LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 17

Search options

  1. Article ; Online: Editorial: Microbiota and asthma.

    Bautista-Becerril, Brandon / Budden, Kurtis F / Falfán-Valencia, Ramcés

    Frontiers in allergy

    2023  Volume 4, Page(s) 1297425

    Language English
    Publishing date 2023-11-14
    Publishing country Switzerland
    Document type Editorial
    ISSN 2673-6101
    ISSN (online) 2673-6101
    DOI 10.3389/falgy.2023.1297425
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Emerging therapeutic targets and preclinical models for severe asthma.

    Galvão, Izabela / Kim, Richard Y / Shen, Sijie / Budden, Kurtis F / Vieira, Angélica T / Hansbro, Philip M

    Expert opinion on therapeutic targets

    2020  Volume 24, Issue 9, Page(s) 845–857

    Abstract: Introduction: Asthma is a heterogeneous disease with complex multifactorial causes. It is possible to subclassify asthma into different phenotypes that have distinct immunological features. Eosinophilic asthma is a well-known phenotype of severe asthma; ...

    Abstract Introduction: Asthma is a heterogeneous disease with complex multifactorial causes. It is possible to subclassify asthma into different phenotypes that have distinct immunological features. Eosinophilic asthma is a well-known phenotype of severe asthma; however, a large body of clinical and experimental evidence strongly associates persistent airway inflammation, including the accumulation of neutrophils in the bronchial mucosa, and resistance to corticosteroid therapy and non-Type-2 immune responses with severe asthma. Importantly, mainstay therapies are often ineffective in severe asthma and effective alternatives are urgently needed.
    Areas covered: Here, we discussed recently developed mouse models of severe asthma that recapitulates key features of the disease in humans. We also provide findings from clinically relevant experimental models that have identified potential therapeutic targets for severe asthma. The most relevant publications on the topic of interest were selected from PubMed.
    Expert commentary: Increasing the understanding of disease-causing mechanisms in severe asthma may lead to the identification of novel therapeutic targets and the development of more effective therapies. Intense research interest into investigating the pathophysiological mechanisms of severe asthma has driven the development and interrogation of a myriad of mouse models that aim to replicate hallmark features of severe asthma in humans.
    MeSH term(s) Animals ; Asthma/immunology ; Asthma/physiopathology ; Asthma/therapy ; Disease Models, Animal ; Humans ; Mice ; Molecular Targeted Therapy ; Severity of Illness Index
    Language English
    Publishing date 2020-07-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2020.1786535
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5244: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Comparison of commercially available differentiation media on cell morphology, function, and anti-viral responses in conditionally reprogrammed human bronchial epithelial cells.

    Awatade, Nikhil T / Reid, Andrew T / Nichol, Kristy S / Budden, Kurtis F / Veerati, Punnam Chander / Pathinayake, Prabuddha S / Grainge, Christopher L / Hansbro, Philip M / Wark, Peter A B

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11200

    Abstract: Primary air liquid interface (ALI) cultures of bronchial epithelial cells are used extensively to model airway responses. A recent advance is the development of conditional reprogramming that enhances proliferative capability. Several different media and ...

    Abstract Primary air liquid interface (ALI) cultures of bronchial epithelial cells are used extensively to model airway responses. A recent advance is the development of conditional reprogramming that enhances proliferative capability. Several different media and protocols are utilized, yet even subtle differences may influence cellular responses. We compared the morphology and functional responses, including innate immune responses to rhinovirus infection in conditionally reprogrammed primary bronchial epithelial cells (pBECs) differentiated using two commonly used culture media. pBECs collected from healthy donors (n = 5) were CR using g-irradiated 3T3 fibroblasts and Rho Kinase inhibitor. CRpBECs were differentiated at ALI in either PneumaCult (PN-ALI) or bronchial epithelial growth medium (BEGM)-based differentiation media (BEBM:DMEM, 50:50, Lonza)-(AB-ALI) for 28 days. Transepithelial electrical resistance (TEER), immunofluorescence, histology, cilia activity, ion channel function, and expression of cell markers were analyzed. Viral RNA was assessed by RT-qPCR and anti-viral proteins quantified by LEGENDplex following Rhinovirus-A1b infection. CRpBECs differentiated in PneumaCult were smaller and had a lower TEER and cilia beat frequency compared to BEGM media. PneumaCult media cultures exhibited increased FOXJ1 expression, more ciliated cells with a larger active area, increased intracellular mucins, and increased calcium-activated chloride channel current. However, there were no significant changes in viral RNA or host antiviral responses. There are distinct structural and functional differences in pBECs cultured in the two commonly used ALI differentiation media. Such factors need to be taken into consideration when designing CRpBECs ALI experiments for specific research questions.
    MeSH term(s) Humans ; Bronchi ; Cell Differentiation ; Epithelial Cells ; Chloride Channels ; Cilia ; Culture Media ; Enterovirus Infections
    Chemical Substances Chloride Channels ; Culture Media
    Language English
    Publishing date 2023-07-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-37828-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Microbiome effects on immunity, health and disease in the lung.

