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  1. AU="Buonaguro, Franco Maria"
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  1. Article: Why so much uncertainty about adjuvant HPV vaccines after local treatment? Can the discrepancy between the positive statistical results and the scientific community doubts be solved?

    Giorgi-Rossi, Paolo / Tornesello, Maria Lina / Buonaguro, Franco Maria

    Infectious agents and cancer

    2024  Volume 19, Issue 1, Page(s) 11

    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Editorial
    ZDB-ID 2251117-9
    ISSN 1750-9378
    ISSN 1750-9378
    DOI 10.1186/s13027-024-00572-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Anti-IL6R role in treatment of COVID-19-related ARDS.

    Buonaguro, Franco Maria / Puzanov, Igor / Ascierto, Paolo Antonio

    Journal of translational medicine

    2020  Volume 18, Issue 1, Page(s) 165

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Respiratory Distress Syndrome ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Keywords covid19
    Language English
    Publishing date 2020-04-14
    Publishing country England
    Document type Editorial ; Comment
    ISSN 1479-5876
    ISSN (online) 1479-5876
    DOI 10.1186/s12967-020-02333-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The Role of circRNAs in Human Papillomavirus (HPV)-Associated Cancers.

    Bonelli, Patrizia / Borrelli, Antonella / Tuccillo, Franca Maria / Buonaguro, Franco Maria / Tornesello, Maria Lina

    Cancers

    2021  Volume 13, Issue 5

    Abstract: Circular RNAs (circRNAs) are a new class of "non-coding RNAs" that originate from non-sequential back-splicing of exons and/or introns of precursor messenger RNAs (pre-mRNAs). These molecules are generally produced at low levels in a cell-type-specific ... ...

    Abstract Circular RNAs (circRNAs) are a new class of "non-coding RNAs" that originate from non-sequential back-splicing of exons and/or introns of precursor messenger RNAs (pre-mRNAs). These molecules are generally produced at low levels in a cell-type-specific manner in mammalian tissues, but due to their circular conformation they are unaffected by the cell mRNA decay machinery. circRNAs can sponge multiple microRNAs or RNA-binding proteins and play a crucial role in the regulation of gene expression and protein translation. Many circRNAs have been shown to be aberrantly expressed in several cancer types, and to sustain specific oncogenic processes. Particularly, in virus-associated malignancies such as human papillomavirus (HPV)-associated anogenital carcinoma and oropharyngeal and oral cancers, circRNAs have been shown to be involved in tumorigenesis and cancer progression, as well as in drug resistance, and some are useful diagnostic and prognostic markers. HPV-derived circRNAs, encompassing the HPV E7 oncogene, have been shown to be expressed and to serve as transcript for synthesis of the E7 oncoprotein, thus reinforcing the virus oncogenic activity in HPV-associated cancers. In this review, we summarize research advances in the biogenesis of cell and viral circRNAs, their features and functions in the pathophysiology of HPV-associated tumors, and their importance as diagnostic, prognostic, and therapeutic targets in anogenital and oropharyngeal and oral cancers.
    Language English
    Publishing date 2021-03-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13051173
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Anti-IL6R role in treatment of COVID-19-related ARDS

    Buonaguro, Franco Maria / Puzanov, Igor / Ascierto, Paolo Antonio

    Journal of Translational Medicine

    2020  Volume 18, Issue 1

    Keywords General Biochemistry, Genetics and Molecular Biology ; General Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ISSN 1479-5876
    DOI 10.1186/s12967-020-02333-9
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Anti-IL6R role in treatment of COVID-19-related ARDS

    Buonaguro, Franco Maria / Puzanov, Igor / Ascierto, Paolo Antonio

    Journal of translational medicine, 18(1):165

    2020  

    Keywords Tocilizumab ; COVID-19 ; ARDS ; SARS-CoV-2 ; IL-6 ; covid19
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Telomerase: a good target in hepatocellular carcinoma? An overview of relevant preclinical data.

