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Article ; Online: T-cell responses in asthma exacerbations.

Bryant, Naomi / Muehling, Lyndsey M

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2022 Volume 129, Issue 6, Page(s) 709–718

Abstract: Objective: Asthma is a chronic lung disease comprising multiple endotypes and characterized by periodic exacerbations. A diverse array of T cells has been found to contribute to all endotypes of asthma in pathogenic and regulatory roles. Here, we review ...

Abstract	Objective: Asthma is a chronic lung disease comprising multiple endotypes and characterized by periodic exacerbations. A diverse array of T cells has been found to contribute to all endotypes of asthma in pathogenic and regulatory roles. Here, we review the contributions of CD4+, CD8+, and unconventional T cells in allergic and nonallergic asthma. Data sources: Review of published literature pertaining to conventional and unconventional T-cell types in asthma. Study selections: Recent peer-reviewed articles pertaining to T cells in asthma, with additional peer-reviewed studies for context. Results: Much research in asthma has focused on the roles of CD4+ T Conclusion: Given the diversity and heterogeneity of asthma and T-cell responses, there remain many rich avenues for research to better understand the pathogenesis of asthma. Despite the breadth of T cells in asthma, approved therapeutics remain limited to T
MeSH term(s)	Humans ; Asthma ; Hypersensitivity ; CD8-Positive T-Lymphocytes/pathology ; T-Lymphocytes, Cytotoxic/pathology ; CD4-Positive T-Lymphocytes/pathology ; Th2 Cells
Language	English
Publishing date	2022-07-30
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2022.07.027
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Article ; Online: Nurse Leadership in Home Healthcare.

Bryant, Natasha / Magan, Geralyn

Home healthcare now

2020 Volume 38, Issue 5, Page(s) 287

MeSH term(s)	Delivery of Health Care ; Home Care Services ; Humans ; Leadership ; Nurse Administrators
Language	English
Publishing date	2020-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2814267-6
ISSN	2374-4537 ; 2374-4529
ISSN (online)	2374-4537
ISSN	2374-4529
DOI	10.1097/NHH.0000000000000910
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Article ; Online: Variable lignin structure revealed in

Bryant, Nathan / Engle, Nancy / Tschaplinski, Timothy / Pu, Yunqiao / Ragauskas, Arthur J

RSC advances

2023 Volume 13, Issue 29, Page(s) 20187–20197

Abstract: Lignin has long been a trait of interest, especially in bioenergy feedstocks such ... ...

Abstract	Lignin has long been a trait of interest, especially in bioenergy feedstocks such as
Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra03142j
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Article: Cell wall response of field grown

Bryant, Nathan / Muchero, Wellington / Weber, Rachel A / Barros, Jaime / Chen, Jin-Gui / Tschaplinski, Timothy J / Pu, Yunqiao / Ragauskas, Arthur J

Frontiers in plant science

2023 Volume 14, Page(s) 1089011

Abstract: Due to its ability to spread quickly and result in tree mortality, ...

Abstract	Due to its ability to spread quickly and result in tree mortality,
Language	English
Publishing date	2023-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1089011
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Book ; Online: The Legend of the Grail

Bryant, Nigel

(Arthurian Studies)

2013

Abstract: The Grail legends have been appropriated by novelists as diverse as Umberto Eco and Dan Brown yet very few have read for themselves the original stories from which they came. All the mystery and drama of the Arthurian world are embodied in the ... ...

Series title	Arthurian Studies
Abstract	The Grail legends have been appropriated by novelists as diverse as Umberto Eco and Dan Brown yet very few have read for themselves the original stories from which they came. All the mystery and drama of the Arthurian world are embodied in the extraordinary tales of Perceval, Gawain, Lancelot and Galahad in pursuit of the Holy Grail. The original romances, full of bewildering contradictions and composed by a number of different writers, dazzle with the sheer wealth of their conflicting imagination. In Nigel Bryant's hands, this enthralling material becomes truly accessible. He has constr
Language	English
Size	Online-Ressource (512 p)
Publisher	Boydell & Brewer Group Ltd
Publishing place	New York
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9781843840060 ; 1843840065
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Fallow season CO2 and CH4 fluxes from US mid-south rice-waterfowl habitats

Reba, Michele L / Fong, Bryant N / Rijal, Ishara

Agricultural and forest meteorology. 2019 Aug. 14,

2019

Abstract: Flooding rice fields in the US mid-south during the fallow season (November-March) for migratory waterfowl habitats provides revenue from hunting-related activities and helps with soil retention and water quality. However, flooding has the potential to ... ...

