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  1. Article: Biochemical "decoding" of breast ultrasound images with optoacoustic tomography fusion: First-in-human display of lipid and collagen signals on breast ultrasound.

    Goh, Yonggeng / Balasundaram, Ghayathri / Tan, Hui Min / Putti, Thomas Choudary / Tang, Siau Wei / Ng, Celene Wei Qi / Buhari, Shaik Ahmad / Fang, Eric / Moothanchery, Mohesh / Bi, Renzhe / Olivo, Malini / Quek, Swee Tian

    Photoacoustics

    2022  Volume 27, Page(s) 100377

    Abstract: To date, studies which utilized ultrasound (US) and optoacoustic tomography (OT) fusion (US-OT) in biochemical differentiation of malignant and benign breast conditions have relied on limited biochemical data such as oxyhaemoglobin (OH) and ... ...

    Abstract To date, studies which utilized ultrasound (US) and optoacoustic tomography (OT) fusion (US-OT) in biochemical differentiation of malignant and benign breast conditions have relied on limited biochemical data such as oxyhaemoglobin (OH) and deoxyhaemoglobin (DH) only. There has been no data of the largest biochemical components of breast fibroglandular tissue: lipid and collagen. Here, the authors believe the ability to image collagen and lipids within the breast tissue could serve as an important milestone in breast US-OT imaging with many potential downstream clinical applications. Hence, we would like to present the first-in-human US-OT demonstration of lipid and collagen differentiation in an excised breast tissue from a 38-year-old female.
    Language English
    Publishing date 2022-06-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2716706-9
    ISSN 2213-5979
    ISSN 2213-5979
    DOI 10.1016/j.pacs.2022.100377
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  2. Article: Photoacoustic Tomography Appearance of Fat Necrosis: A First-in-Human Demonstration of Biochemical Signatures along with Histological Correlation.

    Goh, Yonggeng / Balasundaram, Ghayathri / Tan, Hui Min / Putti, Thomas Choudary / Ng, Celene Wei Qi / Fang, Eric / Bi, Renzhe / Tang, Siau Wei / Buhari, Shaik Ahmad / Hartman, Mikael / Chan, Ching Wan / Lim, Yi Ting / Olivo, Malini / Quek, Swee Tian

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 10

    Abstract: A 50-year-old woman with no past medical history presented with a left anterior chest wall mass that was clinically soft, mobile, and non-tender. A targeted ultrasound (US) showed findings suggestive of a lipoma. However, focal "mass-like" nodules seen ... ...

    Abstract A 50-year-old woman with no past medical history presented with a left anterior chest wall mass that was clinically soft, mobile, and non-tender. A targeted ultrasound (US) showed findings suggestive of a lipoma. However, focal "mass-like" nodules seen within the inferior portion suggested malignant transformation of a lipomatous lesion called for cross sectional imaging, such as MRI or invasive biopsy or excision for histological confirmation. A T1-weighted image demonstrated a large lipoma that has a central fat-containing region surrounded by an irregular hypointense rim in the inferior portion, confirming the benignity of the lipoma. An ultrasound-guided photoacoustic imaging (PA) of the excised specimen to derive the biochemical distribution demonstrated the "mass-like" hypoechoic regions on US as fat-containing, suggestive of benignity of lesion, rather than fat-replacing suggestive of malignancy. The case showed the potential of PA as an adjunct to US in improving the diagnostic confidence in lesion characterization.
    Language English
    Publishing date 2022-10-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12102456
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  3. Article: Multi-catheter interstitial accelerated partial breast irradiation - tips and tricks for a good insertion.

    Tang, Johann I / Tan, Poh Wee / Koh, Vicky Yanling / Buhari, Shaik Ahmad

    Journal of contemporary brachytherapy

    2014  Volume 6, Issue 1, Page(s) 85–90

    Abstract: Adjuvant radiotherapy is recommended post breast conserving surgery. Accelerated Partial Breast Irradiation (APBI) offers a more attractive shorter course of treatment over 5 days compared to standard conventional external beam radiotherapy, which is ... ...

