Article ; Online: Transcription factor AP2 controls cnidarian germ cell induction.
2020 Volume 367, Issue 6479, Page(s) 757–762
Abstract: Clonal animals do not sequester a germ line during embryogenesis. Instead, they have adult stem cells that contribute to somatic tissues or gametes. How germ fate is induced in these animals, and whether this process is related to bilaterian embryonic ... ...
| Abstract | Clonal animals do not sequester a germ line during embryogenesis. Instead, they have adult stem cells that contribute to somatic tissues or gametes. How germ fate is induced in these animals, and whether this process is related to bilaterian embryonic germline induction, is unknown. We show that transcription factor AP2 (Tfap2), a regulator of mammalian germ lines, acts to commit adult stem cells, known as i-cells, to the germ cell fate in the clonal cnidarian |
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| MeSH term(s) | Adult Stem Cells/cytology ; Adult Stem Cells/metabolism ; Animals ; Female ; Gametogenesis/genetics ; Gametogenesis/physiology ; Gene Expression Regulation, Developmental ; Germ Cells/cytology ; Gonads/cytology ; Gonads/embryology ; Hydrozoa/cytology ; Hydrozoa/embryology ; Hydrozoa/genetics ; Male ; Transcription Factor AP-2/genetics ; Transcription Factor AP-2/physiology | ||||||||||
| Chemical Substances | Transcription Factor AP-2 | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2020-02-10 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 128410-1 | ||||||||||
| ISSN | 1095-9203 ; 0036-8075 | ||||||||||
| ISSN (online) | 1095-9203 | ||||||||||
| ISSN | 0036-8075 | ||||||||||
| DOI | 10.1126/science.aay6782 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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