments. Since their introduction, surgical synthetic meshes have dramatically transformed POP repair showing superior anatomic outcomes in comparison to traditional approaches. Although significant progress has been attained, among the meshes in clinical use, there is no single mesh appropriate for every surgery. Furthermore, due to the risk of complications including acute and chronic infection, mesh shrinkage, and erosion of the tissue, the benefits of the use of meshes have recently been questioned. The aim of this work is to review the evolution of POP surgery, analyzing the current challenges, and detailing the key factors pertinent to the design of new mesh systems. Starting with a description of the pelvic floor anatomy, the article then presents the traditional treatments used in pelvic organ disorders. Next, the development of synthetic meshes is described with an insight into how their function is dependent on both mesh design variables (i.e., material, structure, and functional treatment) and surgical applications. These are then linked to common mesh-related complications, and an indication of current research aiming to address these issues.
MeSH term(s)	Animals ; Biocompatible Materials/chemistry ; Biocompatible Materials/metabolism ; Extracellular Matrix/metabolism ; Humans ; Mechanical Tests ; Pelvic Organ Prolapse/surgery ; Pelvic Organ Prolapse/therapy ; Pelvis ; Polymers/chemistry ; Polymers/metabolism ; Polytetrafluoroethylene/chemistry ; Polytetrafluoroethylene/metabolism ; Prostheses and Implants ; Quality of Life ; Regeneration ; Surface Properties ; Surgical Mesh ; Treatment Outcome
Chemical Substances	Biocompatible Materials ; Polymers ; Polytetrafluoroethylene (9002-84-0)
Language	English
Publishing date	2019-06-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2099992-6
ISSN	1552-4981 ; 1552-4973 ; 0021-9304
ISSN (online)	1552-4981
ISSN	1552-4973 ; 0021-9304
DOI	10.1002/jbm.b.34432
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Article ; Online: In vitro

Rosas, Jonah M / Atkins, Dixon J / Chau, Allison L / Chen, Yen-Tsung / Bae, Rachel / Cavanaugh, Megan K / Lima, Ricardo I Espinosa / Bordeos, Andrew / Bryant, Michael G / Pitenis, Angela A

Proceedings of the Institution of Mechanical Engineers. Part J, Journal of engineering tribology

2022 Volume 237, Issue 5, Page(s) 1264–1271

Abstract: Silicone elastomer medical implants are ubiquitous in medicine, particularly for breast augmentation. However, when these devices are placed within the body, disruption of the natural biological interfaces occurs, which significantly changes the native ... ...

Abstract	Silicone elastomer medical implants are ubiquitous in medicine, particularly for breast augmentation. However, when these devices are placed within the body, disruption of the natural biological interfaces occurs, which significantly changes the native energy-dissipation mechanisms of living systems. These new interfaces can introduce non-physiological contact pressures and tribological conditions that provoke inflammation and soft tissue damage. Despite their significance, the biotribological properties of implant-tissue and implant-extracellular matrix (ECM) interfaces remain poorly understood. Here, we developed an
Language	English
Publishing date	2022-11-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2032767-5
ISSN	2041-305X ; 1350-6501
ISSN (online)	2041-305X
ISSN	1350-6501
DOI	10.1177/13506501221132897
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Article ; Online: Incorporating corrosion measurement in hip wear simulators: An added complication or a necessity?

Neville, Anne / Hesketh, James / Beadling, Andrew R / Bryant, Michael G / Dowson, Duncan

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

2016 Volume 230, Issue 5, Page(s) 406–420

Abstract: Corrosion is not routinely considered in the assessment of the degradation or the lifetime of total hip replacement bearing surfaces. Biomechanical simulations are becoming ever more complex and are taking into account motion cycles that represent ... ...

Abstract	Corrosion is not routinely considered in the assessment of the degradation or the lifetime of total hip replacement bearing surfaces. Biomechanical simulations are becoming ever more complex and are taking into account motion cycles that represent activities beyond a simple walking gait at 1 Hz, marking a departure from the standard ISO BS 14242. However, the degradation is still very often referred to as wear, even though the material loss occurs due to a combination of tribological and corrosion processes and their interactions. This article evaluates how, by incorporating real-time corrosion measurements in total hip replacement simulations, pre-clinical evaluations and research studies can both yield much more information and accelerate the process towards improved implants.
Language	English
Publishing date	2016-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1065942-0
ISSN	2041-3033 ; 0046-2039 ; 0954-4119
ISSN (online)	2041-3033
ISSN	0046-2039 ; 0954-4119
DOI	10.1177/0954411916642484
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Article ; Online: Exploring mouthfeel in model wines: Sensory-to-instrumental approaches.

Laguna, Laura / Sarkar, Anwesha / Bryant, Michael G / Beadling, Andrew R / Bartolomé, Begoña / Victoria Moreno-Arribas, M

Food research international (Ottawa, Ont.)

2017 Volume 102, Page(s) 478–486

Abstract: Wine creates a group of oral-tactile stimulations not related to taste or aroma, such as astringency or fullness; better known as mouthfeel. During wine consumption, mouthfeel is affected by ethanol content, phenolic compounds and their interactions with ...

