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Article ; Online: An introduction to RNA therapeutics and their potentials.

Bui, Nhat-Le / Chu, Dinh-Toi

Progress in molecular biology and translational science

2024 Volume 203, Page(s) 1–12

Abstract: RNA therapeutics is a biological term regarding the usage of RNA-based molecules for medical purposes. Thanks to the success of mRNA-vaccine production against COVID-19, RNA therapeutics has gained more and more attention and investigation from worldwide ...

Abstract	RNA therapeutics is a biological term regarding the usage of RNA-based molecules for medical purposes. Thanks to the success of mRNA-vaccine production against COVID-19, RNA therapeutics has gained more and more attention and investigation from worldwide scientists. It is considered as one of the promising alternatives for conventional drugs. In this first chapter, we presented an overview of the history and perspectives of RNA therapeutics' development. This chapter also explained the underlying mechanisms of different RNA-based molecules, including antisense oligonucleotide, interfering RNA (iRNA), aptamer, and mRNA, from degrading mRNA to inactivating targeted protein. Although there are many advantages of RNA therapeutics, its challenges in designing RNA chemical structure and the delivery vehicle need to be discussed. We described advanced technologies in the development of drug delivery systems that are positively correlated to the efficacy of the drug. Our aim is to provide a general background of RNA therapeutics to the audience before introducing plenty of more detailed parts, including clinical applications in certain diseases in the following chapters of the "RNA therapeutics" book.
MeSH term(s)	Humans ; RNA, Small Interfering ; Oligonucleotides, Antisense ; Drug Delivery Systems ; RNA, Messenger/genetics ; RNA, Messenger/therapeutic use
Chemical Substances	RNA, Small Interfering ; Oligonucleotides, Antisense ; RNA, Messenger
Language	English
Publishing date	2024-01-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2471995-X
ISSN	1878-0814 ; 0079-6603 ; 1877-1173
ISSN (online)	1878-0814
ISSN	0079-6603 ; 1877-1173
DOI	10.1016/bs.pmbts.2023.12.020
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Article ; Online: Adrenoceptors and SCD1 in adipocytes/adipose tissues: The expression and variation in health and obesity.

Chu, Dinh-Toi / Bui, Nhat-Le / Le, Ngoc Hoan

Progress in molecular biology and translational science

2022 Volume 194, Page(s) 311–332

Abstract: Obesity, considered a metabolic disorder, is one of the most significant health issues that the community has to cope with today. A rising number of studies have been conducted to find out promising genetic targets for obese treatment. The sympathetic ... ...

Abstract	Obesity, considered a metabolic disorder, is one of the most significant health issues that the community has to cope with today. A rising number of studies have been conducted to find out promising genetic targets for obese treatment. The sympathetic nervous system was proven to possess remarkable roles in energy metabolism, including the stimulation of lipolysis as well as thermogenesis, via distinct adrenoceptors appearing on the membrane of adipocyte. A decrease of β-adrenoceptor expression has been observed in obese individuals, which is related to reducing energy expenditure and developing obesity. While that the deficiency of stearoyl-CoA desaturase-1 (SCD1), which is a promising target for treatments of metabolic diseases, decreases oxidation and promotes the synthesis of fatty acids. Here, we emphasized several differences between distinct adrenoceptor subtypes, including their mRNA expression level and function in white adipose tissue and brown adipose tissue. We also highlighted SCD1's roles related to the progression of adipocytes and its changing expression under the obese condition in both rodents and humans, and furthermore, tried to figure out the interaction between adrenoceptors and SCD1 in adipose tissue.
MeSH term(s)	Humans ; Adipocytes/metabolism ; Adipose Tissue/metabolism ; Adiposity ; Obesity/metabolism ; Receptors, Adrenergic/metabolism ; Stearoyl-CoA Desaturase/genetics ; Stearoyl-CoA Desaturase/metabolism
Chemical Substances	Receptors, Adrenergic ; SCD1 protein, human (EC 1.14.19.1) ; Stearoyl-CoA Desaturase (EC 1.14.19.1)
Language	English
Publishing date	2022-07-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2471995-X
ISSN	1878-0814 ; 0079-6603 ; 1877-1173
ISSN (online)	1878-0814
ISSN	0079-6603 ; 1877-1173
DOI	10.1016/bs.pmbts.2022.06.024
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Article ; Online: Computational tools supporting known miRNA identification.

