Article ; Online: Development and Characterisation of a New Patient-Derived Xenograft Model of AR-Negative Metastatic Castration-Resistant Prostate Cancer.
2024 Volume 13, Issue 8
Abstract: As the treatment landscape for prostate cancer gradually evolves, the frequency of treatment-induced neuroendocrine prostate cancer (NEPC) and double-negative prostate cancer (DNPC) that is deficient for androgen receptor (AR) and neuroendocrine (NE) ... ...
| Abstract | As the treatment landscape for prostate cancer gradually evolves, the frequency of treatment-induced neuroendocrine prostate cancer (NEPC) and double-negative prostate cancer (DNPC) that is deficient for androgen receptor (AR) and neuroendocrine (NE) markers has increased. These prostate cancer subtypes are typically refractory to AR-directed therapies and exhibit poor clinical outcomes. Only a small range of NEPC/DNPC models exist, limiting our molecular understanding of this disease and hindering our ability to perform preclinical trials exploring novel therapies to treat NEPC/DNPC that are urgently needed in the clinic. Here, we report the development of the CU-PC01 PDX model that represents AR-negative mCRPC with PTEN/RB/PSMA loss and |
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| MeSH term(s) | Male ; Humans ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/metabolism ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Animals ; Receptors, Androgen/metabolism ; Receptors, Androgen/genetics ; Mice ; Xenograft Model Antitumor Assays ; Phenylthiohydantoin/pharmacology ; Phenylthiohydantoin/analogs & derivatives ; Phenylthiohydantoin/therapeutic use ; Neoplasm Metastasis ; Nitriles/pharmacology ; Disease Models, Animal ; Benzamides/pharmacology ; Phthalazines/pharmacology ; Phthalazines/therapeutic use ; Piperazines |
| Chemical Substances | Receptors, Androgen ; Phenylthiohydantoin (2010-15-3) ; enzalutamide (93T0T9GKNU) ; Nitriles ; Benzamides ; olaparib (WOH1JD9AR8) ; Phthalazines ; Piperazines |
| Language | English |
| Publishing date | 2024-04-12 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2661518-6 |
| ISSN | 2073-4409 ; 2073-4409 |
| ISSN (online) | 2073-4409 |
| ISSN | 2073-4409 |
| DOI | 10.3390/cells13080673 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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