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  1. Article ; Online: Outcome of the randomized control screening trials on oral, cervix and breast cancer from India and way forward in COVID-19 pandemic situation.

    Budukh, Atul M / Dikshit, Rajesh / Chaturvedi, Pankaj

    International journal of cancer

    2021  Volume 149, Issue 8, Page(s) 1619–1620

    MeSH term(s) Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/virology ; Early Detection of Cancer/statistics & numerical data ; Female ; Humans ; India/epidemiology ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/epidemiology ; Prognosis ; Randomized Controlled Trials as Topic/methods ; SARS-CoV-2/isolation & purification ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/epidemiology
    Language English
    Publishing date 2021-06-30
    Publishing country United States
    Document type Letter
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.33712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cancer pattern in Varanasi district from Uttar Pradesh state of India, a foundation for cancer control based on the first report of the population-based cancer registry.

    Budukh, Atul M / Pradhan, Satyajit / Singh, Virendra B / Khanna, Divya / Bagal, Sonali S / Chakravarti, Priyal S / Sharma, Anand N / Vishwakarma, Rajesh K / Shinde, Shraddha S / Khargekar, Naveen C / Chaturvedi, Pankaj / Dikshit, Rajesh P / Shukla, Vijay K / Badwe, Rajendra A

    Indian journal of cancer

    2023  

    Abstract: Background: The cancer registry provides reliable data from the population. In this article, we provide cancer burden and its patterns from the Varanasi district.: Methods: The method adopted by the Varanasi cancer registry is community interaction ... ...

    Abstract Background: The cancer registry provides reliable data from the population. In this article, we provide cancer burden and its patterns from the Varanasi district.
    Methods: The method adopted by the Varanasi cancer registry is community interaction along with regular visits to more than 60 sources to collect data on cancer patients. The cancer registry was established by the Tata Memorial Centre, Mumbai, in 2017 covering 4 million population (57% rural and 43% urban population).
    Results: The registry has recorded 1,907 incidence cases (1,058 male and 849 female). The age-adjusted incidence rate per 100,000 population in male and female of Varanasi district is 59.2 and 52.1, respectively. One in 15 male and one in 17 female are at risk of developing the disease. Mouth and tongue cancers are the predominant cancers in male, whereas breast, cervix uteri, and gallbladder are the leading cancer sites among the female. In female, cervix uteri cancer is significantly higher (double) in rural areas when compared with urban areas (rate ratio [RR] 0.5, 95% confidence interval [CI; 0.36, 0.72]), whereas in male, mouth cancer is higher in urban areas when compared with rural areas (RR 1.4, 95% CI [1.11, 1.72]). More than 50% of cancer cases in male are due to tobacco consumption. There may be underreporting of the cases.
    Conclusion: The results of the registry warrant policies and activities related to early detection services for the mouth, cervix uteri, and breast cancers. The Varanasi cancer registry is the foundation for cancer control and will play an important role in the evaluation of the interventions.
    Language English
    Publishing date 2023-02-27
    Publishing country India
    Document type Journal Article
    ZDB-ID 410194-7
    ISSN 1998-4774 ; 0019-509X
    ISSN (online) 1998-4774
    ISSN 0019-509X
    DOI 10.4103/ijc.IJC_44_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Determinants of completion of cancer directed treatment: an experience from a rural cancer centre, Sangrur, Punjab state, India.

    Budukh, Atul M / Chaudhary, Debashish / Sancheti, Sankalp / Dora, Tapas / Goel, Alok Kumar / Singla, Anshul / Sali, Akash / Shinde, Shraddha / Chauhan, Kuldeep Singh / Kadam, Prithviraj / Mohammad, Raza / Kapoor, Rakesh / Chaturvedi, Pankaj / Dikshit, Rajesh P / Badwe, Rajendra A

    Ecancermedicalscience

    2021  Volume 15, Page(s) 1313

    Abstract: In low and middle-income countries, access to cancer diagnosis and treatment is suboptimal. Further, compliance to cancer treatment is a major issue due to various reasons including financial barriers, lack of family support and fear of treatment. This ... ...

