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  1. Article ; Online: The impact of eye-tracking on patient safety in critical care.

    Hofmaenner, Daniel A / Buehler, Philipp K

    Journal of clinical monitoring and computing

    2022  Volume 36, Issue 6, Page(s) 1577–1579

    Abstract: Patient safety has become a high priority in health care. The recognition, prevention and reduction of human errors are crucial for patient care. Diverse approaches to analyze roots of errors exist, however they all bear relevant limitations. In contrast, ...

    Abstract Patient safety has become a high priority in health care. The recognition, prevention and reduction of human errors are crucial for patient care. Diverse approaches to analyze roots of errors exist, however they all bear relevant limitations. In contrast, the technology of eye-tracking offers objective and measurable parameters linked to eye movements, allowing temporal and spatial assessment of visual patterns. Diverse studies in critical care have proved the usefulness of eye-tracking to analyze real-life scenarios. These insights could contribute to increased patient safety.
    MeSH term(s) Humans ; Patient Safety ; Eye-Tracking Technology ; Eye Movements ; Critical Care
    Language English
    Publishing date 2022-04-19
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-022-00844-y
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  2. Article ; Online: Eye-tracking as a tool to evaluate defibrillator handling.

    Buehler, Philipp K / Wendel-Garcia, Pedro David / Hofmaenner, Daniel A

    Resuscitation plus

    2024  Volume 17, Page(s) 100566

    Language English
    Publishing date 2024-03-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-5204
    ISSN (online) 2666-5204
    DOI 10.1016/j.resplu.2024.100566
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  3. Article ; Online: Answer: How much surface can we debride with bromelain safely?

    Buehler, Philipp K / Hofmaenner, Daniel A

    Burns : journal of the International Society for Burn Injuries

    2021  Volume 47, Issue 7, Page(s) 1690

    MeSH term(s) Bromelains/therapeutic use ; Burns ; Humans
    Chemical Substances Bromelains (9001-00-7)
    Language English
    Publishing date 2021-05-04
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 197308-3
    ISSN 1879-1409 ; 0305-4179
    ISSN (online) 1879-1409
    ISSN 0305-4179
    DOI 10.1016/j.burns.2021.04.022
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  4. Article ; Online: Eye-tracking during newborn intubations.

    Buehler, Philipp K / Wendel-Garcia, Pedro David / Hofmaenner, Daniel A

    Pediatric research

    2023  Volume 94, Issue 2, Page(s) 418–419

    MeSH term(s) Infant, Newborn ; Humans ; Eye-Tracking Technology ; Intubation, Intratracheal
    Language English
    Publishing date 2023-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-02630-1
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  5. Article ; Online: High Positive End-Expiratory Pressure and Lung Recruitment in Moderate to Severe Acute Respiratory Distress Syndrome: Does One Size Really Fit All?

    Wendel-Garcia, Pedro D / Roche-Campo, Ferran / Buehler, Philipp K

    American journal of respiratory and critical care medicine

    2022  Volume 205, Issue 11, Page(s) 1260–1262

    MeSH term(s) Humans ; Lung ; Network Meta-Analysis ; Positive-Pressure Respiration ; Respiratory Distress Syndrome/therapy ; Thorax
    Language English
    Publishing date 2022-03-15
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202202-0281ED
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  6. Article ; Online: Effect of central venous pressure on fluid delivery during start-up of syringe infusion pumps for microinfusion.

    Weiss, Markus / Wendel-Garcia, Pedro David / Cannizzaro, Vincenzo / Buehler, Philipp K / Kleine-Brueggeney, Maren

    Paediatric anaesthesia

    2023  Volume 33, Issue 10, Page(s) 837–843

    Abstract: Background: Intravenous administration of highly concentrated and potent drugs at low flow rates is common practice, particularly in critically ill children. Drug delivery during infusion start-up can be considerably delayed by intrinsic factors of ... ...

