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  1. AU="Buehler, Nicholas J"
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  1. Artikel ; Online: An Update: National Institutes of Health Research Funding for Palliative Medicine 2016-2020.

    Buehler, Nicholas J / Frydman, Julia L / Morrison, R Sean / Gelfman, Laura P

    Journal of palliative medicine

    2022  Band 26, Heft 4, Seite(n) 509–516

    Abstract: Background: ...

    Abstract Background:
    Mesh-Begriff(e) United States ; Humans ; Palliative Medicine ; Biomedical Research ; Palliative Care ; Financing, Organized ; National Institutes of Health (U.S.)
    Sprache Englisch
    Erscheinungsdatum 2022-10-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2022.0316
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 5440: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Artikel: A sentiment analysis on online psychiatrist reviews to identify clinical attributes of psychiatrists that shape the therapeutic alliance.

    Park, Soo Hwan / Cheng, Christopher P / Buehler, Nicholas J / Sanford, Timothy / Torrey, William

    Frontiers in psychiatry

    2023  Band 14, Seite(n) 1174154

    Abstract: Background: While online reviews from physician rating websites are increasingly utilized by healthcare providers to better understand patient needs, it remains difficult to objectively identify areas for improvement in providing psychiatric care.: ... ...

    Abstract Background: While online reviews from physician rating websites are increasingly utilized by healthcare providers to better understand patient needs, it remains difficult to objectively identify areas for improvement in providing psychiatric care.
    Objectives: To quantitatively characterize the sentiment of online written reviews of psychiatrists to determine clinical attributes that can be strengthened to improve psychiatrists' therapeutic alliance with their patients.
    Materials and methods: Sentiment scores of 6,400 written reviews of 400 US-based psychiatrists on a US-based online physician rating website were obtained through a natural-language-processing-based sentiment analysis. Relationships among sentiment scores, average star ratings, and demographics were examined. Linguistic analyses determined words and bigrams that were highly associated with reviews with the most positive and negative sentiment.
    Findings: Sentiment scores were significantly correlated with average star ratings of the psychiatrists (
    Conclusion: Psychiatrists who are younger and located in the Northeast receive more positive reviews; there may be potential for demographic bias among patient reviewers. Patients positively rate psychiatrists who make them feel heard and comfortable but negatively rate encounters centered around medications and their side effects. Our study lends quantitative evidence to support the importance of thorough and empathetic communication of psychiatrists in building a strong therapeutic alliance.
    Sprache Englisch
    Erscheinungsdatum 2023-06-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1174154
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Fanconi anemia-independent DNA inter-strand crosslink repair in eukaryotes.

    Rogers, Cody M / Simmons Iii, Robert H / Fluhler Thornburg, Gabriella E / Buehler, Nicholas J / Bochman, Matthew L

    Progress in biophysics and molecular biology

    2020  Band 158, Seite(n) 33–46

    Abstract: DNA inter-strand crosslinks (ICLs) are dangerous lesions that can be caused by a variety of endogenous and exogenous bifunctional compounds. Because covalently linking both strands of the double helix locally disrupts DNA replication and transcription, ... ...

    Abstract DNA inter-strand crosslinks (ICLs) are dangerous lesions that can be caused by a variety of endogenous and exogenous bifunctional compounds. Because covalently linking both strands of the double helix locally disrupts DNA replication and transcription, failure to remove even a single ICL can be fatal to the cell. Thus, multiple ICL repair pathways have evolved, with the best studied being the canonical Fanconi anemia (FA) pathway. However, recent research demonstrates that different types of ICLs (e.g., backbone distorting vs. non-distorting) can be discriminated by the cell, which then mounts a specific repair response using the FA pathway or one of a variety of FA-independent ICL repair pathways. This review focuses on the latter, covering current work on the transcription-coupled, base excision, acetaldehyde-induced, and SNM1A/RecQ4 ICL repair pathways and highlighting unanswered questions in the field. Answering these questions will provide mechanistic insight into the various pathways of ICL repair and enable ICL-inducing agents to be more effectively used as chemotherapeutics.
    Mesh-Begriff(e) Acetaldehyde/chemistry ; Animals ; Antineoplastic Agents/pharmacology ; Chemistry, Pharmaceutical/methods ; Cross-Linking Reagents/chemistry ; DNA/chemistry ; DNA/genetics ; DNA Damage ; DNA Repair ; DNA Replication ; DNA-Binding Proteins/metabolism ; Endodeoxyribonucleases/genetics ; Fanconi Anemia/genetics ; Fanconi Anemia/metabolism ; Humans ; Mice ; Mutagenesis ; Neoplasms/genetics ; Neoplasms/pathology ; Signal Transduction/genetics ; Transcription, Genetic
    Chemische Substanzen Antineoplastic Agents ; Cross-Linking Reagents ; DNA-Binding Proteins ; DNA (9007-49-2) ; Endodeoxyribonucleases (EC 3.1.-) ; Acetaldehyde (GO1N1ZPR3B)
    Sprache Englisch
    Erscheinungsdatum 2020-08-30
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 209302-9
    ISSN 1873-1732 ; 0079-6107
    ISSN (online) 1873-1732
    ISSN 0079-6107
    DOI 10.1016/j.pbiomolbio.2020.08.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: The yeast Hrq1 helicase stimulates Pso2 translesion nuclease activity and thereby promotes DNA interstrand crosslink repair.

    Rogers, Cody M / Lee, Chun-Ying / Parkins, Samuel / Buehler, Nicholas J / Wenzel, Sabine / Martínez-Márquez, Francisco / Takagi, Yuichiro / Myong, Sua / Bochman, Matthew L

    The Journal of biological chemistry

    2020  Band 295, Heft 27, Seite(n) 8945–8957

    Abstract: DNA interstrand crosslink (ICL) repair requires a complex network of DNA damage response pathways. Removal of the ICL lesions is vital, as they are physical barriers to essential DNA processes that require the separation of duplex DNA, such as ... ...

    Abstract DNA interstrand crosslink (ICL) repair requires a complex network of DNA damage response pathways. Removal of the ICL lesions is vital, as they are physical barriers to essential DNA processes that require the separation of duplex DNA, such as replication and transcription. The Fanconi anemia (FA) pathway is the principal mechanism for ICL repair in metazoans and is coupled to DNA replication. In
    Mesh-Begriff(e) DNA/metabolism ; DNA Damage/physiology ; DNA Repair/physiology ; DNA-Binding Proteins/metabolism ; Endodeoxyribonucleases/metabolism ; RecQ Helicases/metabolism ; RecQ Helicases/physiology ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Saccharomyces cerevisiae Proteins/physiology
    Chemische Substanzen DNA-Binding Proteins ; Saccharomyces cerevisiae Proteins ; DNA (9007-49-2) ; Endodeoxyribonucleases (EC 3.1.-) ; PSO2 protein, S cerevisiae (EC 3.1.-) ; Hrq1 protein, S cerevisiae (EC 3.6.1.-) ; RECQL4 protein, human (EC 3.6.1.-) ; RecQ Helicases (EC 3.6.4.12)
    Sprache Englisch
    Erscheinungsdatum 2020-05-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.RA120.013626
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.108: Hefte anzeigen Standort:
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