    Shukla, Shakti D / Budden, Kurtis F / Neal, Rachael / Hansbro, Philip M

    Clinical & translational immunology

    2017  Volume 6, Issue 3, Page(s) e133

    Abstract: Chronic respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF), are among the leading causes of mortality and morbidity worldwide. In the past decade, the interest in the role of microbiome in ... ...

    Abstract Chronic respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF), are among the leading causes of mortality and morbidity worldwide. In the past decade, the interest in the role of microbiome in maintaining lung health and in respiratory diseases has grown exponentially. The advent of sophisticated multiomics techniques has enabled the identification and characterisation of microbiota and their roles in respiratory health and disease. Furthermore, associations between the microbiome of the lung and gut, as well as the immune cells and mediators that may link these two mucosal sites, appear to be important in the pathogenesis of lung conditions. Here we review the recent evidence of the role of normal gastrointestinal and respiratory microbiome in health and how dysbiosis affects chronic pulmonary diseases. The potential implications of host and environmental factors such as age, gender, diet and use of antibiotics on the composition and overall functionality of microbiome are also discussed. We summarise how microbiota may mediate the dynamic process of immune development and/or regulation focusing on recent data from both clinical human studies and translational animal studies. This furthers the understanding of the pathogenesis of chronic pulmonary diseases and may yield novel avenues for the utilisation of microbiota as potential therapeutic interventions.
    Language English
    Publishing date 2017-03-10
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2694482-0
    ISSN 2050-0068
    ISSN 2050-0068
    DOI 10.1038/cti.2017.6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Antiviral Responses of Tissue-resident CD49a

    Cooper, Grace E / Mayall, Jemma / Donovan, Chantal / Haw, Tatt J / Budden, Kurtis F / Hansbro, Nicole G / Blomme, Evy E / Maes, Tania / Kong, Chia Wei / Horvat, Jay C / Khakoo, Salim I / Wilkinson, Tom M A / Hansbro, Philip M / Staples, Karl J

    American journal of respiratory and critical care medicine

    2022  Volume 207, Issue 5, Page(s) 553–565

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Humans ; Mice ; Animals ; Integrin alpha1/metabolism ; Influenza, Human/metabolism ; Integrin alpha2/metabolism ; Pulmonary Disease, Chronic Obstructive/genetics ; Killer Cells, Natural ; Lung/metabolism ; Lung Diseases/metabolism ; Antiviral Agents
    Chemical Substances Integrin alpha1 ; Integrin alpha2 ; Antiviral Agents
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202205-0848OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: The role of the microbiome and the NLRP3 inflammasome in the gut and lung.

    Donovan, Chantal / Liu, Gang / Shen, Sj / Marshall, Jacqueline E / Kim, Richard Y / Alemao, Charlotte A / Budden, Kurtis F / Choi, Jaesung P / Kohonen-Corish, Maija / El-Omar, Emad M / Yang, Ian A / Hansbro, Philip M

    Journal of leukocyte biology

    2020  Volume 108, Issue 3, Page(s) 925–935

    Abstract: The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome, is one of the most well-characterized inflammasomes, activated by pathogen-associated molecular patterns and damage- ... ...

