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  1. Article ; Online: Editorial: Non-canonical NF-κB signaling in immune-mediated inflammatory diseases and malignancies.

    Tas, Sander W / Bryant, Vanessa L / Cook, Matthew C

    Frontiers in immunology

    2023  Volume 14, Page(s) 1252939

    MeSH term(s) Humans ; NF-kappa B/metabolism ; Signal Transduction ; Neoplasms
    Chemical Substances NF-kappa B
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1252939
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  2. Article: B cells in lung cancer-not just a bystander cell: a literature review.

    Leong, Tracy L / Bryant, Vanessa L

    Translational lung cancer research

    2021  Volume 10, Issue 6, Page(s) 2830–2841

    Abstract: Metastatic lung cancer represents a significant global issue where it is responsible for the most cancer diagnoses and deaths worldwide. Treatment for advanced lung cancer has undergone a series of paradigm shifts from chemotherapy to targeted molecular ... ...

    Abstract Metastatic lung cancer represents a significant global issue where it is responsible for the most cancer diagnoses and deaths worldwide. Treatment for advanced lung cancer has undergone a series of paradigm shifts from chemotherapy to targeted molecular agents to the most recent immunotherapy strategies. The most successful of the latter involves antibodies that block inhibitory receptors on tumor infiltrating T cells, thereby enhancing T cell activity against tumor cells. However, only a subset of patients demonstrate durable responses to these drugs and treatment resistance is common. Emerging evidence suggests that a critical role exists for B cells as more than a bystander immune cell in the tumor microenvironment (TME). However, this role is likely context-specific where B cells comprise distinct subtypes with unique effector functions that may result in anti- or pro-tumor effects. As such, the balance between various B cell subtypes affects the net B cell impact upon tumor immunity. To date, the factors needed to polarize B cell function toward anti-tumor activity are unclear. Understanding B cell biology in the lung cancer setting will help redefine and refine treatment strategies to augment anti-tumor immunity. This article presents a review of the literature describing the current knowledge of the development and function of B cells, and explores their role in lung cancer and potential as an immunotherapeutic strategy and as a predictive marker for response to immune checkpoint blockade.
    Language English
    Publishing date 2021-07-22
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-20-788
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  3. Article ; Online: Inborn errors of human B cell development, differentiation, and function.

    Tangye, Stuart G / Nguyen, Tina / Deenick, Elissa K / Bryant, Vanessa L / Ma, Cindy S

    The Journal of experimental medicine

    2023  Volume 220, Issue 7

    Abstract: B cells develop from hematopoietic stem cells in the bone marrow. Once generated, they serve multiple roles in immune regulation and host defense. However, their most important function is producing antibodies (Ab) that efficiently clear invading ... ...

    Abstract B cells develop from hematopoietic stem cells in the bone marrow. Once generated, they serve multiple roles in immune regulation and host defense. However, their most important function is producing antibodies (Ab) that efficiently clear invading pathogens. This is achieved by generating memory B cells that rapidly respond to subsequent Ag exposure, and plasma cells (PCs) that continually secrete Ab. These B cell subsets maintain humoral immunity and host protection against recurrent infections for extended periods of time. Thus, the generation of antigen (Ag)-specific memory cells and PCs underlies long-lived serological immunity, contributing to the success of most vaccines. Our understanding of immunity is often derived from animal models. However, analysis of individuals with monogenic defects that disrupt immune cell function are unprecedented models to link genotypes to clinical phenotypes, establish mechanisms of disease pathogenesis, and elucidate critical pathways for immune cell development and differentiation. Here, we review fundamental breakthroughs in unraveling the complexities of humoral immunity in humans that have come from the discovery of inborn errors disrupting B cell function.
    MeSH term(s) Animals ; Humans ; B-Lymphocytes ; Plasma Cells ; Cell Differentiation ; Immunity, Humoral ; B-Lymphocyte Subsets ; Antibodies/metabolism
    Chemical Substances Antibodies
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20221105
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  4. Article ; Online: Life, death, and antibodies.

    Bryant, Vanessa L / Hodgkin, Philip D

    Science (New York, N.Y.)

    2017  Volume 358, Issue 6360, Page(s) 171–172

    MeSH term(s) Antibodies/immunology ; Apoptosis ; B-Lymphocytes ; Germinal Center/physiology ; Humans
    Chemical Substances Antibodies
    Language English
    Publishing date 2017--13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aap8728
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  5. Article: Impaired IgM Memory B Cell Function Is Common in Coeliac Disease but Conjugate Pneumococcal Vaccination Induces Robust Protective Immunity.

