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  1. Book ; Online: Klinische Entscheidungsfindung mit Künstlicher Intelligenz

    Samhammer, David / Beck, Susanne / Budde, Klemens / Burchardt, Aljoscha / Faber, Michelle / Gerndt, Simon / Möller, Sebastian / Osmanodja, Bilgin / Roller, Roland / Dabrock, Peter

    Ein interdisziplinärer Governance-Ansatz

    (essentials)

    2023  

    Series title essentials
    Keywords Public health & preventive medicine ; Health economics ; Nursing ; Ethics & moral philosophy ; Renal medicine & nephrology ; Künstliche Intelligenz ; Maschinelles Lernen ; Medizin ; Klinik ; Entscheidungsfindung ; Meaningful Human Control ; Bedeutsame menschliche Kontrolle ; Governance ; Medizinische Unterstützungssysteme
    Language German
    Size 1 electronic resource (66 pages)
    Publisher Springer Nature
    Publishing place Berlin, Heidelberg
    Document type Book ; Online
    Note German
    HBZ-ID HT030378013
    ISBN 9783662670071 ; 3662670070
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Klinische Entscheidungsfindung mit Künstlicher Intelligenz

    Samhammer, David / Beck, Susanne / Budde, Klemens / Burchardt, Aljoscha / Faber, Michelle / Gerndt, Simon / Möller, Sebastian / Osmanodja, Bilgin / Roller, Roland / Dabrock, Peter

    Ein interdisziplinärer Governance-Ansatz

    (essentials)

    2023  

    Author's details von David Samhammer, Susanne Beck, Klemens Budde, Aljoscha Burchardt, Michelle Faber, Simon Gerndt, Sebastian Möller, Bilgin Osmanodja, Roland Roller, Peter Dabrock
    Series title essentials
    Keywords Public health ; Medical care ; Medical Ethics ; Nursing ethics ; Technology—Moral and ethical aspects ; Nephrology
    Language German
    Size 1 Online-Ressource (XI, 66 S. 1 Abb)
    Edition 1st ed. 2023
    Publisher Springer Berlin Heidelberg ; Imprint: Springer
    Publishing place Berlin, Heidelberg
    Document type Book ; Online
    HBZ-ID HT030028617
    ISBN 978-3-662-67008-8 ; 9783662670071 ; 3-662-67008-9 ; 3662670070
    DOI 10.1007/978-3-662-67008-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Conference proceedings: Medizinische Spitzenforschung in Deutschland

    Budde, Klemens / Färber, Lothar

    [Symposium ... 2009] ; mit 12 Tabellen

    2010  

    Author's details hrsg.von Lothar Färber ... Mit Beitr. von Klemens Budde
    Keywords Deutschland ; Medizin ; Forschung ; Geschichte 2010
    Subject Wissenschaftliche Forschung ; Forschungen ; Humanmedizin ; Heilkunst ; Medicine
    Language German
    Size XVI, 136 S. : Ill., graph. Darst., Kt.
    Publisher Schattauer
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT016655527
    ISBN 978-3-7945-2818-9 ; 3-7945-2818-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 193 order for loan Magazin

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  4. Book: Sirolimus (Rapamune)

    Andrassy, Joachim / Budde, Klemens / Gutzmer, Ralf / Kauke, Teresa

    Langzeitdaten zu donorspezifischen Antikörpern, Metaanalyse zur tumorprotektiven Wirkung, Hauttumorprotektion

    (Praxis Report ; 10. Jahrgang, Heft 14 (Dezember 2018))

    2018  

    Author's details Herausgeber PD Dr. med. Joachim Andrassy, München; Prof. Dr. med. Klemens Budde, Berlin; Prof. Dr. med. Ralf Gutzmer, Hannover; PD Dr. med. Teresa Kauke, München
    Series title Praxis Report ; 10. Jahrgang, Heft 14 (Dezember 2018)
    Collection
    Language German
    Size 11 Seiten, Illustrationen, Diagramme, 27 cm
    Publisher Thieme
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT020015364
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 6809 -10,14- verfügbar in Königswinter Königswinter

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  5. Article ; Online: Back to the Future With Co-Stimulation Blockade.

    Flechner, Stuart M / Budde, Klemens

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 11752

    MeSH term(s) Humans ; Immunosuppressive Agents ; Abatacept ; Graft Rejection ; Graft Survival
    Chemical Substances Immunosuppressive Agents ; Abatacept (7D0YB67S97)
    Language English
    Publishing date 2023-07-24
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.11752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: A first small step toward personalized immunosuppression.

    Budde, Klemens / Rostaing, Lionel

    Kidney international

    2023  Volume 104, Issue 4, Page(s) 652–654

    Abstract: Lloberas et al. provide further evidence for the benefits of an individualized tacrolimus dosing algorithm based on population pharmacokinetics and pharmacogenetics. Better tacrolimus dosing could prevent underexposure and overexposure and potentially ... ...

    Abstract Lloberas et al. provide further evidence for the benefits of an individualized tacrolimus dosing algorithm based on population pharmacokinetics and pharmacogenetics. Better tacrolimus dosing could prevent underexposure and overexposure and potentially save costs. Most important, this could be the start of precision medicine in kidney transplantation, incorporating improved immunologic and donor quality assessments, advanced biopsy readouts, innovative pharmacogenomics for drug safety, and novel diagnostic and outcome algorithms to guide a truly personalized therapy.
    MeSH term(s) Tacrolimus/adverse effects ; Immunosuppression Therapy ; Algorithms ; Biopsy ; Kidney Transplantation/adverse effects
    Chemical Substances Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2023-06-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2023.06.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Stronger together: Lessons from the iBox qualification process.