    Abstract The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome, is one of the most well-characterized inflammasomes, activated by pathogen-associated molecular patterns and damage-associated molecular patterns, including from commensal or pathogenic bacterial and viral infections. The NLRP3 inflammasome promotes inflammatory cell recruitment and regulates immune responses in tissues such as the gastrointestinal tract and the lung, and is involved in many diseases that affect the gut and lung. Recently, the microbiome in the gut and the lung, and the crosstalk between these organs (gut-lung axis), has been identified as a potential mechanism that may influence disease in a bidirectional manner. In this review, we focus on themes presented in this area at the 2019 World Congress on Inflammation. We discuss recent evidence on how the microbiome can affect NLRP3 inflammasome responses in the gut and lung, the role of this inflammasome in regulating gut and lung inflammation in disease, and its potential role in the gut-lung axis. We highlight the exponential increase in our understanding of the NLRP3 inflammasome due to the synthesis of the NLRP3 inflammasome inhibitor, MCC950, and propose future studies that may further elucidate the roles of the NLRP3 inflammasome in gut and lung diseases.
    MeSH term(s) Aging/immunology ; Air Pollutants/toxicity ; Animals ; Asthma/immunology ; Cigarette Smoking/immunology ; Colitis/immunology ; Colitis/microbiology ; Colitis/therapy ; Dysbiosis/immunology ; Fecal Microbiota Transplantation ; Furans ; Gastrointestinal Microbiome/immunology ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Humans ; Indenes ; Inflammasomes/immunology ; Inflammation/immunology ; Intestines/immunology ; Lung/immunology ; Mice ; Mice, Knockout ; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors ; NLR Family, Pyrin Domain-Containing 3 Protein/deficiency ; NLR Family, Pyrin Domain-Containing 3 Protein/physiology ; Pneumonia, Bacterial/immunology ; Pneumonia, Viral/immunology ; Pulmonary Disease, Chronic Obstructive/immunology ; Specific Pathogen-Free Organisms ; Sulfonamides ; Sulfones/pharmacology ; Symbiosis
    Chemical Substances Air Pollutants ; Furans ; Heterocyclic Compounds, 4 or More Rings ; Indenes ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, mouse ; Sulfonamides ; Sulfones ; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide (6RS86E2BWQ)
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.3MR0720-472RR
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Emerging pathogenic links between microbiota and the gut-lung axis.

    Budden, Kurtis F / Gellatly, Shaan L / Wood, David L A / Cooper, Matthew A / Morrison, Mark / Hugenholtz, Philip / Hansbro, Philip M

    Nature reviews. Microbiology

    2017  Volume 15, Issue 1, Page(s) 55–63

    Abstract: The microbiota is vital for the development of the immune system and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the respiratory tract and the gut have recently been linked to alterations in immune responses and to ... ...

    Abstract The microbiota is vital for the development of the immune system and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the respiratory tract and the gut have recently been linked to alterations in immune responses and to disease development in the lungs. In this Opinion article, we review the microbial species that are usually found in healthy gastrointestinal and respiratory tracts, their dysbiosis in disease and interactions with the gut-lung axis. Although the gut-lung axis is only beginning to be understood, emerging evidence indicates that there is potential for manipulation of the gut microbiota in the treatment of lung diseases.
    MeSH term(s) Bacteria/classification ; Bacteria/metabolism ; Dysbiosis/microbiology ; Gastrointestinal Microbiome/physiology ; Gastrointestinal Tract/microbiology ; Humans ; Lung/microbiology ; Lung Diseases/microbiology ; Respiratory Tract Infections/microbiology
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2139054-X
    ISSN 1740-1534 ; 1740-1526
    ISSN (online) 1740-1534
    ISSN 1740-1526
    DOI 10.1038/nrmicro.2016.142
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5865: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 74: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Faecal microbial transfer and complex carbohydrates mediate protection against COPD.

    Budden, Kurtis F / Shukla, Shakti D / Bowerman, Kate L / Vaughan, Annalicia / Gellatly, Shaan L / Wood, David L A / Lachner, Nancy / Idrees, Sobia / Rehman, Saima Firdous / Faiz, Alen / Patel, Vyoma K / Donovan, Chantal / Alemao, Charlotte A / Shen, Sj / Amorim, Nadia / Majumder, Rajib / Vanka, Kanth S / Mason, Jazz / Haw, Tatt Jhong /
    Tillet, Bree / Fricker, Michael / Keely, Simon / Hansbro, Nicole / Belz, Gabrielle T / Horvat, Jay / Ashhurst, Thomas / van Vreden, Caryn / McGuire, Helen / Fazekas de St Groth, Barbara / King, Nicholas J C / Crossett, Ben / Cordwell, Stuart J / Bonaguro, Lorenzo / Schultze, Joachim L / Hamilton-Williams, Emma E / Mann, Elizabeth / Forster, Samuel C / Cooper, Matthew A / Segal, Leopoldo N / Chotirmall, Sanjay H / Collins, Peter / Bowman, Rayleen / Fong, Kwun M / Yang, Ian A / Wark, Peter A B / Dennis, Paul G / Hugenholtz, Philip / Hansbro, Philip M

    Gut

    2024  Volume 73, Issue 5, Page(s) 751–769

    Abstract: Objective: Chronic obstructive pulmonary disease (COPD) is a major cause of global illness and death, most commonly caused by cigarette smoke. The mechanisms of pathogenesis remain poorly understood, limiting the development of effective therapies. The ... ...