Do, Van-Quy / Hoang-Thi, Chuc / Pham, Thanh-Truong / Bui, Nhat-Le / Kim, Dinh-Thai / Chu, Dinh-Toi

Progress in molecular biology and translational science

2024 Volume 203, Page(s) 225–242

Abstract: The study of small RNAs is a field that is expanding quickly. Other functional short RNA molecules other than microRNAs, and gene expression regulators, have been found in animals and plants. MicroRNAs play a significant role in host-microbe interactions, ...

Abstract	The study of small RNAs is a field that is expanding quickly. Other functional short RNA molecules other than microRNAs, and gene expression regulators, have been found in animals and plants. MicroRNAs play a significant role in host-microbe interactions, and parasite microRNAs may affect the host's innate immunity. Furthermore, short RNAs are intriguing non-invasive biomarker possibilities because they can be found in physiological fluids. These trends suggest that for many researchers, quick and simple techniques for expression profiling and subsequent downstream analysis of miRNA-seq data are crucial. We selected sRNAtoolbox to make integrated sRNA research easier. Each tool can be used separately or to explore and analyze sRNAbench results in further depth. A special focus was placed on the tools' usability. We review available miRNA research tools to have an overview of the evaluation of the tools. Mainly we evaluate the tool sRNAtoolbox.
MeSH term(s)	Animals ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Software ; Plants/genetics ; Computational Biology/methods ; Sequence Analysis, RNA/methods
Chemical Substances	MicroRNAs
Language	English
Publishing date	2024-01-30
Publishing country	Netherlands
Document type	Review ; Journal Article
ZDB-ID	2471995-X
ISSN	1878-0814 ; 0079-6603 ; 1877-1173
ISSN (online)	1878-0814
ISSN	0079-6603 ; 1877-1173
DOI	10.1016/bs.pmbts.2023.12.018
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Role of DNA methylation in diabetes and obesity.

Chu, Dinh-Toi / Bui, Nhat-Le / Vu Thi, Hue / Nguyen Thi, Yen-Vy

Progress in molecular biology and translational science

2023 Volume 197, Page(s) 153–170

Abstract: Due to the fact that the upward trend of several metabolic disorders such as diabetes and obesity, in individuals especially monozygotic twins, who are under the same effects from the environment, are not similar, the role of epigenetic elements like DNA ...

Abstract	Due to the fact that the upward trend of several metabolic disorders such as diabetes and obesity, in individuals especially monozygotic twins, who are under the same effects from the environment, are not similar, the role of epigenetic elements like DNA methylation needs taking into account. In this chapter, emerging scientific evidence supporting the strong relationship between changes in DNA methylation and those diseases' development was summarized. Changing in the expression level of diabetes/obesity-related genes through being silenced by methylation can be the underlying mechanism of this phenomenon. Genes with abnormal methylation status are potential biomarkers for early prediction and diagnosis. Moreover, methylation-based molecular targets should be investigated as a new treatment for both T2D and obesity.
MeSH term(s)	Humans ; DNA Methylation ; Epigenesis, Genetic ; Diabetes Mellitus ; Obesity ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-02-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2471995-X
ISSN	1878-0814 ; 0079-6603 ; 1877-1173
ISSN (online)	1878-0814
ISSN	0079-6603 ; 1877-1173
DOI	10.1016/bs.pmbts.2023.01.008
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Article ; Online: Phage for regenerative medicine and cosmetics.

Bui, Nhat-Le / Nguyen, Mai Anh / Nguyen, Manh-Long / Bui, Quoc-Cuong / Chu, Dinh-Toi

Progress in molecular biology and translational science

2023 Volume 201, Page(s) 241–259

Abstract: Phage or bacteriophage is a specific virus with the ability to defeat bacteria. Because of the rising prevalence of antimicrobial-resistant bacteria, the bacteriophage is now receiving interest again, with it application in skin infection or acne ... ...