    Abstract Adjuvant radiotherapy is recommended post breast conserving surgery. Accelerated Partial Breast Irradiation (APBI) offers a more attractive shorter course of treatment over 5 days compared to standard conventional external beam radiotherapy, which is often protracted. Multi-catheter interstitial APBI offers excellent dosimetric coverage. This article describes two insertion techniques for multi-catheter interstitial APBI, the operator dependent freehand technique, and the easier to learn template technique. The indications, benefits, and drawbacks of these two techniques are discussed.
    Language English
    Publishing date 2014-02-19
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 2627721-9
    ISSN 2081-2841 ; 1689-832X
    ISSN (online) 2081-2841
    ISSN 1689-832X
    DOI 10.5114/jcb.2014.40767
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  4. Article ; Online: Impact of contrast-enhanced mammography in surgical management of breast cancers for women with dense breasts: a dual-center, multi-disciplinary study in Asia.

    Goh, Yonggeng / Chou, Chen-Pin / Chan, Ching Wan / Buhari, Shaik Ahmad / Hartman, Mikael / Tang, Siau Wei / Ng, Celene Wei Qi / Pillay, Premilla / Chua, Wynne / Jagmohan, Pooja / Sterling, Eide / Wong, Ying Mei / Tan, Loon Ying / Ong, Han Yang / Pan, Huay-Ben / Lee, Herng-Sheng / Hung, Bao-Hui / Quek, Swee Tian

    European radiology

    2022  Volume 32, Issue 12, Page(s) 8226–8237

    Abstract: Objective: To evaluate the impact of pre-operative contrast-enhanced mammography (CEM) in breast cancer patients with dense breasts.: Methods: We conducted a retrospective review of 232 histologically proven breast cancers in 200 women (mean age: 53 ... ...

    Abstract Objective: To evaluate the impact of pre-operative contrast-enhanced mammography (CEM) in breast cancer patients with dense breasts.
    Methods: We conducted a retrospective review of 232 histologically proven breast cancers in 200 women (mean age: 53.4 years ± 10.2) who underwent pre-surgical CEM imaging across two Asian institutions (Singapore and Taiwan). Majority (95.5%) of patients had dense breast tissue (BI-RADS category C or D). Surgical decision was recorded in a simulated blinded multi-disciplinary team setting on two separate scenarios: (i) pre-CEM setting with standard imaging, and clinical and histopathological results; and (ii) post-CEM setting with new imaging and corresponding histological findings from CEM. Alterations in surgical plan (if any) because of CEM imaging were recorded. Predictors CEM of patients who benefitted from surgical plan alterations were evaluated using logistic regression.
    Results: CEM resulted in altered surgical plans in 36 (18%) of 200 patients in this study. CEM discovered clinically significant larger tumor size or extent in 24 (12%) patients and additional tumors in 12 (6%) patients. CEM also detected additional benign/false-positive lesions in 13 (6.5%) of the 200 patients. Significant predictors of patients who benefitted from surgical alterations found on multivariate analysis were pre-CEM surgical decision for upfront breast conservation (OR, 7.7; 95% CI, 1.9-32.1; p = 0.005), architectural distortion on mammograms (OR, 7.6; 95% CI, 1.3-42.9; p = .022), and tumor size of ≥ 1.5 cm (OR, 1.5; 95% CI, 1.0-2.2; p = .034).
    Conclusion: CEM is an effective imaging technique for pre-surgical planning for Asian breast cancer patients with dense breasts.
    Key points: • CEM significantly altered surgical plans in 18% (nearly 1 in 5) of this Asian study cohort with dense breasts. • Significant patient and imaging predictors for surgical plan alteration include (i) patients considered for upfront breast-conserving surgery; (ii) architectural distortion lesions; and (iii) tumor size of ≥ 1.5 cm. • Additional false-positive/benign lesions detected through CEM were uncommon, affecting only 6.5% of the study cohort.
    MeSH term(s) Humans ; Female ; Middle Aged ; Mammography/methods ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Breast Density ; Breast/diagnostic imaging ; Breast/surgery ; Breast/pathology ; Retrospective Studies ; Sensitivity and Specificity
    Language English
    Publishing date 2022-07-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-022-08906-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3300: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article: Accelerated partial breast irradiation in an Asian population: dosimetric findings and preliminary results of a multicatheter interstitial program.