    Abstract In low and middle-income countries, access to cancer diagnosis and treatment is suboptimal. Further, compliance to cancer treatment is a major issue due to various reasons including financial barriers, lack of family support and fear of treatment. This article discusses the determinants of treatment completion in cancer patients of a government-run hospital, in a rural part of Punjab in India. The Sangrur hospital-based cancer registry data for the year 2018 have been used. We have registered 2,969 cancer cases, out of which 2,528 (85%) cases were eligible for the analysis. Of the total 2,528 cases, 1,362 (54%) cases completed the cancer directed treatment and 1,166 (46%) did not. The data have been collected from the electronic medical record (EMR) department and entered into
    Language English
    Publishing date 2021-11-01
    Publishing country England
    Document type Journal Article
    ISSN 1754-6605
    ISSN 1754-6605
    DOI 10.3332/ecancer.2021.1313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prevalence of tobacco use and tobacco-dependent cancers in males in the Rural Cancer Registry population at Barshi, India.

    Thorat, Ranjit V / Panse, Nandkumar S / Budukh, Atul M / Dinshaw, Ketayun A / Nene, Bhagwan M / Jayant, Kasturi

    Asian Pacific journal of cancer prevention : APJCP

    2009  Volume 10, Issue 6, Page(s) 1167–1170

    Abstract: Background: In the Rural Cancer Registry at Barshi (western Maharashtra, India), it has been found that the incidence of cancer is relatively low.: Aim: To explain the low incidence of tobacco related cancers in males on the basis of prevalence of ... ...

    Abstract Background: In the Rural Cancer Registry at Barshi (western Maharashtra, India), it has been found that the incidence of cancer is relatively low.
    Aim: To explain the low incidence of tobacco related cancers in males on the basis of prevalence of their tobacco habits.
    Setting and design: Simple random sample of villages from Barshi Rural Cancer Registry.
    Material and methods: A tobacco survey was carried out in 5,319 adult males. Site specific incidence data for Barshi and Mumbai Cancer Registries were available from published reports in the National Cancer Registry Programme. Published report of prevalence of tobacco habits in Mumbai males was available.
    Results: The tobacco survey showed that the prevalence of smoking compared to Mumbai was low (9.9% vs 23.6%) and the incidence of smoking dependent cancers viz., cancers of oropharynx, larynx and lung were significantly low (P< 0.05). However, although the proportion of tobacco chewers is higher in Barshi compared to Mumbai, the incidence rates for cancer of hypopharynx and oral cancer which are predominantly chewing dependent did not show higher rate than in Mumbai.
    Conclusions: The low incidence of smoking dependent cancers in males can be explained by the low prevalence of smoking habit but further studies are needed to explain the observed incidence of predominantly chewing dependent cancers.
    MeSH term(s) Adolescent ; Adult ; Chi-Square Distribution ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/etiology ; Humans ; Incidence ; India/epidemiology ; Lung Neoplasms/epidemiology ; Lung Neoplasms/etiology ; Male ; Middle Aged ; Mouth Neoplasms/epidemiology ; Mouth Neoplasms/etiology ; Prevalence ; Registries ; Risk Factors ; Rural Population ; Tobacco Use Disorder/complications ; Tobacco Use Disorder/epidemiology
    Language English
    Publishing date 2009
    Publishing country Thailand
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2476-762X
    ISSN (online) 2476-762X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: HPV screening for cervical cancer in rural India.

    Sankaranarayanan, Rengaswamy / Nene, Bhagwan M / Shastri, Surendra S / Jayant, Kasturi / Muwonge, Richard / Budukh, Atul M / Hingmire, Sanjay / Malvi, Sylla G / Thorat, Ranjit / Kothari, Ashok / Chinoy, Roshan / Kelkar, Rohini / Kane, Shubhada / Desai, Sangeetha / Keskar, Vijay R / Rajeshwarkar, Raghevendra / Panse, Nandkumar / Dinshaw, Ketayun A

    The New England journal of medicine

    2009  Volume 360, Issue 14, Page(s) 1385–1394

    Abstract: Background: In October 1999, we began to measure the effect of a single round of screening by testing for human papillomavirus (HPV), cytologic testing, or visual inspection of the cervix with acetic acid (VIA) on the incidence of cervical cancer and ... ...

