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  1. Book ; Online: Novel Molecules in Diabetes Melitus, Dyslipidemia and Cardiovascular Disease

    Vesa, Cosmin Mihai / Bungau, Simona Gabriela

    2023  

    Keywords Research & information: general ; Biology, life sciences ; nicotinamide mononucleotide ; retinal ischemia/reperfusion ; oxidative stress ; neuroprotection ; inflammation ; sacubitril/valsartan ; mortality ; morbidity ; heart failure ; ejection fraction ; diabetes mellitus ; α-glucosidase ; abietane diterpenoids ; levopimaric acid ; quinopimaric acid ; molecular docking ; ADMET ; PFK15 synthesis ; sunitinib L-malate ; HUVEC ; angiogenesis ; synergy ; cardiovascular medicine ; diabetes ; hypertension ; GIP ; GLP-1 ; glucagon ; incretins ; LY3298176 ; meta-analysis ; obesity ; SUMMIT ; SURMOUNT ; SURPASS ; SYNERGY ; Tirzepatide ; common carotid artery occlusion ; retinal ischemia ; dyslipidemia ; statin ; children ; adolescents ; metabolic syndrome ; liver ; hsa-miR-193b-3p ; peroxisome proliferator activated receptor gamma coactivator 1 alpha ; lipid metabolism ; n/a ; empagliflozin ; type 2 diabetes mellitus ; leptin ; sphingolipids ; sphingomyelinase ; vasorelaxation ; endothelial nitric oxide synthase ; type 2 diabetes ; thromboxane prostanoid receptor
    Language English
    Size 1 electronic resource (152 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030377998
    ISBN 9783036576848 ; 3036576843
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Antioxidant Activity of Essential Oils

    Tit, Delia Mirela / Bungau, Simona Gabriela

    2023  

    Keywords Research & information: general ; Biology, life sciences ; allyl compounds ; molecular dynamic ; antioxidant enzyme ; oxidative stress ; phytochemical study ; Artemisia judaica ; essential oil ; wound healing ; inflammatory markers ; antibiofilm activity ; antioxidant activity ; Ammi visnaga L. ; chemical composition ; gas chromatography-mass spectrometry ; circular economy ; volatile compounds ; antioxidants ; pro-oxidants ; enzymatic activity ; gas chromatography ; proanthocyanidins ; polyphenols ; Salvia officinalis ; chemical analysis ; aromatherapy ; inhalation ; TBARS ; FRAP ; colour parameter ; linseed and vitamin E ; oregano and rosemary ; microbiological profile ; beef meat ; phytochemicals ; medicinal plants ; plant-based nanostructures ; eco-friendly nanotherapeutics ; therapeutics ; phytobiotics ; apiaceae family ; Valeriana pilosa ; antioxidant activities ; molecular docking ; Embelia ribes Burm ; Vidanga ; essential oils/extracts ; embelin ; vilangin ; pharmacology ; phytochemistry ; plant-based compounds ; natural products ; Amazon ; medicinal plant ; bioactive compounds ; S. edelbergii ; essential oils ; GC-MS analysis ; in vitro and in vivo biological activities ; antioxidant ; phytotoxic ; molecular modeling ; virtual ligand screening ; Amazonian natural products ; Artemia salina ; 1,8-cineole ; (Z)-α-trans-bergamotene ; citrus essential oils ; natural aromatic compounds ; therapeutic effects of citrus EOs ; characterization of citrus EOs ; new species ; Rosmarinus officinalis ; Salvia rosmarinus ; aromatic herbs ; wastes ; residues ; LC-HRMS/MS ; sweet orange ; cold pressing ; hydrodistillation ; scavenging activity ; reducing capacity ; virulence factors ; quorum sensing ; n/a
    Language English
    Size 1 electronic resource (374 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030375288
    ISBN 9783036569482 ; 3036569480
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Online: Natural Products for Chronic Diseases: A Ray of Hope

    Hassan, Syed Shams ul / Abdel-Daim, Mohamed M / Behl, Tapan / Bungau, Simona Gabriela