    Abstract Background: Intravenous administration of highly concentrated and potent drugs at low flow rates is common practice, particularly in critically ill children. Drug delivery during infusion start-up can be considerably delayed by intrinsic factors of syringe infusion pump assemblies. The impact of central venous pressures on the course of start-up fluid delivery of such microinfusions remains unknown.
    Methods: Infusion volumes delivered after activation of the start button in a conventional 50 mL syringe infusion pump assembly equilibrated (representing classical in vitro testing) and not equilibrated (representing real clinical conditions) to central venous pressure levels of 0, 10 and 20 mmHg at a set infusion flow rate of 1 mL/h were measured using a fluidic flow sensor.
    Results: The experimental setup mimicking real life conditions demonstrated considerable differences in fluid delivery during pump start-up depending on central venous pressure. A central venous pressure of 0 mmHg resulted in massive fluid delivery at infusion start-up, while central venous pressure levels of 10 and 20 mmHg resulted in retrograde flows with related mean (95% CI) zero-drug delivery times of 3.22 (2.98-3.46) min and 4.51 (4.33-4.69) min, respectively (p < .0001).
    Conclusion: Depending on central venous pressure level, connection and starting a new syringe pump can result in significant antegrade or retrograde fluid volumes. In clinical practice, this can lead to hemodynamic instability and hence requires clinical alertness. Further research and methods to improve start-up performance in syringe infusion pump systems are desirable.
    MeSH term(s) Child ; Humans ; Central Venous Pressure ; Pharmaceutical Preparations ; Infusion Pumps ; Infusions, Intravenous
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2023-07-05
    Publishing country France
    Document type Journal Article
    ZDB-ID 1086049-6
    ISSN 1460-9592 ; 1155-5645
    ISSN (online) 1460-9592
    ISSN 1155-5645
    DOI 10.1111/pan.14717
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  7. Article: Severe Toxic Epidermal Necrolysis and Drug Reaction with Eosinophilia and Systemic Symptoms Overlap Syndrome Treated with Benralizumab: A Case Report.

    Zeller, Felix K / Bader, Patrick R / Nägeli, Mirjam C / Buehler, Philipp K / Schuepbach, Reto A

    Case reports in dermatology

    2022  Volume 14, Issue 2, Page(s) 203–209

    Abstract: TEN/DRESS overlap syndrome can be difficult to diagnose, especially if it is masked by comorbidities in critically ill patients in intensive care units. The existing therapy for the two conditions is also a major challenge for the treating team. A ... ...

    Abstract TEN/DRESS overlap syndrome can be difficult to diagnose, especially if it is masked by comorbidities in critically ill patients in intensive care units. The existing therapy for the two conditions is also a major challenge for the treating team. A possible alternative, especially for refractory cases, is benralizumab as an IL-5-receptor alpha-chain-specific humanized monoclonal antibody (IgG1k). We are able to show a successful treatment in this case report.
    Language English
    Publishing date 2022-07-14
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2505300-0
    ISSN 1662-6567
    ISSN 1662-6567
    DOI 10.1159/000525752
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  8. Article ; Online: Cuffed endotracheal tubes in neonates and infants of less than 3 kg body weight-A retrospective audit.

    Zander, Désirée / Grass, Beate / Weiss, Markus / Buehler, Philipp K / Schmitz, Achim

    Paediatric anaesthesia

    2021  Volume 31, Issue 5, Page(s) 604–610

    Abstract: Background: Large prospective clinical studies have shown that modern cuffed pediatric tracheal tubes can be used safely, even in children weighing ≥3 kg. There is a growing interest in their use in children weighing <3 kg so that they, too, can benefit ...

    Abstract Background: Large prospective clinical studies have shown that modern cuffed pediatric tracheal tubes can be used safely, even in children weighing ≥3 kg. There is a growing interest in their use in children weighing <3 kg so that they, too, can benefit from the potential advantages, particularly the high probability of these tubes fitting into and sealing the pediatric airway at the first intubation attempt. This study aimed to find a cut-off body weight for procedures requiring a cuffed tracheal tube to seal the airway in children weighing <3 kg and to evaluate the frequency and predictive factors for the requirement to place a cuffed instead of an uncuffed tracheal tube.
    Methods: This study was a retrospective analysis of 269 children weighing 2000-2999 g, primarily intubated by pediatric anesthetists. Frequency of intubation with uncuffed Sheridan tubes versus cuffed Microcuff
    Results: The 149 (55.4%) children were finally intubated with a cuffed tracheal tube. Logistic regression demonstrated that body weight at tracheal intubation and birth weight were the strongest predictors for the appropriateness of cuffed/uncuffed tracheal tubes. The threshold weight at tracheal intubation was 2700 g for a probability >50% of using a cuffed tracheal tube.
    Conclusion: Half of the children weighing 2000-2999 g received a Microcuff
    MeSH term(s) Body Weight ; Child ; Equipment Design ; Humans ; Infant ; Infant, Newborn ; Intubation, Intratracheal ; Prospective Studies ; Retrospective Studies
    Language English
    Publishing date 2021-03-16
    Publishing country France
    Document type Journal Article
    ZDB-ID 1086049-6
    ISSN 1460-9592 ; 1155-5645
    ISSN (online) 1460-9592
    ISSN 1155-5645
    DOI 10.1111/pan.14104
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  9. Article ; Online: Indications and contraindications for extracorporeal life support for severe heart or lung failure: a systematic review.

    Brandi, Giovanna / Drewniak, Daniel / Buehler, Philipp K / Budilivschi, Ana / Steiger, Peter / Krones, Tanja

    Minerva anestesiologica

    2020  Volume 87, Issue 2, Page(s) 199–209

    Abstract: Introduction: The effectiveness of extracorporeal life support (ECLS) in critically ill patients remains unclear despite a substantial increase in its use. This study critically assesses existing ECLS guidelines, consensus statements, and position ... ...

