Article ; Online: Liver Stiffness Is Markedly Decreased After Chronic Hepatitis C Treatment.
2022 Volume 38, Issue 2, Page(s) 142–148
Abstract: Aim: The aim of the study was to demonstrate the liver stiffness (LS) change in chronic hepatitis C (CHC) patients obtained by elastography point quantification technique in before and after antiviral treatment (AVT).: Material and methods: This ... ...
| Abstract | Aim: The aim of the study was to demonstrate the liver stiffness (LS) change in chronic hepatitis C (CHC) patients obtained by elastography point quantification technique in before and after antiviral treatment (AVT). Material and methods: This prospective study included 84 patients diagnosed with CHC who had not previously received treatment for CHC and who had an indication for using direct-acting AVT. Necessary measurements were recorded with noninvasive liver fibrosis (LF) examinations. Posttreatment control of patients was carried out (ombitasvir + paritaprevir + ritonavir) + 3 months after the start of treatment for those treated with dasabuvir and 6 months after the start of treatment for patients treated with sofosbuvir + ribavirin. Liver stiffness changed after AVT is accepted as (Δ-LS), LS before AVT-LS after AVT. Results: Basal LS was found to decrease significantly after AVT (8.00 ± 2.56 kPa vs 6.95 ± 2.86 kPa, P < 0.05). Similar aspartate aminotransferase-to-platelet ratio index and platelet number fibrosis 4 indices were observed before and after AVT (P > 0.05). It was observed that Δ-LS value after AVT was lower in patients with Child-Pugh class A cirrhosis than patients without cirrhosis (P < 0.05). In the comparison between Δ-LS value after AVT and LF score determined by liver biopsy, it was seen that the greatest Δ-LS value was in patients with fibrosis score of 3. An independent relationship was found between Δ-LS after AVT and LF score determined by biopsy (P < 0.05). Conclusions: The LS value determined by the elastography point quantification technique is more effective than other noninvasive laboratory methods in demonstrating the CHC treatment response in clinical practice. |
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| MeSH term(s) | Antiviral Agents/therapeutic use ; Elasticity Imaging Techniques/methods ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/diagnostic imaging ; Hepatitis C, Chronic/drug therapy ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/diagnostic imaging ; Prospective Studies |
| Chemical Substances | Antiviral Agents |
| Language | English |
| Publishing date | 2022-06-01 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 645107-x |
| ISSN | 1536-0253 ; 0894-8771 |
| ISSN (online) | 1536-0253 |
| ISSN | 0894-8771 |
| DOI | 10.1097/RUQ.0000000000000572 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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