Article ; Online: PRC1 sustains the integrity of neural fate in the absence of PRC2 function.
2022 Volume 11
Abstract: Polycomb repressive complexes (PRCs) 1 and 2 maintain stable cellular memories of early fate decisions by establishing heritable patterns of gene repression. PRCs repress transcription through histone modifications and chromatin compaction, but their ... ...
Abstract | Polycomb repressive complexes (PRCs) 1 and 2 maintain stable cellular memories of early fate decisions by establishing heritable patterns of gene repression. PRCs repress transcription through histone modifications and chromatin compaction, but their roles in neuronal subtype diversification are poorly defined. We found that PRC1 is essential for the specification of segmentally restricted spinal motor neuron (MN) subtypes, while PRC2 activity is dispensable to maintain MN positional identities during terminal differentiation. Mutation of the core PRC1 component |
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MeSH term(s) | Animals ; Animals, Genetically Modified ; Chickens ; Embryonic Stem Cells/metabolism ; Gene Expression Regulation, Developmental ; Mice ; Motor Neurons/metabolism ; Polycomb Repressive Complex 1/genetics ; Polycomb Repressive Complex 1/metabolism ; Polycomb Repressive Complex 2/genetics ; Polycomb Repressive Complex 2/metabolism |
Chemical Substances | Polycomb Repressive Complex 2 (EC 2.1.1.43) ; Polycomb Repressive Complex 1 (EC 2.3.2.27) |
Language | English |
Publishing date | 2022-01-07 |
Publishing country | England |
Document type | Journal Article ; Research Support, N.I.H., Extramural |
ZDB-ID | 2687154-3 |
ISSN | 2050-084X ; 2050-084X |
ISSN (online) | 2050-084X |
ISSN | 2050-084X |
DOI | 10.7554/eLife.72769 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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