Abstract	Flooding rice fields in the US mid-south during the fallow season (November-March) for migratory waterfowl habitats provides revenue from hunting-related activities and helps with soil retention and water quality. However, flooding has the potential to increase greenhouse gas (GHG) emissions. Research on GHG emissions in US mid-south during the fallow season has been limited. Eddy covariance (EC) systems measuring CO2 and CH4 fluxes were installed during the 2015-2016, 2016-2017, and 2017-2018 fallow seasons at paired production-sized fields in NE Arkansas. Rice residue was burned after harvest at both field locations. The paired fields were separated by an access road and consisted of one field flooded (F) with precipitation by installing barriers to prevent drainage and the other field allowed to drain or non-flooded field (NF). Flooding did not influence CO2 emissions during the fallow season significantly. However, F fields emitted 45±2% more CH4 than NF fields. The three-year fallow season average was 1408±185 kg CO2-C ha-1 season-1 and 12.5±2.0 kg CH4-C ha-1 season-1 in F fields and 1355±132 kg CO2-C ha-1 season-1 and 8.6±1.4 kg CH4-C ha-1 season-1 in NF fields. Methane contributed 5 to 10% global warming potential (GWP), reported as CO2 equivalents from CO2 and CH4 measurements. The three-year fallow season average GWP was not different by treatment. Increases in fallow season GWP were noted to increase after rice cultivation. These findings will improve our overall understanding and modeling of GHG emissions from agricultural fields during an understudied but important period of the year.
Keywords	carbon dioxide ; crop production ; drainage ; eddy covariance ; fallow ; global warming potential ; greenhouse gas emissions ; greenhouse gases ; habitats ; income ; methane ; methane production ; migratory birds ; models ; Oryza sativa ; paddies ; rice ; soil ; water quality ; Arkansas
Language	English
Dates of publication	2019-0814
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	409905-9
ISSN	0168-1923
ISSN	0168-1923
DOI	10.1016/j.agrformet.2019.107709
Database	NAL-Catalogue (AGRICOLA)

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Article: Fallow season CO2 and CH4 fluxes from U.S. mid-south rice-waterfowl habitats

Reba, Michele L / Fong, Bryant N / Rijal, Ishara

Agricultural and forest meteorology. 2019 Aug., v. 75, no. 3

2019

Abstract: Flooding rice fields in the U.S. mid-south during the fallow season (November-March) for migratory bird habitats provides revenue from hunting-related activities and helps with soil retention and water quality. However, flooding has the potential to ... ...

Abstract	Flooding rice fields in the U.S. mid-south during the fallow season (November-March) for migratory bird habitats provides revenue from hunting-related activities and helps with soil retention and water quality. However, flooding has the potential to increase greenhouse gas (GHG) emissions. Research on GHG emissions during this time has been limited. Eddy covariance (EC) systems measuring CO(2)nd CH4 fluxes were installed during the 2015-2016, 2016-2017, and 2017-2018 fallow seasons and during the previous growing seasons at paired fields in NE Arkansas. The paired fields consisted of one field flooded (F) with precipitation by installing barriers to prevent drainage and the other field allowed to drain or non-flooded (NF). Emissions from the fallow season accounted for 32-34% of the growing season CO( 2missions and 20-22% of growing season CH4 emissions, with fallow flooding contributing roughly 2% more than NF fields. Flooding did not influence CO(2)missions significantly. However, considering only the fallow season, F fields emitted 45±2% more CH4 than NF fields. The three-year fallow season average was 1355±132 kg CO(2) ha(-1)eason(-1)nd 8.6±1.4 kg CH4-C ha(-1)eason(-1)n NF fields, and 1408±185 kg CO(-) ha(-1)eason(-1)nd 12.5±2.0 kg CH4-C ha(-1)eason(-1)n F fields. Methane contributed on average 7±1% to total fallow season global warming potential (GWP), reported as CO( 2)uivalents from CO(2) and H4 measurements. The three-year fallow season average GWP was not different by treatment. Increases in fallow season GWP were noted to increase after rice cultivation. These findings will improve our overall understanding and modeling of GHG emissions from agricultural fields during an understudied but important period of the year.
Keywords	drainage ; eddy covariance ; forests ; greenhouse gases ; income ; meteorology ; methane ; migratory birds ; rice ; soil ; water quality ; Arkansas
Language	English
Dates of publication	2019-08
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	409905-9
ISSN	0168-1923
ISSN	0168-1923
DOI	10.2489/jswc.75.3.291
Database	NAL-Catalogue (AGRICOLA)

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Article: Facing the threat of equine influenza.

Elton, D / Bryant, N

Equine veterinary journal

2011 Volume 43, Issue 3, Page(s) 250–258

Abstract: Despite the availability of vaccines, equine influenza virus (EIV) continues to pose a threat to the racing industry. The virus spreads rapidly in unprotected populations and large scale outbreaks, such as those in South Africa in 2003 and Australia in ... ...