    Abstract Objective: Chronic obstructive pulmonary disease (COPD) is a major cause of global illness and death, most commonly caused by cigarette smoke. The mechanisms of pathogenesis remain poorly understood, limiting the development of effective therapies. The gastrointestinal microbiome has been implicated in chronic lung diseases via the gut-lung axis, but its role is unclear.
    Design: Using an
    Results: FMT alleviated hallmark features of COPD (inflammation, alveolar destruction, impaired lung function), gastrointestinal pathology and systemic immune changes. Protective effects were additive to smoking cessation, and transfer of CS-associated microbiota after antibiotic-induced microbiome depletion was sufficient to increase lung inflammation while suppressing colonic immunity in the absence of CS exposure. Disease features correlated with the relative abundance of
    Conclusion: The gut microbiome contributes to COPD pathogenesis and can be targeted therapeutically.
    MeSH term(s) Humans ; Mice ; Animals ; Pulmonary Disease, Chronic Obstructive/etiology ; Lung/metabolism ; Lung/pathology ; Pneumonia/etiology ; Inflammation/metabolism ; Carbohydrates/pharmacology
    Chemical Substances Carbohydrates
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-330521
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Microbiome-focused asthma management strategies.

    Shukla, Shakti D / Shastri, Madhur D / Chong, Wai Chin / Dua, Kamal / Budden, Kurtis F / Mahmood, Malik Quasir / Hansbro, Nicole G / Keely, Simon / Eri, Rajaraman / Patel, Rahul P / Peterson, Gregory M / Hansbro, Philip M

    Current opinion in pharmacology

    2019  Volume 46, Page(s) 143–149

    Abstract: Asthma is a common, heterogeneous and serious disease with high prevalence globally. Poorly controlled, steroid-resistant asthma is particularly important as there are no effective therapies and it exerts substantial healthcare and societal burden. The ... ...

    Abstract Asthma is a common, heterogeneous and serious disease with high prevalence globally. Poorly controlled, steroid-resistant asthma is particularly important as there are no effective therapies and it exerts substantial healthcare and societal burden. The role of microbiomes, particularly in chronic diseases has generated considerable interest in recent times. Existing evidence clearly demonstrates an association between asthma initiation and the microbiome, both respiratory and gastro-intestinal, although its' roles are poorly understood when assessing the asthma progression or heterogeneity (i.e. phenotypes/endotypes) across different geographical locations. Moreover, modulating microbiomes could be preventive and/or therapeutic in patients with asthma warrants urgent attention. Here, we review recent advances in assessing the role of microbiomes in asthma and present the challenges associated with the potential therapeutic utility of modifying microbiomes in management.
    MeSH term(s) Animals ; Asthma/microbiology ; Asthma/therapy ; Humans ; Intestines/microbiology ; Lung/microbiology ; Microbiota
    Language English
    Publishing date 2019-07-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2019.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5608: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Functional effects of the microbiota in chronic respiratory disease.

    Budden, Kurtis F / Shukla, Shakti D / Rehman, Saima Firdous / Bowerman, Kate L / Keely, Simon / Hugenholtz, Philip / Armstrong-James, Darius P H / Adcock, Ian M / Chotirmall, Sanjay H / Chung, Kian Fan / Hansbro, Philip M

    The Lancet. Respiratory medicine

    2019  Volume 7, Issue 10, Page(s) 907–920

    Abstract: The composition of the lung microbiome is increasingly well characterised, with changes in microbial diversity or abundance observed in association with several chronic respiratory diseases such as asthma, cystic fibrosis, bronchiectasis, and chronic ... ...

    Abstract The composition of the lung microbiome is increasingly well characterised, with changes in microbial diversity or abundance observed in association with several chronic respiratory diseases such as asthma, cystic fibrosis, bronchiectasis, and chronic obstructive pulmonary disease. However, the precise effects of the microbiome on pulmonary health and the functional mechanisms by which it regulates host immunity are only now beginning to be elucidated. Bacteria, viruses, and fungi from both the upper and lower respiratory tract produce structural ligands and metabolites that interact with the host and alter the development and progression of chronic respiratory diseases. Here, we review recent advances in our understanding of the composition of the lung microbiome, including the virome and mycobiome, the mechanisms by which these microbes interact with host immunity, and their functional effects on the pathogenesis, exacerbations, and comorbidities of chronic respiratory diseases. We also describe the present understanding of how respiratory microbiota can influence the efficacy of common therapies for chronic respiratory disease, and the potential of manipulation of the microbiome as a therapeutic strategy. Finally, we highlight some of the limitations in the field and propose how these could be addressed in future research.
    MeSH term(s) Chronic Disease ; Humans ; Immunity/physiology ; Lung/microbiology ; Microbiota/immunology ; Microbiota/physiology ; Respiration Disorders/immunology ; Respiration Disorders/microbiology ; Respiratory System/microbiology
    Language English
    Publishing date 2019-04-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(18)30510-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 7041: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top