    Moscatelli, Olivia G / Russell, Amy K / Henneken, Lee M / Hardy, Melinda Y / Mazarakis, Nadia / Higgins, Rachel / Ekin, Jesse / McLeod, Harry / Simkin, Paul / Licciardi, Paul V / Bryant, Vanessa L / Tye-Din, Jason A

    Vaccines

    2024  Volume 12, Issue 2

    Abstract: Coeliac disease (CD) is associated with hyposplenism, an acquired impairment of spleen function associated with reduced IgM memory B cells and increased susceptibility to serious pneumococcal infection. Little is known about the immune implications of ... ...

    Abstract Coeliac disease (CD) is associated with hyposplenism, an acquired impairment of spleen function associated with reduced IgM memory B cells and increased susceptibility to serious pneumococcal infection. Little is known about the immune implications of hyposplenism in CD or the optimal pneumococcal vaccination strategy. In this study, the immune effects of hyposplenism in CD, and the accuracy of screening approaches and protective responses induced by two different pneumococcal vaccines were examined. Active and treated CD cohorts, and healthy and surgically splenectomised controls underwent testing for the presence of Howell-Jolly bodies and pitted red cells, spleen ultrasound, and immune assessment of IgM memory B cell frequency and IgM memory B cell responses to T cell-dependent (TD) or T cell-independent (TI) stimulation. Responses following conjugate (TD) and polysaccharide (TI) pneumococcal vaccination were compared using ELISA and opsonophagocytic assays. Although hyposplenism is rare in treated CD (5.1%), functional B cell defects are common (28-61%) and are not detected by current clinical tests. Conjugate pneumococcal vaccination induced superior and sustained protection against clinically relevant serotypes. Clinical practice guidelines in CD should recommend routine pneumococcal vaccination, ideally with a conjugate vaccine, of all patients in lieu of hyposplenism screening.
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12020214
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  6. Article ; Online: A single-center experience of COVID-19 infection in patients with primary immunodeficiency.

    Zhou, Jessie J / Jin, Celina / Leang, Zhi Xiang / Chatelier, Josh / Godsell, Jack / Tsang, Sylvia / Douglass, Jo A / Yong, Michelle K / Slavin, Monica / Bryant, Vanessa L / Slade, Charlotte A / Chan, Samantha

    The journal of allergy and clinical immunology. Global

    2024  Volume 3, Issue 2, Page(s) 100241

    Abstract: Background: Reported outcomes in patients with primary immunodeficiency (PID) infected by coronavirus disease 2019 (COVID-19) have been variable owing to a combination of viral strain heterogeneity, differences in patient populations and health systems, ...

    Abstract Background: Reported outcomes in patients with primary immunodeficiency (PID) infected by coronavirus disease 2019 (COVID-19) have been variable owing to a combination of viral strain heterogeneity, differences in patient populations and health systems, and local availability of vaccination and specific COVID-19 therapies. There are few reports on the experience of Australian patients with PID during the pandemic.
    Objectives: In this retrospective study, we describe the baseline characteristics and short-term outcomes of patients with PID who were infected by COVID-19 and known to the Royal Melbourne Hospital, a major tertiary center in Victoria, Australia.
    Methods: Between April 2021 and April 2022, a total of 31 of 138 patients with PID were affected by COVID-19. More than half of them had 3 vaccine doses at the time of infection (which at the time was considered being fully vaccinated) and received COVID-19-targeted treatment.
    Results: All of the infected patients had ambulatory disease, with no cases of morbidity or mortality. In line with the current literature, the PID subtypes described did not appear to independently predict worse outcomes.
    Conclusions: Some protective factors include this cohort's relatively younger average age and its high uptake of vaccination and COVID-19 therapies.
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ISSN 2772-8293
    ISSN (online) 2772-8293
    DOI 10.1016/j.jacig.2024.100241
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  7. Article: When B cells break bad: development of pathogenic B cells in Sjögren's syndrome.

    Reed, Joanne H / Verstappen, Gwenny Matthea / Rischmueller, Maureen / Bryant, Vanessa L

    Clinical and experimental rheumatology

    2020  Volume 38 Suppl 126, Issue 4, Page(s) 271–282

    Abstract: Primary Sjögren's syndrome (pSS) is often considered a B cell-mediated disease, yet the precise role of B cells in the pathogenesis is not fully understood. This is exemplified by the failure of multiple clinical trials directed at B cell depletion or ... ...

    Abstract Primary Sjögren's syndrome (pSS) is often considered a B cell-mediated disease, yet the precise role of B cells in the pathogenesis is not fully understood. This is exemplified by the failure of multiple clinical trials directed at B cell depletion or inhibition. To date, most prognostic markers for severe disease outcomes are autoantibodies, but the underlying mechanisms by which B cells drive diverse disease presentations in pSS likely extend beyond autoantibody production. Here we outline an expanded role of B cells in disease pathogenesis drawing on examples from animal models of SS, and from other autoimmune diseases that share similar clinical or immunological abnormalities. We focus on recent findings from the detailed analysis of pathogenic B cells in patients with pSS to propose strategies for patient stratification to improve clinical trial outcomes. We conclude that an integrated cellular, molecular and genetic analysis of patients with pSS will reveal the underlying pathogenic mechanisms and guide precision medicine.
    MeSH term(s) Animals ; Autoantibodies ; Autoimmune Diseases ; B-Lymphocytes ; Humans ; Sjogren's Syndrome/diagnosis
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2020-09-22
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
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  8. Article ; Online: The Expanding Spectrum of NFkB1 Deficiency.

