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  1. Book ; Thesis: Die Bedeutung der Werkstoffkunde am Beispiel des Amalgams

    Bunse, Marco

    zahntechnische, historische, soziale und ökonomische Einflüsse im 20. Jhdt

    2001  

    Author's details vorgelegt von Marco Bunse
    Language German
    Size 191 S. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Düsseldorf, Univ., Diss., 2001
    HBZ-ID HT013166488
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 D 1289 order for loan Magazin

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  2. Article ; Online: Generation of Redirected Engineered Human Chimeric Antigen Receptor (CAR) T Cells.

    Bunse, Mario / Höpken, Uta E

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2521, Page(s) 67–83

    Abstract: Chimeric antigen receptor (CAR) T cell therapy that involves genetic engineering a patient's own immune cells with antigen-specific receptors has shown remarkable efficacy in blood cancer treatment. Numerous clinical studies with CAR T cells targeting ... ...

    Abstract Chimeric antigen receptor (CAR) T cell therapy that involves genetic engineering a patient's own immune cells with antigen-specific receptors has shown remarkable efficacy in blood cancer treatment. Numerous clinical studies with CAR T cells targeting the blood cell surface protein CD19 led to the FDA 's first approval of a genetically engineered cell therapy. The process of generating potent CAR T cells involves several carefully performed manufacturing steps. Here, we describe the generation of redirected engineered human CAR T cells for preclinical studies starting with the CAR design, retroviral gene transfer, detection of CAR expression, and expansion of transduced T cells.
    MeSH term(s) Antigens, CD19 ; Humans ; Immunotherapy, Adoptive ; Neoplasms ; Receptors, Antigen/genetics ; Receptors, Antigen, T-Cell/metabolism ; Receptors, Chimeric Antigen/metabolism ; T-Lymphocytes
    Chemical Substances Antigens, CD19 ; Receptors, Antigen ; Receptors, Antigen, T-Cell ; Receptors, Chimeric Antigen
    Language English
    Publishing date 2022-06-23
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2441-8_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Mikroanalyse erneuten Alkoholkonsums nach einer umfassenden stationären Entzugsbehandlung bei Alkoholabhängigen

    Bunse, Maria

    1995  

    Author's details vorgelegt von Maria Bunse, geb. Jacobi
    Language German
    Size 70, [33] Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Lübeck, Med. Univ., Diss., 1996
    Note Mikrofiche-Ausg.: 2 Mikrofiches
    HBZ-ID HT007910019
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 MB 1740 order for loan Magazin

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  4. Book ; Online: Regularization-Based Methods for Ordinal Quantification

    Bunse, Mirko / Moreo, Alejandro / Sebastiani, Fabrizio / Senz, Martin

    2023  

    Abstract: Quantification, i.e., the task of training predictors of the class prevalence values in sets of unlabeled data items, has received increased attention in recent years. However, most quantification research has concentrated on developing algorithms for ... ...

    Abstract Quantification, i.e., the task of training predictors of the class prevalence values in sets of unlabeled data items, has received increased attention in recent years. However, most quantification research has concentrated on developing algorithms for binary and multiclass problems in which the classes are not ordered. Here, we study the ordinal case, i.e., the case in which a total order is defined on the set of n>2 classes. We give three main contributions to this field. First, we create and make available two datasets for ordinal quantification (OQ) research that overcome the inadequacies of the previously available ones. Second, we experimentally compare the most important OQ algorithms proposed in the literature so far. To this end, we bring together algorithms proposed by authors from very different research fields, such as data mining and astrophysics, who were unaware of each others' developments. Third, we propose a novel class of regularized OQ algorithms, which outperforms existing algorithms in our experiments. The key to this gain in performance is that our regularization prevents ordinally implausible estimates, assuming that ordinal distributions tend to be smooth in practice. We informally verify this assumption for several real-world applications.

    Comment: 45 pages
    Keywords Computer Science - Machine Learning
    Subject code 006
    Publishing date 2023-10-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: CD19-targeting CAR T cells protect from ANCA-induced acute kidney injury.

