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  1. Article ; Online: The impact of colonialism on head and neck cancer in Brazil: a historical essay focussing on tobacco, alcohol and slavery.

    Figueiredo Lebre Martins, Beatriz Nascimento / Dos Santos, Erison Santana / Fonseca, Felipe Paiva / William, William Nassib / Bueno de Oliveira, Thiago / Marta, Gustavo Nader / Freitas Chaves, Aline Lauda / Prado-Ribeiro, Ana Carolina / Ayo-Yusuf, Olalekan / Curado, Maria Paula / Saes, Alexandre Macchione / Kowalski, Luiz Paulo / Santos-Silva, Alan Roger

    Lancet regional health. Americas

    2024  Volume 31, Page(s) 100690

    Abstract: Colonialism's enduring impact on Brazil has had significant implications for health and oncology outcomes. This historical essay delves into the profound changes brought about by the transatlantic slave trade from Africa to the Americas, particularly in ... ...

    Abstract Colonialism's enduring impact on Brazil has had significant implications for health and oncology outcomes. This historical essay delves into the profound changes brought about by the transatlantic slave trade from Africa to the Americas, particularly in terms of its influence on the economy, sociocultural habits, and health outcomes. This essay explores the enduring connections between the colonial period's operational dynamics in Brazil and the current epidemiological panorama of head and neck cancer (HNC). The examination provides original insights on the role of tobacco and alcohol production and consumption, alongside the investigation of structural racism, which contributes to disparities in access to diagnosis, treatment, and prognosis for patients with HNC. This article presents novel visions and an analysis of evidence-based strategies to disrupt the adverse impact of colonialism's legacy on the epidemiology of HNC in Brazil.
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2667-193X
    ISSN (online) 2667-193X
    DOI 10.1016/j.lana.2024.100690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prognostic impact and potential predictive role of baseline circulating tumor cells in locally advanced head and neck squamous cell carcinoma.

    Bueno de Oliveira, Thiago / Camila Braun, Alexcia / Ribaldo Nicolau, Ulisses / Ali Abdallah, Emne / da Silva Alves, Vanessa / Hugo Fonseca de Jesus, Victor / Fernando Calsavara, Vinicius / Paulo Kowaslki, Luiz / Domingos Chinen, Ludmilla T

    Oral oncology

    2021  Volume 121, Page(s) 105480

    Abstract: Objectives: The prognostic impact of circulating tumor cells (CTCs) or circulating tumor microemboli (CTM) in locally advanced head and neck squamous cell carcinoma (LA-HNSCC) is yet to be determined, with conflicting results in previous trials. The ... ...

    Abstract Objectives: The prognostic impact of circulating tumor cells (CTCs) or circulating tumor microemboli (CTM) in locally advanced head and neck squamous cell carcinoma (LA-HNSCC) is yet to be determined, with conflicting results in previous trials. The role of induction chemotherapy (ICT) in the management of LA-HNSCC is controversial with no predictive biomarkers to guide treatment strategy in this scenario. The aim of this trial is to determine the prognostic impact of CTCs and CTM, their biomarkers expression by immunocytochemistry (ICC), and its potential role as predictors of ICT benefit in LA-HNSCC.
    Materials and methods: Prospective study, with newly diagnosed stage III/IV non-metastatic LA-HNSCC patients treated with curative intent. Blood samples analyzed for CTCs and CTM before treatment using the ISET method.
    Results: A total of 83 patients were included. CTCs counts were an independent prognostic factor for overall survival (OS; HR: 1.17; 95 %CI: 1.05-1.31; p = 0.005) and progression free survival (PFS; HR:1.14; 95 %CI: 1.03-1.26; p = 0.007). Using the Lausen and Schumacher technique, 2.8 CTCs/mL for OS and 3.8 CTCs/mL for PFS were defined as the best cut-offs. CTM were detected in 27.7% of patients, correlating with worse PFS (HR = 2.70; IC95%: 1.30-5.58; p = 0.007). MRP-7 expression in CTM correlated with worse OS (HR = 3.49; 95 %CI: 1.01-12.04; p = 0.047) and PFS (HR = 3.62; 95 %CI: 1.08-12.13; p = 0.037). CTCs counts were predictive of complete response to treatment (OR = 0.74; 95 %CI: 0.58-0.95; p = 0.022) and high counts (cut-off 3.8/mL) and CTM were potential predictors of ICT benefit.
    Conclusion: CTCs/CTM had significant prognostic impact and potential role as predictors of ICT benefit in LA-HNSCC.
    MeSH term(s) Biomarkers, Tumor ; Head and Neck Neoplasms/therapy ; Humans ; Neoplastic Cells, Circulating ; Prognosis ; Prospective Studies ; Squamous Cell Carcinoma of Head and Neck/therapy
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2021-08-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2021.105480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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