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  1. Article: New Structures Reveal Interaction Dynamics in Respiratory Supercomplexes.

    Brzezinski, Peter

    Trends in biochemical sciences

    2019  Volume 45, Issue 1, Page(s) 3–5

    Abstract: Mitochondrial energy conversion involves a chain of membrane-bound proteins that are wired to conduct an electron current, which drives transmembrane proton translocation. These enzymes associate to form supercomplexes, but the functional relevance of ... ...

    Abstract Mitochondrial energy conversion involves a chain of membrane-bound proteins that are wired to conduct an electron current, which drives transmembrane proton translocation. These enzymes associate to form supercomplexes, but the functional relevance of the higher-order structures is unknown. A recent study by Letts et al. presents structures of a supercomplex, which suggest how the interaction choreography may control overall functionality.
    MeSH term(s) Electron Transport ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism
    Language English
    Publishing date 2019-11-19
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2019.10.011
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  2. Article: New Structures Reveal Interaction Dynamics in Respiratory Supercomplexes

    Brzezinski, Peter

    Trends in biochemical sciences. 2020 Jan., v. 45, no. 1

    2020  

    Abstract: Mitochondrial energy conversion involves a chain of membrane-bound proteins that are wired to conduct an electron current, which drives transmembrane proton translocation. These enzymes associate to form supercomplexes, but the functional relevance of ... ...

    Abstract Mitochondrial energy conversion involves a chain of membrane-bound proteins that are wired to conduct an electron current, which drives transmembrane proton translocation. These enzymes associate to form supercomplexes, but the functional relevance of the higher-order structures is unknown. A recent study by Letts et al. presents structures of a supercomplex, which suggest how the interaction choreography may control overall functionality.
    Keywords energy conversion ; enzymes ; mitochondria ; proteins
    Language English
    Dates of publication 2020-01
    Size p. 3-5.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 194220-7
    ISSN 0968-0004 ; 0376-5067
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2019.10.011
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  3. Article ; Online: Partial Ribosomal Nontranscribed Spacer Sequences Distinguish Rhagoletis zephyria (Diptera: Tephritidae) From the Apple Maggot, R. pomonella.

    Smith, J J / Brzezinski, P / Dziedziula, J / Rosenthal, E / Klaus, M

    Journal of economic entomology

    2022  Volume 115, Issue 2, Page(s) 647–661

    Abstract: The apple maggot, Rhagoletis pomonella (Walsh), was introduced into the apple-growing regions of the Pacific Northwest in the U.S.A. during the past 60-100 yr. Apple maggot (larvae, puparia, and adults) is difficult to distinguish from its ... ...

    Abstract The apple maggot, Rhagoletis pomonella (Walsh), was introduced into the apple-growing regions of the Pacific Northwest in the U.S.A. during the past 60-100 yr. Apple maggot (larvae, puparia, and adults) is difficult to distinguish from its morphologically similar sister species, Rhagoletis zephyria Snow, which is native and abundant in the Pacific Northwest. While morphological identifications are common practice, a simple, inexpensive assay based on genetic differences would be very useful when morphological traits are unclear. Here we report nucleotide substitution and insertion-deletion mutations in the nontranscribed spacer (NTS) of the ribosomal RNA gene cistron of R. pomonella and R. zephyria that appear to be diagnostic for these two fly species. Insertion-deletion variation is substantial and results in a 49 base-pair difference in PCR amplicon size between R. zephyria and R. pomonella that can be scored using agarose gel electrophoresis. PCR amplification and DNA sequencing of 766 bp of the NTS region from 38 R. pomonella individuals and 35 R. zephyria individuals from across their geographic ranges led to the expected PCR fragments of approx. 840 bp and 790 bp, respectively, as did amplification and sequencing of a smaller set of 26 R. pomonella and 16 R. zephyria flies from a sympatric site in Washington State. Conversely, 633 bp mitochondrial COI barcode sequences from this set of flies were polyphyletic with respect to R. pomonella and R. zephyria. Thus, differences in NTS PCR products on agarose gels potentially provide a simple way to distinguish between R. pomonella and R. zephyria.
    MeSH term(s) Animals ; Diptera ; Larva ; Malus ; Tephritidae/genetics ; Washington
    Language English
    Publishing date 2022-01-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3031-4
    ISSN 1938-291X ; 0022-0493
    ISSN (online) 1938-291X
    ISSN 0022-0493
    DOI 10.1093/jee/toab264
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  4. Article ; Online: Cryo-EM structure and function of S. pombe complex IV with bound respiratory supercomplex factor.

    Moe, Agnes / Ädelroth, Pia / Brzezinski, Peter / Näsvik Öjemyr, Linda

    Communications chemistry

    2023  Volume 6, Issue 1, Page(s) 32

    Abstract: Fission yeast Schizosaccharomyces pombe serves as model organism for studying higher eukaryotes. We combined the use of cryo-EM and spectroscopy to investigate the structure and function of affinity purified respiratory complex IV (CIV) from S. pombe. ... ...