    Abstract Introduction: The effectiveness of extracorporeal life support (ECLS) in critically ill patients remains unclear despite a substantial increase in its use. This study critically assesses existing ECLS guidelines, consensus statements, and position papers to systematically review them for agreements and differences regarding indications and contraindications for ECLS.
    Evidence acquisition: The aims of this review were to identify available indications and contraindications for ECLS and to evaluate the quality of the evidence on which they are based. Documents containing recommendations regarding indications and/or contraindications for ECLS in adults (aged 18+) were identified through Medline, EMBASE, and CENTRAL searches. Additional documents were identified from guideline-specific databases and the internet websites of professional societies. Based on the Appraisal of Guidelines for Research and Evaluation (AGREE II), four independent reviewers assessed the rigor of development and quality of the documents.
    Evidence synthesis: Eleven documents met the inclusion criteria. Three documents received an average score of ≥50% in all domains. However, the Editorial independence domain only scored <50% in most of the documents. Overall, 13 cardiac and 13 pulmonary ECLS indications, and 23 cardiac and 14 pulmonary contraindications were identified. Indications and contraindications for ECLS use are variable across the documents included and leave considerable room for interpretation.
    Conclusions: The documents included for review show considerable variability, with little consensus on indications and contraindications. This lack of consensus may reflect a lack of clarity regarding ECLS utility. Additionally, it may reveal the necessity for individualized, patient-dependent criteria supported by the best evidence available.
    MeSH term(s) Adult ; Consensus ; Contraindications ; Extracorporeal Membrane Oxygenation ; Humans ; Lung ; Respiratory Insufficiency
    Language English
    Publishing date 2020-08-04
    Publishing country Italy
    Document type Journal Article ; Systematic Review
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.20.14513-9
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    Zs.MO 192: Show issues

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  10. Article ; Online: Simulated dimensional compatibility of uncuffed and cuffed tracheal tubes for selective endobronchial intubation in children.

    Moser, Berthold / Kemper, Michael / Dullenkopf, Alexander / Dave, Mital H / Buehler, Philipp K / Weiss, Markus

    Paediatric anaesthesia

    2020  Volume 31, Issue 2, Page(s) 167–177

    Abstract: Background: Cuffed tracheal tubes have recently been recommended for selective endobronchial intubation to establish single-lung ventilation even in smaller children. This implies that, compared with uncuffed tracheal tubes, the cuffed tracheal tubes ... ...

    Abstract Background: Cuffed tracheal tubes have recently been recommended for selective endobronchial intubation to establish single-lung ventilation even in smaller children. This implies that, compared with uncuffed tracheal tubes, the cuffed tracheal tubes selected will be smaller and therefore have a shorter length. We hypothesized that cuffed tracheal tubes might be of insufficient length for selective endobronchial intubation if the tube cuff were fully immersed in the left or right mainstem bronchus.
    Methods: The distance from the proximal end of the tracheal tube to the upper border of the cuff in cuffed tracheal tubes and to the upper margin of the Murphy eye in uncuffed tracheal tubes, respectively, was assessed in sizes 3.0-7.0 mm internal diameter. The raw data sets of two previously performed studies obtained from 337 children aged from birth to 16 years, including the distances "teeth to tracheal tube tip" and "tracheal tube tip to carina," were used to calculate age-, weight-, and height-related data for the distance from "teeth to carina." Tracheal tube dimensions were compared with age-related distances from "teeth to carina," applying published recommendations for the selection of uncuffed and cuffed tracheal tubes for selective endobronchial intubation in children.
    Results: The differences between the length of the age-related tracheal tube and the tracheal tube insertion length required to guarantee full insertion of the tracheal tube cuff or the Murphy eye within the mainstem bronchus ranged from -3.5 to 52.6 mm in cuffed tracheal tubes and from 42.3 to 83.3 mm in uncuffed tracheal tubes.
    Conclusions: For many age groups of patients requiring selective endobronchial intubation, the lengths of cuffed tracheal tubes, in contrast to those of uncuffed tracheal tubes, were revealed to be critically short for safe taping outside the oral cavity with the cuff placed completely within the right or left mainstem bronchus.
    MeSH term(s) Bronchi ; Child ; Equipment Design ; Humans ; Intubation, Intratracheal ; Respiration, Artificial ; Trachea
    Language English
    Publishing date 2020-11-17
    Publishing country France
    Document type Journal Article
    ZDB-ID 1086049-6
    ISSN 1460-9592 ; 1155-5645
    ISSN (online) 1460-9592
    ISSN 1155-5645
    DOI 10.1111/pan.14058
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