    Tornesello, Maria Lina / Tornesello, Anna Lucia / Starita, Noemy / Cerasuolo, Andrea / Izzo, Francesco / Buonaguro, Luigi / Buonaguro, Franco Maria

    Expert opinion on therapeutic targets

    2022  Volume 26, Issue 9, Page(s) 767–780

    Abstract: Introduction: The expression of telomerase reverse transcriptase (TERT) in liver is restricted to rare cells, that are able to replace senescent hepatocytes and regenerate tissue in response to hepatic damage, while becoming extinguished in ... ...

    Abstract Introduction: The expression of telomerase reverse transcriptase (TERT) in liver is restricted to rare cells, that are able to replace senescent hepatocytes and regenerate tissue in response to hepatic damage, while becoming extinguished in differentiated progeny cells. TERT gene is permanently activated in liver neoplasms from the very early stage of the hepatocarcinogenesis mainly through the accumulation of genetic alterations, virus-related insertional mutagenesis and somatic mutations in the TERT promoter region. Several lines of evidence suggest that telomerase, beyond the canonical function of telomeres elongation, has multiple oncogenic activities in cancer cells and may represent a promising therapeutic target in hepatocellular carcinoma (HCC).
    Areas covered: We review the mechanisms of activation of telomerase in HCC, the canonical and non-canonical functions of TERT as well as experimental strategies to directly target telomerase or to inhibit pathways associated with telomerase activity.
    Expert opinion: TERT holoenzyme and telomerase components represent promising therapeutic targets in the treatment of liver malignancies. Several chemical agents and natural products known to alter telomerase activity are under evaluation for their potency to inhibit telomeres attrition in cirrhosis and TERT function in liver cancer. Therefore, this review outlines the current strategies pursued to suppress the multiple mechanisms of the major telomerase components in liver cancer.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Telomerase/genetics ; Telomerase/metabolism ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Telomere/metabolism
    Chemical Substances Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2022-11-18
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2022.2147062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5244: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Antimicrobial Peptides as Anticancer Agents: Functional Properties and Biological Activities.

    Tornesello, Anna Lucia / Borrelli, Antonella / Buonaguro, Luigi / Buonaguro, Franco Maria / Tornesello, Maria Lina

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 12

    Abstract: Antimicrobial peptides (AMPs), or host defense peptides, are small cationic or amphipathic molecules produced by prokaryotic and eukaryotic organisms that play a key role in the innate immune defense against viruses, bacteria and fungi. AMPs have either ... ...

    Abstract Antimicrobial peptides (AMPs), or host defense peptides, are small cationic or amphipathic molecules produced by prokaryotic and eukaryotic organisms that play a key role in the innate immune defense against viruses, bacteria and fungi. AMPs have either antimicrobial or anticancer activities. Indeed, cationic AMPs are able to disrupt microbial cell membranes by interacting with negatively charged phospholipids. Moreover, several peptides are capable to trigger cytotoxicity of human cancer cells by binding to negatively charged phosphatidylserine moieties which are selectively exposed on the outer surface of cancer cell plasma membranes. In addition, some AMPs, such as LTX-315, have shown to induce release of tumor antigens and potent damage associated molecular patterns by causing alterations in the intracellular organelles of cancer cells. Given the recognized medical need of novel anticancer drugs, AMPs could represent a potential source of effective therapeutic agents, either alone or in combination with other small molecules, in oncology. In this review we summarize and describe the properties and the mode of action of AMPs as well as the strategies to increase their selectivity toward specific cancer cells.
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/therapeutic use ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Humans ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Oligopeptides/chemistry ; Oligopeptides/therapeutic use ; Pore Forming Cytotoxic Proteins/chemistry ; Pore Forming Cytotoxic Proteins/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Antineoplastic Agents ; LTX-315 ; Oligopeptides ; Pore Forming Cytotoxic Proteins
    Keywords covid19
    Language English
    Publishing date 2020-06-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25122850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  9. Article ; Online: The Role of Circulating Free DNA and MicroRNA in Non-Invasive Diagnosis of HBV- and HCV-Related Hepatocellular Carcinoma.

    Pezzuto, Francesca / Buonaguro, Luigi / Buonaguro, Franco Maria / Tornesello, Maria Lina

    International journal of molecular sciences

    2018  Volume 19, Issue 4

    Abstract: Hepatocellular carcinoma (HCC) is the third and the fifth leading cause of cancer related death worldwide in men and in women, respectively. HCC generally has a poor prognosis, with a very low 5-year overall survival, due to delayed diagnosis and ... ...