Abstract	Phage or bacteriophage is a specific virus with the ability to defeat bacteria. Because of the rising prevalence of antimicrobial-resistant bacteria, the bacteriophage is now receiving interest again, with it application in skin infection or acne treatment. Moreover, bacteriophages also express their efficacy in wound healing or skin regeneration. Thanks to the development of bioengineering technology, phage display, which is a technique using bacteriophage as a tool, has recently been applied in many biotechnological and medical fields, especially in regenerative medicines. Bacteriophages can be used as nanomaterials, delivery vectors, growth factor alternatives, or in several bacteriophage display-derived therapeutics and stem cell technology. Although bacteriophage is no doubt to be a potential and effective alternative in modern medicine, there are still controversial evidence about the antibacterial efficacy as well as the affinity to expected targets of bacteriophage. Future mission is to optimize the specificity, stability, affinity and biodistribution of phage-derived substances. In this chapter, we focused on introducing several mechanisms and applications of bacteriophage and analyzing its future potential in regenerative medicines as well as cosmetics via previous research's results.
Language	English
Publishing date	2023-04-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2471995-X
ISSN	1878-0814 ; 0079-6603 ; 1877-1173
ISSN (online)	1878-0814
ISSN	0079-6603 ; 1877-1173
DOI	10.1016/bs.pmbts.2023.03.017
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The impact of COVID-19 and other factors on the usage status of the biologic drug therapies for rheumatoid arthritis: A study from Vietnam.

Bui, Hai-Binh / Lai, Hong-Thinh / Nguyen, Thanh-Lam / Vu, Thuy-Duong / Bui, Nhat-Le / Nguyen, Van-Hung / Tran, Thi-To-Chau / Nguyen, Thi-Phuong-Thuy / Nguyen, Thi-Ngoc-Lan / Al-Tawfiq, Jaffar A / Chu, Dinh-Toi

Reumatologia clinica

2024 Volume 20, Issue 3, Page(s) 128–135

Abstract: Objectives: To describe the status of using biological Disease Modifying Anti Rheumatic Drugs (bDMARDs) to treat rheumatoid arthritis (RA) and related factors. In addition, the study determined the impact of COVID-19 on the usage of bDMARDs.: Methods!# ...

Abstract	Objectives: To describe the status of using biological Disease Modifying Anti Rheumatic Drugs (bDMARDs) to treat rheumatoid arthritis (RA) and related factors. In addition, the study determined the impact of COVID-19 on the usage of bDMARDs. Methods: This is a cross-sectional study and included 219 RA patients over 18 years old. The Kaplan-Meier method and the log-rank test (p<0.05) were used to estimate the retention time and compare between different times. Cox regression analysis was used to determine the factors affecting the retention time of biological drugs (p<0.05). Results: Out of 1967 courses of treatment, there were 149 (7.6%) drug discontinuations, 760 (38.6%) doses extensions and 64 (3.3%) drug switch. Moderate disease level and choosing tumor necrosis factor (TNF) inhibitors initially were associated with retention time of COVID-19. Drug discontinuations and dose extensions increased after COVID-19 emergence. The retention time during COVID-19 was significantly different from that of pre-COVID-19. Gender, type of first-used bDMARD, conventional synthetic DMARDs (csDMARDs) and corticoid usage status, disease activity levels were associated with retention time. Conclusion: The presence of COVID-19 has a significant effect on usage status of the biologic drug. Further longitudinal studies are needed to clarify the relationship between COVID-19 and drug usage as well as related factors.
MeSH term(s)	Humans ; Adolescent ; Vietnam ; Cross-Sectional Studies ; COVID-19 ; Arthritis, Rheumatoid/drug therapy ; Antirheumatic Agents/therapeutic use ; Biological Products/therapeutic use
Chemical Substances	Antirheumatic Agents ; Biological Products
Language	English
Publishing date	2024-02-21
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5743
ISSN (online)	2173-5743
DOI	10.1016/j.reumae.2024.02.003
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Article ; Online: Exploring the Potential of Stem Cell-Based Therapy for Aesthetic and Plastic Surgery.

Tran, Dang-Khoa / Phuong, Thuy Nguyen Thi / Bui, Nhat-Le / Singh, Vijai / Looi, Qi Hao / Koh, Benson / Zaman, Ungku Mohd Shahrin B Mohd / Foo, Jhi Biau / Wu, Chia-Ching / Show, Pau Loke / Chu, Dinh-Toi

IEEE reviews in biomedical engineering

2023 Volume 16, Page(s) 386–402

Abstract: Over the last decade, stem cell-associated therapies are widely used because of their potential in self-renewable and multipotent differentiation ability. Stem cells have become more attractive for aesthetic uses and plastic surgery, including scar ... ...