    Abstract Fission yeast Schizosaccharomyces pombe serves as model organism for studying higher eukaryotes. We combined the use of cryo-EM and spectroscopy to investigate the structure and function of affinity purified respiratory complex IV (CIV) from S. pombe. The reaction sequence of the reduced enzyme with O
    Language English
    Publishing date 2023-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929562-2
    ISSN 2399-3669 ; 2399-3669
    ISSN (online) 2399-3669
    ISSN 2399-3669
    DOI 10.1038/s42004-023-00827-3
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  5. Article: The use of isotretinoin in acne therapy in early childhood and its effect on the occurrence of acne symptoms later in life. Eight-year follow-up.

    Brzezinski, Piotr / Wollina, Uwe / Smigielski, Janusz / Borowska, Katarzyna

    Postepy dermatologii i alergologii

    2022  Volume 39, Issue 4, Page(s) 682–687

    Abstract: Introduction: Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous follicles that affects patients of all ages.: Aim: Use of isotretinoin in the early stages of the disease to prevent subsequent lesions of acne, including ... ...

    Abstract Introduction: Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous follicles that affects patients of all ages.
    Aim: Use of isotretinoin in the early stages of the disease to prevent subsequent lesions of acne, including prolonged treatment and acne scars at a later age.
    Material and methods: A retrospective, comparative study was carried between January 2010 and November 2018. The study population consisted of 90 children aged 9-18 years with acne. During treatment by isotretinoin the clinical evaluation was done every month. Patients were divided into three groups according to age. One of the qualification criteria was follow-up visits.
    Results: A total of 90 children (67.8% females; mean age: 13.5 years) were enrolled. In group A (30 individuals - aged 9-11) and B (30 individuals - aged 12-13), treatment was terminated 2 months after clinical improvement (mean: 3 months). In control group C (30 individuals - aged 14-18), treatment was carried out using average cumulative dose 135 mg/kg bw/day. All groups showed up for follow-up. after 1 to 8 years. In groups A and B, 13 people underwent a second acne treatment; in 3.33% oral isotretinoin was used, in 18.33% topical treatment. In group C, 30 (100%) individuals underwent a second acne treatment; in 20% oral isotretinoin was used, and 80% required a topical treatment. Acne scars and post acne hyperpigmentation have been documented in 73.33% in group C.
    Conclusions: Early, reasonable and short-term use of isotretinoin can reduce the incidence of acne in the future and reduce the occurrence of secondary acne symptoms.
    Language English
    Publishing date 2022-09-01
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2596142-1
    ISSN 1642-395X
    ISSN 1642-395X
    DOI 10.5114/ada.2022.118921
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  6. Article ; Online: Giant, aggressive Merkel cell carcinoma of the right arm.

    Brzeziński, Piotr / Słomka, Justyna / Kitowska, Aleksandra / Bimbi, Cesar

    Anais brasileiros de dermatologia

    2022  Volume 98, Issue 2, Page(s) 252–255

    MeSH term(s) Humans ; Carcinoma, Merkel Cell/pathology ; Arm/pathology ; Skin Neoplasms/pathology ; Lymphatic Metastasis
    Language English
    Publishing date 2022-12-14
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1016/j.abd.2021.11.010
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    Zs.A 359: Show issues Location:
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    Zs.MO 344: Show issues

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  7. Article: Kaposi’s varicelliform eruption as a potentially life-threatening complication in Darier’s disease. Eczema herpeticatum (Kaposi’s varicelliform eruption) - eine potenziell lebensbedrohliche Komplikation beim Morbus Darier

    BIMBI, CÉSAR / KYRIAKOU, GEORGIA / BRZEZINSKI, PIOTR / WOLLINA, UWE

    Kosmetische Medizin

    2023  Volume 44, Issue 4, Page(s) 172

    Language German
    Document type Article
    ZDB-ID 1432524-X
    ISSN 1430-4031
    Database Current Contents Medicine

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  8. Article: Structure and Mechanism of Respiratory III–IV Supercomplexes in Bioenergetic Membranes

    Brzezinski, Peter / Moe, Agnes / Ädelroth, Pia

    Chemical reviews. 2021 June 29, v. 121, no. 15

    2021  

    Abstract: In the final steps of energy conservation in aerobic organisms, free energy from electron transfer through the respiratory chain is transduced into a proton electrochemical gradient across a membrane. In mitochondria and many bacteria, reduction of the ... ...

    Abstract In the final steps of energy conservation in aerobic organisms, free energy from electron transfer through the respiratory chain is transduced into a proton electrochemical gradient across a membrane. In mitochondria and many bacteria, reduction of the dioxygen electron acceptor is catalyzed by cytochrome c oxidase (complex IV), which receives electrons from cytochrome bc₁ (complex III), via membrane-bound or water-soluble cytochrome c. These complexes function independently, but in many organisms they associate to form supercomplexes. Here, we review the structural features and the functional significance of the nonobligate III₂IV₁/₂ Saccharomyces cerevisiae mitochondrial supercomplex as well as the obligate III₂IV₂ supercomplex from actinobacteria. The analysis is centered around the Q-cycle of complex III, proton uptake by CytcO, as well as mechanistic and structural solutions to the electronic link between complexes III and IV.
    Keywords Gibbs free energy ; Saccharomyces cerevisiae ; electrochemistry ; electron transfer ; electron transport chain ; energy conservation ; mitochondria ; oxygen ; water solubility
    Language English
    Dates of publication 2021-0629
    Size p. 9644-9673.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.1c00140
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  9. Article ; Online: Immunohistochemical analysis of the ligamentum mucosum is the key to understand its clinical usefulness.

