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  1. Article ; Online: Treatment issues in recurrent

    Budi, Noah / Safdar, Nasia / Rose, Warren E

    FEMS microbes

    2020  Volume 1, Issue 1, Page(s) xtaa001

    Abstract: Clostridioides ... ...

    Abstract Clostridioides difficile
    Language English
    Publishing date 2020-09-23
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2633-6685
    ISSN (online) 2633-6685
    DOI 10.1093/femsmc/xtaa001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Efficacy of Omadacycline or Vancomycin Combined With Germinants for Preventing Clostridioides difficile Relapse in a Murine Model.

    Budi, Noah D / Godfrey, Jared J / Safdar, Nasia / Shukla, Sanjay K / Rose, Warren E

    The Journal of infectious diseases

    2022  Volume 227, Issue 5, Page(s) 622–630

    Abstract: Background: Clostridioides difficile infections (CDI) and recurrence (rCDI) are major health care burdens. Recurrence is likely caused by spores in the gastrointestinal tract that germinate after antibiotic therapy. This murine study explores germinant- ... ...

    Abstract Background: Clostridioides difficile infections (CDI) and recurrence (rCDI) are major health care burdens. Recurrence is likely caused by spores in the gastrointestinal tract that germinate after antibiotic therapy. This murine study explores germinant-antibiotic combinations for CDI.
    Methods: Previously described murine models were evaluated using C. difficile VPI 10463. The severe model compared omadacycline versus vancomycin in survival, weight loss, clinical scoring, and C. difficile toxin production. The nonsevere model compared these antibiotics with and without germinants (solution of sodium taurocholate, taurine, sodium docusate, calcium gluconate). Additionally, colon histopathology, bile acid analysis, environmental/spore shedding, and 16S sequencing was evaluated.
    Results: In the severe model, omadacycline-treated mice had 60% survival versus 13.3% with vancomycin (hazard ratio [HR], 0.327; 95% confidence interval [CI],.126-.848; P = .015) along with decreased weight loss, and disease severity. In the nonsevere model, all mice survived with antibiotic-germinant treatment versus 60% antibiotics alone (HR, 0.109; 95% CI, .02-.410; P = .001). Omadacycline resulted in less changes in bile acids and microbiota composition. Germinant-treated mice showed no signs of rCDI, spore shedding, or significant toxin production at 15 days.
    Conclusions: In murine models of CDI, omadacycline improved survival versus vancomycin. Germinant-antibiotic combinations were more effective at preventing rCDI compared to antibiotics alone without inducing toxin production.
    MeSH term(s) Animals ; Mice ; Vancomycin/therapeutic use ; Clostridioides ; Clostridioides difficile ; Disease Models, Animal ; Anti-Bacterial Agents/therapeutic use ; Recurrence ; Clostridium Infections/therapy ; Bile Acids and Salts ; Weight Loss
    Chemical Substances Vancomycin (6Q205EH1VU) ; omadacycline (090IP5RV8F) ; Anti-Bacterial Agents ; Bile Acids and Salts
    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiac324
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh II Zs.50: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 445: Show issues

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  3. Article ; Online: Omadacycline compared to vancomycin when combined with germinants to disrupt the life cycle of

    Budi, Noah / Godfrey, Jared J / Safdar, Nasia / Shukla, Sanjay K / Rose, Warren E

    Antimicrobial agents and chemotherapy

    2021  Volume 65, Issue 5

    Abstract: Clostridioides ... ...

    Abstract Clostridioides difficile
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01431-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Einzelsignatur: Show issues

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  4. Article ; Online: Association of variants in selected genes mediating host immune response with duration of Staphylococcus aureus bacteremia.

    Carter, Tonia C / Ye, Zhan / Ivacic, Lynn C / Budi, Noah / Rose, Warren E / Shukla, Sanjay K

    Genes and immunity

    2020  Volume 21, Issue 4, Page(s) 240–248

    Abstract: Host genetic variation may be a contributing factor to variability in Staphylococcus aureus bacteremia duration. We assessed whether 28 single nucleotide polymorphisms (SNPs) in seven genes (TLR2, TLR4, TIRAP, IRAK4, TRAF6, NOD2, and CISH) that mediate ... ...

    Abstract Host genetic variation may be a contributing factor to variability in Staphylococcus aureus bacteremia duration. We assessed whether 28 single nucleotide polymorphisms (SNPs) in seven genes (TLR2, TLR4, TIRAP, IRAK4, TRAF6, NOD2, and CISH) that mediate host immune response were associated with S. aureus bacteremia duration. Subjects included 158 patients with short-term (≤4 days) and 44 with persistent (>4 days) S. aureus bacteremia from an academic medical center. In single SNP analyses, the minor allele frequencies of three TIRAP SNPs (rs655540, rs563011, and rs8177376) were higher in persistent bacteremia (P < 0.05). A haplotype with all three minor alleles was also associated with persistent bacteremia (P = 0.037). The minor allele frequencies of four other TIRAP SNPs (rs8177342, rs4937114, rs3802813, and rs4937115) were higher in short-term bacteremia (P < 0.05), and a haplotype containing the four minor alleles was associated with short-term bacteremia (P = 0.045). All seven SNPs are located in binding sites for proteins or noncoding RNAs that regulate transcription. None of the associations remained statistically significant after adjustment for multiple comparisons. Further investigation is needed to understand how genetic variation in TIRAP and other host immune genes may influence the duration of S. aureus bacteremia.
    MeSH term(s) Alleles ; Bacteremia/genetics ; Bacteremia/immunology ; Genetic Predisposition to Disease ; Genotyping Techniques ; Host-Pathogen Interactions ; Humans ; Immunity ; Polymorphism, Single Nucleotide ; Staphylococcal Infections/genetics ; Staphylococcal Infections/immunology ; Staphylococcus aureus
    Language English
    Publishing date 2020-06-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2060566-3
    ISSN 1476-5470 ; 1466-4879
    ISSN (online) 1476-5470
    ISSN 1466-4879
    DOI 10.1038/s41435-020-0101-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5592: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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