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  1. Article ; Online: Structural and Biological Features of G-Quadruplex Aptamers as Promising Inhibitors of the STAT3 Signaling Pathway.

    Esposito, Veronica / Benigno, Daniela / Bello, Ivana / Panza, Elisabetta / Bucci, Mariarosaria / Virgilio, Antonella / Galeone, Aldo

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: In this paper, we investigate the structural and biological features of G-quadruplex (G4) aptamers as promising antiproliferative compounds affecting the STAT3 signalling pathway. Targeting the STAT3 protein through high-affinity ligands to reduce its ... ...

    Abstract In this paper, we investigate the structural and biological features of G-quadruplex (G4) aptamers as promising antiproliferative compounds affecting the STAT3 signalling pathway. Targeting the STAT3 protein through high-affinity ligands to reduce its levels or activity in cancer has noteworthy therapeutic potential. T40214 (
    MeSH term(s) Humans ; Male ; Aptamers, Nucleotide/chemistry ; Cell Line ; G-Quadruplexes ; Neoplasms ; Signal Transduction ; STAT3 Transcription Factor/metabolism ; Female
    Chemical Substances Aptamers, Nucleotide ; STAT3 protein, human ; STAT3 Transcription Factor
    Language English
    Publishing date 2023-05-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Improving the Biological Properties of Thrombin-Binding Aptamer by Incorporation of 8-Bromo-2'-Deoxyguanosine and 2'-Substituted RNA Analogues.

    Virgilio, Antonella / Benigno, Daniela / Aliberti, Carla / Vellecco, Valentina / Bucci, Mariarosaria / Esposito, Veronica / Galeone, Aldo

    International journal of molecular sciences

    2023  Volume 24, Issue 21

    Abstract: Thrombin-binding aptamer (TBA) is one of the best-known G-quadruplex (G4)-forming aptamers. By adopting its peculiar chair-like G4 structure, TBA can efficiently bind to thrombin, thus producing an anticoagulant effect. The major limit to its therapeutic ...

    Abstract Thrombin-binding aptamer (TBA) is one of the best-known G-quadruplex (G4)-forming aptamers. By adopting its peculiar chair-like G4 structure, TBA can efficiently bind to thrombin, thus producing an anticoagulant effect. The major limit to its therapeutic application is represented by its poor thermal and biological resistance. Therefore, numerous research studies have been focused on the design of TBA analogues with chemical modifications to improve its pharmacokinetic and pharmacodynamic properties. To maintain the functional recognition to protein surface on which TBA anticoagulant activity depends, it is essential to preserve the canonical antiparallel topology of the TBA quadruplex core. In this paper, we have designed three TBA variants with modified G-tetrads to evaluate the effects of nucleobase and sugar moiety chemical modifications on biological properties of TBA, preserving its chair-like G-quadruplex structure. All derivatives contain 8-bromo-2'-deoxyguanosine (G
    MeSH term(s) Aptamers, Nucleotide/chemistry ; G-Quadruplexes ; Thrombin/metabolism ; Anticoagulants/pharmacology
    Chemical Substances thrombin aptamer (145563-68-4) ; 8-bromo-2'-deoxyguanosine ; Aptamers, Nucleotide ; Thrombin (EC 3.4.21.5) ; Anticoagulants
    Language English
    Publishing date 2023-10-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115529
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  3. Article: CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure

    Katsouda, Antonia / Markou, Maria / Zampas, Paraskevas / Varela, Aimilia / Davos, Constantinos H / Vellecco, Valentina / Cirino, Giuseppe / Bucci, Mariarosaria / Papapetropoulos, Andreas

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1090654

    Abstract: Hydrogen sulfide ( ... ...

    Abstract Hydrogen sulfide (H
    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1090654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Erucin, an H

    Bello, Ivana / Smimmo, Martina / d'Emmanuele di Villa Bianca, Roberta / Bucci, Mariarosaria / Cirino, Giuseppe / Panza, Elisabetta / Brancaleone, Vincenzo

    International journal of molecular sciences

    2023  Volume 24, Issue 7

    Abstract: Breast cancer is the most frequent form of cancer occurring in women of any age. Among the different types, the triple-negative breast cancer (TNBC) subtype is recognized as the most severe form, being associated with the highest mortality rate. ... ...

