Article: Effects of sub-lethal doses of fentanyl on vital physiologic functions and withdrawal-like behaviors in adult goats.
2023 Volume 14, Page(s) 1277601
Abstract: Synthetic opioids like fentanyl have improved the standard of care for many patients in the clinical setting, but their abuse leads to tens of thousands of overdose deaths annually. The current opioid epidemic underscores a critical need for insights ... ...
| Abstract | Synthetic opioids like fentanyl have improved the standard of care for many patients in the clinical setting, but their abuse leads to tens of thousands of overdose deaths annually. The current opioid epidemic underscores a critical need for insights into the physiological effects of fentanyl on vital functions. High doses of opioids in small mammals cause opioid-induced respiratory depression (OIRD) leading to hypoventilation, hypoxemia, and hypercapnia. In addition, opioids can also increase the alveolar to arterial oxygen (A-a) gradient and airway dysfunction. However, little is known about the physiologic effects of sub-lethal doses of opioids in large mammals. Here we report the effects of a sub-lethal dose range of fentanyl (25-125 μg/kg; IV) on vital physiologic functions over 90 min (min) and withdrawal-like behaviors over the subsequent 4 h (h) in adult female goats ( |
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| Language | English |
| Publishing date | 2023-10-11 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2564217-0 |
| ISSN | 1664-042X |
| ISSN | 1664-042X |
| DOI | 10.3389/fphys.2023.1277601 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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