    Koh, Yaling Vicky / Tan, Poh Wee / Buhari, Shaik Ahmad / Iau, Philip / Chan, Ching Wan / Shen, Liang / Tan, Sing Huang / Tang, Johann I-Hsiung

    OncoTargets and therapy

    2016  Volume 9, Page(s) 5561–5566

    Abstract: Introduction: Accelerated partial breast irradiation (APBI) using the multicatheter method has excellent cosmesis and low rates of long-term toxicity. However, there are few studies looking at the feasibility of this procedure and the outcomes in an ... ...

    Abstract Introduction: Accelerated partial breast irradiation (APBI) using the multicatheter method has excellent cosmesis and low rates of long-term toxicity. However, there are few studies looking at the feasibility of this procedure and the outcomes in an Asian population. This study aims to look at outcomes at our hospital.
    Methods: We identified 121 patients treated with APBI at our center between 2008 and 2014. The median follow-up for our patient group was 30 months (range 3.7-66.5). The prescribed dose per fraction was 3.4 Gy in 10 fractions. In this study population, 71% of the patients were Chinese while 15% (n=19) were of other Asian ethnicity.
    Results: In this study, the median breast volume was 850 cc (range 216-2,108) with 59.5% (n=72) patients with a breast volume of <1,000 cc. The average planning target volume was 134 cc (range 28-324). The number of catheters used ranged from 8 to 25 with an average of 18 catheters used per patient. We achieved an average dose homogeneity index of 0.76 in our patients. The average D90(%) was 105% and the average D90(Gy) was 3.6 Gy per fraction. The median volume receiving 100% of the prescribed dose (V100) was 161.7 cc (range 33.9-330.1), 150% of the prescribed dose (V150) and 200% of the prescribed dose (V200) was 39.4 cc (range 14.6-69.6) and 14.72 cc (range 6.48-22.25), respectively. Our dosimetric outcomes were excellent even in patients with breast volume under 1,000 cc. There were no cases of grade 3 skin toxicity or acute pneumonitis. Two patients had a postoperative infection and two patients had fat necrosis postprocedure.
    Conclusion: Multicatheter high dose rate APBI is a safe and feasible procedure that can be carried out with minimal toxicity in Asian patients with breast volumes under 1,000 cc.
    Language English
    Publishing date 2016-09-08
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495130-4
    ISSN 1178-6930
    ISSN 1178-6930
    DOI 10.2147/OTT.S106758
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  6. Article ; Online: One-step nucleic acid amplification assay also predicts axillary lymph node status in breast cancer patients: further molecular diagnostic evidence.

    Wang, Tingting / Buhari, Shaik Ahmad / Pang, Brendan / Putti, Thomas C / Salto-Tellez, Manuel

    European journal of cancer (Oxford, England : 1990)

    2013  Volume 49, Issue 18, Page(s) 3945–3946

    MeSH term(s) Breast Neoplasms/genetics ; Female ; Humans ; Keratin-9/genetics ; Lymph Nodes/metabolism ; RNA, Messenger/genetics
    Chemical Substances Keratin-9 ; RNA, Messenger
    Language English
    Publishing date 2013-12
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2013.09.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 456: Show issues Location:
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    Zs.MO 583: Show issues

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  7. Article: Association between Breast Cancer Polygenic Risk Score and Chemotherapy-Induced Febrile Neutropenia: Null Results.