    Bryant, Vanessa L / Tangye, Stuart G

    Journal of clinical immunology

    2016  Volume 36, Issue 6, Page(s) 531–532

    MeSH term(s) Haploinsufficiency ; Herpesvirus 4, Human ; Humans ; Immunologic Deficiency Syndromes ; NF-kappa B p50 Subunit/genetics ; Polymorphism, Genetic
    Chemical Substances NF-kappa B p50 Subunit ; NFKB1 protein, human
    Language English
    Publishing date 2016-06-23
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-016-0310-5
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  9. Article ; Online: Chemokines, their receptors and human disease: the good, the bad and the itchy.

    Bryant, Vanessa L / Slade, Charlotte A

    Immunology and cell biology

    2015  Volume 93, Issue 4, Page(s) 364–371

    Abstract: Chemokines are a highly specialized group of cytokines that coordinate trafficking and homing of leucocytes between bone marrow, lymphoid organs and sites of infection or inflammation. They are also responsible for structural organization within lymphoid ...

    Abstract Chemokines are a highly specialized group of cytokines that coordinate trafficking and homing of leucocytes between bone marrow, lymphoid organs and sites of infection or inflammation. They are also responsible for structural organization within lymphoid organs. Aberrant expression or function of these molecules, or their receptors, has been linked to protection or susceptibility to specific infectious diseases, as well as the risk of autoimmune disease and malignancy, revealing critical roles of chemokines and their receptors in human health, disease and therapeutics. In this review, we focus on human diseases that provide lessons regarding the critical role of these specialized and complex cytokines.
    MeSH term(s) Animals ; Cell Movement/genetics ; Chemokines/genetics ; Chemokines/immunology ; Genetic Predisposition to Disease ; Humans ; Immunity, Innate/genetics ; Infection/immunology ; Inflammation/immunology ; Mutation/genetics ; Pruritus/immunology ; Receptors, Chemokine/genetics ; Receptors, Chemokine/metabolism ; T-Lymphocytes/physiology
    Chemical Substances Chemokines ; Receptors, Chemokine
    Language English
    Publishing date 2015-04-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1038/icb.2015.23
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  10. Article ; Online: The Rapidly Expanding Genetic Spectrum of Common Variable Immunodeficiency-Like Disorders.

    Ameratunga, Rohan / Edwards, Emily S J / Lehnert, Klaus / Leung, Euphemia / Woon, See-Tarn / Lea, Edward / Allan, Caroline / Chan, Lydia / Steele, Richard / Longhurst, Hilary / Bryant, Vanessa L

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 6, Page(s) 1646–1664

    Abstract: The understanding of common variable immunodeficiency disorders (CVID) is in evolution. CVID was previously a diagnosis of exclusion. New diagnostic criteria have allowed the disorder to be identified with greater precision. With the advent of next- ... ...

    Abstract The understanding of common variable immunodeficiency disorders (CVID) is in evolution. CVID was previously a diagnosis of exclusion. New diagnostic criteria have allowed the disorder to be identified with greater precision. With the advent of next-generation sequencing (NGS), it has become apparent that an increasing number of patients with a CVID phenotype have a causative genetic variant. If a pathogenic variant is identified, these patients are removed from the overarching diagnosis of CVID and are deemed to have a CVID-like disorder. In populations where consanguinity is more prevalent, the majority of patients with severe primary hypogammaglobulinemia will have an underlying inborn error of immunity, usually an early-onset autosomal recessive disorder. In nonconsanguineous societies, pathogenic variants are identified in approximately 20% to 30% of patients. These are often autosomal dominant mutations with variable penetrance and expressivity. To add to the complexity of CVID and CVID-like disorders, some genetic variants such as those in TNFSF13B (transmembrane activator calcium modulator cyclophilin ligand interactor) predispose to, or enhance, disease severity. These variants are not causative but can have epistatic (synergistic) interactions with more deleterious mutations to worsen disease severity. This review is a description of the current understanding of genes associated with CVID and CVID-like disorders. This information will assist clinicians in interpreting NGS reports when investigating the genetic basis of disease in patients with a CVID phenotype.
    MeSH term(s) Humans ; Common Variable Immunodeficiency/diagnosis ; Common Variable Immunodeficiency/genetics ; Common Variable Immunodeficiency/complications ; Mutation/genetics ; Phenotype ; Agammaglobulinemia/complications
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.01.048
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