    Gonera, Bartosz / Wysiadecki, Grzegorz / Kurtys, Konrad / Brzeziński, Piotr / Borowski, Andrzej / Olewnik, Łukasz

    Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

    2023  Volume 249, Page(s) 152106

    Abstract: Ligamentum Mucosum(LM) is a ligamentous structure within the synovial layer of the knee joint capsule. For a long time LM was perceived as the vestigial remnant from the embryological development of the knee. Being treated as an irrelevant structure LM ... ...

    Abstract Ligamentum Mucosum(LM) is a ligamentous structure within the synovial layer of the knee joint capsule. For a long time LM was perceived as the vestigial remnant from the embryological development of the knee. Being treated as an irrelevant structure LM was often the first victim of shaver during arthroscopy. However, last years have shown increased interest in this structure due to its potentially significant clinical role. Our aim was to classify LM based on its morphological characteristics and examine its microanatomy using immunohistochemical analysis to reveal the potential clinical value for surgeons. We have examined sixteen fresh frozen lower limbs, 6 females (mean age 83.1 ± 3.4 years) and 10 males (mean age 84.2 ± 6.8 years). Classical histological H+E stain was routinely conducted. Subsequently, CD31 antibody (DAKO, Monoclonal Mouse Anti-Human, Clone JC70A) was used to mark vascular epithelium. Monoclonal Mouse Anti-Human Neurofilament Protein (NFP) antibody (DAKO, Clone 2F11) was used to expose the nerves. Moreover, we have conducted arthroscopic visualizing and suturing LM to the torn ACL during routinely performed arthroscopic suturing of the ACL. The dissection process has revealed that LM was present only in 75% of cases. Histological examination confirmed the presence of longitudinal collagen fiber bundles in all samples. Tiny nerves were confirmed by NFP, along the subsynovial layer in all samples. CD-31 immunostain revealed the presence of many vascular vessels along the entire ligament, especially well developed at its distal end. Our study has revealed that LM contains rich vascular network. Thus, it may be a donor for the revascularization process after ACL tear or reconstruction which may improve the recovery. Another great advantage of the LM is the presence of nerves along the subsynovial layer, hopefully they may serve as the source of reinnervation and hence better clinical outcome. Based on our results we believe that seemingly irrelevant LM may be very useful during surgical procedures in the knee region. Suturing LM to the ACL may not only prevent the infrapatellar fat pad from subluxation but also improve the blood flow and reinnervation of the injured ACL. Until now there are only a few studies examining microanatomy of the LM. This basic knowledge may serve as the foundation for surgical procedures. Hopefully our findings may be useful for surgeons while planning surgical procedures or clinicians while diagnosing patients who suffer anterior knee pain.
    MeSH term(s) Male ; Female ; Animals ; Mice ; Knee Joint/anatomy & histology ; Anterior Cruciate Ligament Injuries ; Anterior Cruciate Ligament/surgery ; Arthroscopy/methods
    Language English
    Publishing date 2023-05-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1106738-x
    ISSN 1618-0402 ; 0940-9602
    ISSN (online) 1618-0402
    ISSN 0940-9602
    DOI 10.1016/j.aanat.2023.152106
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    Ub I Zs.55: Show issues Location:
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  10. Article ; Online: Structure and Mechanism of Respiratory III-IV Supercomplexes in Bioenergetic Membranes.

    Brzezinski, Peter / Moe, Agnes / Ädelroth, Pia

    Chemical reviews

    2021  Volume 121, Issue 15, Page(s) 9644–9673

    Abstract: In the final steps of energy conservation in aerobic organisms, free energy from electron transfer through the respiratory chain is transduced into a proton electrochemical gradient across a membrane. In mitochondria and many bacteria, reduction of the ... ...

    Abstract In the final steps of energy conservation in aerobic organisms, free energy from electron transfer through the respiratory chain is transduced into a proton electrochemical gradient across a membrane. In mitochondria and many bacteria, reduction of the dioxygen electron acceptor is catalyzed by cytochrome
    MeSH term(s) Cell Membrane/enzymology ; Electron Transport ; Electron Transport Complex III/chemistry ; Electron Transport Complex III/metabolism ; Electron Transport Complex IV/chemistry ; Electron Transport Complex IV/metabolism ; Protons ; Saccharomyces cerevisiae/cytology ; Saccharomyces cerevisiae/enzymology
    Chemical Substances Protons ; Electron Transport Complex IV (EC 1.9.3.1) ; Electron Transport Complex III (EC 7.1.1.8)
    Language English
    Publishing date 2021-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.1c00140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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