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  1. Article ; Online: Hands-on synthesis of furanamides and evaluation of their antimicrobial activity

    Mercogliano, Marcello / Iesce, Maria Rosaria / Alfieri, Maria Laura / Buommino, Elisabetta / DellaGreca, Marina

    Natural Product Research. 2023 Oct. 18, v. 37, no. 20 p.3484-3491

    2023  

    Abstract: Diverse natural and synthetic furan derivatives have shown biological activity. Here, we describe the preparation of benzyl and arylethyl β-furanamides with OH or OMe aryl substituents by an adapted sustainable method from a furoic acid using methyl ... ...

    Abstract Diverse natural and synthetic furan derivatives have shown biological activity. Here, we describe the preparation of benzyl and arylethyl β-furanamides with OH or OMe aryl substituents by an adapted sustainable method from a furoic acid using methyl chloroformate. Symmetric and asymmetric β,β’-furanamides have instead been prepared using azabenzotriazole based catalyst (HATU). The products have been evaluated for their antimicrobial properties on Gram positive and Gram negative bacteria. Just a minimal not-significant activity has been observed in some derivatives.
    Keywords antimicrobial properties ; catalysts ; furans ; Amidic bond formation ; antimicrobial activity ; furanamides ; organic acids
    Language English
    Dates of publication 2023-1018
    Size p. 3484-3491.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2087220
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Unveiling the modulation of

    Barone, Simona / Mateu, Baptiste / Turco, Luigia / Pelliccia, Sveva / Lembo, Francesca / Summa, Vincenzo / Buommino, Elisabetta / Brindisi, Margherita

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1340585

    Abstract: Bacterial infections represent a key public health issue due to the occurrence of multidrug-resistant bacteria. Recently, the amount of data supporting the dynamic control of epigenetic pathways by environmental cues has triggered research efforts toward ...

    Abstract Bacterial infections represent a key public health issue due to the occurrence of multidrug-resistant bacteria. Recently, the amount of data supporting the dynamic control of epigenetic pathways by environmental cues has triggered research efforts toward the clarification of their role in microbial infections. Among protein post-translational modifications, reversible acetylation is the most implicated in the feedback to environmental stimuli and in cellular homeostasis. Accordingly, the latest studies identified the histone deacetylase 6 (HDAC6) enzyme as a crucial player in the complex molecular machinery underlying bacterial clearance or killing. A very important milestone for the elucidation of the consequence of HDAC6 activity in bacterial infections is herein described, unveiling for the first time the role of a potent HDAC6 inhibitor in interfering with biofilm formation and modulating virulence factors of
    Language English
    Publishing date 2024-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1340585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hands-on synthesis of furanamides and evaluation of their antimicrobial activity.

    Mercogliano, Marcello / Iesce, Maria Rosaria / Alfieri, Maria Laura / Buommino, Elisabetta / DellaGreca, Marina

    Natural product research

    2022  Volume 37, Issue 20, Page(s) 3484–3491

    Abstract: Diverse natural and synthetic furan derivatives have shown biological activity. Here, we describe the preparation of benzyl and arylethyl β-furanamides with OH or OMe aryl substituents by an adapted sustainable method from a furoic acid using methyl ... ...

    Abstract Diverse natural and synthetic furan derivatives have shown biological activity. Here, we describe the preparation of benzyl and arylethyl β-furanamides with OH or OMe aryl substituents by an adapted sustainable method from a furoic acid using methyl chloroformate. Symmetric and asymmetric β,β'-furanamides have instead been prepared using azabenzotriazole based catalyst (HATU). The products have been evaluated for their antimicrobial properties on Gram positive and Gram negative bacteria. Just a minimal not-significant activity has been observed in some derivatives.
    Language English
    Publishing date 2022-06-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2087220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Rejuvenating the [1, 2, 3]-triazolo [1,5-a]quinoxalin-4(5

    Pelliccia, Sveva / Alfano, Antonella Ilenia / Gomes Da Assunção, Beatriz Ramos / Turco, Luigia / Lembo, Francesca / Summa, Vincenzo / Buommino, Elisabetta / Brindisi, Margherita

    Frontiers in chemistry

    2023  Volume 11, Page(s) 1126427

    Abstract: The [1,2,3]-triazolo [1,5-a] quinoxalin-4( ... ...