    Abstract Background: In October 1999, we began to measure the effect of a single round of screening by testing for human papillomavirus (HPV), cytologic testing, or visual inspection of the cervix with acetic acid (VIA) on the incidence of cervical cancer and the associated rates of death in the Osmanabad district in India.
    Methods: In this cluster-randomized trial, 52 clusters of villages, with a total of 131,746 healthy women between the ages of 30 and 59 years, were randomly assigned to four groups of 13 clusters each. The groups were randomly assigned to undergo screening by HPV testing (34,126 women), cytologic testing (32,058), or VIA (34,074) or to receive standard care (31,488, control group). Women who had positive results on screening underwent colposcopy and directed biopsies, and those with cervical precancerous lesions or cancer received appropriate treatment.
    Results: In the HPV-testing group, cervical cancer was diagnosed in 127 subjects (of whom 39 had stage II or higher), as compared with 118 subjects (of whom 82 had advanced disease) in the control group (hazard ratio for the detection of advanced cancer in the HPV-testing group, 0.47; 95% confidence interval [CI], 0.32 to 0.69). There were 34 deaths from cancer in the HPV-testing group, as compared with 64 in the control group (hazard ratio, 0.52; 95% CI, 0.33 to 0.83). No significant reductions in the numbers of advanced cancers or deaths were observed in the cytologic-testing group or in the VIA group, as compared with the control group. Mild adverse events were reported in 0.1% of screened women.
    Conclusions: In a low-resource setting, a single round of HPV testing was associated with a significant reduction in the numbers of advanced cervical cancers and deaths from cervical cancer.
    MeSH term(s) Acetic Acid ; Adult ; Biopsy ; Cervical Intraepithelial Neoplasia/diagnosis ; Cervical Intraepithelial Neoplasia/epidemiology ; Cervical Intraepithelial Neoplasia/virology ; Colposcopy ; Cytological Techniques ; Female ; Humans ; Incidence ; India ; Mass Screening/methods ; Middle Aged ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/diagnosis ; Predictive Value of Tests ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/mortality ; Uterine Cervical Neoplasms/virology
    Chemical Substances Acetic Acid (Q40Q9N063P)
    Language English
    Publishing date 2009-04-02
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa0808516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Screening for cervical cancer in India: How much will it cost? A trial based analysis of the cost per case detected.

    Legood, Rosa / Gray, Alastair M / Mahé, Cedric / Wolstenholme, Jane / Jayant, Kasturi / Nene, Bhagwan M / Shastri, Surendra S / Malvi, Sylla G / Muwonge, Richard / Budukh, Atul M / Sankaranarayanan, Rengaswamy

    International journal of cancer

    2005  Volume 117, Issue 6, Page(s) 981–987

    Abstract: The cost and cost effectiveness of screening previously unscreened women by VIA, cytology or HPV testing was investigated within a large cluster randomised trial involving 131,178 women in rural India. All resources involved in implementation, training, ... ...