    Lodka, Dörte / Zschummel, Maria / Bunse, Mario / Rousselle, Anthony / Sonnemann, Janis / Kettritz, Ralph / Höpken, Uta E / Schreiber, Adrian

    Annals of the rheumatic diseases

    2024  Volume 83, Issue 4, Page(s) 499–507

    Abstract: Objectives: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are life-threatening systemic autoimmune diseases manifesting in the kidneys as necrotizing crescentic glomerulonephritis (NCGN). ANCA antigens are myeloperoxidase ...

    Abstract Objectives: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are life-threatening systemic autoimmune diseases manifesting in the kidneys as necrotizing crescentic glomerulonephritis (NCGN). ANCA antigens are myeloperoxidase (MPO) or proteinase 3. Current treatments include steroids, cytotoxic drugs and B cell-depleting antibodies. The use of chimeric antigen receptor (CAR) T cells in autoimmune diseases is a promising new therapeutic approach. We tested the hypothesis that CAR T cells targeting CD19 deplete B cells, including MPO-ANCA-producing B cells, thereby protecting from ANCA-induced NCGN.
    Methods: We tested this hypothesis in a preclinical MPO-AAV mouse model. NCGN was established by immunisation of MPO
    Results: CD19 CAR T cells efficiently migrated to and persisted in bone marrow, spleen, peripheral blood and kidneys for up to 8 weeks. CD19 CAR T cells, but not control CAR T cells, depleted B cells and plasmablasts, enhanced the MPO-ANCA decline, and most importantly protected from NCGN.
    Conclusion: Our proof-of-principle study may encourage further exploration of CAR T cells as a treatment for ANCA-vasculitis patients with the goal of drug-free remission.
    MeSH term(s) Humans ; Mice ; Animals ; Antibodies, Antineutrophil Cytoplasmic ; Glomerulonephritis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis ; Acute Kidney Injury ; T-Lymphocytes ; Peroxidase
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic ; Peroxidase (EC 1.11.1.7)
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2023-224875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.114: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 167: Show issues

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  6. Article: Ein Name spricht für Heilkraft - Wundklee. (Anthyllis vulneraria L.) und was uns seine Chemie heute verheißt

    Lorenz, P. / Bunse, M. / Stintzing, F. C. / Kammerer, D. R.

    Zeitschrift für Arznei- und Gewürzpflanzen

    2020  Volume 25, Issue 4, Page(s) 148

    Language German ; English
    Document type Article
    ZDB-ID 1353645-X
    ISSN 1431-9292
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 6451: Show issues

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  7. Article: Sonographische Quantifizierung der Wangenschwellung

    Bunse, M.

    Wehrmedizin und Wehrpharmazie

    2008  Volume 32, Issue 2, Page(s) 20

    Language German
    Document type Article
    ZDB-ID 506117-9
    ISSN 0043-2148
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 487: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Insight into the Secondary Metabolites of

    Bunse, Marek / Lorenz, Peter / Stintzing, Florian C / Kammerer, Dietmar R

    Plants (Basel, Switzerland)

    2021  Volume 10, Issue 6

    Abstract: The present study aimed at the identification and quantitation of phenolic compounds, fatty acids, and further characteristic substances in the seeds ... ...

    Abstract The present study aimed at the identification and quantitation of phenolic compounds, fatty acids, and further characteristic substances in the seeds of
    Language English
    Publishing date 2021-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10061219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; Thesis: RNAi-mediated knockdown of the endogenous TCR improves safety of immunotherapy with TCR gene-modified T cells

    Bunse, Mario

    2014  

    Author's details von Mario Bunse
    Language English
    Size Online-Ressource, Ill., graph. Darst.
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Humboldt-Univ., Diss.--Berlin, 2014
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Book ; Online ; Thesis: RNAi-mediated knockdown of the endogenous TCR improves safety of immunotherapy with TCR gene-modified T cells

    Bunse, Mario

    2014  

    Author's details von Mario Bunse
    Language English
    Size Online-Ressource, Ill., graph. Darst.
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Humboldt-Univ., Diss.--Berlin, 2014
    Database Former special subject collection: coastal and deep sea fishing

    Full text online

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