    Abstract Hepatocellular carcinoma (HCC) is the third and the fifth leading cause of cancer related death worldwide in men and in women, respectively. HCC generally has a poor prognosis, with a very low 5-year overall survival, due to delayed diagnosis and treatment. Early tumour detection and timely intervention are the best strategies to reduce morbidity and mortality in HCC patients. Histological evaluation of liver biopsies is the gold standard for cancer diagnosis, although it is an invasive, time-consuming and expensive procedure. Recently, the analysis of circulating free DNA (cfDNA) and RNA molecules released by tumour cells in body fluids, such as blood serum, saliva and urine, has attracted great interest for development of diagnostic assays based on circulating liver cancer molecular biomarkers. Such "liquid biopsies" have shown to be useful for the identification of specific molecular signatures in nucleic acids released by cancer cells, such as gene mutations and altered methylation of DNA as well as variations in the levels of circulating microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Body fluids analysis may represent a valuable strategy to monitor liver disease progression in subjects chronically infected with hepatitis viruses or cancer relapse in HCC treated patients. Several studies showed that qualitative and quantitative assays evaluating molecular profiles of circulating cell-free nucleic acids could be successfully employed for early diagnosis and therapeutic management of HCC patients. This review describes the state of art on the use of liquid biopsy for cancer driver gene mutations, deregulated DNA methylation as well as miRNA levels in HCC diagnosis.
    MeSH term(s) Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/therapy ; Circulating MicroRNA/blood ; Circulating Tumor DNA/blood ; Disease-Free Survival ; Hepatitis B/blood ; Hepatitis B/mortality ; Hepatitis B/therapy ; Hepatitis C/blood ; Hepatitis C/mortality ; Hepatitis C/therapy ; Humans ; Liver Neoplasms/blood ; Liver Neoplasms/mortality ; Liver Neoplasms/therapy ; RNA, Neoplasm/blood ; Survival Rate
    Chemical Substances Circulating MicroRNA ; Circulating Tumor DNA ; RNA, Neoplasm
    Language English
    Publishing date 2018-03-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms19041007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Clinical Significance of Telomerase Reverse-Transcriptase Promoter Mutations in Hepatocellular Carcinoma.

    Pezzuto, Francesca / Izzo, Francesco / De Luca, Pasquale / Biffali, Elio / Buonaguro, Luigi / Tatangelo, Fabiana / Buonaguro, Franco Maria / Tornesello, Maria Lina

    Cancers

    2021  Volume 13, Issue 15

    Abstract: Telomerase reactivation during hepatocarcinogenesis is recurrently caused by two point mutations occurring most frequently at the nucleotide -124 (95%) and occasionally at the nucleotide -146 (<5%) upstream of the TERT translational start site in ... ...

    Abstract Telomerase reactivation during hepatocarcinogenesis is recurrently caused by two point mutations occurring most frequently at the nucleotide -124 (95%) and occasionally at the nucleotide -146 (<5%) upstream of the TERT translational start site in hepatocellular carcinoma (HCC). In this study, we designed a droplet digital PCR (ddPCR) assay to detect TERT promoter (TERTp) nucleotide change G>A at position -124 and to quantify the mutant allele frequency (MAF) in 121 primary liver cancers, including 114 HCC along with 23 autologous cirrhotic tissues, five cholangiocarcinoma (CC), and two hepato-cholangiocarcinoma (HCC-CC). All cases were evaluated for tumour markers such as α-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA). We compared the sensitivity of ddPCR and Sanger sequencing and investigated the prognostic relevance of TERTp mutations. The TERTp G>A transition was identified in 63.6% and 52.1% of HCC samples by ddPCR and Sanger sequencing, respectively. One out of 23 (4.3%) peri-tumour tissues tested positive only by ddPCR. One out of five CC (20%) and none of the HCC-CC were found concordantly mutated by the two methods. The TERTp MAF ranged from 2% to 66%, and the large majority (85.5%) of mutated samples showed a value above 20%. A statistically significant correlation was found between TERTp mutation and tumour size (
    Language English
    Publishing date 2021-07-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13153771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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