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  1. Article: Encephalomyelitis Associated with Anti-myelin Oligodendrocyte Glycoprotein Antibodies and Adenovirus.

    Barnea Melamed, Shirel / Ganelin-Cohen, Esther / Bulkowstein, Yarden / Shapira Rootman, Mika / Krause, Irit

    The Israel Medical Association journal : IMAJ

    2023  Volume 25, Issue 5, Page(s) 346–348

    MeSH term(s) Humans ; Animals ; Adenoviridae ; Encephalomyelitis/diagnosis ; Autoantibodies ; Adenoviridae Infections/complications ; Adenoviridae Infections/diagnosis ; Oligodendroglia ; Glycoproteins ; Myelin-Oligodendrocyte Glycoprotein ; Encephalomyelitis, Autoimmune, Experimental
    Chemical Substances Autoantibodies ; Glycoproteins ; Myelin-Oligodendrocyte Glycoprotein
    Language English
    Publishing date 2023-05-28
    Publishing country Israel
    Document type Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5470: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Improving pediatric idiopathic intracranial hypertension care: a retrospective cohort study.

    Nitzan-Luques, Adi / Bulkowstein, Yarden / Barnoy, Noa / Aran, Adi / Reif, Shimon / Gilboa, Tal

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 19218

    Abstract: To describe the clinical course and prognosis of pediatric idiopathic intracranial hypertension (IIH) and examine the preferred management setting. IIH is characterized by increased intracranial pressure and is often associated with headaches and visual ... ...

    Abstract To describe the clinical course and prognosis of pediatric idiopathic intracranial hypertension (IIH) and examine the preferred management setting. IIH is characterized by increased intracranial pressure and is often associated with headaches and visual complaints. IIH is a preventable cause of vision loss in children. Hence, a rapid diagnosis followed by prompt treatment and follow-up is essential. However, standardization of the management of IIH in the pediatric population is not well established. Computerized medical charts of all 82 pediatric (< 18 years) patients diagnosed with IIH between 2007 and 2018 in the metropolitan area of Jerusalem were reviewed. Comparison was made between children followed in a multidisciplinary clinic in tertiary centers and those followed elsewhere. Detailed demographic and clinical data, as well as data regarding the follow-up setting and clinical course of the disease, were collected and analyzed. Recurrent IIH-related hospital returns were selected as a measurable marker for the uncontrolled disease. Recurrent IIH-related hospital return rate was significantly lower and occurred later among children followed by multidisciplinary teams compared to individual experts. Follow-up in multidisciplinary clinics improve the quality of life, and financial burden and may prevent permanent visual impairment in children with IIH.
    MeSH term(s) Humans ; Child ; Pseudotumor Cerebri/diagnosis ; Pseudotumor Cerebri/therapy ; Retrospective Studies ; Quality of Life ; Intracranial Hypertension/complications ; Headache/complications
    Language English
    Publishing date 2022-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-23960-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The manifestations of metabolic acidosis during acetazolamide treatment in a cohort of pediatric idiopathic intracranial hypertension.

    Bulkowstein, Yarden / Nitzan-Luques, Adi / Schnapp, Aviad / Barnoy, Noa / Reif, Shimon / Gilboa, Tal / Volovesky, Oded

    Pediatric nephrology (Berlin, Germany)

    2023  Volume 39, Issue 1, Page(s) 185–191

    Abstract: Background: Idiopathic intracranial hypertension is characterized by increased intracranial pressure with unidentified pathology. Despite its use as the first-line treatment, data on acetazolamide's effectiveness and safety in pediatric idiopathic ... ...

    Abstract Background: Idiopathic intracranial hypertension is characterized by increased intracranial pressure with unidentified pathology. Despite its use as the first-line treatment, data on acetazolamide's effectiveness and safety in pediatric idiopathic intracranial hypertension is sparse. This study's objective was to assess those issues and the need for routine blood gas monitoring during treatment.
    Methods: Retrospective observational cohort study, based on multicenter computerized medical charts of pediatric patients with idiopathic intracranial hypertension diagnosed between 2007-2018 in three medical centers serving one metropolitan area (an estimated population of 400,000 children). Clinical and laboratory data of children up to 18 years old, fulfilling the Friedman criteria and taking acetazolamide, were collected and analyzed.
    Results: Sixty-eight patients were included with a mean acetazolamide treatment duration of 8.5 months and a median maximal dose 18 mg/kg/d. Sixty-two children had mild (76%), moderate (13%), or severe (1.5%) metabolic acidosis. At least one adverse effect (neurologic, gastrointestinal, renal) was recorded among 27% of patients. No significant difference was found between the mean pH of children with or without clinical adverse effects (p = 0.35). No correlation was found between laboratory acidosis and adverse effect severity (p = 0.3), or between median acetazolamide dose and acidosis level (p = 0.57).
    Conclusions: Although laboratory finding of metabolic acidosis is common among patients with idiopathic intracranial hypertension treated with acetazolamide, it is not correlated with clinics. Therefore, we recommend sending blood tests during acetazolamide treatment based on clinical judgment. A higher resolution version of the Graphical abstract is available as Supplementary information.
    MeSH term(s) Humans ; Child ; Acetazolamide/adverse effects ; Pseudotumor Cerebri/drug therapy ; Pseudotumor Cerebri/diagnosis ; Carbonic Anhydrase Inhibitors/adverse effects ; Retrospective Studies ; Acidosis/chemically induced ; Acidosis/drug therapy
    Chemical Substances Acetazolamide (O3FX965V0I) ; Carbonic Anhydrase Inhibitors
    Language English
    Publishing date 2023-07-22
    Publishing country Germany
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-023-06084-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2196: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Clinical improvement of a toddler with COVID-19 focal cerebral arteriopathy possibly due to intra-arterial nimodipine.

    Avital, Dekel / Peretz, Shlomi / Perlow, Eliauh / Konen, Osnat / Inbar, Edna / Bulkowstein, Yarden / Nahum, Elhanan / Aharoni, Sharon / Vig, Lital Cohen / Nevo, Yoram / Auriel, Eitan / Straussberg, Rachel

    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society

    2022  Volume 40, Page(s) 40–43

    Abstract: Pediatric stroke is considered an infrequent complication of COVID-19. Focal cerebral arteriopathy (FCA) is one of the most common causes of arterial ischemic stroke in a previously healthy child. The present report describes a toddler with FCA most ... ...

    Abstract Pediatric stroke is considered an infrequent complication of COVID-19. Focal cerebral arteriopathy (FCA) is one of the most common causes of arterial ischemic stroke in a previously healthy child. The present report describes a toddler with FCA most likely induced by SARS-CoV-2 infection who showed significant clinical improvement that may be related to injection of intra-arterial nimodipine. To our knowledge, this is the first reported use of nimodipine in this setting.
    MeSH term(s) COVID-19/complications ; Cerebral Arterial Diseases/complications ; Cerebral Arterial Diseases/diagnostic imaging ; Cerebral Arterial Diseases/drug therapy ; Child ; Child, Preschool ; Humans ; Nimodipine/therapeutic use ; SARS-CoV-2 ; Stroke/diagnostic imaging ; Stroke/drug therapy ; Stroke/etiology
    Chemical Substances Nimodipine (57WA9QZ5WH)
    Language English
    Publishing date 2022-07-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1397146-3
    ISSN 1532-2130 ; 1090-3798
    ISSN (online) 1532-2130
    ISSN 1090-3798
    DOI 10.1016/j.ejpn.2022.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4867: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 641: Show issues

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