    2023  

    Keywords Research & information: general ; Chemistry ; guaiane dimer ; melanoma ; molecular docking ; ADMET ; MM-GBSA ; marine drugs ; diabetes mellitus ; cancer ; cardiovascular disorders ; neurodegeneration ; shrimp (Penaeus Chinensis) ; peptides ; immunosuppression gut microbiota ; cyclophosphamide ; gut health ; prostate cancer ; nummularic acid ; docking ; apoptosis ; BAX ; p53 ; echimidine ; echimidine isomers ; hepatotoxicity ; Echium plantagineum L. ; rat hepatocytes primary culture ; Fragaria indica ; α-glucosidase ; α-amylase ; antioxidant ; bioactives ; antidiabetic ; diabetes ; antibacterial activity ; total phenolic contents ; total flavonoid contents ; DPPH ; ABTS ; antidiabetic enzymes ; HPLC-UV ; GC-MS ; endogenous hydrogen sulfide ; breast cancer ; signaling pathway ; tumor growth ; Michael products ; anti-inflammatory ; analgesic ; carrageenan ; COX-2 ; 5-LOX ; Pleurospermum candollei ; natural compounds ; thrombolytic ; antibacterial ; pharmaceuticals ; berbamine ; bergapten ; carveol ; paclitaxel ; ELISA ; Western blot ; n/a
    Language English
    Size 1 electronic resource (232 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030376394
    ISBN 9783036569543 ; 3036569545
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article: Cardio-Renal Metabolic Syndrome: Interdisciplinary Diagnostic Methods.

    Bungau, Simona Gabriela

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: Medical interdisciplinarity in making a correct diagnosis is of the utmost importance for an optimal treatment, which should include both effective therapeutic means (drugs and/or surgery) and the complex aspects (nutrition, lifestyle, rehabilitation, ... ...

    Abstract Medical interdisciplinarity in making a correct diagnosis is of the utmost importance for an optimal treatment, which should include both effective therapeutic means (drugs and/or surgery) and the complex aspects (nutrition, lifestyle, rehabilitation, etc [...].
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13020265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Antioxidant Activity of Essential Oils.

    Tit, Delia Mirela / Bungau, Simona Gabriela

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: In recent few years, the high efficacy of herbal antioxidant products in various diseases has been reported [ ... ]. ...

    Abstract In recent few years, the high efficacy of herbal antioxidant products in various diseases has been reported [...].
    Language English
    Publishing date 2023-02-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12020383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Novel Molecules in Diabetes Mellitus, Dyslipidemia and Cardiovascular Disease.

    Vesa, Cosmin Mihai / Bungau, Simona Gabriela

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: The purpose of this Special Issue is to present the impact in clinical practice as well as in medical research of novel molecules that have been introduced in the treatment of diabetes mellitus, dyslipidaemia, and cardiovascular disease [ ... ]. ...

    Abstract The purpose of this Special Issue is to present the impact in clinical practice as well as in medical research of novel molecules that have been introduced in the treatment of diabetes mellitus, dyslipidaemia, and cardiovascular disease [...].
    MeSH term(s) Humans ; Cardiovascular Diseases ; Diabetes Mellitus, Type 2 ; Dyslipidemias/drug therapy ; Risk Factors
    Language English
    Publishing date 2023-02-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24044029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Nanomedical approaches in the realm of rheumatoid arthritis.

    Radu, Andrei-Flavius / Bungau, Simona Gabriela

    Ageing research reviews

    2023  Volume 87, Page(s) 101927

    Abstract: Rheumatoid arthritis (RA) is a heterogeneous autoimmune inflammatory disorder defined by the damage to the bone and cartilage in the synovium, which causes joint impairment and an increase in the mortality rate. It is associated with an incompletely ... ...

    Abstract Rheumatoid arthritis (RA) is a heterogeneous autoimmune inflammatory disorder defined by the damage to the bone and cartilage in the synovium, which causes joint impairment and an increase in the mortality rate. It is associated with an incompletely elucidated pathophysiological mechanism. Even though disease-modifying antirheumatic drugs have contributed to recent improvements in the standard of care for RA, only a small fraction of patients is able to attain and maintain clinical remission without the necessity for ongoing immunosuppressive drugs. The evolution of tolerance over time as well as patients' inability to respond to currently available therapy can alter the overall management of RA. A significant increase in the research of RA nano therapies due to the possible improvements they may provide over traditional systemic treatments has been observed. New approaches to getting beyond the drawbacks of existing treatments are presented by advancements in the research of nanotherapeutic techniques, particularly drug delivery nano systems. Via passive or active targeting of systemic delivery, therapeutic drugs can be precisely transported to and concentrated in the affected sites. As a result, nanoscale drug delivery systems improve the solubility and bioavailability of certain drugs and reduce dose escalation. In the present paper, we provide a thorough overview of the possible biomedical applications of various nanostructures in the diagnostic and therapeutic management of RA, derived from the shortcomings of conventional therapies. Moreover, the paper suggests the need for improvement on the basis of research directions and properly designed clinical studies.
    MeSH term(s) Humans ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Antirheumatic Agents/therapeutic use ; Antirheumatic Agents/chemistry ; Drug Delivery Systems ; Longitudinal Studies
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2023-04-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2023.101927
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5579: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Antioxidant Activity of Essential Oils

    Tit, Delia Mirela / Bungau, Simona Gabriela

    Antioxidants. 2023 Feb. 05, v. 12, no. 2

    2023  

    Abstract: In recent few years, the high efficacy of herbal antioxidant products in various diseases has been reported [ ... ] ...