    Ong, Seeu Si / Ho, Peh Joo / Khng, Alexis Jiaying / Lim, Elaine Hsuen / Wong, Fuh Yong / Tan, Benita Kiat-Tee / Lim, Swee Ho / Tan, Ern Yu / Tan, Su-Ming / Tan, Veronique Kiak Mien / Dent, Rebecca / Tan, Tira Jing Ying / Ngeow, Joanne / Madhukumar, Preetha / Hamzah, Julie Liana Bte / Sim, Yirong / Lim, Geok Hoon / Pang, Jinnie Siyan / Alcantara, Veronica Siton /
    Chan, Patrick Mun Yew / Chen, Juliana Jia Chuan / Kuah, Sherwin / Seah, Jaime Chin Mui / Buhari, Shaik Ahmad / Tang, Siau Wei / Ng, Celene Wei Qi / Li, Jingmei / Hartman, Mikael

    Cancers

    2022  Volume 14, Issue 11

    Abstract: Background: The hypothesis that breast cancer (BC) susceptibility variants are linked to chemotherapy-induced toxicity has been previously explored. Here, we investigated the association between a validated 313-marker-based BC polygenic risk score (PRS) ...

    Abstract Background: The hypothesis that breast cancer (BC) susceptibility variants are linked to chemotherapy-induced toxicity has been previously explored. Here, we investigated the association between a validated 313-marker-based BC polygenic risk score (PRS) and chemotherapy-induced neutropenia without fever and febrile neutropenia (FNc) in Asian BC patients.
    Methods: This observational case-control study of Asian BC patients treated with chemotherapy included 161 FNc patients, 219 neutropenia patients, and 936 patients who did not develop neutropenia. A continuous PRS was calculated by summing weighted risk alleles associated with overall, estrogen receptor- (ER-) positive, and ER-negative BC risk. PRS distributions neutropenia or FNc cases were compared to controls who did not develop neutropenia using two-sample
    Results: PRS distributions were not significantly different in any of the comparisons. Higher PRS
    Conclusion: BC PRS was not strongly associated with chemotherapy-induced neutropenia or FNc.
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14112714
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  8. Article: Jejunal Dieulafoy lesion with massive lower intestinal bleeding.

    Nga, Min En / Buhari, Shaik Ahmad / Iau, Philip T / Raju, Gangaraju C

    International journal of colorectal disease

    2007  Volume 22, Issue 11, Page(s) 1417–1418

    MeSH term(s) Adult ; Endoscopy ; Gastrointestinal Hemorrhage/complications ; Humans ; Intestinal Mucosa/blood supply ; Intestinal Mucosa/pathology ; Jejunal Diseases/complications ; Male ; Tomography, X-Ray Computed
    Language English
    Publishing date 2007-11
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-006-0227-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2121: Show issues Location:
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  9. Article ; Online: Cohort profile: The Singapore Breast Cancer Cohort (SGBCC), a multi-center breast cancer cohort for evaluation of phenotypic risk factors and genetic markers.

    Ho, Peh Joo / Yeoh, Yen Shing / Miao, Hui / Lim, Swee Ho / Tan, Ern Yu / Tan, Benita Kiat Tee / Tan, Veronique Kiak Mien / Tan, Su Ming / Yong, Wei Sean / Wong, Fuh Yong / Madhukumar, Preetha / Chan, Ching Wan / Iau, Philip Tsau Choong / Lee, Soo Chin / Putti, Thomas / Buhari, Shaik Ahmad / Lee, Jin Yee / Lim, Geok Hoon / Woo, Evan /
    Yan, Zhiyan / Chan, Patrick Mun Yew / Chen, Juliana Jia Chuan / Lu, Sarah Qinghui / Dent, Rebecca / Lee, Wai Peng / Mok, Chi Wei / Seah, Jaime Chin Mui / Sim, Xueling / van Dam, Rob Martinus / Chia, Kee Seng / Li, Jingmei / Hartman, Mikael

    PloS one

    2021  Volume 16, Issue 4, Page(s) e0250102

    Abstract: This article aims to provide a detailed description of the Singapore Breast Cancer Cohort (SGBCC), an ongoing multi-ethnic cohort established with the overarching goal to identify genetic markers for breast cancer risk, prognosis and treatment response, ... ...