Abstract	Wine creates a group of oral-tactile stimulations not related to taste or aroma, such as astringency or fullness; better known as mouthfeel. During wine consumption, mouthfeel is affected by ethanol content, phenolic compounds and their interactions with the oral components. Mouthfeel arises through changes in the salivary film when wine is consumed. In order to understand the role of each wine component, eight different model wines with/without ethanol (8%), glycerol (10g/L) and commercial tannins (1g/L) were described using a trained panel. Descriptive analysis techniques were used to train the panel and measure the intensity of the mouthfeel attributes. Alongside, the suitability of different instrumental techniques (rheology, particle size, tribology and microstructure, using Transmission Electron Microscopy (TEM)) to measure wine mouthfeel sensation was investigated. Panelists discriminated samples based on their tactile-related components (ethanol, glycerol and tannins) at the levels found naturally in wine. Higher scores were found for all sensory attributes in the samples containing ethanol. Sensory astringency was associated mainly with the addition of tannins to the wine model and glycerol did not seem to play a discriminating role at the levels found in red wines. Visual viscosity was correlated with instrumental viscosity (R=0.815, p=0.014). Hydrodynamic diameter of saliva showed an increase in presence of tannins (almost 2.5-3-folds). However, presence of ethanol or glycerol decreased hydrodynamic diameter. These results were related with the sensory astringency and earthiness as well as with the formation of nano-complexes as observed by TEM. Rheologically, the most viscous samples were those containing glycerol or tannins. Tribology results showed that at a boundary lubrication regime, differences in traction coefficient lubrication were due by the presence of glycerol. However, no differences in traction coefficients were observed in presence/absence of tannins. It is therefore necessary to use an integrative approach that combines complementary instrumental techniques for mouthfeel perception characterization.
MeSH term(s)	Dynamic Light Scattering ; Ethanol/analysis ; Glycerol/analysis ; Humans ; Hydrogen-Ion Concentration ; Judgment ; Microscopy, Electron, Transmission ; Mouth/innervation ; Particle Size ; Rheology ; Tannins/analysis ; Taste ; Taste Perception ; Touch ; Touch Perception ; Viscosity ; Wine/analysis
Chemical Substances	Tannins ; Ethanol (3K9958V90M) ; Glycerol (PDC6A3C0OX)
Language	English
Publishing date	2017-09-08
Publishing country	Canada
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2017.09.009
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Article ; Online: Evidence for the dissolution of molybdenum during tribocorrosion of CoCrMo hip implants in the presence of serum protein.

Simoes, Thiago A / Bryant, Michael G / Brown, Andy P / Milne, Steven J / Ryan, Mary / Neville, Anne / Brydson, Rik

Acta biomaterialia

2016 Volume 45, Page(s) 410–418

Abstract: We have characterized CoCrMo, Metal-on-Metal (MoM) implant, wear debris particles and their dissolution following cycling in a hip simulator, and have related the results to the tribocorrosion of synthetic wear debris produced by milling CoCrMo powders ... ...

Abstract	We have characterized CoCrMo, Metal-on-Metal (MoM) implant, wear debris particles and their dissolution following cycling in a hip simulator, and have related the results to the tribocorrosion of synthetic wear debris produced by milling CoCrMo powders in solutions representative of environments in the human body. Importantly, we have employed a modified ICP-MS sample preparation procedure to measure the release of ions from CoCrMo alloys during wear simulation in different media; this involved use of nano-porous ultrafilters which allowed complete separation of particles from free ions and complexes in solution. As a result, we present a new perspective on the release of metal ions and formation of metal complexes from CoCrMo implants. The new methodology enables the mass balance of ions relative to complexes and particles during tribocorrosion in hip simulators to be determined. A much higher release of molybdenum ions relative to cobalt and chromium has been measured. The molybdenum dissolution was enhanced by the presence of bovine serum albumin (BSA), possibly due to the formation of metal-protein complexes. Overall, we believe that the results could have significant implications for the analysis and interpretation of metal ion levels in fluids extracted from hip arthroplasty patients; we suggest that metal levels, including molybdenum, be analysed in these fluids using the protocol described here. Statement of significance: We have developed an important new protocol for the analysis of metal ion levels in fluids extracted from hip implant patients and also hip simulators. Using this procedure, we present a new perspective on the release of metal ions from CoCrMo alloy implants, revealing significantly lower levels of metal ion release during tribocorrosion in hip simulators than previously thought, combined with the release of much higher percentages of molybdenum ions relative to cobalt and chromium. This work is of relevance, both from the perspective of the fundamental science and study of metal-protein interactions, enabling understanding of the ongoing problem associated with the biotribocorrosion and the link to inflammation associated with Metal-on-Metal (MoM) hip implants made from CoCrMo alloys.
MeSH term(s)	Alloys/chemistry ; Animals ; Cattle ; Corrosion ; Hip Prosthesis/adverse effects ; Ions ; Molybdenum/chemistry ; Serum Albumin, Bovine/pharmacology ; Spectrophotometry, Atomic ; Spectroscopy, Fourier Transform Infrared ; Time Factors
Chemical Substances	Alloys ; Ions ; Serum Albumin, Bovine (27432CM55Q) ; Molybdenum (81AH48963U)
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2173841-5
ISSN	1878-7568 ; 1742-7061
ISSN (online)	1878-7568
ISSN	1742-7061
DOI	10.1016/j.actbio.2016.08.051
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