    Abstract In recent few years, the high efficacy of herbal antioxidant products in various diseases has been reported [...]
    Keywords antioxidant activity ; antioxidants ; essential oils
    Language English
    Dates of publication 2023-0205
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12020383
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Management of Rheumatoid Arthritis: An Overview.

    Radu, Andrei-Flavius / Bungau, Simona Gabriela

    Cells

    2021  Volume 10, Issue 11

    Abstract: Rheumatoid arthritis (RA) is a multifactorial autoimmune disease of unknown etiology, primarily affecting the joints, then extra-articular manifestations can occur. Due to its complexity, which is based on an incompletely elucidated pathophysiological ... ...

    Abstract Rheumatoid arthritis (RA) is a multifactorial autoimmune disease of unknown etiology, primarily affecting the joints, then extra-articular manifestations can occur. Due to its complexity, which is based on an incompletely elucidated pathophysiological mechanism, good RA management requires a multidisciplinary approach. The clinical status of RA patients has improved in recent years due to medical advances in diagnosis and treatment, that have made it possible to reduce disease activity and prevent systemic complications. The most promising results were obtained by developing disease-modifying anti-rheumatic drugs (DMARDs), the class to which conventional synthetic, biologic, and targeted synthetic drugs belong. Furthermore, ongoing drug development has led to obtaining molecules with improved efficacy and safety profiles, but further research is needed until RA turns into a curable pathology. In the present work, we offer a comprehensive perspective on the management of RA, by centralizing the existing data provided by significant literature, emphasizing the importance of an early and accurate diagnosis associated with optimal personalized treatment in order to achieve better outcomes for RA patients. In addition, this study suggests future research perspectives in the treatment of RA that could lead to higher efficacy and safety profiles and lower financial costs.
    MeSH term(s) Antirheumatic Agents/chemistry ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/pathology ; Arthritis, Rheumatoid/physiopathology ; Arthritis, Rheumatoid/therapy ; Humans ; Models, Biological ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances Antirheumatic Agents ; Protein Kinase Inhibitors
    Language English
    Publishing date 2021-10-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10112857
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Insights into the Medical Evaluation of Ekbom Syndrome: An Overview.

    Mindru, Florina Madalina / Radu, Andrei-Flavius / Bumbu, Adrian Gheorghe / Radu, Ada / Bungau, Simona Gabriela

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: Ekbom syndrome, also known as delusional parasitosis (DP) or delusional infestation, is an uncommon psychiatric disorder distinguished by an enduring conviction of parasitic infestation, persisting notwithstanding the presence of medical evidence to the ... ...

    Abstract Ekbom syndrome, also known as delusional parasitosis (DP) or delusional infestation, is an uncommon psychiatric disorder distinguished by an enduring conviction of parasitic infestation, persisting notwithstanding the presence of medical evidence to the contrary. Primarily affecting middle-aged women, DP can manifest either as isolated psychological distress or as a component within a more intricate psychiatric framework, substantially influencing the quality of life for affected individuals. Its pathophysiological mechanism involves uncertain dopaminergic imbalances and dysfunction in the dopamine transporter system. Dermatologists often play a pivotal role in diagnosis, as patients first seek dermatological assessments of their signs and symptoms. However, DP frequently originates from underlying psychiatric disorders or medical variables, manifesting with neurological and infectious causative factors. The diagnostic complexity is attributed to patients' resolute convictions, leading to delayed psychiatric intervention. First-line DP treatment involves antipsychotics, with newer agents demonstrating promising prospects, but the lack of standardized protocols poses a significant therapeutic challenge. In this narrative review, both a comprehensive approach to this uncommon pathology and an update on the state of knowledge in this medical subfield focused on optimizing the management of DP are provided. The complexity of DP underlying its uncommon nature and the incomplete understanding of its pathophysiology highlight the need for further research through multicenter studies and multidisciplinary teams to enhance therapeutic efficacy and safety.
    MeSH term(s) Middle Aged ; Humans ; Female ; Quality of Life ; Delusional Parasitosis/diagnosis ; Delusional Parasitosis/drug therapy ; Delusional Parasitosis/psychology ; Antipsychotic Agents/therapeutic use ; Dopamine/therapeutic use ; Interdisciplinary Studies
    Chemical Substances Antipsychotic Agents ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2024-02-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25042151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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