Abstract	Over the last decade, stem cell-associated therapies are widely used because of their potential in self-renewable and multipotent differentiation ability. Stem cells have become more attractive for aesthetic uses and plastic surgery, including scar reduction, breast augmentation, facial contouring, hand rejuvenation, and anti-aging. The current preclinical and clinical studies of stem cells on aesthetic uses also showed promising outcomes. Adipose-derived stem cells are commonly used for fat grafting that demonstrated scar improvement, anti-aging, skin rejuvenation properties, etc. While stem cell-based products have yet to receive approval from the FDA for aesthetic medicine and plastic surgery. Moving forward, the review on the efficacy and potential of stem cell-based therapy for aesthetic and plastic surgery is limited. In the present review, we discuss the current status and recent advances of using stem cells for aesthetic and plastic surgery. The potential of cell-free therapy and tissue engineering in this field is also highlighted. The clinical applications, advantages, and limitations are also discussed. This review also provides further works that need to be investigated to widely apply stem cells in the clinic, especially in aesthetic and plastic contexts.
MeSH term(s)	Humans ; Surgery, Plastic ; Adipose Tissue/transplantation ; Cicatrix ; Stem Cells ; Esthetics
Language	English
Publishing date	2023-01-05
Publishing country	United States
Document type	Review ; Journal Article
ISSN	1941-1189
ISSN (online)	1941-1189
DOI	10.1109/RBME.2021.3134994
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Factors affecting innovation capacity in Vietnamese Southern high technology industries

Doan Thi Hong Van / Bui Nhat Le Uyen

Journal of economic development Vol. 24, No. 3 , p. 66-93

2017 Volume 24, Issue 3, Page(s) 66–93

Author's details	Doan Thi Hong Van, Bui Nhat Le Uyen
Keywords	Innovation ; Total quality management ; Human resources ; Absorbtive capacity ; Collaboration networks ; High-tech industry
Language	English
Publisher	University of Economics Hochiminh City
Publishing place	Hochiminh City
Document type	Article
ZDB-ID	2869684-0 ; 2841564-4
ISSN	1859-1116
ISSN	1859-1116
Database	ECONomics Information System

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Article: Phage engineering and phage-assisted CRISPR-Cas delivery to combat multidrug-resistant pathogens.

Khambhati, Khushal / Bhattacharjee, Gargi / Gohil, Nisarg / Dhanoa, Gurneet K / Sagona, Antonia P / Mani, Indra / Bui, Nhat Le / Chu, Dinh-Toi / Karapurkar, Janardhan Keshav / Jang, Su Hwa / Chung, Hee Yong / Maurya, Rupesh / Alzahrani, Khalid J / Ramakrishna, Suresh / Singh, Vijai

Bioengineering & translational medicine

2022 Volume 8, Issue 2, Page(s) e10381

Abstract: Antibiotic resistance ranks among the top threats to humanity. Due to the frequent use of antibiotics, society is facing a high prevalence of multidrug resistant pathogens, which have managed to evolve mechanisms that help them evade the last line of ... ...

Abstract	Antibiotic resistance ranks among the top threats to humanity. Due to the frequent use of antibiotics, society is facing a high prevalence of multidrug resistant pathogens, which have managed to evolve mechanisms that help them evade the last line of therapeutics. An alternative to antibiotics could involve the use of bacteriophages (phages), which are the natural predators of bacterial cells. In earlier times, phages were implemented as therapeutic agents for a century but were mainly replaced with antibiotics, and considering the menace of antimicrobial resistance, it might again become of interest due to the increasing threat of antibiotic resistance among pathogens. The current understanding of phage biology and clustered regularly interspaced short palindromic repeats (CRISPR) assisted phage genome engineering techniques have facilitated to generate phage variants with unique therapeutic values. In this review, we briefly explain strategies to engineer bacteriophages. Next, we highlight the literature supporting CRISPR-Cas9-assisted phage engineering for effective and more specific targeting of bacterial pathogens. Lastly, we discuss techniques that either help to increase the fitness, specificity, or lytic ability of bacteriophages to control an infection.
Language	English
Publishing date	2022-08-06
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2380-6761
ISSN	2380-6761
DOI	10.1002/btm2.10381
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