    Abstract The cost and cost effectiveness of screening previously unscreened women by VIA, cytology or HPV testing was investigated within a large cluster randomised trial involving 131,178 women in rural India. All resources involved in implementation, training, management, recruitment, screening and diagnosis were identified and costed. We estimated the total costs and detection rates for each cluster and used these data to calculate an average cluster cost and detection rate for each screening approach. These estimates were combined to estimate a cost per case of cervical intraepithelial neoplasia grade 2/3 or invasive cancer (CIN 2/3+) detected. The average total costs per 1,000 women eligible for screening were US dollar 3,917, US dollar 6,609 and US dollar 11,779 with VIA, cytology and HPV respectively. The cost of detecting a case of CIN2/3+ using VIA was dollar 522 (95% CI dollar 429- dollar 652). Our results suggest that more CIN2/3+ cases would be detected in the same population if cytology were used instead of VIA and each additional case would cost US dollar 1065 (95% CI dollar 713- dollar2175). Delivering cervical cancer screening is potentially expensive in a low-income country although costs might be lower outside a trial setting. We found screening with VIA to be the least expensive option, but it also detected fewer cases of CIN2/3+ than other methods; its long-term cost-effectiveness will depend on the long-term benefits of early detection. Cytology was more effective at detecting cases than VIA but was also more expensive. Our findings indicate that HPV may not be a cost effective screening strategy in India at current consumable prices.
    MeSH term(s) Adult ; Biopsy ; Cervical Intraepithelial Neoplasia/diagnosis ; Cervix Uteri/virology ; Colposcopy/economics ; Cost-Benefit Analysis ; Costs and Cost Analysis ; Cytodiagnosis/economics ; Female ; Humans ; India ; Laboratories/economics ; Mass Screening/economics ; Middle Aged ; Papillomaviridae/isolation & purification ; Rural Population ; Uterine Cervical Neoplasms/diagnosis
    Language English
    Publishing date 2005-12-20
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.21220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A cluster randomized controlled trial of visual, cytology and human papillomavirus screening for cancer of the cervix in rural India.

    Sankaranarayanan, Rengaswamy / Nene, Bhagwan M / Dinshaw, Ketayun A / Mahe, Cedric / Jayant, Kasturi / Shastri, Surendra S / Malvi, Sylla G / Chinoy, Roshini / Kelkar, Rohini / Budukh, Atul M / Keskar, Vijay / Rajeshwarker, Raghevendra / Muwonge, Richard / Kane, Shubhada / Parkin, Donald Maxwell / Chauhan, Madanmohan K / Desai, Sangeetha / Fontaniere, Bernard / Frappart, Lucien /
    Kothari, Ashok / Lucas, Eric / Panse, Nandkumar

    International journal of cancer

    2005  Volume 116, Issue 4, Page(s) 617–623

    Abstract: The impact of screening by visual inspection with acetic acid (VIA), cytology or HPV testing on cervical cancer incidence and mortality is investigated in a cluster randomized controlled trial in India. We report findings after the screening phase, when ... ...

    Abstract The impact of screening by visual inspection with acetic acid (VIA), cytology or HPV testing on cervical cancer incidence and mortality is investigated in a cluster randomized controlled trial in India. We report findings after the screening phase, when 52 clusters, with a total of 142,701 women aged 30-59 years in Osmanabad District, India, were randomized into 4 arms for a single round of screening by trained midwives with either VIA, cytology or HPV testing as well as a control group. All laboratory tests were done locally. Test-positive women underwent investigations (colposcopy/biopsy) and treatment in the base hospital. Data on participation, test positivity, positive predictive value and detection rates of cervical neoplasia were analyzed using cluster design methodology. Of the eligible women, 72-74% were screened. Test positivity rates were 14.0% for VIA, 7.0% for cytology and 10.3% for HPV. The detection rate of high-grade lesions was similar in all intervention arms (0.7% for VIA, 1.0% for cytology and 0.9% for HPV testing) (p = 0.06, Mann-Whitney test). While the detection rate for VIA dropped to 0.5% with declining test positivity during the course of the study, it remained constant for cytology and HPV testing. Over 85% of women with high-grade lesions received treatment. Our results show that a high level of participation and good-quality cytology can be achieved in low-resource settings. VIA is a useful alternative but requires careful monitoring. Detection rates obtained by HPV testing were similar to cytology, despite higher investments.
    MeSH term(s) Acetic Acid ; Adult ; Cost Control ; Cytological Techniques/economics ; DNA, Viral/analysis ; Female ; Humans ; India ; Mass Screening/economics ; Mass Screening/methods ; Middle Aged ; Patient Participation ; Predictive Value of Tests ; Reproducibility of Results ; Rural Population ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/virology
    Chemical Substances DNA, Viral ; Acetic Acid (Q40Q9N063P)
    Language English
    Publishing date 2005-09-10
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.21050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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