    Abstract Breast cancer is the most frequent form of cancer occurring in women of any age. Among the different types, the triple-negative breast cancer (TNBC) subtype is recognized as the most severe form, being associated with the highest mortality rate. Currently, there are no effective treatments for TNBC. For this reason, the research of novel therapeutics is urgently needed. Natural products and their analogs have historically made a major contribution to pharmacotherapy and the treatment of various human diseases, including cancer. In this study, we explored the potential anti-cancer effects of erucin, the most abundant H
    MeSH term(s) Humans ; Female ; Triple Negative Breast Neoplasms/metabolism ; Cell Line, Tumor ; Apoptosis ; Isothiocyanates/pharmacology ; Isothiocyanates/therapeutic use ; Autophagy ; Cell Proliferation
    Chemical Substances erucin (CTE370DL3U) ; isothiocyanic acid (3129-90-6) ; Isothiocyanates
    Language English
    Publishing date 2023-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24076764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hydrogen sulfide and epigenetics: Novel insights into the cardiovascular effects of this gasotransmitter.

    Spezzini, Jacopo / Piragine, Eugenia / d'Emmanuele di Villa Bianca, Roberta / Bucci, Mariarosaria / Martelli, Alma / Calderone, Vincenzo

    British journal of pharmacology

    2023  Volume 180, Issue 14, Page(s) 1793–1802

    Abstract: Epigenetics studies the heritable modifications of genome expression that do not affect the nucleotide sequence. Epigenetic modifications can be divided into: DNA methylation, histone modifications, and modulation of genome expression by non-coding RNAs. ...

    Abstract Epigenetics studies the heritable modifications of genome expression that do not affect the nucleotide sequence. Epigenetic modifications can be divided into: DNA methylation, histone modifications, and modulation of genome expression by non-coding RNAs. Alteration of these mechanisms can alter the phenotype, and can lead to disease onset. The endogenous gasotransmitter hydrogen sulfide (H
    MeSH term(s) Epigenesis, Genetic ; Gasotransmitters/metabolism ; Hydrogen Sulfide/metabolism ; DNA Methylation ; Histones/metabolism
    Chemical Substances Gasotransmitters ; Hydrogen Sulfide (YY9FVM7NSN) ; Histones
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.16083
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  6. Article ; Online: Hydrogen sulfide pathway and skeletal muscle: an introductory review.

    Vellecco, Valentina / Armogida, Chiara / Bucci, Mariarosaria

    British journal of pharmacology

    2018  Volume 175, Issue 15, Page(s) 3090–3099

    Abstract: The presence of the ... ...

    Abstract The presence of the H
    MeSH term(s) Animals ; Cystathionine beta-Synthase/metabolism ; Cystathionine gamma-Lyase/metabolism ; Humans ; Hydrogen Sulfide/metabolism ; Muscle, Skeletal/metabolism ; Signal Transduction
    Chemical Substances Cystathionine beta-Synthase (EC 4.2.1.22) ; Cystathionine gamma-Lyase (EC 4.4.1.1) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2018-06-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.14358
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  7. Article ; Online: Biphasic inflammatory response induced by intra-plantar injection of L-cysteine: Role of CBS-derived H

    Vellecco, Valentina / Esposito, Erika / Indolfi, Chiara / Saviano, Anella / Panza, Elisabetta / Bucci, Mariarosaria / Brancaleone, Vincenzo / Cirino, Giuseppe / d'Emmanuele di Villa Bianca, Roberta / Sorrentino, Raffaella / Mitidieri, Emma

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 167, Page(s) 115536

    Abstract: This study investigates the inflammatory response to intra-plantar injection of L-cysteine in a murine model. L-cysteine induces a two-phase response: an early phase lasting 6 h and a late phase peaking at 24 h and declining by 192 h. The early phase ... ...

    Abstract This study investigates the inflammatory response to intra-plantar injection of L-cysteine in a murine model. L-cysteine induces a two-phase response: an early phase lasting 6 h and a late phase peaking at 24 h and declining by 192 h. The early phase shows increased neutrophil accumulation at 2 h up to 24 h, followed by a reduction at 48 h. On the other hand, the late phase exhibits increased macrophage infiltration peaking at 96 h. Inhibition of cystathionine β-synthase (CBS), the first enzyme in the transsulfuration pathway, significantly reduces L-cysteine-induced edema, suggesting its dependence on CBS-derived hydrogen sulfide (H
    Language English
    Publishing date 2023-09-22
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115536
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  8. Article ; Online: Nitric oxide and hydrogen sulfide: the gasotransmitter paradigm of the vascular system.