    Abstract This article aims to provide a detailed description of the Singapore Breast Cancer Cohort (SGBCC), an ongoing multi-ethnic cohort established with the overarching goal to identify genetic markers for breast cancer risk, prognosis and treatment response, as well as to understand the ethnic differences in disease risk and outcome in an Asian setting. The cohort comprises of breast cancer patients aged 21 years and above from six public hospitals which diagnose and treat nearly 76% breast cancer cases in Singapore. Self-reported data on sociodemographic and lifestyle, reproductive risk factors, medical history and family history of breast or ovarian cancer is collected using a structured questionnaire. Clinical data on tumour characteristics, and treatment modalities are obtained through medical record. Bio-specimens (blood or saliva) is collected at recruitment. Follow-up on survival information is done through routine linkage with the Registry of Births and Deaths. As of 31 December 2016, 7,768 subjects have been recruited to the study with 76% subjects contributed bio-specimens. The SGBCC provides a valuable platform which offers a unique, large and rich resource for new research ideas on breast cancer related phenotypic risk factors and genetic markers.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Breast/pathology ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/physiopathology ; Cohort Studies ; Female ; Genetic Markers ; Genetic Predisposition to Disease ; Humans ; Longitudinal Studies ; Middle Aged ; Ovarian Neoplasms ; Prognosis ; Risk Factors ; Singapore/epidemiology ; Surveys and Questionnaires
    Chemical Substances Genetic Markers
    Language English
    Publishing date 2021-04-26
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0250102
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  10. Article ; Online: High expression of intratumoral stromal proteins is associated with chemotherapy resistance in breast cancer.

    Wang, Tingting / Srivastava, Supriya / Hartman, Mikael / Buhari, Shaik Ahmad / Chan, Ching-Wan / Iau, Philip / Khin, Lay Wai / Wong, Andrea / Tan, Sing-Huang / Goh, Boon-Cher / Lee, Soo-Chin

    Oncotarget

    2016  Volume 7, Issue 34, Page(s) 55155–55168

    Abstract: We studied the changes of intratumoral stromal proteins including THBS1, TNC, FN, SPARC and α-SMA, following neoadjuvant chemotherapy. The underlying mechanisms by which THBS1 and TNC regulated resistance to docetaxel were further studied using ... ...

    Abstract We studied the changes of intratumoral stromal proteins including THBS1, TNC, FN, SPARC and α-SMA, following neoadjuvant chemotherapy. The underlying mechanisms by which THBS1 and TNC regulated resistance to docetaxel were further studied using functional studies. 100 patients with newly diagnosed breast cancer were treated with alternating sequential doxorubicin and docetaxel. Immunohistochemistry (IHC) staining for stromal proteins was performed on pre- and post-treatment core biopsies respectively. THBS1 and TNC were further validated with IHC in an independent cohort of 31 patients. A high baseline combined expression score of the 5 stromal proteins predicted independently for poor progression-free (HRadjusted 2.22, 95% CI 1.06-4.64) and overall survival (HRadjusted 5.94, 95% CI 2.25-15.71). After 1-2 cycles of chemotherapy, increased expression of THBS1, TNC, FN, SPARC and α-SMA was seen in patients with subsequent pathological lymph node involvement at surgery. Increased expression of THBS1 and TNC compared to baseline was also seen in intrinsically resistant tumors, but not in sensitive ones. Both THBS1 and TNC-associated chemoresistance were confirmed in an independent validation cohort. Exogenous THBS1 and TNC protected MCF-7 cells against proliferation inhibition induced by docetaxel through activating integrin β1/mTOR pathway. Thus, up-regulation of THBS1, TNC, FN, SPARC and α-SMA following neoadjuvant chemotherapy was associated with chemotherapy resistance in breast cancer patients. Functional studies showed THBS1 and TNC to mediate chemoresistance through the integrin β1/mTOR pathway, suggesting that therapies targeting integrin β1/mTOR pathway may be a promising strategy to overcome chemotherapy resistance.
    Language English
    Publishing date 2016-08-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.10894
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