Abstract	Despite the availability of vaccines, equine influenza virus (EIV) continues to pose a threat to the racing industry. The virus spreads rapidly in unprotected populations and large scale outbreaks, such as those in South Africa in 2003 and Australia in 2007, can cost billions of pounds. Like other influenza viruses, EIV undergoes antigenic variation, enabling it to evade antibodies generated against previous infection or vaccination. The UK has an active surveillance programme to monitor antigenic drift and participates in an international collaboration with other countries in Europe, Japan and the USA to select suitable vaccine strains. Selection is primarily based upon characterisation of the viral haemagglutinin (HA), the surface protein that induces a protective antibody response; this protein is an important component of commercial vaccines. In recent years vaccine technology has improved and diagnostic methods have become increasingly sensitive, both play a crucial part in facilitating the international movement of horses. Mathematical modelling techniques have been applied to study the risk factors involved in outbreaks and provide valuable information about the impact of vaccination. Other factors, such as pathogenicity, are poorly understood for EIV yet may play an important role in the spread of a particular virus. They may also affect the ability of the virus to cross the species barrier, as seen with the transfer to dogs in the USA. Severity of infection is likely to be influenced by more than one gene, but differences in the NS1 protein are believed to influence the cytokine response in the horse and have been manipulated to produce potential vaccine strains.
MeSH term(s)	Animals ; Horse Diseases/epidemiology ; Horse Diseases/prevention & control ; Horse Diseases/virology ; Horses ; Influenza A virus/classification ; Influenza A virus/immunology ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/immunology ; Orthomyxoviridae Infections/epidemiology ; Orthomyxoviridae Infections/prevention & control ; Orthomyxoviridae Infections/veterinary
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2011-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	41606-x
ISSN	0425-1644
ISSN	0425-1644
DOI	10.1111/j.2042-3306.2010.00357.x
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Article ; Online: Identification of LRRK2 missense variants in the accelerating medicines partnership Parkinson's disease cohort.

Bryant, Nicole / Malpeli, Nicole / Ziaee, Julia / Blauwendraat, Cornelis / Liu, Zhiyong / West, Andrew B

Human molecular genetics

2021 Volume 30, Issue 6, Page(s) 454–466

Abstract: Pathogenic missense variants in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified through linkage analysis in familial Parkinson disease (PD). Subsequently, other missense variants with lower effect sizes on PD risk have emerged, as well ...

Abstract	Pathogenic missense variants in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified through linkage analysis in familial Parkinson disease (PD). Subsequently, other missense variants with lower effect sizes on PD risk have emerged, as well as non-coding polymorphisms (e.g. rs76904798) enriched in PD cases in genome-wide association studies. Here we leverage recent whole-genome sequences from the Accelerating Medicines Partnership-Parkinson's Disease (AMP-PD) and the Genome Aggregation (gnomAD) databases to characterize novel missense variants in LRRK2 and explore their relationships with known pathogenic and PD-linked missense variants. Using a computational prediction tool that successfully classifies known pathogenic LRRK2 missense variants, we describe an online web-based resource that catalogs characteristics of over 1200 LRRK2 missense variants of unknown significance. Novel high-pathogenicity scoring variants, some identified exclusively in PD cases, tightly cluster within the ROC-COR-Kinase domains. Structure-function predictions support that some of these variants exert gain-of-function effects with respect to LRRK2 kinase activity. In AMP-PD participants, all p.R1441G carriers (N = 89) are also carriers of the more common PD-linked variant p.M1646T. In addition, nearly all carriers of the PD-linked p.N2081D missense variant are also carriers of the LRRK2 PD-risk variant rs76904798. These results provide a compendium of LRRK2 missense variants and how they associate with one another. While the pathogenic p.G2019S variant is by far the most frequent high-pathogenicity scoring variant, our results suggest that ultra-rare missense variants may have an important cumulative impact in increasing the number of individuals with LRRK2-linked PD.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Cohort Studies ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Male ; Middle Aged ; Mutation, Missense ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Young Adult
Chemical Substances	LRRK2 protein, human (EC 2.7.11.1) ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 (EC 2.7.11.1)
Language	English
Publishing date	2021-02-24
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/ddab058
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Book ; Online: A Perceforest Reader

Bryant, Nigel

Selected Episodes from Perceforest: The Prehistory of Arthur's Britain

2012

Abstract: Perceforest is one of the largest and certainly the most extraordinary of the late Arthurian romances, and is almost completely unknown except to a handful of scholars. But it is a work of exceptional richness and importance, and has been justly ... ...

Abstract	Perceforest is one of the largest and certainly the most extraordinary of the late Arthurian romances, and is almost completely unknown except to a handful of scholars. But it is a work of exceptional richness and importance, and has been justly described
Language	English
Size	Online-Ressource (130 p.)
Publisher	Boydell & Brewer
Publishing place	Woodbridge
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9781843842903 ; 1843842904
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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