    Cirino, Giuseppe / Vellecco, Valentina / Bucci, Mariarosaria

    British journal of pharmacology

    2017  Volume 174, Issue 22, Page(s) 4021–4031

    Abstract: There are several reviews on NO and hydrogen sulfide (H: Linked articles: This article is part of a themed section on Targeting Inflammation to Reduce Cardiovascular Disease Risk. To view the other articles in this section visit http://onlinelibrary ... ...

    Abstract There are several reviews on NO and hydrogen sulfide (H
    Linked articles: This article is part of a themed section on Targeting Inflammation to Reduce Cardiovascular Disease Risk. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.22/issuetoc and http://onlinelibrary.wiley.com/doi/10.1111/bcp.v82.4/issuetoc.
    MeSH term(s) Animals ; Cardiovascular System/metabolism ; Gasotransmitters/metabolism ; Humans ; Hydrogen Sulfide/metabolism ; Nitric Oxide/metabolism
    Chemical Substances Gasotransmitters ; Nitric Oxide (31C4KY9ESH) ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2017-05-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.13815
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  9. Article ; Online: Interleukin-17A (IL-17A): A silent amplifier of COVID-19.

    Maione, Francesco / Casillo, Gian Marco / Raucci, Federica / Salvatore, Cristian / Ambrosini, Giovanna / Costa, Luisa / Scarpa, Raffaele / Caso, Francesco / Bucci, Mariarosaria

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2021  Volume 142, Page(s) 111980

    Abstract: One of the hallmarks of COVID-19 is the cytokine storm that provokes primarily pneumonia followed by systemic inflammation. Emerging evidence has identified a potential link between elevated interleukin-17A (IL-17A) levels and disease severity and ... ...

    Abstract One of the hallmarks of COVID-19 is the cytokine storm that provokes primarily pneumonia followed by systemic inflammation. Emerging evidence has identified a potential link between elevated interleukin-17A (IL-17A) levels and disease severity and progression. Considering that per se, IL-17A can activate several inflammatory pathways, it is plausible to hypothesize an involvement of this cytokine in COVID-19 clinical outcomes. Thus, IL-17A could represent a marker of disease progression and/or a target to develop therapeutic strategies. This hypothesis paper aims to propose this "unique" cytokine as a silent amplifier of the COVID-19 immune response and (potentially) related therapy.
    MeSH term(s) Biomarkers/blood ; COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/immunology ; Cytokine Release Syndrome/etiology ; Cytokine Release Syndrome/immunology ; Disease Progression ; Drug Discovery ; Humans ; Inflammation Mediators/metabolism ; Interleukin-17/blood ; Interleukin-17/immunology ; Severity of Illness Index
    Chemical Substances Biomarkers ; Inflammation Mediators ; Interleukin-17
    Language English
    Publishing date 2021-07-29
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2021.111980
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  10. Article ; Online: Hydrogen sulfide donor AP123 restores endothelial nitric oxide-dependent vascular function in hyperglycemia via a CREB-dependent pathway.

    Montanaro, Rosangela / Vellecco, Valentina / Torregrossa, Roberta / Casillo, Gian Marco / Manzo, Onorina Laura / Mitidieri, Emma / Bucci, Mariarosaria / Castaldo, Sigismondo / Sorrentino, Raffaella / Whiteman, Matthew / Smimmo, Martina / Carriero, Flavia / Terrazzano, Giuseppe / Cirino, Giuseppe / d'Emmanuele di Villa Bianca, Roberta / Brancaleone, Vincenzo

    Redox biology

    2023  Volume 62, Page(s) 102657

    Abstract: Diabetes is associated with severe vascular complications involving the impairment of endothelial nitric oxide synthase (eNOS) as well as cystathionine γ-lyase (CSE) activity. eNOS function is suppressed in hyperglycaemic conditions, resulting in reduced ...

    Abstract Diabetes is associated with severe vascular complications involving the impairment of endothelial nitric oxide synthase (eNOS) as well as cystathionine γ-lyase (CSE) activity. eNOS function is suppressed in hyperglycaemic conditions, resulting in reduced NO bioavailability, which is paralleled by reduced levels of hydrogen sulfide (H
    MeSH term(s) Mice ; Animals ; Cattle ; Hydrogen Sulfide/pharmacology ; Hydrogen Sulfide/metabolism ; Nitric Oxide/metabolism ; Endothelial Cells/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Hyperglycemia/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Acetylcholine/metabolism
    Chemical Substances Hydrogen Sulfide (YY9FVM7NSN) ; Nitric Oxide (31C4KY9ESH) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Acetylcholine (N9YNS0M02X)
    Language English
    Publishing date 2023-03-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2023.102657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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