    Abstract The [1,2,3]-triazolo [1,5-a] quinoxalin-4(5
    Language English
    Publishing date 2023-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2023.1126427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Zooming into Gut Dysbiosis in Parkinson's Disease: New Insights from Functional Mapping.

    Turco, Luigia / Opallo, Nicola / Buommino, Elisabetta / De Caro, Carmen / Pirozzi, Claudio / Mattace Raso, Giuseppina / Lembo, Francesca / Coretti, Lorena

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Gut dysbiosis has been involved in the pathogenesis and progression of Parkinson's disease (PD), but the mechanisms through which gut microbiota (GM) exerts its influences deserve further study. Recently, we proposed a two-hit mouse model of PD in which ... ...

    Abstract Gut dysbiosis has been involved in the pathogenesis and progression of Parkinson's disease (PD), but the mechanisms through which gut microbiota (GM) exerts its influences deserve further study. Recently, we proposed a two-hit mouse model of PD in which ceftriaxone (CFX)-induced dysbiosis amplifies the neurodegenerative phenotype generated by striatal 6-hydroxydopamine (6-OHDA) injection in mice. Low GM diversity and the depletion of key gut colonizers and butyrate producers were the main signatures of GM alteration in this model. Here, we used the phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt2) to unravel candidate pathways of cell-to-cell communication associated with dual-hit mice and potentially involved in PD progression. We focused our analysis on short-chain fatty acids (SCFAs) metabolism and quorum sensing (QS) signaling. Based on linear discriminant analysis, combined with the effect size results, we found increased functions linked to pyruvate utilization and a depletion of acetate and butyrate production in 6-OHDA+CFX mice. The specific arrangement of QS signaling as a possible result of the disrupted GM structure was also observed. With this exploratory study, we suggested a scenario in which SCFAs metabolism and QS signaling might represent the effectors of gut dysbiosis potentially involved in the designation of the functional outcomes that contribute to the exacerbation of the neurodegenerative phenotype in the dual-hit animal model of PD.
    MeSH term(s) Mice ; Animals ; Parkinson Disease/metabolism ; Dysbiosis/metabolism ; Phylogeny ; Oxidopamine ; Butyrates
    Chemical Substances Oxidopamine (8HW4YBZ748) ; Butyrates
    Language English
    Publishing date 2023-06-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Phytochemical Investigation of

    Guzzo, Francesca / Buommino, Elisabetta / Landrum, Leslie / Russo, Rosita / Lembo, Francesca / Fiorentino, Antonio / D'Abrosca, Brigida

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 5

    Abstract: ... Species ... ...

    Abstract Species of
    Language English
    Publishing date 2023-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12051046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Gallomyrtucommulones G and H, New Phloroglucinol Glycosides, from Bioactive Fractions of

    Guzzo, Francesca / Durán, Alexandra G / Sanna, Cinzia / Marasco, Rosangela / Molfetta, Nicola / Buommino, Elisabetta / Fiorentino, Antonio / D'Abrosca, Brigida

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 20

    Abstract: Myrtaceae family is a continuous source of antimicrobial agents. In the search for novel antimicrobial agents ... ...

    Abstract Myrtaceae family is a continuous source of antimicrobial agents. In the search for novel antimicrobial agents against
    MeSH term(s) Myrtus/chemistry ; Phloroglucinol/chemistry ; Staphylococcus aureus ; Staphylococcus ; Glycosides/pharmacology ; Glycosides/analysis ; Microbial Sensitivity Tests ; Plant Leaves/chemistry ; Phytochemicals/pharmacology ; Phytochemicals/analysis ; Anti-Infective Agents/analysis ; Anti-Bacterial Agents/chemistry ; Plant Extracts/chemistry
    Chemical Substances Phloroglucinol (DHD7FFG6YS) ; Glycosides ; Phytochemicals ; Anti-Infective Agents ; Anti-Bacterial Agents ; Plant Extracts
    Language English
    Publishing date 2022-10-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27207109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  8. Article ; Online: Synthesis and antimicrobial properties of guanidine-functionalized labdane type diterpenoids.