    Budde, Klemens / Kaplan, Bruce

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2023  Volume 23, Issue 10, Page(s) 1478–1480

    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Editorial
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1016/j.ajt.2023.05.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5542: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Six pills less: no benefit for bicarbonate supplementation in renal allograft recipients.

    Budde, Klemens / Halleck, Fabian

    Lancet (London, England)

    2023  Volume 401, Issue 10376, Page(s) 526–527

    MeSH term(s) Humans ; Kidney Transplantation ; Bicarbonates ; Kidney ; Allografts ; Dietary Supplements
    Chemical Substances Bicarbonates
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)02630-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.5: Show issues Location:
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    Zs.MG 94: Show issues

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  9. Article ; Online: Das Deutsche Transplantationsregister – eine Analyse der Altdaten 2006–2016.

    Otto, Gerd / Budde, Klemens / Bara, Christoph / Gottlieb, Jens

    Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))

    2024  

    Abstract: Introduction: In 2018, medical transplant data from three institutions were merged to create a German transplant registry. Since June 2021, access to data of the registry has been available. It was planned to analyze the registry data in order to ... ...

    Title translation The German Transplant Registry - An Analysis of Legacy Data 2006-2016.
    Abstract Introduction: In 2018, medical transplant data from three institutions were merged to create a German transplant registry. Since June 2021, access to data of the registry has been available. It was planned to analyze the registry data in order to compare special allocation rules with regular allocation for heart, liver, lung, and kidney transplantation. Our approach led to a quality analysis of the registry.
    Methods: Upon request, legacy data (2006-2016) of the registry was provided, divided into 61 elements. From these elements, the user had to compile the required dataset. Data checks were performed for completeness, correct allocation of information, and consistency among different sources. Software used for these tasks included R, SQL, and Excel.
    Results: The initial elements ("waiting list" elements) of the four types of transplantations contained data from a total of 80,259 originally listed patients. However, these patients were only partially present in other elements resulting in complete datasets reflecting waiting time in only 23%, 30%, 50%, and 96%, and for post-transplantation outcomes in 14%, 11%, 38%, and 13% (heart, liver, lung, and kidney transplantation, respectively). The linking of urgency information with clinical data was successful in only a small proportion, with only 6% for heart transplantation. Incorrect and thus implausible allocations in the case of special allocation rules indicated incorrect entries in the registry. Data from different data providers were inconsistent.
    Discussion: The incompleteness and incorrect data allocation raise doubts about the reliability of scientific studies based on the transplant registry. The complex structure also hinders the compilation of a reliable dataset, which is uncommon internationally. New data (acquisition since 2017) has only been available since December 2023.
    Conclusion: The transplant registry urgently needs restructuring. Competent clinical data management, involving transplant medical expertise, and continuous quality controls are essential in this process.
    Language German
    Publishing date 2024-03-11
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 1101426-x
    ISSN 1439-4421 ; 0941-3790 ; 0949-7013
    ISSN (online) 1439-4421
    ISSN 0941-3790 ; 0949-7013
    DOI 10.1055/a-2251-5627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Un I Zs.402: Show issues Location:
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  10. Article ; Online: Cellular Immunobiology and Molecular Mechanisms in Alloimmunity-Pathways of Immunosuppression.

    Schrezenmeier, Eva / Dörner, Thomas / Halleck, Fabian / Budde, Klemens

    Transplantation

    2023  Volume 108, Issue 1, Page(s) 148–160

    Abstract: Current maintenance immunosuppression commonly comprises a synergistic combination of tacrolimus as calcineurin inhibitor (CNI), mycophenolic acid, and glucocorticoids. Therapy is often individualized by steroid withdrawal or addition of belatacept or ... ...

    Abstract Current maintenance immunosuppression commonly comprises a synergistic combination of tacrolimus as calcineurin inhibitor (CNI), mycophenolic acid, and glucocorticoids. Therapy is often individualized by steroid withdrawal or addition of belatacept or inhibitors of the mechanistic target of rapamycin. This review provides a comprehensive overview of their mode of action, focusing on the cellular immune system. The main pharmacological action of CNIs is suppression of the interleukin-2 pathway that leads to inhibition of T cell activation. Mycophenolic acid inhibits the purine pathway and subsequently diminishes T and B cell proliferation but also exerts a variety of effects on almost all immune cells, including inhibition of plasma cell activity. Glucocorticoids exert complex regulation via genomic and nongenomic mechanisms, acting mainly by downregulating proinflammatory cytokine signatures and cell signaling. Belatacept is potent in inhibiting B/T cell interaction, preventing formation of antibodies; however, it lacks the potency of CNIs in preventing T cell-mediated rejections. Mechanistic target of rapamycin inhibitors have strong antiproliferative activity on all cell types interfering with multiple metabolic pathways, partly explaining poor tolerability, whereas their superior effector T cell function might explain their benefits in the case of viral infections. Over the past decades, clinical and experimental studies provided a good overview on the underlying mechanisms of immunosuppressants. However, more data are needed to delineate the interaction between innate and adaptive immunity to better achieve tolerance and control of rejection. A better and more comprehensive understanding of the mechanistic reasons for failure of immunosuppressants, including individual risk/benefit assessments, may permit improved patient stratification.
    MeSH term(s) Humans ; Mycophenolic Acid/therapeutic use ; Abatacept ; Immunosuppressive Agents/adverse effects ; Tacrolimus/therapeutic use ; Calcineurin Inhibitors/adverse effects ; Immunosuppression Therapy ; Sirolimus/pharmacology ; Graft Rejection/prevention & control
    Chemical Substances Mycophenolic Acid (HU9DX48N0T) ; Abatacept (7D0YB67S97) ; Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM) ; Calcineurin Inhibitors ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 488: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 509: Show issues

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