Article ; Online: Epigenetic impact of the social and physical environment on brain and body.
Metabolism: clinical and experimental
2019 Volume 100S, Page(s) 153941
Abstract: Modern biomedical scientists are often trapped in silos of knowledge and practice, such as those who study brain structure, function and behavior, on the one hand, and body systems and disorders, on the other. Scientists and physicians in each of those ... ...
| Abstract | Modern biomedical scientists are often trapped in silos of knowledge and practice, such as those who study brain structure, function and behavior, on the one hand, and body systems and disorders, on the other. Scientists and physicians in each of those silos have not often paid attention to the brain-body communication that leads to multi-morbidity of systemic and brain-related disorders [eg. depression with diabetes or cardiovascular disease]. Outside of biomedicine, social scientists have long recognized the impact of the social and physical environment on individuals and populations but have not usually connected these effects with changes in underlying biology. However, with the rise of epigenetics, science and the public understanding of science is leaving an era in which the DNA sequence was thought to be "destiny" and entering an era where the environment shapes the biology and behavior of individuals and groups through its interactive effects on brain and body. It does so, at least in part, by shaping epigenetically the structure and function of brain and body systems that show a considerable amount of adaptive plasticity throughout development and adult life. This results in substantial individual differences even between identical twins. These individual differences are produced epigenetically by the two-way interaction between the brain and hormones, immune system mediators and the autonomic nervous system. Disorders, then, are often multimorbid involving both brain and body, such as depression with diabetes and cardiovascular disease. It is therefore imperative to incorporate into "precision medicine" a better understanding of how these differences affect the efficacy of pharmacological, behavioral and psychosocial interventions. This article presents an overview of this new synthesis, using as an example emerging evidence about the linkages between systemic inflammation, insulin resistance and mental health and neurodegenerative diseases. |
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| MeSH term(s) | Brain/physiology ; Brain/physiopathology ; Disease/etiology ; Disease/genetics ; Environment ; Epigenomics ; Gene-Environment Interaction ; Humans ; Precision Medicine/methods ; Social Environment |
| Language | English |
| Publishing date | 2019-10-15 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 80230-x |
| ISSN | 1532-8600 ; 0026-0495 |
| ISSN (online) | 1532-8600 |
| ISSN | 0026-0495 |
| DOI | 10.1016/j.metabol.2019.07.005 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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