    Grinco, Marina / Morarescu, Olga / Lembo, Francesca / Ungur, Nicon / Turco, Luigia / Coretti, Lorena / Carbone, Marianna / Celentano, Carmela / Ciavatta, Maria Letizia / Mollo, Ernesto / Kulcitki, Veaceslav / Buommino, Elisabetta

    European journal of medicinal chemistry

    2023  Volume 264, Page(s) 115981

    Abstract: The occurrence of increased antibiotic resistance has reduced the availability of drugs effective in the control of infectious diseases, especially those caused by various combinations of bacteria and/or fungi that are often associated with poorer ... ...

    Abstract The occurrence of increased antibiotic resistance has reduced the availability of drugs effective in the control of infectious diseases, especially those caused by various combinations of bacteria and/or fungi that are often associated with poorer patient outcomes. In the hunt for novel antibiotics of interest to treat polymicrobial diseases, molecules bearing guanidine moieties have recently come to the fore in designing and optimizing antimicrobial agents. Due to their remarkable antibacterial and antifungal activities, labdane diterpenes are also attracting increasing interest in antimicrobial drug discovery. In this study, six different guanidines prenylated with labdanic fragments were synthesized and evaluated for their antimicrobial properties. Assays were carried out against both non-resistant and antibiotic-resistant bacteria strains, while their possible antifungal activities have been tested on the yeast Candida albicans. Two of the synthesized compounds, namely labdan-8,13(R)-epoxy-15-oyl guanidine and labdan-8,13(S)-epoxy-15-oyl guanidine, were finally selected as the best candidates for further developments in drug discovery, due to their antimicrobial effects on both Gram-negative and Gram-positive bacterial strains, their fungicide action, and their moderate toxicity in vivo on zebrafish embryos. The study also provides insights into the structure-activity relationships of the guanidine-functionalized labdane-type diterpenoids.
    MeSH term(s) Animals ; Humans ; Antifungal Agents/pharmacology ; Guanidine/pharmacology ; Zebrafish ; Anti-Infective Agents/pharmacology ; Anti-Bacterial Agents/pharmacology ; Bacteria ; Diterpenes/pharmacology ; Candida albicans ; Guanidines/pharmacology ; Microbial Sensitivity Tests
    Chemical Substances Antifungal Agents ; Guanidine (JU58VJ6Y3B) ; Anti-Infective Agents ; Anti-Bacterial Agents ; Diterpenes ; Guanidines
    Language English
    Publishing date 2023-12-12
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2023.115981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Plant Derived Natural Products against

    Guzzo, Francesca / Scognamiglio, Monica / Fiorentino, Antonio / Buommino, Elisabetta / D'Abrosca, Brigida

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 21

    Abstract: Bacteria are social organisms able to build complex structures, such as biofilms, that are highly organized surface-associated communities of microorganisms, encased within a self- produced extracellular matrix. Biofilm is commonly associated with many ... ...

    Abstract Bacteria are social organisms able to build complex structures, such as biofilms, that are highly organized surface-associated communities of microorganisms, encased within a self- produced extracellular matrix. Biofilm is commonly associated with many health problems since its formation increases resistance to antibiotics and antimicrobial agents, as in the case of
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/therapeutic use ; Biofilms/drug effects ; Humans ; Phytochemicals/chemistry ; Phytochemicals/therapeutic use ; Pseudomonas aeruginosa/physiology ; Staphylococcus aureus/physiology
    Chemical Substances Anti-Bacterial Agents ; Phytochemicals
    Language English
    Publishing date 2020-10-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25215024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  10. Article: Antimicrobial Activity of a Lipidated Temporin L Analogue against Carbapenemase-Producing

    Roscetto, Emanuela / Bellavita, Rosa / Paolillo, Rossella / Merlino, Francesco / Molfetta, Nicola / Grieco, Paolo / Buommino, Elisabetta / Catania, Maria Rosaria

    Antibiotics (Basel, Switzerland)

    2021  Volume 10, Issue 11

    Abstract: Over the years, the increasing acquisition of antibiotic resistance genes has led to the emergence of highly resistant bacterial strains and the loss of standard antibiotics' efficacy, including β-lactam/β-lactamase inhibitor combinations and the last ... ...

    Abstract Over the years, the increasing acquisition of antibiotic resistance genes has led to the emergence of highly resistant bacterial strains and the loss of standard antibiotics' efficacy, including β-lactam/β-lactamase inhibitor combinations and the last line carbapenems.
    Language English
    Publishing date 2021-10-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics10111312
    Database MEDical Literature Analysis and Retrieval System OnLINE

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